Protein Alignment Col4a1 and Col4a1

DIOPT Version :10

• Sequence 1: NP_723044.1
• Gene: Col4a1 / 33727
• FlyBaseID: FBgn0000299
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: XP_061513844.1
• Gene: Col4a1 / 1280160
• VectorBaseID: AGAMI1_004479
• Length: 1778
• Species: Anopheles gambiae
• Alignment Length: 1782
• Identity: 1011/1782 - (56%)
• Similarity: 1188/1782 - (66%)
• Gaps: 55/1782 - (3%)

  Fly    23 AQFWKTAGTAGSIQDSVKHYNRNEPKFP------IDDSYDIVDSAGVARGDLPPKNCTAGYAGCV 81
            ||||  |.:..:....|..:.|.|.::|      ||.||.|:|:|...:|. |.||||:| ..|:
Mosquito    23 AQFW--ASSNNNDNSGVGLFKRQEQEYPRQLAPQIDPSYSIMDTASGPQGP-PGKNCTSG-GCCL 83

  Fly    82 PKCIAEKGNRGLPGPLGPTGLKGEMGFPGMEGPSGDKGQKGDPGPYGQRGDKGERGSPGLHGQAG 146
            |||.|||||||||||:|..|.||..||||.||..|:||.||:|||.|.:|.||:||..||.|..|
Mosquito    84 PKCFAEKGNRGLPGPMGLKGAKGVRGFPGSEGLPGEKGTKGEPGPVGLQGPKGDRGRDGLPGYPG 148

  Fly   147 VPGVQGPAGNPGAPGINGKDGCDGQDGIPGLEGLSGMPGPRGYAGQLGSKGEKGEPAKENGDYAK 211
            :||..|..|.|||||:.|:|||:|.||:|||.||.|.||||||||..|:||||||||:...:|.|
Mosquito   149 IPGTNGVPGVPGAPGLAGRDGCNGTDGLPGLSGLPGNPGPRGYAGIPGTKGEKGEPARHPENYNK 213

  Fly   212 GEKGEPGWRGTAGLAGPQ------GFPGEKGERGDSGPYGAKGPRGEHG--LKGEKGASCYGPMK 268
            |:|||||..|..||.|||      ||||..||:|..|..|.:|.||:.|  :|||||.
Mosquito   214 GQKGEPGNDGLEGLPGPQGEVGPRGFPGRPGEKGVPGTPGVRGERGDKGVCIKGEKGQ------- 271

  Fly   269 PGAPGIKGEKGEPASSFPVKPTHTVMGPRGDMGQKGEPGLVGRKGEPGPEGDTGLDGQ---KGEK 330
                  ||.|||..  :....|.|..||:|:.|.:||||..||.||.|..||.|..|:   ||||
Mosquito   272 ------KGAKGEEV--YGATGTTTTTGPKGEKGDRGEPGEPGRSGEKGQAGDRGQVGERGHKGEK 328

  Fly   331 GLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGNPGQKGEPGRAGATGKPGLLGPPGPPGG 395
            ||||.||.|||.|||||.|..|||||||..||:||.|..|.||||||.|..|:||:.||.|.|||
Mosquito   329 GLPGQPGPRGRDGNFGPVGLPGQKGDRGSEGLHGLKGQSGPKGEPGRDGIPGQPGIAGPAGAPGG 393

  Fly   396 GRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQKGGAGLPGRPGNEGPPGKKGEKGTA 460
            |.|.||.|||||||||.|..||:|::|.||..|.:|..|.|||.|:|||||.||.||.||:||.:
Mosquito   394 GEGRPGAPGPKGPRGYEGPQGPKGMDGFDGEKGERGQMGPKGGQGVPGRPGPEGMPGDKGDKGES 458

  Fly   461 GLNGPKGSIGPIGHPGPPGPEGQKGDAGLPGYGIQGSKGDAGIPGYPGLKGSKGERGFKGNAGAP 525
            |..|..|..||.|:||.|||||.:|:.|.|||||.|.||:||:.|:|||||.||||||||..|.|
Mosquito   459 GSVGMPGPQGPRGYPGQPGPEGLRGEPGQPGYGIPGQKGNAGMAGFPGLKGQKGERGFKGVMGTP 523

  Fly   526 GDSKLGRPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGLPGIP 590
            ||:|.||||.||..|..|:||:.||||.||.||:.|:||::||:|:.||.|.|||||..|..|.|
Mosquito   524 GDAKEGRPGAPGLPGRDGEKGEPGRPGLPGAKGERGLKGELGGRCTDCRPGMKGDKGERGYAGEP 588

  Fly   591 GKDGARGPPGERGYPGERGHDGINGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKGD 655
            |:.||.|.||||||||..|.||..|..|.||.|||.|..|.||.:||||:.|...:..::|:|||
Mosquito   589 GRPGASGVPGERGYPGMPGEDGTPGLRGEPGPKGEPGLLGPPGPSGEPGRDAEIPMDQLKPIKGD 653

  Fly   656 KGYPGAPGAKGVQGFKGAEGLPGIPGPKGEFGFKGEKGLSGAPGN---DGTPGRAGRDGYPGIPG 717
            |   |..|..|:.|.||.:|.||..||:|:.|.:|.||..|.||.   ||.||..|:||.||..|
Mosquito   654 K---GEKGENGLMGIKGEKGFPGPVGPEGKMGLRGMKGDKGRPGEAGIDGAPGAPGKDGLPGRHG 715

  Fly   718 QSIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCA-----LDEIKMPAKGNKGEPGQTGMPGPPG 777
            |::|||||..|..|..||||..|.||.|||||.||     |:|......|.:||.|..|:.|..|
Mosquito   716 QTVKGEPGLKGNVGYSGDKGDKGYSGLKGEPGRCASIPPNLEEAIRGPPGTQGEKGAPGIQGIRG 780

  Fly   778 EDGSPGERGYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQP 842
            :.|..||:|.||::||.||.|.||..|||||.|.||||||.|.:|.||.||:||:.|.||..|..
Mosquito   781 DKGEMGEQGRTGMQGNAGPPGAPGPVGPRGLTGLRGEKGNTGPLGPPGAPGRDGMPGAPGLPGSK 845

  Fly   843 GPRGEPGISRPGPMGPPGLNGLQGEKGDRGPTGPIGFPGADGSVGYPGDRGDAGLPGVSGRPGIV 907
            |.:|:||:|..||.||.|..||:|.|||||..|..|.||..|||||||::||.|:||..|.||.|
Mosquito   846 GGKGDPGLSMVGPPGPKGNPGLRGPKGDRGGMGDRGDPGQPGSVGYPGEKGDLGIPGQPGFPGEV 910

  Fly   908 GEKGDVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGV 972
            |.||:.||.||||..|.||.||:|||:|..|.||:.|:||::|:||.||:.|..||||.|||.|.
Mosquito   911 GPKGEPGPKGPAGHPGAPGRPGMDGVKGLAGLKGDVGAPGVIGLPGQKGEMGQAGNDGLKGFQGR 975

  Fly   973 TGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQGLDG 1037
            .|..|..|..|:.|..||||:.|..|..|..|..|..|..|.||::|.|||:||||.||...|.|
Mosquito   976 KGMMGAPGIQGVRGPQGAKGEPGEKGDRGEIGMKGLMGQTGPPGMLGPKGDKGLAGLPGPACLPG 1040

  Fly  1038 MPGEKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHGRAG 1102
            :.||||::|:.|.:||||.||.|||||||||||..||||:.|..|..|..|.||..|:..:||.|
Mosquito  1041 LSGEKGDKGYTGPEGPPGEPGAASEKGQKGEPGVPGLRGNDGLPGLEGPSGPKGDAGVPGYGRPG 1105

  Fly  1103 PPGEKGDQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAGAPGAV 1167
            |.|||||.|.:||:|..|:||.||:.|:.|..|..|:||:.|.||:||||.|||||||.|..|..
Mosquito  1106 PQGEKGDVGLTGINGLPGLNGVKGDMGVPGFPGVKGDKGTTGLPGVPGAPCMDGLPGAEGPAGPR 1170

  Fly  1168 GYPGDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQG 1232
            ||.|::|.|||||..|..|..||.|..||.|..|..|.||:||:.|.||||||...|:||||..|
Mosquito  1171 GYDGEKGFKGEPGRIGERGELGEKGDQGLMGPVGLMGRKGDRGVPGSPGLPATAAAIKGDKGEPG 1235

  Fly  1233 ERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGDIGPRGEIGYPGVTIKG 1297
            ..|..|..|:.|..||.|..|..|..|.:||.|.||.:||||:||.|||:||.||.|.....:||
Mosquito  1236 FPGAIGRPGKVGAPGLPGDMGTKGEMGIQGLPGLPGPAGLNGLPGMKGDMGPMGEKGDSCPVVKG 1300

  Fly  1298 EKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGLVGLPGPIGP---AGSKGERGLAGSPGQP 1359
            |||||||||:.||.   |.|||:||:|..||:|.||.:|.|||.||   .|.||:||.:|..|:|
Mosquito  1301 EKGLPGRPGKMGRD---GPPGLLGEKGDKGLSGLPGPMGPPGPPGPLGRQGEKGDRGDSGLMGRP 1362

  Fly  1360 GQDGFPGAPGLKGDTGPQGFKGERGLNGFEGQKGDKGDRGLQGPSGLPGLVGQKGDTGYPGLNGN 1424
            |:||.||..|.:|..||||.||::|..||.|.||::|:||..|.:||.|..|.|||.|.|||.|.
Mosquito  1363 GKDGLPGPQGQRGLPGPQGEKGDQGPPGFIGPKGERGERGRDGMNGLNGPQGLKGDRGMPGLEGV 1427

  Fly  1425 DGPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGMLPPPGPKGEPGQPGRNGPKGEPGRPGERG 1489
            .|..|..||:|..|..|..|.:|.||..|||||...|||. .||.||.||.|||||:.|.||..|
Mosquito  1428 AGLPGMVGEKGDRGLPGMAGLNGAPGEKGQKGETPQLPPQ-RKGPPGPPGFNGPKGDKGMPGLAG 1491

  Fly  1490 LIGIQGERGEKGERGLIGETGNVGRPGPKGDRGEPGERGYEGAIGLIGQKGEPGAPAPAALDYLT 1554
            ..||.|..|..||.||.|..|..|..|.:||.|..|..|.:||.||.|.|||||....:| .|.|
Mosquito  1492 PAGIPGAPGAPGEMGLRGFEGARGLQGLRGDVGPEGRPGRDGAPGLPGPKGEPGRDCESA-PYYT 1555

  Fly  1555 GILITRHSQSETVPACSAGHTELWTGYSLLYVDGNDYAHNQDLGSPGSCVPRFSTLPVLSCGQNN 1619
            |||:.|||||:.||.|..||.:||.||||||||||||.|||||||.||||.:|||||||:|||||
Mosquito  1556 GILLVRHSQSDEVPMCEPGHLKLWDGYSLLYVDGNDYPHNQDLGSAGSCVRKFSTLPVLACGQNN 1620

  Fly  1620 VCNYASRNDKTFWLTTNAAIPMMPVENIEIRQYISRCVVCEAPANVIAVHSQTIEVPDCPNGWEG 1684
            :||||||||:||||:|:|.||||||...|:|.|||||.|||||.|||||||||:.:|:|||||:|
Mosquito  1621 ICNYASRNDRTFWLSTSAPIPMMPVTENEMRPYISRCTVCEAPTNVIAVHSQTLHIPECPNGWDG 1685

  Fly  1685 LWIGYSFLMHTAVGNGGGGQALQSPGSCLEDFRATPFIECNGAKGTCHFYETMTSFWMYNLESSQ 1749
            ||||||||||||||:|||||:|..||||||||||||||||||.||.||:|||.||||:.:||..|
Mosquito  1686 LWIGYSFLMHTAVGHGGGGQSLSGPGSCLEDFRATPFIECNGGKGHCHYYETQTSFWLVSLEDHQ 1750

  Fly  1750 PFERPQQQTIKAGERQSHVSRCQVCMK 1776
            .|:||:|||:|||...|.|||||||::
Mosquito  1751 QFQRPEQQTLKAGNLLSRVSRCQVCIR 1777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	gly_rich_SclB	<107..>361	CDD:468478	145/264 (55%)
		gly_rich_SclB	<355..>642	CDD:468478	175/286 (61%)
		gly_rich_SclB	<543..820	CDD:468478	149/284 (52%)
		gly_rich_SclB	<727..>968	CDD:468478	134/245 (55%)
		gly_rich_SclB	<969..>1218	CDD:468478	132/248 (53%)
		gly_rich_SclB	<1186..>1420	CDD:468478	125/236 (53%)
		gly_rich_SclB	<1321..>1547	CDD:468478	118/228 (52%)
		C4	1555..1662	CDD:128421	80/106 (75%)
		C4	1663..1777	CDD:128421	85/114 (75%)
Col4a1	XP_061513844.1	None