Protein Alignment Col4a1 and Col17a1

DIOPT Version :10

• Sequence 1: NP_723044.1
• Gene: Col4a1 / 33727
• FlyBaseID: FBgn0000299
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_001402769.1
• Gene: Col17a1 / 294027
• RGDID: 1311130
• Length: 1465
• Species: Rattus norvegicus
• Alignment Length: 1363
• Identity: 417/1363 - (30%)
• Similarity: 503/1363 - (36%)
• Gaps: 464/1363 - (34%)

  Fly   191 GQLGSKGEKGEP-AKENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKG---PRG 251
            |.|.:...|.:. :.||..|   ::|..|.||.:|:||..|..|..|..|  |.:||..   |.|
  Rat   409 GDLNTVSTKSKAISAENHSY---DRGVGGGRGKSGVAGGGGGGGGGGSGG--GTWGAAPAWCPCG 468

  Fly   252 E--------------------------------HGLKG-----EKGASCYGPMKPGAPGIKGEK- 278
            .                                ..||.     ||....|..:      :|.::
  Rat   469 SCCSWWKWLLGLLLTWLLLLGLLFGLIALAEEVRKLKARVEELEKTKVLYHDI------VKTDRS 527

  Fly   279 ------GEPASSFPVKPTHTVMGP------RGDMGQKG-------------EPGLVGRKGEPGPE 318
                  ||..|          :||      ..|.||:.             |.|  ..:|.|||:
  Rat   528 SRDRLQGEAPS----------LGPGLSKAEMDDYGQEAIWLFVRNKLMTEQENG--NLRGSPGPK 580

  Fly   319 GDTGLDGQKGEKGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGNPGQKGEPGRAGATGK 383
            ||||..|.||::||||.||..|..|:.||.|..||||..|:||:.               |..|:
  Rat   581 GDTGSQGPKGDRGLPGIPGTPGPLGHPGPEGPKGQKGSIGDPGME---------------GPIGQ 630

  Fly   384 PGLLGPPGPPGGGRGTPGPP--GPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQKGGAGLPGRPG 446
            .||.||.|||    |.||||  |.||.||..|..||:||.||.|.|
  Rat   631 RGLAGPMGPP----GEPGPPGSGEKGDRGIAGEQGPRGLPGVPGSP------------------- 672

  Fly   447 NEGPPGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQKGDAGLPGYGIQGSKGDAGIPGYPGLKG 511
                          ||.|..||.||.|.||..||:|.:|:.||||.     |||.|:.|.||.||
  Rat   673 --------------GLRGTSGSPGPQGPPGSVGPQGLRGEVGLPGV-----KGDKGLVGPPGPKG 718

  Fly   512 SKGERGFKGNAGAPGDSKLGRPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAG 576
            .:||:|.:|..|.||..     |.|||.|.||.||..|..|..||:|.
  Rat   719 DQGEKGPRGLTGEPGIR-----GLPGAVGEPGAKGAMGPAGPDGQQGS----------------- 761

  Fly   577 PKGDKGTSGLPGIPGKDGARGPPGERGYPGERGHDGINGQTGPPGEKGEDGRTGLPGATGEPGKP 641
             :|::|.:|:|      |||||                                 ||.||:||||
  Rat   762 -RGEQGLTGMP------GARGP---------------------------------PGPTGDPGKP 786

  Fly   642 ALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGAEGLPGIPGPKGEFGFKGEKGLSGAPGNDGTPGR 706
                                    |:.|.:|.:|||                        |||||
  Rat   787 ------------------------GLTGPQGPQGLP------------------------GTPGR 803

  Fly   707 AGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTG 771
            .|..|.||.||:.:..|                         ||.|   |.:|     |.||..|
  Rat   804 PGTKGEPGAPGRVMTSE-------------------------GSSA---ITVP-----GPPGPPG 835

  Fly   772 MPGPPGEDGSPGERGYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVP--GNPGKDGLRG 834
            ..||||..|:||..|..||.|..||:|.||:.|...||..........|.||.  |.||..|.||
  Rat   836 AMGPPGPPGTPGPAGPAGLPGQQGPRGEPGLAGDSFLNSGSSISEVLSAQGVDFRGPPGPPGPRG 900

  Fly   835 IPGRN--GQPGPRGEPGISRPGPMGPPGLNGLQGEKGDRGPTGPIGFPGADGSVGYPGDRGDAGL 897
            .||.:  |.|||||.||...|||.||||......|....||.||   ||.      ||.:||.|.
  Rat   901 PPGPSIPGPPGPRGPPGEGVPGPPGPPGSFLTDSETFFSGPPGP---PGP------PGPKGDQGD 956

  Fly   898 PGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAP- 961
            |||.|.|||.|........|.....||||.|            |.||.||.:...|.:..|...
  Rat   957 PGVPGTPGIPGGLSHGTSSGTMYAQGPPGPP------------GPPGPPGSLSSSGQELQRYIAE 1009

  Fly   962 --GNDGPKGF-AGVTGAPGKRGPAG----IPG------------VSGAKGDKGATGLTG------ 1001
              .:|..:.: :||.|.||..||.|    |.|            ||..:......||:.
  Rat  1010 YMQSDNIRTYLSGVQGPPGPPGPPGPVITITGETFDYSQLASQVVSYLRSSGYGVGLSSASSSED 1074

  Fly  1002 -------NDGPVGGR----GPPGAPGLMGIKGDQGLA----GAPGQQGLDGMPGEKGNQGFPGLD 1051
                   ||.....|    ||||.||..|:.||..|.    |...:..|:.|.....:.|.||..
  Rat  1075 ILAMLRRNDVWQYLRQHLVGPPGPPGPPGVSGDGSLLSLDYGELSRHILNYMSSSGISFGHPGPP 1139

  Fly  1052 GPPGLPGDASE------KGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHGRAGPPGEKGDQ 1110
            |||||||.:.|      :|       |..|...||   ||.||..|:||.|
  Rat  1140 GPPGLPGTSYEELLTMLRG-------SDYRDIIGP---PGPPGPPGIPGSA-------------- 1180

  Fly  1111 GRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYPGDRGD 1175
             .|.|...| ::......||..:         .|.||.||.||..|.||.:.|  ...|..:..|
  Rat  1181 -WSSISVED-LSSYLHTAGLSSI---------AGPPGPPGPPGPRGPPGVSAA--LATYAAENSD 1232

  Fly  1176 KGEPGLSGLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGERGY---- 1236
            .....|     :...|.|.......|.|||.|.   :|.||      |.....||...||.
  Rat  1233 NFRSEL-----ISYLTSPDVRSFIVGPPGPPGP---QGPPG------DYNWGSGSSARRGTSYSS 1283

  Fly  1237 ---TGEK--GEQGERGLTGPAGVAGAKG-DRGLQGPPGASGLNGIPGAKGDI---GPRGEIGYPG 1292
               ||..  |..||.|..| ||..|..| |.|..|..||:...|:.|..|:.   ...|::.|..
  Rat  1284 SMGTGRTNGGSLGEGGAFG-AGDGGPYGTDVGPGGGYGAAAGGGVYGTNGESFRGSFTGDLDYNT 1347

  Fly  1293 VTIKGEKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGLVGLPGPIGPAGSKGE-------- 1349
            :.::..:.:.       ||||           |.|:|..  :.|.|||.||.|....
  Rat  1348 LALRVSESMQ-------RQGL-----------LQGMAYT--VQGPPGPQGPPGISKVFSAYSNVT 1392

  Fly  1350 -------RGLAGSPGQPGQDGFPGAPGLKGDTGPQGFKGERGLNGFEGQKGDKGDRGLQGPSG 1405
                   |.....||.|||.|..|.||.|||.||.|.:|..|..|..|.||:|||:|.|..:|
  Rat  1393 QDLMDFFRTYGAIPGPPGQKGDMGTPGPKGDRGPAGPRGPPGPPGPRGNKGEKGDKGDQVYTG 1455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	gly_rich_SclB	<107..>361	CDD:468478	65/236 (28%)
		gly_rich_SclB	<355..>642	CDD:468478	96/288 (33%)
		gly_rich_SclB	<543..820	CDD:468478	71/276 (26%)
		gly_rich_SclB	<727..>968	CDD:468478	88/247 (36%)
		gly_rich_SclB	<969..>1218	CDD:468478	83/292 (28%)
		gly_rich_SclB	<1186..>1420	CDD:468478	78/248 (31%)
		gly_rich_SclB	<1321..>1547	CDD:468478	38/100 (38%)
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
Col17a1	NP_001402769.1	gly_rich_SclB	<557..>813	CDD:468478	139/424 (33%)