DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and Col11a1

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	XP_006501032.1	Gene:	Col11a1 / 12814	MGIID:	88446	Length:	1816	Species:	Mus musculus

Alignment Length:	1550	Identity:	603/1550 - (38%)
Similarity:	706/1550 - (45%)	Gaps:	359/1550 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 GTAGSIQDSVKHYN-----------------RNEPKFPIDDSYDIVDSAGVARGDLPPKNCTAGY 77
            |...:|.|..:.||                 .|||. |:::.:              .:....|.
Mouse   307 GVQANIVDDFQDYNYGTMEPYQTETPRRVSGSNEPN-PVEEGF--------------TEEYLTGE 356

  Fly    78 AGCVPKCIAEK---GNRGLPG---PLGPTGLKGEMGF-------------------PGM------ 111
            ...|.:..:|.   ||:|:.|   .|...|..||..|                   ||:
Mouse   357 DYDVQRNTSEDILYGNKGVDGRDSDLLVDGDLGEYDFYEYKEYEERTTTSPNEEFGPGVPAETDF 421

  Fly   112 -------EGPSGDKGQKGDP----------GPYGQRGDKGERGSPGLHGQAGVPGVQGPAGNPGA 159
                   .|..|:|||||:|          ||.|..|..|..|.|||.|.:|:||..|..|.||.
Mouse   422 TETSINGHGAYGEKGQKGEPAVVEPGMLVEGPPGPAGPAGLMGPPGLQGPSGLPGDPGDRGPPGR 486

  Fly   160 PGINGKDGCDGQDGIPGLEGLSGMPG-----PRGYAGQLGSKGE--KGEPAKENGDYAKGE---K 214
            |            |:||.:||.|.||     |..|.|. ||||.  ..:.|:......:..   :
Mouse   487 P------------GLPGADGLPGPPGTMLMLPFRYGGD-GSKGPTISAQEAQAQAILQQARIALR 538

  Fly   215 GEPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKGPRGEHGLKGEKGASCYGPMKPGAPGIKGEKG 279
            |.||..|..|..||.|.||..|.:|:||..|.:||||..|..|..|.    |.|.|.||..|.:|
Mouse   539 GPPGPMGLTGRPGPVGGPGSAGAKGESGDPGPQGPRGVQGPPGPTGK----PGKRGRPGADGGRG 599

  Fly   280 EPASSFPVKPTHTVMGPRGDMGQKGEPGLVGRKGEPGPEGDTGLDGQKGEKGLPGGPGDRGRQGN 344
            .|..|          |.:||.|..|.|||      ||.:|..|..|.:|..||||..|.||..|.
Mouse   600 MPGES----------GSKGDRGFDGLPGL------PGDKGHRGERGPQGPPGLPGDDGMRGEDGE 648

  Fly   345 FGPPGSTGQKGDRGEPGLNGLPGNPGQKGEPGRAGATGKPGLLGPPGPPG--GGRGTPGPPGPKG 407
            .||.|..|:.|.||..|..|.||.|||.|       .|  |:.||.||.|  |.:|.|||||.:|
Mouse   649 IGPRGLPGEAGPRGLLGPRGTPGPPGQPG-------IG--GIDGPQGPKGNMGPQGEPGPPGQQG 704

  Fly   408 PRGYVGAPGPQGLNGVDGLPGPQGYNGQKGGAGLPGRPGNEGPPGKKGEKGTAGLNGPKGSIGPI 472
            ..|..|.|||||..|..|..|||   |:.|.|||||..|..|.|||:|:.|..|..||.|..|||
Mouse   705 NPGPQGLPGPQGPIGPPGEKGPQ---GKPGLAGLPGADGPPGHPGKEGQSGEKGALGPPGPQGPI 766

  Fly   473 GHPGPPGPEGQKGDAGLPGYGIQGSKGDAGIPGYPGLKGSKGERGFKGNAGAPGDSKLGRPGTPG 537
            |:|||.|.:|..|..||     :||||:.|..|:||.||..|.:|.:|        ::|:.|..|
Mouse   767 GYPGPRGVKGADGVRGL-----KGSKGEKGEDGFPGFKGDMGLKGDRG--------EVGQVGPRG 818

  Fly   538 AAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGLPGIPGKDGARGPPGER 602
            ..|..|.||.||..|.||..|               :||.||..|..||||.||:.|.:|..|..
Mouse   819 EDGPEGPKGRAGPTGDPGPSG---------------QAGEKGKLGVPGLPGYPGRQGPKGSTGFP 868

  Fly   603 GYPGERGHDGINGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKGDKGYPGAPGAKGV 667
            |:||..|..|..|..|.||.:|:.|.||..|:                  :|.:|..|.||.||.
Mouse   869 GFPGANGEKGARGIAGKPGPRGQRGPTGPRGS------------------RGARGPTGKPGPKGT 915

  Fly   668 QGFKGAEGLPGIPGPKGEFGFKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGA 732
            .|..|.      |||.||.|.:|.:|..|.||..|.||.||:||.||.|||  :||.||.|:.|.
Mouse   916 SGGDGP------PGPPGERGPQGPQGPVGFPGPKGPPGPAGKDGLPGHPGQ--RGETGFQGKTGP 972

  Fly   733 KGDKGSFGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQ 797
            .|..|..|..|..||.|..             ||.|..|.||||||.|.||..|..|.||:.|||
Mouse   973 PGPGGVVGPQGPTGETGPI-------------GERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQ 1024

  Fly   798 GPPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPGISRPGPMGPPGLN 862
            |..|.:||.                        |:||.||..|.||.:|.||:
Mouse  1025 GISGKDGPA------------------------GIRGFPGERGLPGAQGAPGL------------ 1053

  Fly   863 GLQGEKGDRGPTGPIGFPGADGSVGYPGDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGV 927
                 ||..||.||      .|.||.||:||.||..|..|.|   |..|..||.||||..|.||.
Mouse  1054 -----KGGEGPQGP------QGPVGSPGERGSAGTAGPIGLP---GRPGPQGPPGPAGEKGAPGE 1104

  Fly   928 PGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKG 992
            .|..|..||||.:|.      ||:||..|..|:||.||.|            |..|.||..|:||
Mouse  1105 KGPQGPAGRDGVQGP------VGLPGPAGPAGSPGEDGDK------------GEIGEPGQKGSKG 1151

  Fly   993 DKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLP 1057
            |||.   .|..||.|.:||.||||:.|  || |..|..||||:.|..|::|.:|||||.||.||
Mouse  1152 DKGE---NGPPGPPGLQGPVGAPGIAG--GD-GEPGPRGQQGMFGQKGDEGARGFPGLPGPIGL- 1209

  Fly  1058 GDASEKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHGRAGPPGEKGDQGRSGIDGRDGIN 1122
                 :|..|.||..|..||.||.|.||.||.:        |..||.|..|.||..|..|..|:.
Mouse  1210 -----QGLPGPPGEKGENGDVGPMGPPGPPGPR--------GPQGPNGADGPQGPPGSIGSVGVV 1261

  Fly  1123 GEKGEQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYPGDRGDKGEPGLSGLPGL 1187
            |:|||.|..|..|.|||.||.|..|..|..|..|.|||||..|..|.|||.|.||.|
Mouse  1262 GDKGEPGEAGNPGPPGEAGSGGLKGERGEKGEAGPPGAAGPAGIKGPPGDDGPKGNP-------- 1318

  Fly  1188 KGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGERGYTGEKGEQGERGLTGPA 1252
                |||   ||.|.|||.||.|..||.|       :.|||         ||.|:.|:.|..||:
Mouse  1319 ----GPV---GFPGDPGPPGEPGPAGQDG-------VGGDK---------GEDGDPGQPGPPGPS 1360

  Fly  1253 GVAGAKGDRGLQGPPGASGLNGIPGAKGDIGPRGEIGYPGVTIKGEKGLPGRPGRNGRQGLIGAP 1317
            |.||..|..|.:|||||||..|..|.||..|..|..|.||.|  |..|..|..|:.|.:||.|.|
Mouse  1361 GEAGPPGPPGKRGPPGASGSEGRQGEKGAKGEAGAEGPPGKT--GPVGPQGPSGKPGPEGLRGIP 1423

  Fly  1318 GLIGERGLPGLAGEPGLVGLPGPIGPAGSKGERGLAGSPGQPGQDGFPGAPGLKGDTGPQGFKGE 1382
            |.:||:||||.||:.   |.|||:||                     ||.||||||.|.:|.||.
Mouse  1424 GPVGEQGLPGAAGQD---GPPGPLGP---------------------PGLPGLKGDPGSKGEKGH 1464

  Fly  1383 RGLNGF---EGQKGDKGDRGLQGPSGLPGLVGQKGDTGYPGLNGNDGPVGAPGERGFTGPKGRDG 1444
            .||.|.   .|::|:||||||.|..|.|   |.|||.|.|   |..||:|.||..|..||.|..|
Mouse  1465 PGLIGLIGPPGEQGEKGDRGLPGTQGSP---GAKGDGGIP---GPAGPIGPPGPPGLPGPAGPKG 1523

  Fly  1445 RDGTPGLPGQKGEPGMLPPPGPKGEPGQPGRNGPKGEPGRPGERGLIGIQGERGE 1499
            ..|:.|..||||:.||..||||.|.||:..:..|...| :...|....|||:.|:
Mouse  1524 NKGSSGPTGQKGDSGMPGPPGPPGPPGEVIQPLPILSP-KKTRRHTESIQGDAGD 1577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	30/98 (31%)
		Collagen	322..380	CDD:189968	26/57 (46%)
		Collagen	413..465	CDD:189968	26/51 (51%)
		Collagen	499..561	CDD:189968	23/61 (38%)
		Collagen	574..632	CDD:189968	27/57 (47%)
		Collagen	657..714	CDD:189968	26/56 (46%)
		Collagen	765..824	CDD:189968	24/58 (41%)
		Collagen	854..911	CDD:189968	19/56 (34%)
		Collagen	884..943	CDD:189968	30/58 (52%)
		Collagen	923..982	CDD:189968	22/58 (38%)
		Collagen	1028..1085	CDD:189968	27/56 (48%)
		Collagen	1229..1287	CDD:189968	24/57 (42%)
		Collagen	1318..1376	CDD:189968	23/57 (40%)
		Collagen	1399..1458	CDD:189968	28/58 (48%)
		Collagen	1477..1534	CDD:189968	7/22 (32%)
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
Col11a1	XP_006501032.1	TSPN	37..228	CDD:214560
		Collagen	809..866	CDD:189968	27/79 (34%)
		Collagen	851..910	CDD:189968	26/76 (34%)
		Collagen	1106..1155	CDD:189968	27/66 (41%)
		Collagen	1388..1437	CDD:189968	24/50 (48%)
		COLFI	1585..1814	CDD:366624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810