DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and Col3a1

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_034060.2	Gene:	Col3a1 / 12825	MGIID:	88453	Length:	1464	Species:	Mus musculus

Alignment Length:	1685	Identity:	615/1685 - (36%)
Similarity:	724/1685 - (42%)	Gaps:	419/1685 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 IVDSAGVARGDL----PPKNCTAGYAGCVP--KCIAEKGNRGLPGPLGPTGLKGEMGFPGMEGPS 115
            :.||..|...|:    .|.:|....   :|  :|.|.......|.|:.|.|             .
Mouse    55 VCDSGSVLCDDIICDEEPLDCPNPE---IPFGECCAICPQPSTPAPVLPDG-------------H 103

  Fly   116 GDKGQKGDPGPYGQRGDKGERGSPGLHGQAGVPGVQGPAGNPG------APGINGKDGCDGQDGI 174
            |.:|.||||||   .|..|..|.|||.||   ||:.||.|:||      ..|.|.....|..|..
Mouse   104 GPQGPKGDPGP---PGIPGRNGDPGLPGQ---PGLPGPPGSPGICESCPTGGQNYSPQFDSYDVK 162

  Fly   175 PGLEGLSGMPGPRGYAGQLGSKGEKGEPAKENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERG 239
            .|:.|:.|.|||.|..|..|..|..|.|         |..|.||::      ||.|.||:.|..|
Mouse   163 SGVGGMGGYPGPAGPPGPPGPPGSSGHP---------GSPGSPGYQ------GPPGEPGQAGPAG 212

  Fly   240 DSGPYGAKGPRGEHGLKGEKGASCYGPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPRGDMGQKG 304
            ..||.||.||.|..|..||.|       :||.|   ||:|.|             ||.|..|..|
Mouse   213 PPGPPGALGPAGPAGKDGESG-------RPGRP---GERGLP-------------GPPGIKGPAG 254

  Fly   305 EPGLVGRKGEPGPEGDTGLDGQKGEKGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGNP 369
            .||.      ||.:|..|.||:.||||..|.||.:|..|..|..|:.|..|.||.||..|.||.|
Mouse   255 MPGF------PGMKGHRGFDGRNGEKGETGAPGLKGENGLPGDNGAPGPMGPRGAPGERGRPGLP 313

  Fly   370 GQKGEPGRAGATGKPGLLGPPGPPGGGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNG 434
            |..|..|..||.|..|..|||||||.. |.||.||.||..|..|:||..|..|..|.|||||:.|
Mouse   314 GAAGARGNDGARGSDGQPGPPGPPGTA-GFPGSPGAKGEVGPAGSPGSNGSPGQRGEPGPQGHAG 377

  Fly   435 QKGGAGLPGRPGNEGPPGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQKGDAGLPGYGIQGSKG 499
            .:|.   ||.|||.|.||.|||.|.||:.|..|.||.   .|||||.|..        ||.|::|
Mouse   378 AQGP---PGPPGNNGSPGGKGEMGPAGIPGAPGLIGA---RGPPGPAGTN--------GIPGTRG 428

  Fly   500 DAGIPGYPGLKGSKGERGFKGNAGAPGDSKLGRPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKG 564
            .:|.||..|.||..|.||.:|.||:|              |.||.||:.|:.|:||:.|..|:.|
Mouse   429 PSGEPGKNGAKGEPGARGERGEAGSP--------------GIPGPKGEDGKDGSPGEPGANGLPG 479

  Fly   565 DVGGKCSSCRAGPKGDKGTSGLPGIPGKDGARGPPGERGYPGERGHDGINGQTGPPGEKGEDGRT 629
            ..|.:      ||.|.:|.:|..||||:   :|||||||.||..|..|:      .||.|.||..
Mouse   480 AAGER------GPSGFRGPAGPNGIPGE---KGPPGERGGPGPAGPRGV------AGEPGRDGTP 529

  Fly   630 GLPGATGEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGAEGLPGIPGPKGEFGFKGEKGL 694
            |.||..|.||.|               |.||..|..|..|.:|..|.||.|||.|..|..|..|.
Mouse   530 GGPGIRGMPGSP---------------GGPGNDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGF 579

  Fly   695 SGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCALDEIKMP 759
            .|..||||.||:
Mouse   580 PGPKGNDGAPGK----------------------------------------------------- 591

  Fly   760 AKGNKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVP 824
             .|.:|.||..|:|||.|::            |.||||||||.      .||.|:||:.|.
Mouse   592 -NGERGGPGGPGLPGPAGKN------------GETGPQGPPGP------TGPAGDKGDSGP---- 633

  Fly   825 GNPGKDGLRGIPGRNGQPGPRGEPGISRPGPMGPPGLNGLQGEKGDRGPTGPIGFPGADGSVGYP 889
              ||..||:||||..|.||..|:||  .|||.|..|..|..|.|||.|.               |
Mouse   634 --PGPQGLQGIPGTGGPPGENGKPG--EPGPKGEVGAPGAPGGKGDSGA---------------P 679

  Fly   890 GDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEPGSPGLVGMPGN 954
            |:||.   ||.:|.||..|..|..||.|..|.|||||.||..            |||||.|||
Mouse   680 GERGP---PGTAGIPGARGGAGPPGPEGGKGPAGPPGPPGAS------------GSPGLQGMP-- 727

  Fly   955 KGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMG 1019
             |:||.||:.|||   |..|.||..|..|:|               |.|||.|..||.|.||..|
Mouse   728 -GERGGPGSPGPK---GEKGEPGGAGADGVP---------------GKDGPRGPAGPIGPPGPAG 773

  Fly  1020 IKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTP 1084
            ..||:|..|:|               |.||:.||.|.||   |:|:.|.|         ||||.|
Mouse   774 QPGDKGEGGSP---------------GLPGIAGPRGGPG---ERGEHGPP---------GPAGFP 811

  Fly  1085 GWPGEKGLPGLAVHGRAGPPGEKGDQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPGIP 1149
            |.||:.|.||  ..|..|.|||||:.|..|..|..|.:|..|..|.|||   .||:||.|.||..
Mouse   812 GAPGQNGEPG--AKGERGAPGEKGEGGPPGPAGPTGSSGPAGPPGPQGV---KGERGSPGGPGTA 871

  Fly  1150 GAPGMDGLPGAAGAPGAVGYPGDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAPGPKGERGIRGQ 1214
            |.||..||||.         ||:.|:.|.||.||.|   |:.||         |||.|..|..|.
Mouse   872 GFPGGRGLPGP---------PGNNGNPGPPGPSGAP---GKDGP---------PGPAGNSGSPGN 915

  Fly  1215 PGLPATVPDIRGDKGSQGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPGAK 1279
            ||       |.|.||..|:.|..|..|.||..|..||.|:||..|.|||.|||      |:||.:
Mouse   916 PG-------IAGPKGDAGQPGEKGPPGAQGPPGSPGPLGIAGLTGARGLAGPP------GMPGPR 967

  Fly  1280 GDIGPRGEIGYPGVTIKGEKGLPGRPGRNGR------QGLIGAPGLIGERGLPGLAGEPGLVGLP 1338
            |..||:|        ||||.|.||..|.||.      |||.|.||..||   ||..|.||..|.|
Mouse   968 GSPGPQG--------IKGESGKPGASGHNGERGPPGPQGLPGQPGTAGE---PGRDGNPGSDGQP 1021

  Fly  1339 GPIGPAGSKGERGLAGSPGQPGQDGFPGAPGLKGDTGPQGFKGERGLNGFEGQKGDKGDRGLQGP 1403
            |..|..|.||:||..||||.||..|.||.|   |..||            .|:.||:|:.|..||
Mouse  1022 GRDGSPGGKGDRGENGSPGAPGAPGHPGPP---GPVGP------------SGKSGDRGETGPAGP 1071

  Fly  1404 SGLPGLVGQKGDTGYPGLNGNDGPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGMLPPPGPKG 1468
            ||.||..|.:|..|..|..|:.|..|..|..|..|.:|..|..|.||.||..|..|.:..|||.|
Mouse  1072 SGAPGPAGARGAPGPQGPRGDKGETGERGSNGIKGHRGFPGNPGPPGSPGAAGHQGAIGSPGPAG 1136

  Fly  1469 EPGQPGRNGPKGEPGRPGERGLIGIQGERGEKGERGLIGETGNVGRPGPKGDRGEPGERGYEGAI 1533
            ..|..|.:||.|:.|..|..|.||..|.||.:||||..|..|:.|:|||.|..|.||.....||.
Mouse  1137 PRGPVGPHGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGGAA 1201

  Fly  1534 GLIGQKGE-PGAPAPAALDYLTGILITRHSQSETVPACSAGHTELWTGYSLLYVDGNDYAHNQDL 1597
            .:.|..|| .|..:|...|......|.......::.:.: |..|     ||:..||:
Mouse  1202 AIAGVGGEKSGGFSPYYGDDPMDFKINTEEIMSSLKSVN-GQIE-----SLISPDGS-------- 1252

  Fly  1598 GSPGSCVPRFSTLPVLSCGQNNVCNYASRNDKTFWLTTNAAIPMMPVENIEIRQYISRCVVCEAP 1662
                      ...|..:|.....|:...::.: :|:..|....|..::           |.|...
Mouse  1253 ----------RKNPARNCRDLKFCHPELKSGE-YWVDPNQGCKMDAIK-----------VFCNME 1295

  Fly  1663 ANVIAVHSQTIEVPDCPNGW-------EGLWIGYSFLMHTAVGNGGGGQALQSPGSCLED 1715
            .....:::..:.||. .:.|       :.:|.|.|.        .||.|....|....||
Mouse  1296 TGETCINASPMTVPR-KHWWTDSGAEKKHVWFGESM--------NGGFQFSYGPPDLPED 1346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	23/62 (37%)
		Collagen	322..380	CDD:189968	27/57 (47%)
		Collagen	413..465	CDD:189968	27/51 (53%)
		Collagen	499..561	CDD:189968	24/61 (39%)
		Collagen	574..632	CDD:189968	26/57 (46%)
		Collagen	657..714	CDD:189968	24/56 (43%)
		Collagen	765..824	CDD:189968	23/58 (40%)
		Collagen	854..911	CDD:189968	20/56 (36%)
		Collagen	884..943	CDD:189968	22/58 (38%)
		Collagen	923..982	CDD:189968	27/58 (47%)
		Collagen	1028..1085	CDD:189968	18/56 (32%)
		Collagen	1229..1287	CDD:189968	26/57 (46%)
		Collagen	1318..1376	CDD:189968	28/57 (49%)
		Collagen	1399..1458	CDD:189968	25/58 (43%)
		Collagen	1477..1534	CDD:189968	27/56 (48%)
		C4	1555..1662	CDD:128421	15/106 (14%)
		C4	1663..1777	CDD:128421	12/60 (20%)
Col3a1	NP_034060.2	VWC	33..89	CDD:278520	9/36 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..1195		570/1442 (40%)
		Nonhelical region (N-terminal)	155..169		4/13 (31%)
		Triple-helical region	170..1195		538/1350 (40%)
		Collagen	233..292	CDD:189968	31/87 (36%)
		Collagen	278..331	CDD:189968	24/52 (46%)
		Collagen	353..422	CDD:189968	38/82 (46%)
		Collagen	413..472	CDD:189968	32/80 (40%)
		Collagen	449..502	CDD:189968	26/75 (35%)
		Collagen	1016..1095	CDD:189968	39/93 (42%)
		Collagen	1064..1135	CDD:189968	29/70 (41%)
		COLFI	1231..1463	CDD:279718	26/161 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900