DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and Col19a1

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	XP_006495705.1	Gene:	Col19a1 / 12823	MGIID:	1095415	Length:	1162	Species:	Mus musculus

Alignment Length:	1202	Identity:	431/1202 - (35%)
Similarity:	521/1202 - (43%)	Gaps:	356/1202 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 NRNEPKFPIDDSYDIVDSA------GVARGDLPPKNCTAGYAGCVPKCIAEKGNRGLPGPLGPTG 101
            |.:..|.|..|.:....|:      |.....||.|........|:|    .|...||||.|...|
Mouse   267 NLSPTKCPEQDDFGSTTSSWGTSNTGKMSSYLPGKQELKDTCQCIP----NKEEAGLPGTLRSIG 327

  Fly   102 LKGEMGFPGMEGPSGDKGQKGDPGPYGQRGDKGERGSPGLHGQAGVPGVQGPAGNPGAPGINGKD 166
            .||:.|.|      |:.|..|.||..||   |||:|..|:.|:.      |..|.|||.|.:|.|
Mouse   328 HKGDKGEP------GEHGLDGTPGLPGQ---KGEQGLEGIKGEI------GEKGEPGAKGDSGLD 377

  Fly   167 GCDGQDGIPGLEGLSGMPGPRGYAGQLGSKGEKGEPAKENGDYAKGEKGEPGWRGTAGLAGPQGF 231
            |.:||||:.|..|..|.|||:      |.||:.|.|            |.|...|:.|:.||||.
Mouse   378 GLNGQDGLKGDSGPQGPPGPK------GDKGDMGPP------------GPPALTGSIGIQGPQGP 424

  Fly   232 P---GEKGERGDSGPYGAKGPRGEHGLKGEKGASCYGPMKPGAPGIKGEKGEPASSFPVKPTHTV 293
            |   |::|.||.:||.|..||                |..||.||::|                :
Mouse   425 PGKEGQRGRRGKTGPPGNPGP----------------PGPPGPPGLQG----------------L 457

  Fly   294 MGPRGDMGQKGEPGLVGRKGEPGPEGDTGLDGQKGEKGLPGGPGDRGRQGNFGPPG---STGQKG 355
            ..|.|....||    .|..|..||:      |:||:.||||.||..|.:|:.|.||   :.|:||
Mouse   458 QQPFGGYFNKG----TGEHGASGPK------GEKGDTGLPGFPGSVGPKGHKGEPGEPLTKGEKG 512

  Fly   356 DRGEPGLNGLPGNPGQKGEPGRAGATGKPGLLGPPGPPGGGRGTPGPPGPKGPRGYVGAPGPQGL 420
            |||||||.|..|..|:.|:||..|..|.|||.|..||.|.       .||:||.|.||.||..
Mouse   513 DRGEPGLLGPQGIKGEPGDPGPPGLLGSPGLKGQQGPAGS-------MGPRGPPGDVGLPGEH-- 568

  Fly   421 NGVDGLPGPQGYNGQKGGAGLPGRPGNEGPPGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQKG 485
                |:||.||..|:||..|  ||.|..|.||.||:.|..|::.| |..|..|:||.|||.|.||
Mouse   569 ----GIPGKQGVKGEKGDPG--GRLGPPGLPGLKGDAGPPGISLP-GKPGLDGNPGSPGPRGPKG 626

  Fly   486 DAGLPGYGIQGSKGD-----AGIPGYPGLKGSKGERGFKGNAGAPGDSKLGRPGTPGAAGAPGQK 545
            :.|||  |:.||.||     .||||..|.:|..||.|.:|..|.||  ..|.||.||..||||:.
Mouse   627 ERGLP--GLHGSPGDTGPPGVGIPGRTGSQGPAGEPGIQGPRGLPG--LPGTPGMPGNDGAPGKD 687

  Fly   546 GDAGRPGTPGQKGDMGIKGDVGGK----CSSCRAGPKGDKGTSGLPGIPGKDGARGPPGERGYPG 606
            |..|.||.||....:.:.||:|..    |.:|:|      ...||..|.|.||:.|.||:
Mouse   688 GKPGLPGPPGDPIALPLLGDIGALLKNFCGNCQA------NVPGLKSIKGDDGSTGEPGK----- 741

  Fly   607 ERGHDGINGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQGFK 671
               :|       |...||:                           .|.:|.||.||.:|.:|.|
Mouse   742 ---YD-------PAARKGD---------------------------VGPRGPPGFPGREGPKGSK 769

  Fly   672 GAEGLPGIPGPKGEFGFKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDK 736
            |..|.|||.|.||:.|.:|..|||||||..|.||..||.|:|              |..||||||
Mouse   770 GERGYPGIHGEKGDEGLQGIPGLSGAPGPTGPPGLTGRTGHP--------------GPTGAKGDK 820

  Fly   737 GSFGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQGPPG 801
            ||                         :|.||:   ||||                     ||||
Mouse   821 GS-------------------------EGPPGK---PGPP---------------------GPPG 836

  Fly   802 VEGPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPG-ISRPGPMGPPGLNGLQ 865
            |....| ||.......||.|.|||.||..         |.|||:|:|| :..||.||.|||.|..
Mouse   837 VPLNEG-NGMSSLYKIQGGVNVPGYPGPP---------GPPGPKGDPGPVGEPGAMGLPGLEGFP 891

  Fly   866 GEKGDRGPTGPIGFPGADGSVGYPGDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGI 930
            |.||||||.||            ||..|.:|.||..|.||:.||:|:.||||..|..||.|..|.
Mouse   892 GVKGDRGPAGP------------PGIAGISGKPGAPGPPGVPGEQGERGPIGDTGFPGPEGPSGK 944

  Fly   931 DGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKG 995
            .|:.|:|            |:||.:|..|.||:.|||         |:||..||||..|.:|::|
Mouse   945 PGINGKD------------GLPGAQGIMGKPGDRGPK---------GERGDQGIPGDRGPQGERG 988

  Fly   996 ATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLPGDA 1060
            ..||||..|.:|..||.|:                           ||:.|.||..||||.|
Mouse   989 KPGLTGMKGAIGPVGPAGS---------------------------KGSTGPPGHQGPPGNP--- 1023

  Fly  1061 SEKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHGRAGPPGEKGDQGRSGIDGRDGINGEK 1125
                                 |.||.|.:      ||               |..:.:..||.|.
Mouse  1024 ---------------------GIPGTPAD------AV---------------SFEEIKHYINQEV 1046

  Fly  1126 ---GEQGLQGVWGQ---PGEKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYPGDRGDKGEP--GLS 1182
               .|:.:.....|   |....|..|.|.||.||.|||||..|.||..||.|.:|::|||  ||.
Mouse  1047 LRIFEERMAVFLSQLKLPAAMLSAQAHGRPGPPGKDGLPGPPGDPGPQGYRGQKGERGEPGIGLP 1111

  Fly  1183 GLPGLKGETGPVGLQGFTGAPGPKGERGIRGQ 1214
            |.|||.|.:. |||.|..|||||:|..|..|:
Mouse  1112 GSPGLPGSSA-VGLPGSPGAPGPQGPPGPSGR 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	21/56 (38%)
		Collagen	322..380	CDD:189968	30/60 (50%)
		Collagen	413..465	CDD:189968	22/51 (43%)
		Collagen	499..561	CDD:189968	30/66 (45%)
		Collagen	574..632	CDD:189968	14/57 (25%)
		Collagen	657..714	CDD:189968	31/56 (55%)
		Collagen	765..824	CDD:189968	18/58 (31%)
		Collagen	854..911	CDD:189968	27/56 (48%)
		Collagen	884..943	CDD:189968	24/58 (41%)
		Collagen	923..982	CDD:189968	20/58 (34%)
		Collagen	1028..1085	CDD:189968	11/56 (20%)
		Collagen	1229..1287	CDD:189968
		Collagen	1318..1376	CDD:189968
		Collagen	1399..1458	CDD:189968
		Collagen	1477..1534	CDD:189968
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
Col19a1	XP_006495705.1	TSPN	76..255	CDD:214560
		Collagen	330..387	CDD:189968	29/71 (41%)
		Collagen	476..529	CDD:189968	29/58 (50%)
		Collagen	545..602	CDD:189968	31/71 (44%)
		Collagen	588..644	CDD:189968	28/58 (48%)
		Collagen	629..685	CDD:189968	28/59 (47%)
		Collagen	946..1005	CDD:189968	30/79 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910