DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and COL4A5

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	XP_011529151.2	Gene:	COL4A5 / 1287	HGNCID:	2207	Length:	1696	Species:	Homo sapiens

Alignment Length:	1823	Identity:	831/1823 - (45%)
Similarity:	988/1823 - (54%)	Gaps:	211/1823 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DSVKHYNRNEPKFPIDDS---YDIVDSAGVARGDLPPKNC-TAGYAGCVPKCIAEKGNRGLPGPL 97
            ||.|..||:...|....|   .::.|......|..|...| .:|..|       |||.||.||..
Human     4 DSGKTENRDWEGFCYSTSAYWKNLYDGLLACYGCSPGSKCDCSGIKG-------EKGERGFPGLE 61

  Fly    98 GPTGLKGEMGFPGMEGPSGDKGQKGDPGPYGQRGDKGERGSPGLHGQAGVPGVQGPAGNPGAPGI 162
            |..||.   ||||.|||.|.:|||||.|..|..|.||.||.|||.|..|.||:.|..|:.||||.
Human    62 GHPGLP---GFPGPEGPPGPRGQKGDDGIPGPPGPKGIRGPPGLPGFPGTPGLPGMPGHDGAPGP 123

  Fly   163 NGKDGCDGQDGIPGLEGLSGMPGPRGYAGQLGSKGEKGEPAKENGDYAKGEKGEPGWRGTAGLAG 227
            .|..||:|..|..|..|..|.||.:|..|..|..|.||||.........|.||.||:.|..|:
Human   124 QGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGMKGEPGSIIMSSLPGPKGNPGYPGPPGI-- 186

  Fly   228 PQGFPGEKGERGDSGPYGAKGPRGEHGLKGEKGASCYGPMKPGAPGIKGEKGEPASSFPVKPTHT 292
             ||.|   |..|..||.|..||.|           ..||  ||.||:.|.||....:|
Human   187 -QGLP---GPTGIPGPIGPPGPPG-----------LMGP--PGPPGLPGPKGNMGLNF------- 227

  Fly   293 VMGPRGDMGQKGEPGLVGRKGEPGPEGDTG-------LDGQKGEKGLPGG---PGDRGRQGNFGP 347
             .||:   |:|||.||   :|.|||.|...       ::.|||::||||.   ||..|.:|..||
Human   228 -QGPK---GEKGEQGL---QGPPGPPGQISEQKRPIDVEFQKGDQGLPGDRGPPGPPGIRGPPGP 285

  Fly   348 PGSTGQKGDRGEPGLNGLPGNPGQKGEPGRAGATGKPGLLGPPGPPGGGRGTPGPPGPKGPRGYV 412
            ||  |:||::||      .|.||::|:||:.|..|:||:.|.||.| |..|.||..|.||.:|..
Human   286 PG--GEKGEKGE------QGEPGKRGKPGKDGENGQPGIPGLPGDP-GYPGEPGRDGEKGQKGDT 341

  Fly   413 GAPGPQGLNGVDGLPGPQGYNGQKGGAGLPGRPGNEGPPGKKGEKGTAGLNGPKGS--IGPIGHP 475
            |.|||.||  |...||.....|:||..||||.||.:|..|..|.:|..||.||.|:  :||.|.|
Human   342 GPPGPPGL--VIPRPGTGITIGEKGNIGLPGLPGEKGERGFPGIQGPPGLPGPPGAAVMGPPGPP 404

  Fly   476 GPPGPEGQKGDAGLPGYGIQGSKGDAGIPGYPGLKGSKGERGFKGNAGAPGDSKLGRPGTPGAAG 540
            |.||..|||||.|.||..|.|..|..|.||.|||.|..|..|    ...|...::..||.||..|
Human   405 GFPGERGQKGDEGPPGISIPGPPGLDGQPGAPGLPGPPGPAG----PHIPPSDEICEPGPPGPPG 465

  Fly   541 APGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGLPGIPGKDGARGPPGERGYP 605
            :||.|         |.:|:.|:|||.|..|.:|..     .|.||.||.||..|..||||..|:|
Human   466 SPGDK---------GLQGEQGVKGDKGDTCFNCIG-----TGISGPPGQPGLPGLPGPPGSLGFP 516

  Fly   606 GERGHDGINGQTGP---PGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKGDK---GYPGAPGA 664
            |::|..|..|.|||   ||..|..|..|.||:.||||     |:.....:||||   |.|||||.
Human   517 GQKGEKGQAGATGPKGLPGIPGAPGAPGFPGSKGEPG-----DILTFPGMKGDKGELGSPGAPGL 576

  Fly   665 KGVQGFKGAEGLPGIPGPKGEFG---FKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGF 726
            .|:.|..|.:||||:||||||.|   ||||:   |.|||.|.||..|..|..|.||....|..|.
Human   577 PGLPGTPGQDGLPGLPGPKGEPGGITFKGER---GPPGNPGLPGLPGNIGPMGPPGFGPPGPVGE 638

  Fly   727 HGRDGAKGDKGSFGRSGEKGEPGSCALDEIKMPAK-GNKGEPGQTGMPGPPGEDGSPGERGYTGL 790
            .|..|..|:.|..|..|.||:||    ..|..|.| |..|.||:.|..|.||:.|.||:.|..|:
Human   639 KGIQGVAGNPGQPGIPGPKGDPG----QTITQPGKPGLPGNPGRDGDVGLPGDPGLPGQPGLPGI 699

  Fly   791 KGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPGISRPGP 855
            .|:.|..|.||: |..|..||:|..|..|..|.||.||:.||.|.||..|.|||:||||.:.|||
Human   700 PGSKGEPGIPGI-GLPGPPGPKGFPGIPGPPGAPGTPGRIGLEGPPGPPGFPGPKGEPGFALPGP 763

  Fly   856 MGPPGLNGLQGEKGDRGPTGPIGFPGADGSVGYPGDRGDAGLPGVSGRPGIVGEKGDVGPIGPAG 920
            .|||||.|.   ||..||.|..||||..|.            ||.:|..|:.|.||||||.|..|
Human   764 PGPPGLPGF---KGALGPKGDRGFPGPPGP------------PGRTGLDGLPGPKGDVGPNGQPG 813

  Fly   921 VAGPPGVPGIDGVRGRDGAKGEP---GSPGLVGMPGNKGDRGAPGND--GPKGFAGVTGAPGKRG 980
            ..||||:||| ||:|..|..|.|   |.|||.|:||.|||.|.||.|  ||.|..|..|.||..|
Human   814 PMGPPGLPGI-GVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGPPGLDVPGPPGERGSPGIPGAPG 877

  Fly   981 PAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQGLDGMP------ 1039
            |.|.||..|..|..||:|..|..|.:|..||||.||.:||.|..|:.|..|..||.|.|
Human   878 PIGPPGSPGLPGKAGASGFPGTKGEMGMMGPPGPPGPLGIPGRSGVPGLKGDDGLQGQPGLPGPT 942

  Fly  1040 GEKGNQGFPGLDGPPGLPGDAS---EKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVH-GR 1100
            ||||::|.|||.|||| |.|.:   .||:|||||..|:.|.:||.|..|.||:.|.|||:.. |.
Human   943 GEKGSKGEPGLPGPPG-PMDPNLLGSKGEKGEPGLPGIPGVSGPKGYQGLPGDPGQPGLSGQPGL 1006

  Fly  1101 AGPPGEKGD---QGRSGIDGRDGINGEKGEQGL---QGVWGQPGEKGSVGAPGIPGAP------- 1152
            .||||.||:   .|:.|:.|..|:.|..|:.|.   |||.|.||..|..|.||.||.|
Human  1007 PGPPGPKGNPGLPGQPGLIGPPGLKGTIGDMGFPGPQGVEGPPGPSGVPGQPGSPGLPGQKGDKG 1071

  Fly  1153 -------GMDGLPGAAGAPGAVGYPGD---RGDKGEPGLSGLPGLKGETGPVGLQGFTGAPGPKG 1207
                   |:.||||..|.||..||||:   :|..|:|||.||||..|..|..||.||.|.|||.|
Human  1072 DPGISSIGLPGLPGPKGEPGLPGYPGNPGIKGSVGDPGLPGLPGTPGAKGQPGLPGFPGTPGPPG 1136

  Fly  1208 ERGIRGQPGLPAT--VPDIRGDKGSQGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGAS 1270
            .:||.|.||.|..  .|...|..|..|:.|..||||:.|:.|:.||||..|..|..|. |.||..
Human  1137 PKGISGPPGNPGLPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGEPGQPGF-GNPGPP 1200

  Fly  1271 GLNGIPGAKGDIGPRGEIGYPGVT-IKGEKGLPGRPGRNGRQGLIGAPG--LIGERGLPGLAGEP 1332
            ||.|:.|.|||.|..|..|.||:. .|||.|..|.||..|..|..|:||  |.|.:|.||..|.|
Human  1201 GLPGLSGQKGDGGLPGIPGNPGLPGPKGEPGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQGPP 1265

  Fly  1333 ------GLVGLPGPIGPAGSKGERGLAGSPGQPGQDGFPGAPGLKGDTGPQGFKGERGLNGFEGQ 1391
                  |..|||||.||.|..|..|:.|..|.|||.|.||.||||||.||.|.:|..|..|..|.
Human  1266 GRPGPTGFQGLPGPEGPPGLPGNGGIKGEKGNPGQPGLPGLPGLKGDQGPPGLQGNPGRPGLNGM 1330

  Fly  1392 KGDKGDRGLQGPSGLPGLVGQKGDTGYPGLNGNDGPVGAPGERGFTGPKGRD----GRDGTPGLP 1452
            |||.   ||.|..|.||:.|..|..|..|..|..|.:|.||..|..||.|:.    |..|.||:|
Human  1331 KGDP---GLPGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGPPGLPGPSGQSIIIKGDAGPPGIP 1392

  Fly  1453 GQKGEPGMLPPPGPKGEPGQPGRNGPKGEPGRPGERGLIGIQGERGEKGERGLIGETGNVGRPGP 1517
            ||.|..|:   |||:|..|.||..||.|:|||   .||.|..|..|.||:.||
Human  1393 GQPGLKGL---PGPQGPQGLPGPTGPPGDPGR---NGLPGFDGAGGRKGDPGL------------ 1439

  Fly  1518 KGDRGEPGERGYEGAIGLIGQKGEPGAPAPAALDYLTGILITRHSQSETVPACSAGHTELWTGYS 1582
               .|:||.||.:|..|..|.:|.||.|..:::.:  |.|||||||:...|.|..|..:::.|:|
Human  1440 ---PGQPGTRGLDGPPGPDGLQGPPGPPGTSSVAH--GFLITRHSQTTDAPQCPQGTLQVYEGFS 1499

  Fly  1583 LLYVDGNDYAHNQDLGSPGSCVPRFSTLPVLSCGQNNVCNYASRNDKTFWLTTNAAIP--MMPVE 1645
            ||||.||..||.||||:.|||:.||||:|.:.|..|||||:|||||.::||:|...:|  |.|::
Human  1500 LLYVQGNKRAHGQDLGTAGSCLRRFSTMPFMFCNINNVCNFASRNDYSYWLSTPEPMPMSMQPLK 1564

  Fly  1646 NIEIRQYISRCVVCEAPANVIAVHSQTIEVPDCPNGWEGLWIGYSFLMHTAVGNGGGGQALQSPG 1710
            ...|:.:||||.||||||.|||||||||::|.||.||:.|||||||:|||:.|..|.||||.|||
Human  1565 GQSIQPFISRCAVCEAPAVVIAVHSQTIQIPHCPQGWDSLWIGYSFMMHTSAGAEGSGQALASPG 1629

  Fly  1711 SCLEDFRATPFIECNGAKGTCHFYETMTSFWMYNLESSQPFERPQQQTIKAGERQSHVSRCQVCM 1775
            ||||:||:.|||||:| :|||::|....|||:..::.|..|.:||.:|:|||:.::.:|||||||
Human  1630 SCLEEFRSAPFIECHG-RGTCNYYANSYSFWLATVDVSDMFSKPQSETLKAGDLRTRISRCQVCM 1693

  Fly  1776 KNS 1778
            |.:
Human  1694 KRT 1696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	31/56 (55%)
		Collagen	322..380	CDD:189968	26/67 (39%)
		Collagen	413..465	CDD:189968	24/51 (47%)
		Collagen	499..561	CDD:189968	21/61 (34%)
		Collagen	574..632	CDD:189968	26/60 (43%)
		Collagen	657..714	CDD:189968	33/59 (56%)
		Collagen	765..824	CDD:189968	25/58 (43%)
		Collagen	854..911	CDD:189968	23/56 (41%)
		Collagen	884..943	CDD:189968	26/58 (45%)
		Collagen	923..982	CDD:189968	35/63 (56%)
		Collagen	1028..1085	CDD:189968	32/65 (49%)
		Collagen	1229..1287	CDD:189968	27/57 (47%)
		Collagen	1318..1376	CDD:189968	33/65 (51%)
		Collagen	1399..1458	CDD:189968	27/62 (44%)
		Collagen	1477..1534	CDD:189968	21/56 (38%)
		C4	1555..1662	CDD:128421	58/108 (54%)
		C4	1663..1777	CDD:128421	68/113 (60%)
COL4A5	XP_011529151.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	164	1.000	Domainoid score	I3938
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1354	1.000	Inparanoid score	I139
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41315at33208
OrthoFinder	1	1.000	-	-		FOG0000443
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100768
Panther	1	1.100	-	-	O	PTHR24023
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1239
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.830