DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and COL4A6

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	XP_006724680.1	Gene:	COL4A6 / 1288	HGNCID:	2208	Length:	1708	Species:	Homo sapiens

Alignment Length:	1813	Identity:	801/1813 - (44%)
Similarity:	952/1813 - (52%)	Gaps:	264/1813 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 KCIAEKGNRGLPGPLGPTGLKGEMGFPGMEGPSGDKGQKGDP---GPYGQRGDKGERGSPGLHGQ 144
            :|..|||.||.|||:|..|..|..||.|..|.||.||::|.|   ||||.:||||..|.||..|.
Human    41 QCFPEKGARGRPGPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGPMGVPGFLGI 105

  Fly   145 AGVPGVQGPAGNPGAPGINGKDGCDGQDGIPGLEGLSGMPGPRGYAGQLGSKGEKGEPAKENGDY 209
            .|:||..|..|..|.||::|.:|..|..|.||.:|..|:.||.|..||   ||.||:|....|.:
Human   106 NGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYPGLLGPPGLPGQ---KGSKGDPVLAPGSF 167

  Fly   210 AKGEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKGPRGEHGLKGEKGASCYGPMKPGAPGI 274
             ||.||:||..|..|:.||||.||..|..|.:||.|.:||.|..|..|..|....|  ..|..|:
Human   168 -KGMKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNMGLG--FQGEKGV 229

  Fly   275 KGEKGEPASSFPVKPTHTV--MG-PRGDMGQKGEPGLVGRKGEPGPE-----GDTGLDGQKGEKG 331
            ||:.|.|..:.|...|..:  || |:|..|.|||||..|..|..||.     |.||..|:|||||
Human   230 KGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPKGFPGISGPPGFPGLGTTGEKGEKGEKG 294

  Fly   332 LPGGPGDRGRQGN---FGPPGSTGQKGDRGEPGLNGLPGNPGQKGEPGRAGATGKPG-------- 385
            :||.||.||..|:   .||||..|:||..|.|||||..|..||||:      .|.||
Human   295 IPGLPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIEGQKGD------IGLPGPDVFIDID 353

  Fly   386 ---LLGPPGPPGGGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQKGGAGLPGRPGN 447
               :.|.||.|    |.||.||.||..|..|..||   :||.|||...|..|..|..|.||..|:
Human   354 GAVISGNPGDP----GVPGLPGLKGDEGIQGLRGP---SGVPGLPALSGVPGALGPQGFPGLKGD 411

  Fly   448 EGPPGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQ-----KGDAGLPGY-GIQGSKGDAGIPGY 506
            :|.||:. ..|.|||.|..|..||.|.||||.||.:     ..::|.||. |.||.||:.
Human   412 QGNPGRT-TIGAAGLPGRDGLPGPPGPPGPPSPEFETETLHNKESGFPGLRGEQGPKGNL----- 470

  Fly   507 PGLKGSKGERGFKG-NAGAPGDSKLGRPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKC 570
             ||||.||:.||.. :.|.|      ..|.||..|.||..|..|.||..|.:||.|
Human   471 -GLKGIKGDSGFCACDGGVP------NTGPPGEPGPPGPWGLIGLPGLKGARGDRG--------- 519

  Fly   571 SSCRAGPKGDKGTSGLPGIPGKDGARGPPGERGYPGERGHDGINGQTGPPGEKGEDGRTGLPGAT 635
                :|  |.:|.:|.||:.|..|..||.|::|.|      .::...|.||::|:.|..|..|..
Human   520 ----SG--GAQGPAGAPGLVGPLGPSGPKGKKGEP------ILSTIQGMPGDRGDSGSQGFRGVI 572

  Fly   636 GEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGAEGLPGIPGPKGEFGFKGEKGLSGAPGN 700
            |||||               .|.||.|            ||||:||..|: ||.|||||.|.||.
Human   573 GEPGK---------------DGVPGLP------------GLPGLPGDGGQ-GFPGEKGLPGLPGE 609

  Fly   701 DGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGS---CALDE------- 755
            .|.||.      ||:||   .|.||..|..|..||||..|..|::|.|||   |...|
Human   610 KGHPGP------PGLPG---NGLPGLPGPRGLPGDKGKDGLPGQQGLPGSKGDCCCREVGKGDLD 665

  Fly   756 ----IKMP-----AKGNKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQGPPGV----EGPRG 807
                |.:|     :.|..|.||..|.|||.|..|.||..|..|..|:.|..|.||:    |.| |
Human   666 TERGITLPCIIPGSYGPSGFPGTPGFPGPKGSRGLPGTPGQPGSSGSKGEPGSPGLVHLPELP-G 729

  Fly   808 LNGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPGISRPGPMGPPGLNGLQGEKGDRG 872
            ..||||||   |..|.||.||||||.|:.|..|.||.:|..|.......|.||..||||..|.:|
Human   730 FPGPRGEK---GLPGFPGLPGKDGLPGMIGSPGLPGSKGATGDIFGAENGAPGEQGLQGLTGHKG 791

  Fly   873 PTGPIGFPGADGSVGYP------GDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGID 931
            ..|..|.||..|..|.|      |:||..|.||..|:||..|..|..|..|.:|:.|.||.|||.
Human   792 FLGDSGLPGLKGVHGKPGLLGPKGERGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPGFPGIS 856

  Fly   932 GVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGA 996
            |..|:.|.:|:.|.||.:...|..|.:|.|||   .|..|:.|:||..|.||:|.:||.||:||:
Human   857 GHPGKKGTRGKKGPPGSIVKKGLPGLKGLPGN---PGLVGLKGSPGSPGVAGLPALSGPKGEKGS 918

  Fly   997 TGLTGNDG-PVGGRGPPGAPGLMGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLP--- 1057
            .|..|..| |    |.||.||..|:||..|..|..|..|..|.|||||::|.|   ||.|:|
Human   919 VGFVGFPGIP----GLPGIPGTRGLKGIPGSTGKMGPSGRAGTPGEKGDRGNP---GPVGIPSPR 976

  Fly  1058 ---------GDASEKGQKGE---PGPSGLRGDTGPAGTPGWPGEKGLPGL--AVHGRAGPPGEKG 1108
                     ||...:|..|.   |||.|.:|:.|..|.||.||..||||:  .|.|:.||||..|
Human   977 RPMSNLWLKGDKGSQGSAGSNGFPGPRGDKGEAGRPGPPGLPGAPGLPGIIKGVSGKPGPPGFMG 1041

  Fly  1109 DQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPG----------AAGA 1163
            .:|..|:         ||..|:.|..|.|||.||.|..|.||.||..||||          .:|:
Human  1042 IRGLPGL---------KGSSGITGFPGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGS 1097

  Fly  1164 PGAVGYPGDRGDKGEPGLSGL------PGLKGETGPVGLQ---GFTGAPGPKGERGIRGQPGLPA 1219
            ||..|.||:.|.||..|..||      ||.|||.|.||:.   |..||||..|..|:||:||||
Human  1098 PGPKGQPGESGFKGTKGRDGLIGNIGFPGNKGEDGKVGVSGDVGLPGAPGFPGVAGMRGEPGLP- 1161

  Fly  1220 TVPDIRGDKGSQGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGASG--------LNGIP 1276
                        |..|:.|..|..|..||.||.|..|..|..||.|.||..|        :.|:|
Human  1162 ------------GSSGHQGAIGPLGSPGLIGPKGFPGFPGLHGLNGLPGTKGTHGTPGPSITGVP 1214

  Fly  1277 GAKGDIGPRGEIGYPGVTIKGEKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGLVGLPGPI 1341
            |..|..||:||.||||:.|    |.||:||..|::|..|.|||.|..||||..|    :.||..|
Human  1215 GPAGLPGPKGEKGYPGIGI----GAPGKPGLRGQKGDRGFPGLQGPAGLPGAPG----ISLPSLI 1271

  Fly  1342 -GPAGSKGERGLAGSPGQPGQDGFPGAPG---LKGDTGPQGFKGERGLNGFEGQKGDKGDRGLQG 1402
             |..|..|..||.|..|:||..|.||.||   .:||||..||.      |..|.||.|||:|:.|
Human  1272 AGQPGDPGRPGLDGERGRPGPAGPPGPPGPSSNQGDTGDPGFP------GIPGPKGPKGDQGIPG 1330

  Fly  1403 PSGLPGLVGQKGDTGYPGLNGNDGPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGMLP----- 1462
            .|||||.:|.||..|.||..|..|.||.||:.||.|.||:.|..|:.||   :|:||..|
Human  1331 FSGLPGELGLKGMRGEPGFMGTPGKVGPPGDPGFPGMKGKAGPRGSSGL---QGDPGQTPTAEAV 1392

  Fly  1463 --PPGPKGEPGQPGRNGPKGEPGRPGERGLIGIQGERGEKGERGLIGETGNVGRPGPKGDRGEPG 1525
              ||||.   |.||.:|..|..|.||.:|.:|:||.:|..|..|..|.:|..|.||..||.|.||
Human  1393 QVPPGPL---GLPGIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKDGPSGLPGPPGALGDPGLPG 1454

  Fly  1526 ERGYEGAIGLIGQKGEPGAPAPAALDYLTGILITRHSQSETVPACSAGHTELWTGYSLLYVDGND 1590
            .:|..|..|..||:|..|.|.........|..:.:|||||.||.|..|.::||.|||||:|:|.:
Human  1455 LQGPPGFEGAPGQQGPFGMPGMPGQSMRVGYTLVKHSQSEQVPPCPIGMSQLWVGYSLLFVEGQE 1519

  Fly  1591 YAHNQDLGSPGSCVPRFSTLPVLSCGQNNVCNYASRNDKTFWLTTNAAIPMMPVENIEIRQYISR 1655
            .|||||||..|||:|||||:|.:.|..|.||:||.||||::||:|.|.||||||...:|.|||||
Human  1520 KAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPVSQTQIPQYISR 1584

  Fly  1656 CVVCEAPANVIAVHSQTIEVPDCPNGWEGLWIGYSFLMHTAVGNGGGGQALQSPGSCLEDFRATP 1720
            |.|||||:..||||||.|.:|.||.||..||||||||||||.|..||||:|.|||||||||||||
Human  1585 CSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFLMHTAAGAEGGGQSLVSPGSCLEDFRATP 1649

  Fly  1721 FIECNGAKGTCHFYETMTSFWMYNLESSQPF-ERPQQQTIKAGERQSHVSRCQVCMKN 1777
            ||||:||:||||::....|||:..:|..|.| |.|..:|:|||:..:.|||||||||:
Human  1650 FIECSGARGTCHYFANKYSFWLTTVEERQQFGELPVSETLKAGQLHTRVSRCQVCMKS 1707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	29/59 (49%)
		Collagen	322..380	CDD:189968	32/60 (53%)
		Collagen	413..465	CDD:189968	22/51 (43%)
		Collagen	499..561	CDD:189968	24/62 (39%)
		Collagen	574..632	CDD:189968	19/57 (33%)
		Collagen	657..714	CDD:189968	24/56 (43%)
		Collagen	765..824	CDD:189968	29/62 (47%)
		Collagen	854..911	CDD:189968	26/62 (42%)
		Collagen	884..943	CDD:189968	27/64 (42%)
		Collagen	923..982	CDD:189968	25/58 (43%)
		Collagen	1028..1085	CDD:189968	26/71 (37%)
		Collagen	1229..1287	CDD:189968	24/65 (37%)
		Collagen	1318..1376	CDD:189968	28/61 (46%)
		Collagen	1399..1458	CDD:189968	29/58 (50%)
		Collagen	1477..1534	CDD:189968	24/56 (43%)
		C4	1555..1662	CDD:128421	65/106 (61%)
		C4	1663..1777	CDD:128421	73/114 (64%)
COL4A6	XP_006724680.1	Collagen	359..416	CDD:189968	28/63 (44%)
		Collagen	681..740	CDD:189968	29/62 (47%)
		Collagen	800..859	CDD:189968	25/58 (43%)
		Collagen	905..964	CDD:189968	30/62 (48%)
		Collagen	1029..1088	CDD:189968	29/67 (43%)
		Collagen	1150..1208	CDD:189968	26/70 (37%)
		C4	1485..1589	CDD:279721	62/103 (60%)
		C4	1593..1705	CDD:279721	71/111 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	164	1.000	Domainoid score	I3938
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1354	1.000	Inparanoid score	I139
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41315at33208
OrthoFinder	1	1.000	-	-		FOG0000443
OrthoInspector	1	1.000	-	-		otm41900
orthoMCL	1	0.900	-	-		OOG6_100768
Panther	1	1.100	-	-	O	PTHR24023
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2460
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.900