DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Col4a1 and Col7a1

DIOPT Version :9

Sequence 1:NP_723044.1 Gene:Col4a1 / 33727 FlyBaseID:FBgn0000299 Length:1779 Species:Drosophila melanogaster
Sequence 2:NP_031764.2 Gene:Col7a1 / 12836 MGIID:88462 Length:2944 Species:Mus musculus


Alignment Length:1785 Identity:737/1785 - (41%)
Similarity:884/1785 - (49%) Gaps:362/1785 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 VIAGALVGADAQFWK--TAGTAGSIQDSVKHYNRNEPKFPIDDSYDIVDSAGVAR--GDLPPKNC 73
            |:|.:|||||.:..:  ..||.                 ||.:.:.:.:..|:.|  .||....|
Mouse  1188 VMALSLVGADPEQLRRLAPGTD-----------------PIQNFFAVDNGPGLDRAVSDLAVALC 1235

  Fly    74 TAGY------AGCVPKCIAEKGNRGLPGPLGPTGLKGEMGFPGMEGPSGDKGQKGDPGPYGQRGD 132
            .|..      ..|...|  .||.:|.|   |.|||:|:.|.|   ||.|..|:.|.|||.|..|.
Mouse  1236 QAAVTIEPQTGPCAVHC--PKGQKGEP---GVTGLQGQAGPP---GPPGLPGRTGAPGPQGPPGS 1292

  Fly   133 ---KGERGSPGLHGQAGVPGVQGPAGNPGAPGINGKDGCDGQDGIPGLEGLSGMPGPRGYAGQLG 194
               ||||         |.||.:||.|:||.||:.|.         ||::|.:|.|||||..|:.|
Mouse  1293 TQAKGER---------GFPGPEGPPGSPGLPGVPGS---------PGIKGSTGRPGPRGEQGERG 1339

  Fly   195 SKGEKGEPAKENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKGPRGEHGLKGEK 259
            .:|.||||            ||||  ...|..|| ||||:||:.|.|||.|::||.|:.|.:|  
Mouse  1340 PQGPKGEP------------GEPG--QITGGGGP-GFPGKKGDPGPSGPPGSRGPVGDPGPRG-- 1387

  Fly   260 GASCYGPMKPGAPGI--KGEKGEPASSFPVKPTHTVMGPRGDMGQKGEPGLVGRKGEPGPEGDTG 322
                    .||.|||  ||:||:.....|       .||.....::|:|||.|..|.|||:|..|
Mouse  1388 --------PPGLPGISVKGDKGDRGERGP-------PGPGIGASEQGDPGLPGLPGSPGPQGPAG 1437

  Fly   323 LDGQKGEK--------GLPGGPGDRGRQGNFGPPGSTGQKGDR------GEPGLNGLPGNPGQKG 373
            ..|:||||        ||||.||..|..|..|.||.||.||||      ||||:.|..|:||..|
Mouse  1438 RPGEKGEKGDCEDGGPGLPGQPGPPGEPGLRGAPGMTGPKGDRGLTGTPGEPGVKGERGHPGPVG 1502

  Fly   374 EPGRAGATGKPGLLGPPGPPG--GGRGTPGPPG-PKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQ 435
            ..|..||.|.||:.||.||||  |.||..|.|| |..|....|..|.:|..|..|||||:|.:|.
Mouse  1503 PQGLPGAAGHPGVEGPEGPPGPTGRRGEKGEPGRPGDPAVGPGGAGAKGEKGEAGLPGPRGASGS 1567

  Fly   436 KGGAGLPG--RPGNEGPPGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQKGDAGLPG------- 491
            ||..|.||  .||:.||.|..|::|..||.   |..||.|..||||.:|:.|..|.||       
Mouse  1568 KGEQGAPGLALPGDPGPKGDPGDRGPIGLT---GRAGPTGDSGPPGEKGEPGRPGSPGPVGPRGR 1629

  Fly   492 YGIQGSKGDAGIPGYPGLKGSKGERGF------------KGNAGAPGDSKLGRPGTPGAAGAPGQ 544
            .|..|.|||.||||.|||.|..||||.            ||:.|.||:.  ||.|:||::|..|.
Mouse  1630 DGEAGEKGDEGIPGEPGLPGKAGERGLRGAPGPRGPVGEKGDQGDPGED--GRNGSPGSSGPKGD 1692

  Fly   545 KGDAGRPGTPGQKGDMGI----KGDVGGKCSSCRAGPKGDKGTSGLPGIPGK---DGARGPPGER 602
            :|:.|.||.||:..|.||    ||:.|      :.||:|.||..|.||:.|:   ||.|||||.:
Mouse  1693 RGEPGPPGPPGRLVDAGIESRDKGEPG------QEGPRGPKGDPGPPGVSGERGIDGLRGPPGPQ 1751

  Fly   603 GYPGERGHDGINGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLS---------LIEPLKGDKGY 658
            |.||.||..|..|..|||   |.|||:||.|..|.||.|.|...|         .:..|:|:.|.
Mouse  1752 GDPGVRGPAGDKGDRGPP---GLDGRSGLDGKPGAPGPPGLHGASGKAGDPGRDGLPGLRGEHGP 1813

  Fly   659 PGAPGAKGVQGFKGAEGLPGI------PGPKGEFGFKGEKGLSGAPGND---------GTPGRAG 708
            ||.||..||.|..|.:|.||:      ||..||.|.|||||.|||||.:         |.||..|
Mouse  1814 PGPPGPPGVPGKAGDDGKPGLNGKNGDPGDPGEDGRKGEKGDSGAPGREGPDGPKGERGAPGNPG 1878

  Fly   709 RDGYPGIPGQ---SIKGEPGFHGRDGAKGDKGSFGRSGE---------KGEPGS----------- 750
            ..|.||:|||   ..:|.||..|..|.|||:|..|..||         :|||||           
Mouse  1879 LQGPPGLPGQVGPPGQGFPGVPGITGPKGDRGETGSKGEQGLPGERGLRGEPGSLPNAERLLETA 1943

  Fly   751 ----CALDEI------------KMPAK--GNKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQ 797
                .||.||            .:|.:  |.||:||..|.||..|..|.|||||..|.:|:.|||
Mouse  1944 GIKVSALREIVDTWDESSGSFLPVPERRPGPKGDPGDRGPPGKEGLIGFPGERGLKGERGDPGPQ 2008

  Fly   798 GPPGVE-GPRGLNGPRGEKGNQGAVGVPGNP---------------------------GKDGLRG 834
            ||||:. |.||..||.|..|..|..|:||.|                           |:|||.|
Mouse  2009 GPPGLALGERGPPGPPGLAGEPGKPGIPGLPGRAGGSGEAGRPGERGERGEKGERGDQGRDGLPG 2073

  Fly   835 IPGRNGQPGPRGEPGISRPGP-----MGPPGLNGLQGE---KGDRGPTGPIGFPGADGSVGYPGD 891
            :||..|.|||:  ..|..|||     .|||||.|.:||   .||.||.|..|.||..|.||.||.
Mouse  2074 LPGPPGPPGPK--VAIEEPGPGLAREQGPPGLKGAKGEPGSDGDPGPKGDRGVPGIKGDVGEPGK 2136

  Fly   892 RGDAGLPGV---------SGRPGIVGEKGDVGPIGPAGVAGPPGVPGI---DGVRGRDGAKGEPG 944
            ||..|.||:         .|:||:.|.:|..||:|..|..||||.||:   .|.:|..|.|||||
Mouse  2137 RGHDGNPGLPGERGVAGPEGKPGLQGPRGTPGPVGSHGDPGPPGAPGLAGPAGPQGPSGLKGEPG 2201

  Fly   945 S---PGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPV 1006
            .   ||. |:||..|..|.||..||.|..|..|:||..|..|..|..|..|..|::|..|:.|..
Mouse  2202 ETGPPGR-GLPGPVGAVGLPGPPGPSGLVGPQGSPGLPGQVGETGKPGPPGRDGSSGKDGDRGSP 2265

  Fly  1007 GGRGPPGAPGLMGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLPGDASEKGQKGEPGP 1071
            |..|.||.||.:|.||:.|..|||||. :.|.||.||.:|.|| |....|.|:...||.:|.|||
Mouse  2266 GVPGSPGLPGPVGPKGEPGPVGAPGQV-VVGPPGAKGEKGAPG-DLAGALLGEPGAKGDRGLPGP 2328

  Fly  1072 SGLRGDTGPAGTPGWPGE------------KGLPGLAVH---GRAGPPGEKGDQGRSGIDGRDGI 1121
            .|.:|:.|.||.||.|||            ||.||:.|.   |.:||||.|||.|..|..|..|:
Mouse  2329 RGEKGEAGRAGGPGDPGEDGQKGAPGLKGLKGEPGIGVQGPPGPSGPPGMKGDLGPPGAPGAPGV 2393

  Fly  1122 NGEKGEQGLQGVWGQP---GEKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYPGDRGDKGEPGLSG 1183
            .|..|:.|.:|..|||   ||:|..|.||..||||..|.||..|:.||.|..|.:||||:|| :|
Mouse  2394 VGFPGQTGPRGETGQPGPVGERGLAGPPGREGAPGPLGPPGPPGSAGAPGASGLKGDKGDPG-AG 2457

  Fly  1184 LPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGERGYTGEKGEQGERG- 1247
            |||.:||.|..|::|..|.||.:|.||:.|.||       .||::|.:|..|..|.||::|:.. 
Mouse  2458 LPGPRGERGEPGVRGEDGHPGQEGPRGLVGPPG-------SRGEQGEKGAAGAAGLKGDKGDSAV 2515

  Fly  1248 LTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGDIGPRGEIGYPGVTIKGEKGLPGRPGRNGRQG 1312
            :.||.|..|||||.|.:||.|..         ||.|||||.|.|     |:||..|.||..    
Mouse  2516 IEGPPGPRGAKGDMGERGPRGID---------GDKGPRGESGNP-----GDKGSKGEPGDK---- 2562

  Fly  1313 LIGAPGLIGERGLPGLAGEPGLVGLPGPIGPAGSKGERGLAGSPGQPGQDGFPGAPGLKGD---T 1374
              |:.|.||.|||.|..||||..|:|               |.||.||:||.||..|.|||   .
Mouse  2563 --GSAGSIGVRGLTGPKGEPGAAGIP---------------GEPGAPGKDGIPGFRGDKGDIGFM 2610

  Fly  1375 GPQGFKGERGLNGFEGQKGDKGDRGLQGPSGLPGLVGQKGDTGYPGLNGNDGPVGAPGERGFTGP 1439
            ||:|.|||:|:.|..|:.|::||:|..|..|.|||.|:|||.|.|||.|..   ||||:.|..||
Mouse  2611 GPRGLKGEKGIKGTCGRDGERGDKGEAGFPGRPGLAGKKGDMGEPGLPGQS---GAPGKEGLIGP 2672

  Fly  1440 KGRDGRDGTPGLPGQKGEPGMLPPPGPKGEPGQPGRNGPKGEPGRPGERGLIGIQGERGEKGERG 1504
            ||..|.||..|..|.:||.|...|||..|.||..|.:|..|.||.||..|..|.:|.:|:|||||
Mouse  2673 KGDRGFDGQSGPKGDQGEKGERGPPGVGGFPGPRGNDGSSGPPGPPGGVGPKGPEGLQGQKGERG 2737

  Fly  1505 LIGETGNVGRPGPKGDRGEPGERGYEGAIGLIGQKGEPGAPAPAALDYL----------TGILI- 1558
            ..||: .||.||..|..||.||:|..|..|..|:|||.........|::          .|..| 
Mouse  2738 PPGES-VVGAPGAPGTPGERGEQGRPGPAGPRGEKGEAALTEDDIRDFVRQEMSQHCACQGQFIA 2801

  Fly  1559 ------------TRHSQSETVPACSAGHTE 1576
                        |..||...||.....|.|
Mouse  2802 SGSRPLPGYAADTAGSQLHHVPVLRVSHVE 2831

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Col4a1NP_723044.1 Collagen 104..161 CDD:189968 25/59 (42%)
Collagen 322..380 CDD:189968 33/71 (46%)
Collagen 413..465 CDD:189968 25/53 (47%)
Collagen 499..561 CDD:189968 33/73 (45%)
Collagen 574..632 CDD:189968 31/60 (52%)
Collagen 657..714 CDD:189968 32/71 (45%)
Collagen 765..824 CDD:189968 31/59 (53%)
Collagen 854..911 CDD:189968 32/73 (44%)
Collagen 884..943 CDD:189968 30/70 (43%)
Collagen 923..982 CDD:189968 31/64 (48%)
Collagen 1028..1085 CDD:189968 27/56 (48%)
Collagen 1229..1287 CDD:189968 24/58 (41%)
Collagen 1318..1376 CDD:189968 26/60 (43%)
Collagen 1399..1458 CDD:189968 30/58 (52%)
Collagen 1477..1534 CDD:189968 28/56 (50%)
C4 1555..1662 CDD:128421 9/35 (26%)
C4 1663..1777 CDD:128421
Col7a1NP_031764.2 Nonhelical region (NC1). /evidence=ECO:0000255 18..1254 19/84 (23%)
vWA_collagen_alphaI-XII-like 38..202 CDD:238759
fn3 234..318 CDD:278470
FN3 334..414 CDD:238020
fn3 427..488 CDD:278470
fn3 510..588 CDD:278470
FN3 599..681 CDD:238020
fn3 688..765 CDD:278470
fn3 778..856 CDD:278470
fn3 874..946 CDD:278470
FN3 959..1046 CDD:238020
VWA 1055..1223 CDD:278519 11/51 (22%)
Cell attachment site. /evidence=ECO:0000255 1171..1173
Triple-helical region. /evidence=ECO:0000255 1255..2775 707/1641 (43%)
Interrupted collagenous region. /evidence=ECO:0000255 1255..1475 113/275 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1259..1934 320/744 (43%)
Collagen 1398..1444 CDD:189968 19/52 (37%)
Collagen 1470..1511 CDD:189968 20/40 (50%)
Collagen 1560..1624 CDD:189968 31/66 (47%)
Collagen 1601..1660 CDD:189968 29/58 (50%)
Collagen 1643..1695 CDD:189968 21/53 (40%)
Collagen 1839..1893 CDD:189968 25/53 (47%)
Collagen 1875..1931 CDD:189968 22/55 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1960..2773 379/864 (44%)
Cell attachment site. /evidence=ECO:0000255 2002..2004 0/1 (0%)
Cell attachment site. /evidence=ECO:0000255 2063..2065 0/1 (0%)
Collagen 2099..2158 CDD:189968 27/58 (47%)
Collagen 2233..2292 CDD:189968 26/58 (45%)
Collagen 2275..2338 CDD:189968 30/64 (47%)
Collagen 2448..2497 CDD:189968 26/56 (46%)
Collagen 2481..2559 CDD:189968 40/98 (41%)
Collagen 2530..2589 CDD:189968 34/93 (37%)
Collagen 2575..2632 CDD:189968 30/71 (42%)
Cell attachment site. /evidence=ECO:0000255 2601..2603 0/1 (0%)
Collagen 2605..2664 CDD:189968 30/61 (49%)
Cell attachment site. /evidence=ECO:0000255 2631..2633 0/1 (0%)
Collagen 2641..2693 CDD:189968 29/54 (54%)
Nonhelical region (NC2). /evidence=ECO:0000255 2776..2944 10/56 (18%)
KU 2877..2932 CDD:238057
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BAFZ
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.