DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and COL22A1

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_690848.1	Gene:	COL22A1 / 169044	HGNCID:	22989	Length:	1626	Species:	Homo sapiens

Alignment Length:	1449	Identity:	562/1449 - (38%)
Similarity:	683/1449 - (47%)	Gaps:	341/1449 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 NCTAGYAGCVPKCIAEKGNRGLPGPLGPTGLKGEMGFPGMEGPSGDKGQKGDP--GPYGQRGDKG 134
            :|.||          |||..|:.||:|..|.||::|..|..|..|.||:|||.  ||:|| |:||
Human   477 SCPAG----------EKGEMGVAGPMGLPGPKGDIGAIGPVGAPGPKGEKGDVGIGPFGQ-GEKG 530

  Fly   135 ERGSPGLHGQAGVPGVQGPAGNPGAPGINGKDGCDGQDGIPGLEGLSGMPGPRGYAGQLGSKGEK 199
            |:||.||   .|.||..|..|..|.||..|:.|..|:.|:.|.:|..|:|||.|..|..|.:||:
Human   531 EKGSLGL---PGPPGRDGSKGMRGEPGELGEPGLPGEVGMRGPQGPPGLPGPPGRVGAPGLQGER 592

  Fly   200 GEPAKENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKGPRGEHGLKGEKGASCY 264
            ||         ||.:||.|.||..|..|.   ||:.|::|..||.|..||:||   ||:.|.:
Human   593 GE---------KGTRGEKGERGLDGFPGK---PGDTGQQGRPGPSGVAGPQGE---KGDVGPA-- 640

  Fly   265 GPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPRGDMGQKGEPGLVGRKGEPGPEGDTGLDGQKGE 329
            ||  ||.||                  :|:...|..|::|.||..|.:|.|||.|..|..|.:|.
Human   641 GP--PGVPG------------------SVVQQEGLKGEQGAPGPRGHQGAPGPPGARGPIGPEGR 685

  Fly   330 KGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGNPGQKGEPGRAGATGKPGLLGPPGPPG 394
            .|.||..|.||::|:.||||..|..|.:|.||..|:||.||..|.||..|..|.||..|||||
Human   686 DGPPGLQGLRGKKGDMGPPGIPGLLGLQGPPGPPGVPGPPGPGGSPGLPGEIGFPGKPGPPGP-- 748

  Fly   395 GGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQKGGAGLPGRPGNEGPPGKKGEKGT 459
              .|.||..||.||.|..|..|..|..|.|||||..|..|:.|..||.|||         ||||.
Human   749 --TGPPGKDGPNGPPGPPGTKGEPGERGEDGLPGKPGLRGEIGEQGLAGRP---------GEKGE 802

  Fly   460 AGLNGPKGSIGPIGHPGPPGPEGQKGDAGLPGYGIQGSKGDAGIPGYPGLKGSKGERGFKGNAGA 524
            |||.|.         ||.||..|:|||        ||.||:.|:||..|.:|.|||.|..|..|.
Human   803 AGLPGA---------PGFPGVRGEKGD--------QGEKGELGLPGLKGDRGEKGEAGPAGPPGL 850

  Fly   525 PGDSKLGRPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGLPGI 589
            ||.:.|..|                .|..||::                  ||||:||.   ||:
Human   851 PGTTSLFTP----------------HPRMPGEQ------------------GPKGEKGD---PGL 878

  Fly   590 PGKDGARGPPGERGYPGERGHDGINGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKG 654
            ||:.|.:|.|||.| |        .|.|||||.||::|..|.|||.|.||.|
Human   879 PGEPGLQGRPGELG-P--------QGPTGPPGAKGQEGAHGAPGAAGNPGAP------------- 921

  Fly   655 DKGYPGAPGAKGVQGFKGAEGLPGIPGPKGEFGFKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQS 719
              |:.||||..|..|..||.||.|.||..||.|.||..|..|:||..|..|..|..|.||.||:.
Human   922 --GHVGAPGPSGPPGSVGAPGLRGTPGKDGERGEKGAAGEEGSPGPVGPRGDPGAPGLPGPPGKG 984

  Fly   720 IKGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTGMPGPPGEDGSPGE 784
            ..||||..|..|..|..|:....|:.....:|||.  ....||::|.|   |:||.||..|.||
Human   985 KDGEPGLRGSPGLPGPLGTKAACGKVRGSENCALG--GQCVKGDRGAP---GIPGSPGSRGDPG- 1043

  Fly   785 RGYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPG 849
                           .||.||.|.:||.|:||:.|:.|:||.||..|..|..|..|.||.||.||
Human  1044 ---------------IGVAGPPGPSGPPGDKGSPGSRGLPGFPGPQGPAGRDGAPGNPGERGPPG 1093

  Fly   850 ISRPG---PMGPPGLNGLQGEKGDRGPTGPIGFPGADGSVGYPGDRGDAGLPGVSGRPGIVGEKG 911
              :||   .:.|..:|.|..:..:..|.||.|.|      |.||.:||.|:||..||.|..|:||
Human  1094 --KPGLSSLLSPGDINLLAKDVCNDCPPGPPGLP------GLPGFKGDKGVPGKPGREGTEGKKG 1150

  Fly   912 DVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAP 976
            :         |||||:||..|:.|..|::||.|:.|.||..|::|..|.||..||         |
Human  1151 E---------AGPPGLPGPPGIAGPQGSQGERGADGEVGQKGDQGHPGVPGFMGP---------P 1197

  Fly   977 GKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQGLDGMPGE 1041
            |..||.|..|::||.|..|..|..|.:||.|.:||.|.||:            ||::|.:|..|:
Human  1198 GNPGPPGADGIAGAAGPPGIQGSPGKEGPPGPQGPSGLPGI------------PGEEGKEGRDGK 1250

  Fly  1042 KGNQGFPGLDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHGRAGPPGE 1106
            .|..|.||..|.||||      |.:|..||.|.:|.||.:|.||..||.|..||        ||:
Human  1251 PGPPGEPGKAGEPGLP------GPEGARGPPGFKGHTGDSGAPGPRGESGAMGL--------PGQ 1301

  Fly  1107 KGDQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPGIP---GAPGMDGLPGAAGAPGAVG 1168
            :      |:.|:||..|..|.||.||..|.||:.||.|:||.|   |.||..|..|..|:||..|
Human  1302 E------GLPGKDGDTGPTGPQGPQGPRGPPGKNGSPGSPGEPGPSGTPGQKGSKGENGSPGLPG 1360

  Fly  1169 YPGDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGE 1233
            :.|.||..||||..|:|         |.:|..|.||..|.:|.||.||       |:||||..|.
Human  1361 FLGPRGPPGEPGEKGVP---------GKEGVPGKPGEPGFKGERGDPG-------IKGDKGPPGG 1409

  Fly  1234 RGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKG--------------DIGP 1284
            :|..|:.|..|.:|.||..|..|..|:.|..||||..|..|.||.:|              ::|.
Human  1410 KGQPGDPGIPGHKGHTGLMGPQGLPGENGPVGPPGPPGQPGFPGLRGESPSMETLRRLIQEELGK 1474

  Fly  1285 RGE--IGY-----PGVTIKGEKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGLVGLPGPIG 1342
            :.|  :.|     |...:|..:|.||.||..|:.||.|..|.:||      .|.||..||.||.|
Human  1475 QLETRLAYLLAQMPPAYMKSSQGRPGPPGPPGKDGLPGRAGPMGE------PGRPGQGGLEGPSG 1533

  Fly  1343 PAGSKGERGLAGSPGQPGQDGFPGAPGLKGDTGPQGFKGERGLNGFEGQKGDKGDRGLQGPSGLP 1407
            |.|.|||||..|.||.||       .||:|:.||                              |
Human  1534 PIGPKGERGAKGDPGAPG-------VGLRGEMGP------------------------------P 1561

  Fly  1408 GLVGQKGDTGYPGLNGNDGPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGMLPPPGPKG--EP 1470
            |:.||.|:.||    ..||..|.||.:|.|||.|.      |||||         ||||.|  :|
Human  1562 GIPGQPGEPGY----AKDGLPGIPGPQGETGPAGH------PGLPG---------PPGPPGQCDP 1607

  Fly  1471 GQ----------PGR-NGP 1478
            .|          ||. .||
Human  1608 SQCAYFASLAARPGNVKGP 1626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	28/58 (48%)
		Collagen	322..380	CDD:189968	27/57 (47%)
		Collagen	413..465	CDD:189968	24/51 (47%)
		Collagen	499..561	CDD:189968	19/61 (31%)
		Collagen	574..632	CDD:189968	27/57 (47%)
		Collagen	657..714	CDD:189968	27/56 (48%)
		Collagen	765..824	CDD:189968	22/58 (38%)
		Collagen	854..911	CDD:189968	21/59 (36%)
		Collagen	884..943	CDD:189968	25/58 (43%)
		Collagen	923..982	CDD:189968	25/58 (43%)
		Collagen	1028..1085	CDD:189968	23/56 (41%)
		Collagen	1229..1287	CDD:189968	23/71 (32%)
		Collagen	1318..1376	CDD:189968	26/57 (46%)
		Collagen	1399..1458	CDD:189968	22/58 (38%)
		Collagen	1477..1534	CDD:189968	2/2 (100%)
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
COL22A1	NP_690848.1	vWFA	36..219	CDD:294047
		LamG	239..426	CDD:304605
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..1002		256/627 (41%)
		Collagen	585..635	CDD:189968	25/64 (39%)
		Collagen	654..704	CDD:189968	22/49 (45%)
		Collagen	772..826	CDD:189968	33/79 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1019..1103		40/106 (38%)
		Collagen	1028..1095	CDD:189968	36/87 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1119..1458		167/410 (41%)
		Collagen	1260..1307	CDD:189968	24/66 (36%)
		Collagen	1330..1395	CDD:189968	31/73 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1491..1609		66/179 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910