DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and Col7a1

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_001100328.2	Gene:	Col7a1 / 301012	RGDID:	1311417	Length:	2944	Species:	Rattus norvegicus

Alignment Length:	1752	Identity:	728/1752 - (41%)
Similarity:	867/1752 - (49%)	Gaps:	359/1752 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LVGADAQFWKTAGTAGSIQDSVKHYNRNEPKFPIDDSYDIVDSAGVARGDLPPKNCTAGYA---- 78
            |||||.:..:.....   .|.::.:      |.:|:..|: |.||   .||....|.|..|
  Rat  1193 LVGADPEQLRLLAPG---MDPIQTF------FAVDNGLDL-DRAG---SDLAVALCQAAVAIQPQ 1244

  Fly    79 --GCVPKCIAEKGNRGLPGPLGPTGLKGEMGFPGMEGPSGDKGQKGDPGPYGQRGDKGERGSPG- 140
              .|...|              |.|.|||   ||:.||.|..|..|.||..|:.|..|.:|:||
  Rat  1245 LEPCAVPC--------------PKGQKGE---PGVTGPQGQAGPPGPPGLPGRTGAPGPQGAPGS 1292

  Fly   141 --LHGQAGVPGVQGPAGNPGAPGINGKDGCDGQDGIPGLEGLSGMPGPRGYAGQLGSKGEKGEPA 203
              ..|:.|.||.:||.|:||.||:.|.         ||::|..|..||||..|:.|.:|.||||
  Rat  1293 TQAKGERGFPGPEGPPGSPGLPGVPGS---------PGVKGSPGWSGPRGDRGERGPQGPKGEP- 1347

  Fly   204 KENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKGPRGEHGLKGEKGASCYGPMK 268
                       ||||  ...| .|..|.||:||:.|.|||.|..||.|:.|.:|          .
  Rat  1348 -----------GEPG--QVIG-GGRPGLPGKKGDPGPSGPPGPHGPLGDPGPRG----------P 1388

  Fly   269 PGAPG--IKGEKGEPASSFPVKPTHTVMGPRGDMGQKGEPGLVGRKGEPGPEGDTGLDGQKGEK- 330
            ||.||  :||:||:.....|       .||.....::|.|||.|..|.|||:|..|..|:||||
  Rat  1389 PGLPGTSVKGDKGDRGERGP-------PGPGTGASEQGSPGLPGLPGSPGPQGPPGRTGEKGEKG 1446

  Fly   331 -------GLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGNPGQKGEPGRAGATGKPGLLG 388
                   ||||.||..|..|..|.||.||.||||   ||.|.||.||:|||.|..|..|..||.|
  Rat  1447 DCEDGGPGLPGQPGVPGEPGLRGAPGVTGPKGDR---GLTGTPGEPGEKGERGPPGPVGPQGLPG 1508

  Fly   389 PPGPPG--GGRGTPGPPGPKGPRGYVGAP----------GPQGLNGVDGLPGPQGYNGQKGGAGL 441
            ..|.||  |..|.|||||.:|.:|..|.|          |.:|..|..|||||:|.:|.||..|.
  Rat  1509 AAGRPGVEGPEGPPGPPGRRGEKGEPGRPGDPALGPGGAGAKGEKGDAGLPGPRGASGIKGEQGA 1573

  Fly   442 PG--RPGNEGPPGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQKGDAGLPG-------YGIQGS 497
            ||  .||:.||.|..|::|..||.   |..||.|..||||.:|:.|..|.||       .|..|.
  Rat  1574 PGLALPGDPGPKGDPGDRGPIGLT---GRAGPTGDSGPPGEKGEPGRPGSPGPVGPRGRDGEAGE 1635

  Fly   498 KGDAGIPGYPGLKGSKGERGF------------KGNAGAPGDSKLGRPGTPGAAGAPGQKGDAGR 550
            |||.|.||.|||.|..||||.            |||.|.||:.  ||.||||.:|..|.:|:.|.
  Rat  1636 KGDEGAPGEPGLPGKAGERGLRGAPGPRGPVGEKGNEGDPGED--GRNGTPGPSGPKGDRGEPGP 1698

  Fly   551 PGTPGQKGDMGI----KGDVGGKCSSCRAGPKGDKGTSGLPGIPGK---DGARGPPGERGYPGER 608
            ||.||:..|..:    ||:.|      :.||:|.||..|.||..|:   ||.|||||.:|.||.|
  Rat  1699 PGLPGRLVDAALESRDKGEPG------QEGPRGPKGDPGPPGASGERGIDGLRGPPGPQGDPGVR 1757

  Fly   609 GHDGINGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLS---------LIEPLKGDKGYPGAPGA 664
            |..|..|..|.|   |.|||.||.|..|.||.|.|...|         .:..|:|:.|.||.||.
  Rat  1758 GPAGDKGDRGSP---GLDGRNGLDGKPGAPGPPGLHGASGKAGDPGRDGLPGLRGEHGPPGPPGP 1819

  Fly   665 KGVQGFKGAEGLPGI------PGPKGEFGFKGEKGLSGAPGND---------GTPGRAGRDGYPG 714
            .||.|..|.:|.||:      ||..||.|.|||||.||.||.:         |.||..|..|.||
  Rat  1820 PGVPGKPGDDGKPGLNGKNGEPGDPGEDGRKGEKGDSGVPGREGPDGPKGERGAPGNPGLQGPPG 1884

  Fly   715 IPGQ---SIKGEPGFHGRDGAKGDKGSFGRSGE---------KGEPGSCALDE-------IKMPA 760
            :|||   ..:|.||..|..|.|||:|..|..||         :|||||....|       ||:.|
  Rat  1885 LPGQVGPPGQGFPGVPGVTGPKGDRGETGSKGEQGLPGERGLRGEPGSLPNAERFLETAGIKVSA 1949

  Fly   761 ----------------------KGNKGEPGQTGMPGPPGEDGS---PGERGYTGLKGNTGPQGPP 800
                                  :|.||:||.   |||||::||   |||||..|.:|:.||||||
  Rat  1950 LREIVDTWGESSGSFLLVPERRQGPKGDPGD---PGPPGKEGSIGLPGERGLKGERGDPGPQGPP 2011

  Fly   801 GVE-GPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGE------------PGI-- 850
            |:. |.||..||.|..|..|..|:||.||:.|..|..||.|:.|.|||            ||:
  Rat  2012 GLALGERGPPGPSGLAGEPGKPGIPGLPGRAGAAGEAGRPGERGERGEKGERGEQGRDGHPGLPG 2076

  Fly   851 --SRPGP--------------MGPPGLNGLQGEKGD---RGPTGPIGFPGADGSVGYPGDRGDAG 896
              ..|||              .|||||.|.:||.|.   .||.|..|.||..|..|.||.||..|
  Rat  2077 PPGPPGPKVAIEELGPGPAREQGPPGLKGAKGEPGSDGVPGPKGDRGVPGIKGDAGEPGKRGPDG 2141

  Fly   897 LPGV---------SGRPGIVGEKGDVGPIGPAGVAGPPGVPGI---DGVRGRDGAKGEPGS---P 946
            .||:         .|:||:.|.:|..||:|..|..||||.||:   .|.:|..|.|||||.   |
  Rat  2142 NPGLPGERGVSGPEGKPGLQGPRGTPGPVGSHGDPGPPGAPGLAGPAGPQGPSGLKGEPGETGPP 2206

  Fly   947 GLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGP 1011
            |. |:||..|..|.||..||.|..|..|:||..|..   |.:|..|..|..|.:|.||..||.|.
  Rat  2207 GR-GLPGPTGAVGLPGPPGPSGLVGPQGSPGLPGQV---GETGKPGPPGRDGSSGKDGERGGPGV 2267

  Fly  1012 PGAPGL---MGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSG 1073
            ||.|||   :|.||:.|..|||||. :.|.||.||.:|.|| |....|.|:...||.:|.|||.|
  Rat  2268 PGLPGLPGPVGPKGEPGPVGAPGQV-VVGPPGAKGEKGAPG-DLAGALLGEPGAKGDRGLPGPRG 2330

  Fly  1074 LRGDTGPAGTPGWPGE------------KGLPGLAVH---GRAGPPGEKGDQGRSGIDGRDGING 1123
            .:|:.|.||.||.|||            ||.||:.|.   |.:||||.|||.|..|..|..||.|
  Rat  2331 EKGEAGHAGEPGDPGEDGQKGAPGLKGLKGEPGIGVQGPPGPSGPPGMKGDLGPPGAPGAPGIVG 2395

  Fly  1124 EKGEQGLQGVWGQP---GEKGSVGAPGIPGAP---GMDGLPGAAGAPGAVGYPGDRGDKGEPGLS 1182
            ..|:.|.:|..|||   ||:|..|.||..|||   |..|.||:.|||||.|:.||:||.|    :
  Rat  2396 FPGQPGPRGETGQPGPVGERGLAGPPGREGAPGPLGPPGPPGSVGAPGASGFKGDKGDSG----A 2456

  Fly  1183 GLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGERGYTGEKGEQGERG 1247
            ||||.:||.|..||:|..|.||.:|.||:.|.||       .||::|.:|:.|..|.||::|:..
  Rat  2457 GLPGPRGERGEPGLRGEDGHPGQEGPRGLMGPPG-------SRGERGEKGDPGAAGLKGDKGDSA 2514

  Fly  1248 -LTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGDIGPRGEIGYPGVTIKGEKGLPGRPGRNGRQ 1311
             :.||||..|||||.|.:||.|..         ||.|||||.|.|     |:||..|.||..
  Rat  2515 VIEGPAGPRGAKGDMGERGPRGID---------GDQGPRGESGDP-----GDKGSKGEPGDK--- 2562

  Fly  1312 GLIGAPGLIGERGLPGLAGEPGLVGLPGPIGPAGSKGERGLAGSPGQPGQDGFPGAPGLKGD--- 1373
               |:.|..|.|||.|..||||..|:|               |.||.||:||.||..|.|||
  Rat  2563 ---GSAGSTGVRGLTGPKGEPGAAGIP---------------GEPGAPGKDGAPGFRGDKGDIGF 2609

  Fly  1374 TGPQGFKGERGLNGFEGQKGDKGDRGLQGPSGLPGLVGQKGDTGYPGLNGNDGPVGAPGERGFTG 1438
            |||:|.|||||:.|..|:.|:|||:|..|..|.|||.|:|||.|.||:.|..   ||||:.|..|
  Rat  2610 TGPRGLKGERGVKGTCGRDGEKGDKGEAGFPGRPGLSGKKGDMGDPGIPGQS---GAPGKEGLIG 2671

  Fly  1439 PKGRDGRDGTPGLPGQKGEPGMLPPPGPKGEPGQPGRNGPKGEPGRPGERGLIGIQGERGEKGER 1503
            |||..|.||..|..|.:||.|...|||..|.||..|.:|..|.||.||..|..|.:|.:|:||||
  Rat  2672 PKGDRGFDGQSGPKGDQGEKGERGPPGVGGFPGPRGNDGSSGPPGPPGSIGPKGPEGLQGQKGER 2736

  Fly  1504 GLIGETGNVGRPGPKGDRGEPGERGYEGAIGLIGQKGEPGAPAPAAL--DYLTGILITRHSQ 1563
            |..||: .||.||..|..||.||:|..|..|..|:|||      |||  |.:.|.:....||
  Rat  2737 GPPGES-VVGAPGAPGTPGERGEQGRPGPAGPRGEKGE------AALTEDDIRGFVRQEMSQ 2791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	26/59 (44%)
		Collagen	322..380	CDD:189968	34/65 (52%)
		Collagen	413..465	CDD:189968	26/63 (41%)
		Collagen	499..561	CDD:189968	34/73 (47%)
		Collagen	574..632	CDD:189968	30/60 (50%)
		Collagen	657..714	CDD:189968	31/71 (44%)
		Collagen	765..824	CDD:189968	33/62 (53%)
		Collagen	854..911	CDD:189968	30/82 (37%)
		Collagen	884..943	CDD:189968	29/70 (41%)
		Collagen	923..982	CDD:189968	31/64 (48%)
		Collagen	1028..1085	CDD:189968	27/56 (48%)
		Collagen	1229..1287	CDD:189968	25/58 (43%)
		Collagen	1318..1376	CDD:189968	26/60 (43%)
		Collagen	1399..1458	CDD:189968	29/58 (50%)
		Collagen	1477..1534	CDD:189968	28/56 (50%)
		C4	1555..1662	CDD:128421	3/9 (33%)
		C4	1663..1777	CDD:128421
Col7a1	NP_001100328.2	vWA_collagen_alphaI-XII-like	38..202	CDD:238759
		fn3	236..318	CDD:394996
		fn3	334..406	CDD:394996
		fn3	427..488	CDD:394996
		FN3	510..589	CDD:238020
		FN3	599..681	CDD:238020
		FN3	688..772	CDD:238020
		fn3	778..856	CDD:394996
		fn3	868..935	CDD:394996
		FN3	959..1045	CDD:238020
		VWA	1055..1223	CDD:395045	8/38 (21%)
		PRK07764	<1509..1714	CDD:236090	88/209 (42%)
		Collagen	1580..1635	CDD:396114	22/57 (39%)
		Collagen	1613..1668	CDD:396114	21/54 (39%)
		Collagen	1839..1894	CDD:396114	24/54 (44%)
		Collagen	1878..1932	CDD:396114	22/53 (42%)
		PHA03169	2053..>2202	CDD:223003	55/148 (37%)
		Collagen	2102..2158	CDD:396114	22/55 (40%)
		Collagen	2315..2363	CDD:396114	19/47 (40%)
		PRK12678	2403..>2636	CDD:237171	125/278 (45%)
		Collagen	2457..2511	CDD:396114	27/60 (45%)
		Collagen	2533..2589	CDD:396114	32/90 (36%)
		Collagen	2611..2666	CDD:396114	31/57 (54%)
		Collagen	2728..2774	CDD:396114	25/52 (48%)
		KU	2877..2932	CDD:238057
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349626
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740