Protein Alignment Col4a1 and bli-1

DIOPT Version :10

• Sequence 1: NP_723044.1
• Gene: Col4a1 / 33727
• FlyBaseID: FBgn0000299
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_496311.2
• Gene: bli-1 / 174653
• WormBaseID: WBGene00000251
• Length: 948
• Species: Caenorhabditis elegans
• Alignment Length: 719
• Identity: 190/719 - (26%)
• Similarity: 238/719 - (33%)
• Gaps: 240/719 - (33%)

  Fly   281 PASSFPVKPTHTVMGPRGDMGQKGEPGLVGRKGEPGPEGDT----GLDGQKGEKGLP-------- 333
            |.||.|.||....| ||...|.:..|........| |.|..    |.:.....:..|
 Worm   121 PPSSRPRKPEPPTM-PRTIQGFRAPPPAATSTYRP-PHGSNYDNYGREPASSRRPYPPQQPPSTS 183

  Fly   334 ---GGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGNPGQKG--------EPGRA--GATGKPG 385
               ..|.:|....|..||..||.      |....:|.||.|..        |..||  ..|..|.
 Worm   184 APHSSPNNRTSLYNPQPPPKTGY------PTNPRVPYNPPQPNYTRQPTYPEDNRAPYKPTRSPN 242

  Fly   386 LLGPPGPPGGGRGTPGPPGPKGPRGY-VGAPGPQGLNGVDGLPGPQGYNGQKGGAGLPGRPGNEG 449
             ..||..|.||..:.|...|..||.| ...|...|                      ||.|.::.
 Worm   243 -TPPPRQPSGGYDSDGQTPPSSPRIYNTRRPNNHG----------------------PGYPEDQV 284

  Fly   450 P-----PGKKGEKGTAGLNGPKGS--------IGPI--GH--------PGPPGPEGQKGDAGLPG 491
            |     ||::....|...|.|..:        :.|.  ||        |....|.|::|..  ||
 Worm   285 PTAPPVPGQQRVPPTQTRNPPNPTNTRQPSRPVPPTSDGHIEATTPYNPSAQYPTGKRGSH--PG 347

  Fly   492 YGIQGSKGDAGIPGYPGLKGSKGERGFKGNAGAPGDSKLGRPG-TPGAAGAPGQKGDAGRPGTPG 555
            :|.|..:        ||.:.       :||   |.|....:|. .|  :|.||.:|..|.||.||
 Worm   348 FGPQRPR--------PGTRP-------RGN---PCDQCSAQPNHCP--SGPPGPRGRPGPPGFPG 392

  Fly   556 QKGDMGIKGDVGG-------------KCSSCRAGPKGDKGTSGLPGIPGKDGARGPPGERGYPGE 607
            |.|..|::|..||             .|..|..||.|::|..|.||:||:||.
 Worm   393 QDGPRGLRGLNGGYSGVQPSSYDPVIGCVQCPIGPPGERGPDGTPGVPGEDGI------------ 445

  Fly   608 RGHDGINGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQGFKG 672
            .|..|:|||.|.||..|..|..|:.|:.|.|||                  ||.||..|
 Worm   446 DGEQGVNGQDGQPGAPGAPGYHGMNGSPGTPGK------------------PGLPGRNG------ 486

  Fly   673 AEGLPGIPGPKGEFGFKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKG 737
             :....||||      .|:.|:.|.||.||.||..|..|..|.||  |:|.|   ||||.
 Worm   487 -QSCKSIPGP------PGQPGVMGVPGRDGDPGTDGEHGQDGSPG--IQGPP---GRDGT----- 534

  Fly   738 SFGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTGMPGPPGEDGS----PGERGYTGLKGNTGPQG 798
                ||..|:||..|                    ||.||.||.    |................
 Worm   535 ----SGPDGQPGVSA--------------------PGAPGTDGGYCPCPKRSSKFDFNDAYNDDE 575

  Fly   799 PPGVE--GPRGLNGPRGEK-------------GNQGA-------------VGVPGN---PGKDGL 832
            ..|:|  .|||.:..|.|:             .|.||             |..|..   ..::.:
 Worm   576 KRGLEEHRPRGYDSERAEEPRPRQTVRTNTYDENSGAEHQRRPNYEPSAEVAPPRQDRYEDEERV 640

  Fly   833 RGIPGRNGQPG---------PRGEPGISRPGPMGPPGLNGLQGEKG-DRGPTGPIGFPGADGSVG 887
            |..|.:...|.         |..:|.:.||.|  |......:.|:. :..|..|....|.:.|.|
 Worm   641 REPPPKRPPPPHRQTPHELYPEEQPYVRRPPP--PQNRGNYEVERSREYVPEAPRPRQGYEHSSG 703

  Fly   888 YPGD 891
            |.||
 Worm   704 YGGD 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	gly_rich_SclB	<107..>361	CDD:468478	23/94 (24%)
		gly_rich_SclB	<355..>642	CDD:468478	94/334 (28%)
		gly_rich_SclB	<543..820	CDD:468478	93/308 (30%)
		gly_rich_SclB	<727..>968	CDD:468478	47/210 (22%)
		gly_rich_SclB	<969..>1218	CDD:468478
		gly_rich_SclB	<1186..>1420	CDD:468478
		gly_rich_SclB	<1321..>1547	CDD:468478
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
bli-1	NP_496311.2	Col_cuticle_N	<20..58	CDD:198156
		PHA03247	<122..371	CDD:223021	70/299 (23%)
		gly_rich_SclB	<397..>553	CDD:468478	73/232 (31%)
		PTZ00121	<574..901	CDD:173412	30/136 (22%)
		SspO	781..830	CDD:369735