DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and col1a1b

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_958886.1	Gene:	col1a1b / 325675	ZFINID:	ZDB-GENE-030131-4400	Length:	1449	Species:	Danio rerio

Alignment Length:	1453	Identity:	572/1453 - (39%)
Similarity:	672/1453 - (46%)	Gaps:	291/1453 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLYAAVIAGALVGA---DAQFWKTAGTAGSIQDSVKHYN-----RNEP-KFPIDDSYDIV----- 58
            ||.|||:. |:.|.   |..|       ||.....::||     :.|| :..:.||..::
Zfish    11 LLLAAVVL-AVRGQGEDDISF-------GSCTLEGQNYNDKDVWKPEPCQICVCDSGTVMCDEVI 67

  Fly    59 --DSAGVARGDLPPKNCTAGYAGCVPKCIAEKGNRGLPGPLGPTGLKGEMGFPGMEGPSGDKGQK 121
              |::..|..::|...|      | |.|..|:.......|...|
Zfish    68 CEDTSDCANPEIPDGEC------C-PICPDEEVTAAPEPPYVDT--------------------- 104

  Fly   122 GDPGPYGQRGDKGERGSPGLHGQAGVPGVQGPAGNPGAPGING------------KDGCDGQDGI 174
              .||.|.|||.|..|.||..|..|..|:.||.|.||..|:.|            |.....|.|.
Zfish   105 --VGPAGPRGDPGPVGPPGRDGTPGENGLPGPPGPPGTSGLGGGSFLSQMAYGSEKSSGPPQPGP 167

  Fly   175 PGLEGLSGMPGPRGYAGQLGSKGEKGEPAKENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERG 239
            ||..|..|:|||.|..|..|..|..|||            ||||..|..|..||.|.||:.||.|
Zfish   168 PGPMGPRGLPGPAGSPGPQGFTGPPGEP------------GEPGAPGPMGSRGPPGPPGKNGEDG 220

  Fly   240 DSGPYGAKGPRGEHGLKGEKGASCYGPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPRGDMGQKG 304
            ::|..|..|.||..|.:|.:|.    |..||.|||||.:|.|.          :.|.:||.|..|
Zfish   221 EAGKAGRPGERGAAGPQGARGF----PGTPGLPGIKGHRGFPG----------LDGAKGDAGIAG 271

  Fly   305 EPGLVGRKGEPGPEGDTGLDGQKGEKGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGNP 369
            ..|..|..||.|..|..|..|..||:|.||.||..|.:||.|..|:.|..|..|..|..|.||..
Zfish   272 PKGEAGSPGEAGTPGAMGARGLPGERGRPGPPGPSGARGNDGNTGAAGPPGPTGPAGPPGFPGGA 336

  Fly   370 GQKGEPGRAGATGKPGLLGPPGPPGGGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNG 434
            |.|||.|.||..|..   ||.||    ||.||.|||      .||.||.|..|.||.||.:|..|
Zfish   337 GAKGETGAAGGRGSE---GPQGP----RGEPGNPGP------AGAAGPAGGPGSDGTPGGKGSPG 388

  Fly   435 QKGGAGLPGRPGNEGP---------PGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQKGDAGLP 490
            ..|.||.||.||..||         ||.||..|..||.||||..||.|.|||.||:|..|:||..
Zfish   389 AAGIAGAPGFPGARGPPGPAGPNGAPGPKGNNGDPGLQGPKGDAGPKGEPGPVGPQGLAGNAGEE 453

  Fly   491 G-YGIQGSKGDAGIPGYPGLKGSKGERGFKGNAGAPGDSKLGRPGTPGA---AGAPGQKGDAGRP 551
            | .|.:|..|.||..|.||.:|:.|.||..|:.||||  .||.||..||   .||.|..|::|||
Zfish   454 GKRGARGEPGAAGPVGPPGARGAPGNRGLPGSDGAPG--PLGAPGERGANGPMGAQGASGESGRP 516

  Fly   552 GTPGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGLPGIPGKDGARGPPGERGYPGERGHDGINGQ 616
            |.||..|..|:.|..|......:|||.|..|..|.||.||..|:||.||..|:||.:|.|   |:
Zfish   517 GEPGLPGSKGMTGAPGSPGPDGKAGPSGAPGQDGRPGPPGPAGSRGAPGVMGFPGPKGTD---GE 578

  Fly   617 TGPPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGAEGLPGIPG 681
            :|.|||:|..|.||..||   |||            .||.|.|||||..|          |.  |
Zfish   579 SGKPGERGLAGPTGPLGA---PGK------------DGDIGSPGAPGPAG----------PA--G 616

  Fly   682 PKGEFGFKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKG 746
            .|||.|..|..|..|.||..|..|..|:.|..|:||::        |..|..|.:|..|..||:|
Zfish   617 EKGEQGSAGPSGFQGLPGAQGATGETGKPGEQGLPGEA--------GPSGPSGPRGDRGFPGERG 673

  Fly   747 EPGSCALDEIKMPAKGNKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGP---QGPPGVEGPRGL 808
            .||         |.    |..|..|.||.||.||:.||.|..|..|..||   ||.||..|..|:
Zfish   674 APG---------PG----GPTGPRGAPGSPGNDGAKGEPGAAGANGGVGPAGMQGMPGERGAGGM 725

  Fly   809 NGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPG-ISRPGPMGPPGLNGLQGEKGDRG 872
            .|.||::|:.|..|..|.|||||:||:.|..|.|||.|.|| ...||.:|||||
Zfish   726 PGARGDRGDGGPKGPDGAPGKDGVRGMTGPIGPPGPSGAPGDKGEPGAVGPPGL----------- 779

  Fly   873 PTGPIGFPGADGSVGYPGDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGIDGVRGRD 937
             |||.|.||..|.||.||..|.||.||.:|:||..||.||.||.|.||..||.|..|..|.:|..
Zfish   780 -TGPRGGPGERGEVGAPGPAGFAGPPGGNGQPGAKGETGDSGPKGDAGAPGPAGPVGASGPQGPA 843

  Fly   938 GAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGN 1002
            ||.|..|:.|..|.||..|..||.|..||.|.:|.:|.||..||||..|..||:|:||..|..|.
Zfish   844 GATGPKGARGGAGPPGATGFPGAAGRVGPPGPSGASGPPGPTGPAGKEGQRGARGEKGPAGRPGE 908

  Fly  1003 DGPVGGRGPPGAPGLMGIKGDQGLAGAP------GQQGLDGMPGEKGNQGFPGLDGPPGLPGDAS 1061
            .|..|..||.|..|..|..|..||||||      |.:|:.|:||::|.:||.||.||.|.|
Zfish   909 AGAAGPPGPSGERGSPGPDGPLGLAGAPGPPGVIGSRGIVGLPGQRGERGFGGLAGPSGEP---- 969

  Fly  1062 EKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHGRAGPPGEKGDQGRSGIDGRDGINGEKG 1126
                 |:.||||..|:.||.|..|.||..|.||.|        |.:|:.|..|:.||||..|.||
Zfish   970 -----GKQGPSGPVGERGPPGPMGPPGLSGAPGEA--------GREGNPGHDGVSGRDGPPGPKG 1021

  Fly  1127 EQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYPGDRGDKGEPGLSGLPGLKGET 1191
            ::         ||.|:.|.||.||||         ||||.:|..|..||:||.|.:| |.  |.:
Zfish  1022 DR---------GESGNSGPPGAPGAP---------GAPGPIGPSGKTGDRGEAGPAG-PA--GPS 1065

  Fly  1192 GPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGERGYTGEKGEQGERGLTGPAGVAG 1256
            ||.|.:|..|..||:|:|                      ||.|..||:|.:|.|||:|..||
Zfish  1066 GPAGARGALGPAGPRGDR----------------------GEAGEAGERGMKGHRGLSGMPGV-- 1106

  Fly  1257 AKGDRGLQGPPGASGLNGIPGAKGDIGPRGEIGYPGVTIKGEKGLPGRPGRNGRQGLIGAPGLIG 1321
                   .||||.||..|..||.|..||||.        .|..|.||:.|.||..|.:|.||..|
Zfish  1107 -------PGPPGTSGEQGPAGATGPAGPRGP--------AGSNGSPGKDGMNGVPGPVGPPGPRG 1156

  Fly  1322 ERGLPGLAGEPGLVGLPGPIGPAGSKGERGLAGSPGQPGQDGFPGAPGLKGDTGPQGFKGERGLN 1386
            ..|..|.||.|   |||||.||.||.|       ||:|    |...|  :.:.||...:|
Zfish  1157 RSGEMGPAGAP---GLPGPPGPPGSAG-------PGEP----FLPMP--QQEKGPDPLRG----- 1200

  Fly  1387 GFEGQKGDKGDRGLQGPSGLPGL 1409
            |:........||..:..:.|..|
Zfish  1201 GYRADDASVRDRDSEVDTSLKSL 1223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	18/56 (32%)
		Collagen	322..380	CDD:189968	27/57 (47%)
		Collagen	413..465	CDD:189968	28/60 (47%)
		Collagen	499..561	CDD:189968	32/64 (50%)
		Collagen	574..632	CDD:189968	29/57 (51%)
		Collagen	657..714	CDD:189968	22/56 (39%)
		Collagen	765..824	CDD:189968	28/61 (46%)
		Collagen	854..911	CDD:189968	27/56 (48%)
		Collagen	884..943	CDD:189968	31/58 (53%)
		Collagen	923..982	CDD:189968	26/58 (45%)
		Collagen	1028..1085	CDD:189968	26/62 (42%)
		Collagen	1229..1287	CDD:189968	26/57 (46%)
		Collagen	1318..1376	CDD:189968	22/57 (39%)
		Collagen	1399..1458	CDD:189968	2/11 (18%)
		Collagen	1477..1534	CDD:189968
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
col1a1b	NP_958886.1	VWC	33..88	CDD:214564	12/61 (20%)
		Collagen	223..282	CDD:189968	26/72 (36%)
		Collagen	433..491	CDD:189968	30/59 (51%)
		Collagen	463..522	CDD:189968	31/60 (52%)
		Collagen	511..582	CDD:189968	33/73 (45%)
		Collagen	617..667	CDD:189968	20/57 (35%)
		Collagen	898..957	CDD:189968	25/58 (43%)
		Collagen	1066..1137	CDD:189968	38/109 (35%)
		COLFI	1215..1448	CDD:279718	2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900