DRSC/TRiP Functional Genomics Resources

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Protein Alignment Col4a1 and Col11a2

DIOPT Version :9

Sequence 1:NP_723044.1 Gene:Col4a1 / 33727 FlyBaseID:FBgn0000299 Length:1779 Species:Drosophila melanogaster
Sequence 2:XP_006523622.1 Gene:Col11a2 / 12815 MGIID:88447 Length:1820 Species:Mus musculus


Alignment Length:1621 Identity:609/1621 - (37%)
Similarity:727/1621 - (44%) Gaps:432/1621 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 PIDDSYDIVDSAGVARGDLPP--KNCTAGYAG-------CVPKCIAEKGNRGLPGPLGPTGLKGE 105
            |..||:. .:..|....|.|.  .:.|.||..       ..|...||..:.|.... ||.|||||
Mouse   406 PTADSFQ-AEEYGEGGTDSPAGFYDYTYGYGDDYREETELGPALSAETAHSGAVAH-GPRGLKGE 468

  Fly   106 MGF-------------PGMEGP---SGDKGQKGDPGPYGQRGDKGERGSPGLHGQAGVPGVQGPA 154
            .|.             ||.|||   :|..|.:|:|||.   ||.||||.|   |:||:||..||.
Mouse   469 KGEPAVLEPGMFVEGPPGPEGPAGLAGPPGIQGNPGPV---GDPGERGPP---GRAGLPGSDGPP 527

  Fly   155 GNPGA----PGINGKDGCDGQDGIPGLE------------GLSGMPGPRGYAGQLGSKGEKGEPA 203
            |.||.    |...|..|.|....:...|            .|.|.|||.||.|:.|..|:.|.| 
Mouse   528 GPPGTSLMLPFRFGSSGGDKGPVVAAQEAQAQAILQQARLALRGPPGPMGYTGRPGPLGQPGSP- 591

  Fly   204 KENGDYAKGEKGEPGWRGTAGLAGPQGF---PGEKGERGDSGPYGAKGPRGEHGLKGEKGASCYG 265
                    |.|||.|..|..|..||||.   ||:.|.||.:|..||:|..||.|:||::|..   
Mouse   592 --------GLKGESGDLGPQGPRGPQGLTGPPGKAGRRGRAGADGARGMPGEPGMKGDRGFD--- 645

  Fly   266 PMKPGAPGIKGEKGEPASSFPVKPTHTVMGPRGDMGQKGEPGLVGRKGEPGPEGDTGLDGQKGEK 330
                |.||:.||||:                |||.|.:|.|      |.||.:|:.|.||:.|.:
Mouse   646 ----GLPGLPGEKGQ----------------RGDTGAQGLP------GPPGEDGERGDDGEIGPR 684

  Fly   331 GLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGNPGQKGEPGRAGATGKPGLLGPPGPPGG 395
            ||||..|.||..|..|||               |:||.||.:|..|..|..|..|..|.|||| |
Mouse   685 GLPGESGPRGLLGPKGPP---------------GIPGPPGVRGMDGPHGPKGSLGPQGEPGPP-G 733

  Fly   396 GRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQKGGAGLPGRPGNEGPPGKKGEKGTA 460
            .:||||..|..||:|.:|..|.:|..|..|||      |..|..||||.||.|||||.||.:   
Mouse   734 QQGTPGAQGLPGPQGAIGPHGEKGARGKPGLP------GMPGSDGLPGHPGKEGPPGTKGNQ--- 789

  Fly   461 GLNGPKGSIGPIGHPGPPGPEGQKGDAGLPGYGIQGSKGDAGIPGYPGLKGSKGERGFKGNAGAP 525
               ||.|..||:|:|||.|.:|..|..||.|:  :|.||:.|.||:.|..|.||:||        
Mouse   790 ---GPSGPQGPLGYPGPRGVKGVDGIRGLKGH--KGEKGEDGFPGFKGDIGVKGDRG-------- 841

  Fly   526 GDSKLGRPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGLPGIP 590
               ::|.||:.|..|..|.||..|..|.||..|.|                  |:||..|:||:|
Mouse   842 ---EVGVPGSRGEDGPEGPKGRTGPTGDPGPTGLM------------------GEKGKLGVPGLP 885

  Fly   591 GKDGARGPPGERGYP------GERGHDGINGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLSLI 649
            |..|.:||.|..|:|      ||:|..|::|::||.||:|.                        
Mouse   886 GYPGRQGPKGSLGFPGFPGASGEKGARGLSGKSGPRGERGP------------------------ 926

  Fly   650 EPLKGDKGYPGAPGAKGVQGFKGAEGLPGIPGPKGEFGFKGEKGLSGAPGNDGTPGRAGRDGYPG 714
               .|.:|..|..||.|..|.||..|..|..||.||.|..|.:|.:|.||..|.||.||:||.||
Mouse   927 ---TGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQGPNGFPGPKGPPGPAGKDGLPG 988

  Fly   715 IPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTGMPGPPGED 779
            .|||  :||.||.|:.|..|..|..|..|..||             .|..||.|.:|.||||||.
Mouse   989 HPGQ--RGEVGFQGKTGPPGPPGVVGPQGTAGE-------------SGPMGERGHSGPPGPPGEQ 1038

  Fly   780 GSPGERGYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGP 844
            |.||..|..|.||:.||.|.||.:||.                        ||||.||..|.||.
Mouse  1039 GLPGTSGKEGTKGDPGPPGAPGKDGPA------------------------GLRGFPGERGLPGT 1079

  Fly   845 RGEPGI-SRPGPMGPPGLNGLQGEKGDRGPTGPIGFPGADGSVGYPGDRGDAGLPGVSGRPGIVG 908
            .|.||: ...||.||||..|..||:|..|..||||.||..|..|.||..|:.|:|         |
Mouse  1080 AGGPGLKGNEGPAGPPGPAGSPGERGAAGSGGPIGPPGRPGPQGPPGAAGEKGVP---------G 1135

  Fly   909 EKGDVGPIGPAGVAGPPGVP---GIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFA 970
            |||.:||.|..||.||.|:|   |..||.|.||.|||.|.||..|..||||:.|.|         
Mouse  1136 EKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEHGPP--------- 1191

  Fly   971 GVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQGL 1035
               |.||..||.|.||.:||.|:.||            |||.|..|..|.:|.:|..|.||..||
Mouse  1192 ---GPPGPIGPVGQPGAAGADGEPGA------------RGPQGHFGAKGDEGTRGFNGPPGPIGL 1241

  Fly  1036 DGMP---GEKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAV 1097
            .|:|   ||||..|..|..||||.||..         ||:|..|..||.|:||        |:  
Mouse  1242 QGLPGPSGEKGETGDGGPMGPPGPPGPR---------GPAGPNGADGPQGSPG--------GV-- 1287

  Fly  1098 HGRAGPPGEKGDQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAG 1162
             |..|||||||:.|.|   |..|:.||.|.:|.:|..|:.||.|..|..|.||..|..|..|..|
Mouse  1288 -GNLGPPGEKGEPGES---GSPGVQGEPGVKGPRGERGEKGESGQAGEAGPPGPKGPTGDNGPKG 1348

  Fly  1163 APGAVGYPGDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGD 1227
            .||.||:|||            ||..||.||   :|..||.|.:||.|..||||.|         
Mouse  1349 NPGPVGFPGD------------PGPPGEAGP---RGQDGAKGDRGEDGEPGQPGSP--------- 1389

  Fly  1228 KGSQGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGDIGPRGEIGYPG 1292
                   |.|||.|..|..|..||||..|.:|.:|.:|..|..|..|.||..|.:||        
Mouse  1390 -------GPTGENGPPGPLGKRGPAGTPGPEGRQGEKGAKGDPGAVGAPGKTGPVGP-------- 1439

  Fly  1293 VTIKGEKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGLVGLPGPIGPAGSKGERGLAGSPG 1357
                  .||.|:||.:|.:||   ||.:|::|.||..|:   .|.|||:||              
Mouse  1440 ------AGLAGKPGPDGLRGL---PGSVGQQGRPGATGQ---AGPPGPVGP-------------- 1478

  Fly  1358 QPGQDGFPGAPGLKGDTGPQGFKGERGLNGF---EGQKGDKGDRGLQGPSGLPGLVGQKGDTGYP 1419
                   ||.|||:||.|.:|.||..||.|.   .|::|:||||||.||.|.|   ||||:||.|
Mouse  1479 -------PGLPGLRGDAGAKGEKGHPGLIGLIGPTGEQGEKGDRGLPGPQGSP---GQKGETGIP 1533

  Fly  1420 GLNGNDGPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGMLPPPGPKGEPGQPGRNGPKGEPGR 1484
            |.:|..||.|.||..|.:||||..|..|               |.|||||.|.   .||.|.||.
Mouse  1534 GASGPIGPGGPPGLPGPSGPKGAKGATG---------------PAGPKGEKGV---QGPPGHPGP 1580

  Fly  1485 PGERGLIGIQGERGEKGERGLIGETGNVGRP----GPKGDRGEPGERGYEGAIGLIGQKGEP--G 1543
            |||                        |.:|    .||..|     |..:|:..:..::..|  |
Mouse  1581 PGE------------------------VIQPLPIQMPKKTR-----RSVDGSKLIQDEEAVPTGG 1616

  Fly  1544 AP-APAALDYLTGILI--------------TRHSQSETVPACSAGHTELWTGYSLLYVDGN 1589
            || :||.|:.:.|.|.              |:.|.:.|.......|.||..|.  .:||.|
Mouse  1617 APGSPAGLEEIFGSLDSLREEIEQMRRPAGTQDSPARTCQDLKLCHPELPDGE--YWVDPN 1675

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Col4a1NP_723044.1 Collagen 104..161 CDD:189968 31/76 (41%)
Collagen 322..380 CDD:189968 22/57 (39%)
Collagen 413..465 CDD:189968 22/51 (43%)
Collagen 499..561 CDD:189968 23/61 (38%)
Collagen 574..632 CDD:189968 24/63 (38%)
Collagen 657..714 CDD:189968 27/56 (48%)
Collagen 765..824 CDD:189968 24/58 (41%)
Collagen 854..911 CDD:189968 26/56 (46%)
Collagen 884..943 CDD:189968 28/61 (46%)
Collagen 923..982 CDD:189968 27/61 (44%)
Collagen 1028..1085 CDD:189968 26/59 (44%)
Collagen 1229..1287 CDD:189968 23/57 (40%)
Collagen 1318..1376 CDD:189968 19/57 (33%)
Collagen 1399..1458 CDD:189968 27/58 (47%)
Collagen 1477..1534 CDD:189968 15/60 (25%)
C4 1555..1662 CDD:128421 12/49 (24%)
C4 1663..1777 CDD:128421
Col11a2XP_006523622.1 TSPN 32..213 CDD:214560
PHA03247 <230..518 CDD:223021 40/119 (34%)
Collagen 583..642 CDD:189968 29/67 (43%)
Collagen 631..689 CDD:189968 31/86 (36%)
Collagen 745..804 CDD:189968 33/70 (47%)
Collagen 811..869 CDD:189968 27/70 (39%)
Collagen 853..912 CDD:189968 27/76 (36%)
Collagen 889..946 CDD:189968 23/83 (28%)
Collagen 1204..1253 CDD:189968 24/60 (40%)
Collagen 1279..1325 CDD:189968 24/59 (41%)
Collagen 1375..1433 CDD:189968 28/73 (38%)
Collagen 1411..1470 CDD:189968 27/78 (35%)
COLFI 1624..1819 CDD:197483 13/54 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BAFZ
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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