DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and COL16A1

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_001847.3	Gene:	COL16A1 / 1307	HGNCID:	2193	Length:	1604	Species:	Homo sapiens

Alignment Length:	1533	Identity:	588/1533 - (38%)
Similarity:	691/1533 - (45%)	Gaps:	382/1533 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 ARGDLPP-------KNCTAGYAGCVPKCIAEKGNRGLPGPLGPTGLKGEMG-----------FPG 110
            |..:.||       .|.|...:|  ||  ..||.||||||.|..|.||..|           ...
Human   312 AADECPPCVHGARDSNVTLAPSG--PK--GGKGERGLPGPPGSKGEKGARGNDCVRISPDAPLQC 372

  Fly   111 MEGPSGDKGQKGDPGPYGQRGDKGERGSPGLHGQAGVPGVQGPAGNPGAPG---INGKDGCDGQD 172
            .|||.|:||:.|..||.|..|..||:|..|..|..|:.||.|..|..|.||   :.|..|..|..
Human   373 AEGPKGEKGESGALGPSGLPGSTGEKGQKGEKGDGGIKGVPGKPGRDGRPGEICVIGPKGQKGDP 437

  Fly   173 GIPGLEGLSGMPGPRGYAGQLGSKGEKGEPAKENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGE 237
            |..|.|||:|.|||.|..|..|.    |.|         |..|:||        ||   ||.||:
Human   438 GFVGPEGLAGEPGPPGLPGPPGI----GLP---------GTPGDPG--------GP---PGPKGD 478

  Fly   238 RGDSGPYGAKGPRGEHGLKGEKGASCYGPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPRGDMGQ 302
            :|.||..|.:||.|                |||.||:|||||:|....|..|.    |.:..:|.
Human   479 KGSSGIPGKEGPGG----------------KPGKPGVKGEKGDPCEVCPTLPE----GFQNFVGL 523

  Fly   303 KGEPGLVGRKGEPGP-EGDTGLDGQKGEKGLP--GGPGDRGRQGNFGPPGSTGQKGDRGEPGLNG 364
            .|:||..|..|:|.| .||.|:.|.|||||.|  ......|.|...   .|||..||.|.||. |
Human   524 PGKPGPKGEPGDPVPARGDPGIQGIKGEKGEPCLSCSSVVGAQHLV---SSTGASGDVGSPGF-G 584

  Fly   365 LPGNPGQKGEPGRAGATGKPGLLGPPGPPGGGRGTPGPPGPKGPRGYVGAPG------PQGLNGV 423
            |||.||:.|.||..|..|..|..||       .|:||||||.||.|..||.|      |...|..
Human   585 LPGLPGRAGVPGLKGEKGNFGEAGP-------AGSPGPPGPVGPAGIKGAKGEPCEPCPALSNLQ 642

  Fly   424 DG------LPGPQGYNGQKG--GAGLPGRPGNEGPPGKKGEKGTAGLNGPKGSIGPIGHP----- 475
            ||      ||||.|..|:.|  |.||||:.|..|..|.||:||.||..|..|:.|..|.|
Human   643 DGDVRVVALPGPSGEKGEPGPPGFGLPGKQGKAGERGLKGQKGDAGNPGDPGTPGTTGRPGLSGE 707

  Fly   476 ----GPPGPEGQKGDAGLPGYGIQGSKGD-AGIPGYPGLKGSKGERGFKGNAGAPGDSKLGRPGT 535
                ||.||:|:|||.......:||:..| ||.||.||.||.:|..|    .|.||  |.|:||.
Human   708 PGVQGPAGPKGEKGDGCTACPSLQGTVTDMAGRPGQPGPKGEQGPEG----VGRPG--KPGQPGL 766

  Fly   536 PGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGLPGIPGKDGARGPPG 600
            ||..|.||.||..|.||.||:    |::            ||:|:.|..|||||.|..|.|||||
Human   767 PGVQGPPGLKGVQGEPGPPGR----GVQ------------GPQGEPGAPGLPGIQGLPGPRGPPG 815

  Fly   601 ERGYPGERGHDGINGQT-----------GPPGEKGEDGRTGL------PGATGEPGKPALCDLSL 648
            ..|..|.:|..|:.|.|           ||||..|:.|:|||      .|..||.|:|..|..
Human   816 PTGEKGAQGSPGVKGATGPVGPPGASVSGPPGRDGQQGQTGLRGTPGEKGPRGEKGEPGECSC-- 878

  Fly   649 IEPLKGD---KGYPGAPGA-KGVQGFKGAEGLPGIPGPKGEFGFKGEKGLSGAPGNDGTPGRAGR 709
              |.:||   .|.|||||. .|.....|.:|.||||||.|.   .|..||.|.|||:|.||:
Human   879 --PSQGDLIFSGMPGAPGLWMGSSWQPGPQGPPGIPGPPGP---PGVPGLQGVPGNNGLPGQ--- 935

  Fly   710 DGYPGIPGQ--SIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTGM 772
               ||:..:  |:..|.  |......||    ...|::..||...          .|||.|..|:
Human   936 ---PGLTAELGSLPIEQ--HLLKSICGD----CVQGQRAHPGYLV----------EKGEKGDQGI 981

  Fly   773 PGPPGEDGSPGERGYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIPG 837
            ||.||.|..  .:.:..|:       .|..|..||.|    .:|:.|.||.||.||..||.|..|
Human   982 PGVPGLDNC--AQCFLSLE-------RPRAEEARGDN----SEGDPGCVGSPGLPGPPGLPGQRG 1033

  Fly   838 RNGQPGPRGEPGISRPGPMGPPGLNGLQGEKGDRGPTGPIGFPGADGSVGYPGDRGDAGLPGVSG 902
            ..|.||.||.||  .|||:|||                  |||||.||.|.||.:|:.||
Human  1034 EEGPPGMRGSPG--PPGPIGPP------------------GFPGAVGSPGLPGLQGERGL----- 1073

  Fly   903 RPGIVGEKGDVGPIGP---AGVAGPPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGND 964
             .|:.|:||:.||.|.   .|..||||:|||.|.||..|:.||.|.|            |.||::
Human  1074 -TGLTGDKGEPGPPGQPGYPGATGPPGLPGIKGERGYTGSAGEKGEP------------GPPGSE 1125

  Fly   965 GPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGA 1029
                     |.||..|||                     ||.|.|||.|.   .|.|||||..|.
Human  1126 ---------GLPGPPGPA---------------------GPRGERGPQGN---SGEKGDQGFQGQ 1157

  Fly  1030 PGQQGLDGMPGEKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPG 1094
            |      |.||..|..||||..|.||.||..:|||.:|..|||||.|..||.|.||..|..||.|
Human  1158 P------GFPGPPGPPGFPGKVGSPGPPGPQAEKGSEGIRGPSGLPGSPGPPGPPGIQGPAGLDG 1216

  Fly  1095 LAVHGRAGPPGEKGDQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPG 1159
            |                 .|.||:.|:.|:.|..|..|:.|.||.||..|.||:||.
Human  1217 L-----------------DGKDGKPGLRGDPGPAGPPGLMGPPGFKGKTGHPGLPGP-------- 1256

  Fly  1160 AAGAPGAVGYPGDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVP-- 1222
                      .||.|..|.||.:|.||.:||.|.:|.||..|.||..|..|..|||| ||.:.
Human  1257 ----------KGDCGKPGPPGSTGRPGAEGEPGAMGPQGRPGPPGHVGPPGPPGQPG-PAGISAV 1310

  Fly  1223 DIRGDKGSQGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGDIGPRGE 1287
            .::||:|:.||||..|..|:.|..|..||.|..|..|..|.:||||..|..|.||.|||.|..|:
Human  1311 GLKGDRGATGERGLAGLPGQPGPPGHPGPPGEPGTDGAAGKEGPPGKQGFYGPPGPKGDPGAAGQ 1375

  Fly  1288 IGYPGVTIKGEKGLPGRPGRNGRQGLIGAPGLIGER---GLPGLAGEPGLVGLPGPIG------- 1342
            .|..|.  ||..|:||.||::|..|.:|.||..|||   |.||.:|.|||.|:||.:|
Human  1376 KGQAGE--KGRAGMPGGPGKSGSMGPVGPPGPAGERGHPGAPGPSGSPGLPGVPGSMGDMVNYDE 1438

  Fly  1343 --------------------------------PAGSKGERGLAGSPGQPGQDGFPGAPGLKGDTG 1375
                                            ..|..|..|..|:||:||..|.||.||..|..|
Human  1439 IKRFIRQEIIKMFDERMAYYTSRMQFPMEMAAAPGRPGPPGKDGAPGRPGAPGSPGLPGQIGREG 1503

  Fly  1376 PQGFKGERGLNGFEGQKGDKGDRGLQGPSGLPGLVGQKGDTGYPGLNGNDGPVGAPGERGFTGPK 1440
            .||..|.|||.|.:|:|||.| .|:.|.:||||..|.:|..||             |:.|.|||.
Human  1504 RQGLPGVRGLPGTKGEKGDIG-IGIAGENGLPGPPGPQGPPGY-------------GKMGATGPM 1554

  Fly  1441 GRDGRDGTPGLPGQKGEPGMLPPPGPKGEPGQPGRNGP 1478
               |:.|.||:||         ||||.|:||:.|...|
Human  1555 ---GQQGIPGIPG---------PPGPMGQPGKAGHCNP 1580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	24/67 (36%)
		Collagen	322..380	CDD:189968	27/59 (46%)
		Collagen	413..465	CDD:189968	28/65 (43%)
		Collagen	499..561	CDD:189968	30/62 (48%)
		Collagen	574..632	CDD:189968	31/74 (42%)
		Collagen	657..714	CDD:189968	26/57 (46%)
		Collagen	765..824	CDD:189968	19/58 (33%)
		Collagen	854..911	CDD:189968	20/56 (36%)
		Collagen	884..943	CDD:189968	28/61 (46%)
		Collagen	923..982	CDD:189968	22/58 (38%)
		Collagen	1028..1085	CDD:189968	28/56 (50%)
		Collagen	1229..1287	CDD:189968	27/57 (47%)
		Collagen	1318..1376	CDD:189968	29/99 (29%)
		Collagen	1399..1458	CDD:189968	21/58 (36%)
		Collagen	1477..1534	CDD:189968	1/2 (50%)
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
COL16A1	NP_001847.3	TSPN	50..231	CDD:214560
		Nonhelical region 10 (NC10)	232..374		21/65 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..509		90/240 (38%)
		Triple-helical region 9 (COL9) with 3 imperfections	375..506		67/170 (39%)
		Collagen	375..433	CDD:189968	24/57 (42%)
		Nonhelical region 9 (NC9)	507..521		3/17 (18%)
		Triple-helical region 8 (COL8) with 1 imperfection	522..555		17/32 (53%)
		Cell attachment site. /evidence=ECO:0000255	540..542		0/1 (0%)
		Nonhelical region 8 (NC8)	556..572		2/18 (11%)
		Triple-helical region 7 (COL7) with 1 imperfection	573..631		33/65 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	604..917		142/345 (41%)
		Nonhelical region 7 (NC7)	632..652		4/19 (21%)
		Triple-helical region 6 (COL6) with 1 imperfection	653..723		31/69 (45%)
		Collagen	673..721	CDD:189968	19/47 (40%)
		Nonhelical region 6 (NC6)	724..738		3/13 (23%)
		Triple-helical region 5 (COL5) with 3 imperfections	739..876		65/158 (41%)
		Collagen	756..803	CDD:189968	26/64 (41%)
		Nonhelical region 5 (NC5)	877..887		3/13 (23%)
		Triple-helical region 4 (COL4) with 2 imperfections	888..939		28/59 (47%)
		Nonhelical region 4 (NC4)	940..973		8/48 (17%)
		Triple-helical region 3 (COL3)	974..988		8/13 (62%)
		Nonhelical region 3 (NC3)	989..1011		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1001..1429		222/546 (41%)
		Cell attachment site. /evidence=ECO:0000255	1006..1008		1/1 (100%)
		Triple-helical region 2 (COL2) with 2 imperfections	1012..1433		220/535 (41%)
		Cell attachment site. /evidence=ECO:0000255	1227..1229		0/1 (0%)
		Nonhelical region 2 (NC2)	1434..1472		0/37 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1468..1517		22/48 (46%)
		Triple-helical region 1 (COL1) with 2 imperfections	1473..1578		56/130 (43%)
		Nonhelical region 1 (NC1)	1579..1604		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910