DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and COL19A1

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	XP_011533739.1	Gene:	COL19A1 / 1310	HGNCID:	2196	Length:	1167	Species:	Homo sapiens

Alignment Length:	1197	Identity:	424/1197 - (35%)
Similarity:	518/1197 - (43%)	Gaps:	381/1197 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 KGEPGLVGRKGEPGPEGDTGLDGQKGEKGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPG 367
            |||.||.|..|.||.:|..|..|:.|..|.||.||.:|.||..|..|.||:||::||
Human   316 KGEAGLPGAPGSPGQKGHKGEPGENGLHGAPGFPGQKGEQGFEGSKGETGEKGEQGE-------- 372

  Fly   368 NPGQKGEPGRAGATGKPGLLGPPGPPGGGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGY 432
                ||:|..||..|:.||.|..||       .|||||||.:|..|.|||..|.|..|:.|||
Human   373 ----KGDPALAGLNGENGLKGDLGP-------HGPPGPKGEKGDTGPPGPPALPGSLGIQGPQ-- 424

  Fly   433 NGQKGGAGLPGRPGNEGPPGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQKGDAGLPGYGIQGS 497
                            |||||:|::|..|..||.|..||.|.|||||.:|.....|  ||..:.:
Human   425 ----------------GPPGKEGQRGRRGKTGPPGKPGPPGPPGPPGIQGIHQTLG--GYYNKDN 471

  Fly   498 KG----DAGIPGYPGLKGSKGERGFKGNAGAPGDSKLGRPGTPGAAGAPGQKGDAGRPGTPGQKG 558
            ||    :||     ||||.|||.|.              ||.||:.|..||||:.|.|.|.|:||
Human   472 KGNDEHEAG-----GLKGDKGETGL--------------PGFPGSVGPKGQKGEPGEPFTKGEKG 517

  Fly   559 DMGIKGDVGGKCSSCRAGPKGDKGTSGLPGIPGKDGARGPPGERGYPGERGHDGINGQTGPPGEK 623
            |                  :|:.|..|..|:.|:.|..||||..|.||.:|..|..|..||   :
Human   518 D------------------RGEPGVIGSQGVKGEPGDPGPPGLIGSPGLKGQQGSAGSMGP---R 561

  Fly   624 GEDGRTGLPGATGEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGAEGLPGIPGPKGEFGF 688
            |..|..||||..|.|||         :.:||:||.||           |..|.||:||||||
Human   562 GPPGDVGLPGEHGIPGK---------QGIKGEKGDPG-----------GIIGPPGLPGPKGE--- 603

  Fly   689 KGEKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCAL 753
                                    .|.||:|:.||||..|..||.|.:|
Human   604 ------------------------AGPPGKSLPGEPGLDGNPGAPGPRG---------------- 628

  Fly   754 DEIKMPAKGNKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQGP---PGVEGPRGLNGPRGEK 815
                  .||.:|.||..|.||..|..|       .|:.|.||.|||   ||::|||||
Human   629 ------PKGERGLPGVHGSPGDIGPQG-------IGIPGRTGAQGPAGEPGIQGPRGL------- 673

  Fly   816 GNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPGISRPGPMGPPGLNGLQGEKGDRGPTGPIG-- 878
              .|..|.||.||.|   |:|||:|:||..|.||    .|:..|.|             |.||
Human   674 --PGLPGTPGTPGND---GVPGRDGKPGLPGPPG----DPIALPLL-------------GDIGAL 716

  Fly   879 ---FPG-ADGSVGYPGDRGDAGLPGVSGRPG---IVGEKGDVGPIGPAGVAGPPGVPGIDGVRGR 936
               |.| ...||  ||.:.:.|..|.:|.||   .:..|||:||      .||||:|      ||
Human   717 LKNFCGNCQASV--PGLKSNKGEEGGAGEPGKYDSMARKGDIGP------RGPPGIP------GR 767

  Fly   937 DGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTG 1001
            :|.||..|..|..|:||.|||.|..|..|..|..|.||.||..|..|.||.:||||:|      |
Human   768 EGPKGSKGERGYPGIPGEKGDEGLQGIPGIPGAPGPTGPPGLMGRTGHPGPTGAKGEK------G 826

  Fly  1002 NDGPVGGRGPPGAPGLMGIKGDQGLAGAP--GQQGLDGMPGEKGNQGFPGLDGPPGLPGDASEKG 1064
            :|||.|..||||.||:            |  .:.|:..:...||....|...||||.|      |
Human   827 SDGPPGKPGPPGPPGI------------PFNERNGMSSLYKIKGGVNVPSYPGPPGPP------G 873

  Fly  1065 QKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHGRAGPPGEKGDQGRSGIDGRDGINGEKGEQG 1129
            .||:|||            .|.||..|||||     .|.||.|||:|.:
Human   874 PKGDPGP------------VGEPGAMGLPGL-----EGFPGVKGDRGPA---------------- 905

  Fly  1130 LQGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYPGDRGDKGEPGLSGLPGLKGETGPV 1194
                 |.||..|..|.||.||.||:.|.||..|..|.:|:||..|..|:||::|..|:.
Human   906 -----GPPGIAGMSGKPGAPGPPGVPGEPGERGPVGDIGFPGPEGPSGKPGINGKDGIP------ 959

  Fly  1195 GLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGERGYTGEKGEQGERGLTGPAGVAGAKG 1259
            |.||..|.||.:|.:|.||..|:|       ||:|||||||..|..|.:|..|..||.|..|:.|
Human   960 GAQGIMGKPGDRGPKGERGDQGIP-------GDRGSQGERGKPGLTGMKGAIGPMGPPGNKGSMG 1017

  Fly  1260 DRGLQGPPGASGLNGIPGAKGDIGPRGEIGYPGVTIKGEKGLPGRPGRNGRQGLIGAPGLIGERG 1324
            ..|.|||||:.|:.|||.             ..|:.:..|       :...|.::   .:..||
Human  1018 SPGHQGPPGSPGIPGIPA-------------DAVSFEEIK-------KYINQEVL---RIFEER- 1058

  Fly  1325 LPGLAGEPGLVGLPGPIGPAGSKGERGLAGSPGQPGQDGFPGAPGLKGDTGPQGFKGERGLNGFE 1389
               :|.....:.||..:..|.:.|.      ||.||:||.||.|   ||.||||::
Human  1059 ---MAVFLSQLKLPAAMLAAQAYGR------PGPPGKDGLPGPP---GDPGPQGYR--------- 1102

  Fly  1390 GQKGDKGDRGLQGPSGLPGLVGQKGDTGYPGLNGNDGPVGAPGERGFTGPKGRDGRDGTPGLPGQ 1454
            ||||::|:.|:    |||                                       |:|||||.
Human  1103 GQKGERGEPGI----GLP---------------------------------------GSPGLPGT 1124

  Fly  1455 K--GEPGMLPPPGPKGEPGQPGRNGPK 1479
            .  |.||....|||:|.||..||..|:
Human  1125 SALGLPGSPGAPGPQGPPGPSGRCNPE 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968
		Collagen	322..380	CDD:189968	23/57 (40%)
		Collagen	413..465	CDD:189968	18/51 (35%)
		Collagen	499..561	CDD:189968	27/65 (42%)
		Collagen	574..632	CDD:189968	21/57 (37%)
		Collagen	657..714	CDD:189968	13/56 (23%)
		Collagen	765..824	CDD:189968	24/61 (39%)
		Collagen	854..911	CDD:189968	17/65 (26%)
		Collagen	884..943	CDD:189968	24/61 (39%)
		Collagen	923..982	CDD:189968	28/58 (48%)
		Collagen	1028..1085	CDD:189968	16/58 (28%)
		Collagen	1229..1287	CDD:189968	26/57 (46%)
		Collagen	1318..1376	CDD:189968	18/57 (32%)
		Collagen	1399..1458	CDD:189968	11/60 (18%)
		Collagen	1477..1534	CDD:189968	1/3 (33%)
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
COL19A1	XP_011533739.1	TSPN	75..258	CDD:214560
		Glutenin_hmw	299..>691	CDD:281191	199/541 (37%)
		Collagen	317..369	CDD:189968	25/51 (49%)
		Collagen	499..572	CDD:189968	35/93 (38%)
		Collagen	622..684	CDD:189968	32/99 (32%)
		Collagen	932..981	CDD:189968	21/54 (39%)
		Collagen	966..1020	CDD:189968	27/60 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910