DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Col4a1 and COL1A1

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_000079.2	Gene:	COL1A1 / 1277	HGNCID:	2197	Length:	1464	Species:	Homo sapiens

Alignment Length:	1268	Identity:	540/1268 - (42%)
Similarity:	617/1268 - (48%)	Gaps:	210/1268 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 KGEPG---PEGD---TGLDGQKGEKGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGNPG 370
            |..||   |||:   ...||.:       .|.|:...|..||.|.||.:|.||       |..|
Human    79 KNCPGAEVPEGECCPVCPDGSE-------SPTDQETTGVEGPKGDTGPRGPRG-------PAGP- 128

  Fly   371 QKGEPGRAGATGKPGLLGPPGPPGGGRGTPGPPG------PKGPRGY-------VGAPGPQGLNG 422
                |||.|..|:|||.||||||    |.|||||      |:...||       :..|||.|.:|
Human   129 ----PGRDGIPGQPGLPGPPGPP----GPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSG 185

  Fly   423 VDGLPGPQGYNGQKGGAGLPGRPGNEGPPGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQKGDA 487
            ..|||||         .|.||..|.:||||:.||.|.:|..||:|.      |||||..|..|:|
Human   186 PRGLPGP---------PGAPGPQGFQGPPGEPGEPGASGPMGPRGP------PGPPGKNGDDGEA 235

  Fly   488 GLPG----YGIQGSKGDAGIPGYPGLKGSKGERGFKGNAGAPGDS----KLGRPGTPGAAGAPGQ 544
            |.||    .|..|.:|..|:||..||.|.||.|||.|..||.||:    ..|.||:||..|||||
Human   236 GKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQ 300

  Fly   545 ------KGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGLPGIPGKDGARGPPGERG 603
                  .|:.||||.||..|..|..|..|.      |||.|..|.:|.||.||..||:|..|.:|
Human   301 MGPRGLPGERGRPGAPGPAGARGNDGATGA------AGPPGPTGPAGPPGFPGAVGAKGEAGPQG 359

  Fly   604 YPGERGHDGINGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQ 668
            ..|..|..|:.|:.||||..|..|..|.|||.|:                     |||.||.|..
Human   360 PRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQ---------------------PGAKGANGAP 403

  Fly   669 GFKGAEGLPGIPGPKGEFGFKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAK 733
            |..||.|.||..||.|..|          ||  |.||..|..|.||.||.  ||:.|..|..|..
Human   404 GIAGAPGFPGARGPSGPQG----------PG--GPPGPKGNSGEPGAPGS--KGDTGAKGEPGPV 454

  Fly   734 GDKGSFGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQG 798
            |.:|..|.:||:|:             :|.:||||.||:||||||.|.||.||:.|..|..||:|
Human   455 GVQGPPGPAGEEGK-------------RGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKG 506

  Fly   799 PPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIP------GRNGQPGPRGEPGISRPGPMG 857
            |.|..|..|..||:|..|..|..|..|.||..||.|.|      |:.|.|||.|:.|  ||||.|
Human   507 PAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDG--RPGPPG 569

  Fly   858 PPGLNGLQGEKGDRGPTGPIGFPGADGSVGYPGDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVA 922
            |||.         ||..|.:||||..|:.|.||..|:.|:||..|..|..|:.|:.|..||.|.|
Human   570 PPGA---------RGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPA 625

  Fly   923 GPPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGV 987
            ||.      |.||..|..|.||..||.|..|..|:.|.||..|..|..|..|..|.||..|.||.
Human   626 GPA------GERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGE 684

  Fly   988 SGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQ---GLDGMPGEKGNQGFPG 1049
            .|.:|.         .||.|.||..||||..|.|||.|..||||.|   ||.|||||:|..|.|
Human   685 RGVQGP---------PGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLP- 739

  Fly  1050 LDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTP---GWPGEKGLPGLAVHGRAGPPGEK---G 1108
              ||.|..|||..||..|.||..|:||.|||.|.|   |.||:||..|.:  |.|||.|.:   |
Human   740 --GPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPS--GPAGPTGARGAPG 800

  Fly  1109 DQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYPGDR 1173
            |:|..|..|..|..|..|..|..|..|:||:.|:.|..|.||..|..|.||..|..||.|..|.|
Human   801 DRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGAR 865

  Fly  1174 GDKGEPGLSGLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGERGYTG 1238
            |..|.||.:|.||..|..||         |||.|..|..|.|| ||      |.:|.:|.||.||
Human   866 GSAGPPGATGFPGAAGRVGP---------PGPSGNAGPPGPPG-PA------GKEGGKGPRGETG 914

  Fly  1239 EKGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGDIGPRGEIGYPGVTIKGEKGLPG 1303
            ..|..||.|..||.|.||.||..|..||.||.   |.||.:|..|.||.:|.||.  :||:|.||
Human   915 PAGRPGEVGPPGPPGPAGEKGSPGADGPAGAP---GTPGPQGIAGQRGVVGLPGQ--RGERGFPG 974

  Fly  1304 RPGRNGRQGLIGAPGLIGERGLPGLAGEPGLVGLPGPIGPAGSKGERGLAGSPGQPGQDGFPGAP 1368
            .||.:|..|..|..|..||||.||..|.|||.      ||.|..|..|..|:.|.||:||.|||.
Human   975 LPGPSGEPGKQGPSGASGERGPPGPMGPPGLA------GPPGESGREGAPGAEGSPGRDGSPGAK 1033

  Fly  1369 GLKGDTGPQGFKGERGLNGF------EGQKGDKGDRGLQGPSGLPGLVGQKGDTGYPGLNGNDGP 1427
            |.:|:|||.|..|..|..|.      .|:.||:|:.|..||:|..|.||.:|..|..|..|:.|.
Human  1034 GDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAGPQGPRGDKGE 1098

  Fly  1428 VGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGMLPPPGPKGEPGQPGRNGPKGEPGRPGERGLIG 1492
            .|..|:||..|.:|..|..|.||.||..||      .||.|..|..|..||.|..|.||:.||.|
Human  1099 TGEQGDRGIKGHRGFSGLQGPPGPPGSPGE------QGPSGASGPAGPRGPPGSAGAPGKDGLNG 1157

  Fly  1493 IQGERGEKGERGLIGETGNVGRPGPKGDRGEPG 1525
            :.|..|..|.||..|:.|.||.|||.|..|.||
Human  1158 LPGPIGPPGPRGRTGDAGPVGPPGPPGPPGPPG 1190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968
		Collagen	322..380	CDD:189968	18/57 (32%)
		Collagen	413..465	CDD:189968	22/51 (43%)
		Collagen	499..561	CDD:189968	35/71 (49%)
		Collagen	574..632	CDD:189968	26/57 (46%)
		Collagen	657..714	CDD:189968	23/56 (41%)
		Collagen	765..824	CDD:189968	32/58 (55%)
		Collagen	854..911	CDD:189968	24/56 (43%)
		Collagen	884..943	CDD:189968	24/58 (41%)
		Collagen	923..982	CDD:189968	24/58 (41%)
		Collagen	1028..1085	CDD:189968	34/62 (55%)
		Collagen	1229..1287	CDD:189968	28/57 (49%)
		Collagen	1318..1376	CDD:189968	28/57 (49%)
		Collagen	1399..1458	CDD:189968	25/58 (43%)
		Collagen	1477..1534	CDD:189968	25/49 (51%)
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
COL1A1	NP_000079.2	VWC	40..95	CDD:278520	6/15 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..1214		533/1249 (43%)
		Nonhelical region (N-terminal)	162..178		2/15 (13%)
		Triple-helical region	179..1192		495/1145 (43%)
		Collagen	239..295	CDD:396114	25/55 (45%)
		Collagen	275..324	CDD:396114	22/48 (46%)
		PRK07764	<449..640	CDD:236090	94/220 (43%)
		Collagen	500..556	CDD:396114	23/55 (42%)
		Collagen	686..741	CDD:396114	31/66 (47%)
		Collagen	719..766	CDD:396114	26/49 (53%)
		Cell attachment site. /evidence=ECO:0000255	745..747		0/1 (0%)
		PRK12678	908..>1111	CDD:237171	96/213 (45%)
		Cell attachment site. /evidence=ECO:0000255	1093..1095		0/1 (0%)
		Nonhelical region (C-terminal)	1193..1218
		COLFI	1227..1463	CDD:396131
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810