DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Col4a1 and Col8a1

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_031765.2	Gene:	Col8a1 / 12837	MGIID:	88463	Length:	744	Species:	Mus musculus

Alignment Length:	756	Identity:	296/756 - (39%)
Similarity:	354/756 - (46%)	Gaps:	201/756 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   690 GEKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGF--HGRDGA-KGDKGSFGRSGEKGEPGSC 751
            |:.|||  .|.:....:.|:: ||.:| |.:|..|..  .|::.. |..||....:..:||
Mouse    64 GKDGLS--MGKEMPHMQYGKE-YPHLP-QYMKEIPPVPRMGKEVVPKKGKGEVPLASLRGE---- 120

  Fly   752 ALDEIKMPAKGNKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQGPPGVEGPRGLNGPRGEKG 816
                     :|.:||||..|.|||||..|    .|..|:||..||||.||:
Mouse   121 ---------QGPRGEPGPRGPPGPPGLPG----HGMPGIKGKPGPQGYPGI-------------- 158

  Fly   817 NQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPGISRPGPMGPPGLNGLQGEKGDRGPTGPIGFPG 881
              |..|:||.|||.|..|:||..|:.||:||     .||||.|         |.:||.||.|.||
Mouse   159 --GKPGMPGMPGKPGAMGMPGAKGEIGPKGE-----IGPMGIP---------GPQGPPGPHGLPG 207

  Fly   882 ADGSVGYPGDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEPGSP 946
                :|.||.      ||:.|:||..||:|..||.||.|:.||               |||.|
Mouse   208 ----IGKPGG------PGLPGQPGAKGERGPKGPPGPPGLQGP---------------KGEKG-- 245

  Fly   947 GLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGP 1011
              .||||..|.:|.||..||.            ||.|:|||    |..|.||..|..||:|..||
Mouse   246 --FGMPGLPGLKGPPGMHGPP------------GPVGLPGV----GKPGVTGFPGPQGPLGKPGP 292

  Fly  1012 PGAPGLMGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSGLRG 1076
            ||.|      |.|||.|.||.||..||||    .|.||.||.||.||....||::
Mouse   293 PGEP------GPQGLIGVPGVQGPPGMPG----VGKPGQDGIPGQPGFPGGKGEQ---------- 337

  Fly  1077 DTGPAGTPGWPGEKGLPGLAVHGRAGPPGEKGDQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKG 1141
                 |.||.||..||||:   |:.|.||.|||:|..|:               .||.|..||||
Mouse   338 -----GLPGLPGPPGLPGV---GKPGFPGPKGDRGIGGV---------------PGVLGPRGEKG 379

  Fly  1142 SVGAPGI---PGAPGMDGLPGAAGAPGAVGYPGDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAP 1203
            .:||||:   ||.||:.|:||..|.|||:|:||.:|:.|..|..|.||.|||.   |||||.|.|
Mouse   380 PIGAPGMGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGVVGPQGPPGPKGEP---GLQGFPGKP 441

  Fly  1204 GPKGERGIRGQPGLPATVPDIRGDKGSQGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPG 1268
            |..||.|..|..|||       |..|.:||.|:.|..|..|..||.||.|..|..||:||||||
Mouse   442 GFLGEVGPPGMRGLP-------GPIGPKGEGGHKGLPGLPGVPGLLGPKGEPGIPGDQGLQGPP- 498

  Fly  1269 ASGLNGIPGAKGDIGPRGEIGYPGVTIKGEKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPG 1333
                 ||||..|..||.|..|.||.  |||.||||.|                  |.||: |:||
Mouse   499 -----GIPGIVGPSGPIGPPGIPGP--KGEPGLPGPP------------------GFPGV-GKPG 537

  Fly  1334 LVGLPGPIGPAGSKGERGLAGSPGQPGQDGFPGAPGLKGDTGPQG-FKGERGLNGFEGQK----- 1392
            :.||.||.|..|:.|.:|..|.||.||..|.||.|.:.....||| :..:.|| |.:|.|
Mouse   538 VAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVMPTPSPQGEYLPDMGL-GIDGVKPPHAY 601

  Fly  1393 -GDKGDRGLQGPS-GLPGLVGQKGDTGYPGLNGNDGPVGAP 1431
             |.||..|  ||: .:|....:. ...:|       |||||
Mouse   602 AGKKGKHG--GPAYEMPAFTAEL-TVPFP-------PVGAP 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968
		Collagen	322..380	CDD:189968
		Collagen	413..465	CDD:189968
		Collagen	499..561	CDD:189968
		Collagen	574..632	CDD:189968
		Collagen	657..714	CDD:189968	7/23 (30%)
		Collagen	765..824	CDD:189968	23/58 (40%)
		Collagen	854..911	CDD:189968	23/56 (41%)
		Collagen	884..943	CDD:189968	20/58 (34%)
		Collagen	923..982	CDD:189968	17/58 (29%)
		Collagen	1028..1085	CDD:189968	21/56 (38%)
		Collagen	1229..1287	CDD:189968	28/57 (49%)
		Collagen	1318..1376	CDD:189968	23/57 (40%)
		Collagen	1399..1458	CDD:189968	10/34 (29%)
		Collagen	1477..1534	CDD:189968
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
Col8a1	NP_031765.2	Nonhelical region (NC2)	29..118		16/57 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..395		163/428 (38%)
		Triple-helical region (COL1)	119..572		258/624 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..439		15/29 (52%)
		Collagen	445..502	CDD:189968	31/69 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..590		67/159 (42%)
		Nonhelical region (NC1)	573..744		21/71 (30%)
		C1Q	609..744	CDD:128420	10/34 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910