DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and COL5A2

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_000384.2	Gene:	COL5A2 / 1290	HGNCID:	2210	Length:	1499	Species:	Homo sapiens

Alignment Length:	1791	Identity:	621/1791 - (34%)
Similarity:	751/1791 - (41%)	Gaps:	533/1791 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLPFW---KRLLYAAVIAGALVGADAQ-------------------------FWKTA-------G 30
            |:..|   :.||...|:.|..|...||                         .||.|       .
Human     1 MMANWAEARPLLILIVLLGQFVSIKAQEEDEDEGYGEEIACTQNGQMYLNRDIWKPAPCQICVCD 65

  Fly    31 TAGSIQDSVKHYNRNEPKFPIDDSYDIVDSAGVARGDLPPKNC---------------------T 74
            ....:.|.:             :..|::|.|...   .||..|                     .
Human    66 NGAILCDKI-------------ECQDVLDCADPV---TPPGECCPVCSQTPGGGNTNFGRGRKGQ 114

  Fly    75 AGYAGCVPKCIAEKGNRGLPGPLGPTGLKGEMGFPGMEGPSGDKGQKGDPGPYGQRGDKGERGSP 139
            .|..|.||   ...|.||.|||.||         ||.:||.|::|.||.|||   ||.:|..|.|
Human   115 KGEPGLVP---VVTGIRGRPGPAGP---------PGSQGPRGERGPKGRPGP---RGPQGIDGEP 164

  Fly   140 GLHGQAGVPGVQGPAGNPGAPGINGKD--------GCDGQDGIPGLEGLSGMPGPRGYAGQLGSK 196
            |:.||   ||..||.|:|..||.:|..        |.|.:.|:....||  |||..|
Human   165 GVPGQ---PGAPGPPGHPSHPGPDGLSRPFSAQMAGLDEKSGLGSQVGL--MPGSVG-------- 216

  Fly   197 GEKGEPAKENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKGPRGEHGLKGEKGA 261
                 |.        |.:|..|.:|..|.|||.|.|||.|:.|..||.|::||.|
Human   217 -----PV--------GPRGPQGLQGQQGGAGPTGPPGEPGDPGPMGPIGSRGPEG---------- 258

  Fly   262 SCYGPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPRGDMGQKGEPGLVGRKGEPGPEGDTGLDGQ 326
                  .||.|   ||.|||                   |:.|.||.||..|.|
Human   259 ------PPGKP---GEDGEP-------------------GRNGNPGEVGFAGSP----------- 284

  Fly   327 KGEKGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGNPGQKGEPGRAGATGKPGLLGPPG 391
             |.:|.||.            ||..|.||.||..||.|..|..|..|..|.||.||..|.:||.|
Human   285 -GARGFPGA------------PGLPGLKGHRGHKGLEGPKGEVGAPGSKGEAGPTGPMGAMGPLG 336

  Fly   392 PPGGGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQKGGAGLPGRPGNEGPPGKKGE 456
            |    ||.||..|..||:   ||||.:|.:|:.|.|||.|..|..|.:|.||.|
Human   337 P----RGMPGERGRLGPQ---GAPGQRGAHGMPGKPGPMGPLGIPGSSGFPGNP----------- 383

  Fly   457 KGTAGLNGPKGSIGPIGHPGPPGPEGQKGDAGLPGYGIQGSKGDAGIPGYPGLKGSKGERGFKGN 521
                   |.||..||.|..||.||:||:|:.|.|        |..|.||.||..|:.|..|.||.
Human   384 -------GMKGEAGPTGARGPEGPQGQRGETGPP--------GPVGSPGLPGAIGTDGTPGAKGP 433

  Fly   522 AGAPGDSKLGRPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGL 586
            .|:||.|     |.||:||.         ||:||.:|.               .||:|.:|..|.
Human   434 TGSPGTS-----GPPGSAGP---------PGSPGPQGS---------------TGPQGIRGQPGD 469

  Fly   587 PGIPGKDGARGPPGERGYPGERGHDGINGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLSLIEP 651
            ||:||..|..||.||   ||..   ||.|..|||||:|:.|..|.||..|.||           |
Human   470 PGVPGFKGEAGPKGE---PGPH---GIQGPIGPPGEEGKRGPRGDPGTVGPPG-----------P 517

  Fly   652 LKGDKGYPGAPGAKGVQGFKGAEGLPGIPGPKGEFGFKGEKGLSGAPGNDGTPGRAGRDGYPGIP 716
            : |::|.||.      :||.|::||   |||||..|.:|..|.||..|:.|.|||.|..|.||..
Human   518 V-GERGAPGN------RGFPGSDGL---PGPKGAQGERGPVGSSGPKGSQGDPGRPGEPGLPGAR 572

  Fly   717 GQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTGMPGPPGEDGS 781
            |  :.|.||..|.:|..|..|:.|..|..|.|||.          |.:|:||..|:|||.|..|.
Human   573 G--LTGNPGVQGPEGKLGPLGAPGEDGRPGPPGSI----------GIRGQPGSMGLPGPKGSSGD 625

  Fly   782 PGERGYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRG 846
            ||:                           .||.||   .||||.      ||.||::|:.||
Human   626 PGK---------------------------PGEAGN---AGVPGQ------RGAPGKDGEVGP-- 652

  Fly   847 EPGISRPGPMGPPGLNGLQGEKGDRGPTGPIGFPGADGSVGYPGDRGDAGLPGVSGRPGIVGEKG 911
                  .||:|||   ||.||:|::||.||.||.|..|..|.||:.|..|..||.|.||.
Human   653 ------SGPVGPP---GLAGERGEQGPPGPTGFQGLPGPPGPPGEGGKPGDQGVPGDPGA----- 703

  Fly   912 DVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAP 976
             |||:||.|..|.|               ||.|.||:.|:||.||..|..|.|||||..|.:|.|
Human   704 -VGPLGPRGERGNP---------------GERGEPGITGLPGEKGMAGGHGPDGPKGSPGPSGTP 752

  Fly   977 GKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQGLDGMPGE 1041
            |..||                                 |||.|:.|::|:||.||.:|..|..||
Human   753 GDTGP---------------------------------PGLQGMPGERGIAGTPGPKGDRGGIGE 784

  Fly  1042 K------GNQGFPGLDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHGR 1100
            |      ||.|..||.||.|.||.|...|:||||||.||.|..|..|.||..||.
Human   785 KGAEGTAGNDGARGLPGPLGPPGPAGPTGEKGEPGPRGLVGPPGSRGNPGSRGEN---------- 839

  Fly  1101 AGPPGEKGDQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAGAPG 1165
             ||.|..|..|..|.||:.|:.||.||         ||:||..|:   ||..|:.|.||..|..|
Human   840 -GPTGAVGFAGPQGPDGQPGVKGEPGE---------PGQKGDAGS---PGPQGLAGSPGPHGPNG 891

  Fly  1166 AVGYPGDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGS 1230
            ..|..|.||.:|.||.:|.||..|..||.|..|..|..||.||.|..|.|||       |||.||
Human   892 VPGLKGGRGTQGPPGATGFPGSAGRVGPPGPAGAPGPAGPLGEPGKEGPPGL-------RGDPGS 949

  Fly  1231 QGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGDIGPRGEIGYPGVTI 1295
            .|.                        .||||..||||.      ||.|||   .||.|.|
Human   950 HGR------------------------VGDRGPAGPPGG------PGDKGD---PGEDGQP---- 977

  Fly  1296 KGEKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGLVGLPGPIGPAGSKGERGLAGSPGQPG 1360
             |..|.||..|..|::|::|.||..||||:|||   ||..|.||.:||.|:.|::      |.||
Human   978 -GPDGPPGPAGTTGQRGIVGMPGQRGERGMPGL---PGPAGTPGKVGPTGATGDK------GPPG 1032

  Fly  1361 QDGFPGAPGLKGDTGPQGFKGERGLNGFEGQKGDKGDRGLQGPSGLPGLVGQKGDTGYPGLNGND 1425
            ..|.||:.|..|:.||:|..|..|..|.:|..|::||||..||:||||..|..|..|..|..|:.
Human  1033 PVGPPGSNGPVGEPGPEGPAGNDGTPGRDGAVGERGDRGDPGPAGLPGSQGAPGTPGPVGAPGDA 1097

  Fly  1426 GPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGMLPPPGPKGEPGQPGRNGPKGEPGRP---GE 1487
            |..|.||.||..||.||.|:.|.||..|.:|:.|.....|.:|:.|..|..|.:|.||.|   ||
Human  1098 GQRGDPGSRGPIGPPGRAGKRGLPGPQGPRGDKGDHGDRGDRGQKGHRGFTGLQGLPGPPGPNGE 1162

  Fly  1488 RGLIGIQGERGEKGERGLIGETGNVGRPGPKGDRGEPGERGYEGAIGLIGQKGEPGAPAP----- 1547
            :|..||.|..|.:|..|.:|.:|..|.|||.|..|.||.||..|..|..|..||||.|.|
Human  1163 QGSAGIPGPFGPRGPPGPVGPSGKEGNPGPLGPIGPPGVRGSVGEAGPEGPPGEPGPPGPPGPPG 1227

  Fly  1548 ---AALDYLTGILITRHSQSETVPACSAGHTELWTGYSLLYVDGNDYAHNQDLG--SPG------ 1601
               |||..:.|      ...|::|......||             |.|...|..  .||
Human  1228 HLTAALGDIMG------HYDESMPDPLPEFTE-------------DQAAPDDKNKTDPGVHATLK 1273

  Fly  1602 SCVPRFSTL---------PVLSCGQNNVCNYASRNDKTFWLTTNAAIPMMPVENIEIRQYIS--- 1654
            |...:..|:         |..:|....:|:.|.::.: :|:..|..    .||: .|:.|.:
Human  1274 SLSSQIETMRSPDGSKKHPARTCDDLKLCHSAKQSGE-YWIDPNQG----SVED-AIKVYCNMET 1332

  Fly  1655 --RCVVCEAPANVIAVHSQT---IEVPDCPNGWEGL 1685
              .|:    .||..:|..:|   .:.||....|.||
Human  1333 GETCI----SANPSSVPRKTWWASKSPDNKPVWYGL 1364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	25/56 (45%)
		Collagen	322..380	CDD:189968	19/57 (33%)
		Collagen	413..465	CDD:189968	17/51 (33%)
		Collagen	499..561	CDD:189968	25/61 (41%)
		Collagen	574..632	CDD:189968	27/57 (47%)
		Collagen	657..714	CDD:189968	25/56 (45%)
		Collagen	765..824	CDD:189968	16/58 (28%)
		Collagen	854..911	CDD:189968	28/56 (50%)
		Collagen	884..943	CDD:189968	20/58 (34%)
		Collagen	923..982	CDD:189968	24/58 (41%)
		Collagen	1028..1085	CDD:189968	31/62 (50%)
		Collagen	1229..1287	CDD:189968	16/57 (28%)
		Collagen	1318..1376	CDD:189968	25/57 (44%)
		Collagen	1399..1458	CDD:189968	28/58 (48%)
		Collagen	1477..1534	CDD:189968	27/59 (46%)
		C4	1555..1662	CDD:128421	23/128 (18%)
		C4	1663..1777	CDD:128421	9/26 (35%)
COL5A2	NP_000384.2	VWC	41..96	CDD:278520	10/70 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..1268		579/1564 (37%)
		Collagen	270..328	CDD:189968	29/81 (36%)
		Collagen	312..370	CDD:189968	30/64 (47%)
		PRK07764	<346..553	CDD:236090	110/291 (38%)
		Collagen	495..553	CDD:189968	32/78 (41%)
		Cell attachment site. /evidence=ECO:0000255	506..508		0/1 (0%)
		Collagen	546..603	CDD:189968	24/58 (41%)
		Collagen	591..649	CDD:189968	31/103 (30%)
		Collagen	702..759	CDD:189968	32/110 (29%)
		Collagen	744..796	CDD:189968	24/84 (29%)
		Collagen	819..877	CDD:189968	30/80 (38%)
		Collagen	849..907	CDD:189968	28/69 (41%)
		Cell attachment site. /evidence=ECO:0000255	944..946		1/1 (100%)
		Collagen	1044..1100	CDD:189968	25/55 (45%)
		Cell attachment site. /evidence=ECO:0000255	1067..1069		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	1070..1072		1/1 (100%)
		Collagen	1074..1131	CDD:189968	27/56 (48%)
		Cell attachment site. /evidence=ECO:0000255	1100..1102		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	1127..1129		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	1136..1138		0/1 (0%)
		COLFI	1265..1498	CDD:366624	24/110 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810