DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Col4a1 and COL11A1

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	XP_016855823.1	Gene:	COL11A1 / 1301	HGNCID:	2186	Length:	1857	Species:	Homo sapiens

Alignment Length:	1441	Identity:	565/1441 - (39%)
Similarity:	665/1441 - (46%)	Gaps:	377/1441 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 EKGNRGLP----------GPLGPTGLKGEMGFPGMEGPSGDKGQKGDPGPYGQRGDKGERGSPGL 141
            |||.:|.|          ||.||.|..|.||.||::||:|..|..||.||.|:.|..|..|.||.
Human   475 EKGQKGEPAVVEPGMLVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLPGP 539

  Fly   142 HG-------QAGVPGVQGPA--------------------GNPGAPGINGKDGCDGQDGIPGLEG 179
            .|       :.|..|.:||.                    |.||..|:.|:.|..|..|..|.:|
Human   540 PGTMLMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSSGAKG 604

  Fly   180 LSGMPGPRGYAGQLGSKGEKGEPAKE---NGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERGDS 241
            .||.|||:|..|..|..|..|:|.|.   ..|..:|..||||.:|..|..|..|.||:||.||:.
Human   605 ESGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGER 669

  Fly   242 GPYGAKGPRGEHGLKGEKGASCYGPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPRGDMGQKGEP 306
            ||.|..||.|:.|::||.|.  .||.  |.||..|.:|             ::||||..|..|:|
Human   670 GPQGPPGPPGDDGMRGEDGE--IGPR--GLPGEAGPRG-------------LLGPRGTPGAPGQP 717

  Fly   307 GLVGRKGEPGPEGDTGLDGQKGEKGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGNPGQ 371
            |:.|..|.|||:|:.|..|:.|..|..|.||.:|..|..||.|..|:||.:|:|||.||||..|.
Human   718 GMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGP 782

  Fly   372 KGEPGRAGATGKPGLLGPPGPPGGGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQK 436
            .|.||:.|.:|:.|.|             |||||:||.||   |||:|:.|.||:.|.:|..|:|
Human   783 PGHPGKEGQSGEKGAL-------------GPPGPQGPIGY---PGPRGVKGADGVRGLKGSKGEK 831

  Fly   437 GGAGLPGRPGNEGPPGKKGE------KGTAGLNGPKGSIGPIGHPGPPGPEGQKGDAGLPGYGIQ 495
            |..|.||..|:.|..|.:||      :|..|..||||..||.|.|||.|..|:||..|:|
Human   832 GEDGFPGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVP----- 891

  Fly   496 GSKGDAGIPGYPGLKGSKGERGFKGNAGAPGDSKLGRPGTPGAAGAPGQKGDAGRPGTPGQKGDM 560
                  |:|||||.:|.||..||              ||.|||.|..|.:|.||:||..||:|.
Human   892 ------GLPGYPGRQGPKGSTGF--------------PGFPGANGEKGARGVAGKPGPRGQRGP- 935

  Fly   561 GIKGDVGGKCSSCRAGPKGDKGTSGLPGIPGKDGARGPPGERGYPGERGHDGINGQTGPPGEKGE 625
                          .||:|.:            |||||                  ||.||.||.
Human   936 --------------TGPRGSR------------GARGP------------------TGKPGPKGT 956

  Fly   626 DGRTGLPGATGEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGAEGLPGIPGPKGEFGFKG 690
            .|                          || |.||.||.:|.|            ||:|..||
Human   957 SG--------------------------GD-GPPGPPGERGPQ------------GPQGPVGF-- 980

  Fly   691 EKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCALDE 755
                   ||..|.||..|:||.||.|||  :||.||.|:.|..|..|..|..|..||.|..
Human   981 -------PGPKGPPGPPGKDGLPGHPGQ--RGETGFQGKTGPPGPGGVVGPQGPTGETGPI---- 1032

  Fly   756 IKMPAKGNKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGA 820
                     ||.|..|.||||||.|.||..|..|.||:.||||..|.:||.
Human  1033 ---------GERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPA-------------- 1074

  Fly   821 VGVPGNPGKDGLRGIPGRNGQPGPRGEPGI-SRPGPMGPPGLNGLQGEKGDRGPTGPIGFPGADG 884
                      ||||.||..|.||.:|.||: ...||.||||..|..||:|..|..||||.||..|
Human  1075 ----------GLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPG 1129

  Fly   885 SVGYPGDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEPGSPGLV 949
            ..|.||..|:.|.||..|..|..|..|..||:|..|.|||.|.|      |.||.|||.|.||..
Human  1130 PQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSP------GEDGDKGEIGEPGQK 1188

  Fly   950 GMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGD---KGATGLTGNDGPVGGRGP 1011
            |..|:||:.|.|            |.||.:||.|.||::|..|:   :|..|:.|..|..|.||.
Human  1189 GSKGDKGENGPP------------GPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGF 1241

  Fly  1012 PGAPGLMGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSGLRG 1076
            ||.||.:|:            |||.|.|||||..|..|..||||.||....:|..|..||   :|
Human  1242 PGPPGPIGL------------QGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGP---QG 1291

  Fly  1077 DTGPAGTPGWPGEKGLPGLAVHGRAGPPGEKGDQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKG 1141
            ..|..|:.|..||||.||.|  |..|||||.            |:.|.|||:         ||||
Human  1292 PPGSVGSVGGVGEKGEPGEA--GNPGPPGEA------------GVGGPKGER---------GEKG 1333

  Fly  1142 SVGAPGIPGAPGMDGLPGAAGAPGAVGYPGDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAPGPK 1206
            ..|.            |||||.|||.|.|||.|.||.|            |||   ||.|.|||.
Human  1334 EAGP------------PGAAGPPGAKGPPGDDGPKGNP------------GPV---GFPGDPGPP 1371

  Fly  1207 GERGIRGQPGLPATVPDIRGDKGSQGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGASG 1271
            ||.|..||.|       :.|||         ||.|:.|:.|..||:|.||..|..|.:|||||:|
Human  1372 GEPGPAGQDG-------VGGDK---------GEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAAG 1420

  Fly  1272 LNGIPGAKGDIGPRGEIGYPGVTIKGEKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGLVG 1336
            ..|..|.||..|..|..|.||.|  |..|..|..|:.|.:||.|.||.:||:||||.||:.   |
Human  1421 AEGRQGEKGAKGEAGAEGPPGKT--GPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQD---G 1480

  Fly  1337 LPGPIGPAGSKGERGLAGSPGQPGQDGFPGAPGLKGDTGPQGFKGERGLNGF---EGQKGDKGDR 1398
            .|||:||                     ||.||||||.|.:|.||..||.|.   .|::|:||||
Human  1481 PPGPMGP---------------------PGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDR 1524

  Fly  1399 GLQGPSGLPGLVGQKGDTGYPGLNGNDGPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGMLPP 1463
            ||.|..|.|   |.|||.|.|   |..||:|.||..|..||:|..|..|:.|..||||:.|:
Human  1525 GLPGTQGSP---GAKGDGGIP---GPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGL--- 1580

  Fly  1464 PGPKGEPGQPG 1474
            |||.|.||.||
Human  1581 PGPPGSPGPPG 1591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	27/83 (33%)
		Collagen	322..380	CDD:189968	27/57 (47%)
		Collagen	413..465	CDD:189968	22/57 (39%)
		Collagen	499..561	CDD:189968	26/61 (43%)
		Collagen	574..632	CDD:189968	15/57 (26%)
		Collagen	657..714	CDD:189968	20/56 (36%)
		Collagen	765..824	CDD:189968	24/58 (41%)
		Collagen	854..911	CDD:189968	28/56 (50%)
		Collagen	884..943	CDD:189968	26/58 (45%)
		Collagen	923..982	CDD:189968	23/58 (40%)
		Collagen	1028..1085	CDD:189968	24/56 (43%)
		Collagen	1229..1287	CDD:189968	23/57 (40%)
		Collagen	1318..1376	CDD:189968	23/57 (40%)
		Collagen	1399..1458	CDD:189968	28/58 (48%)
		Collagen	1477..1534	CDD:189968
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
COL11A1	XP_016855823.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810