DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and col4a5

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	XP_004916922.2	Gene:	col4a5 / 100492984	XenbaseID:	XB-GENE-6041869	Length:	1691	Species:	Xenopus tropicalis

Alignment Length:	1810	Identity:	822/1810 - (45%)
Similarity:	975/1810 - (53%)	Gaps:	251/1810 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 TAGYAGC--VPKC-----IAEKGNRGLPGPLGPTGLKGEMGFPGMEGPSGDKGQKGDPGPYGQRG 131
            :|...||  |.||     ..|||.||||      ||:|.:|.||..||      :|.|||.|.:|
Frog    28 SAACQGCTSVSKCDCSGVKGEKGERGLP------GLEGHLGLPGFPGP------EGPPGPRGPKG 80

  Fly   132 DKGERGSPGLHGQAGVPGVQGPAGNPGAPGINGKDGCDGQDGIPGLEGLSGMPGPRGYAGQLGSK 196
            |.|..||||..|..|.||..|..||||.||:.|.|               |.|||.|..|..|:|
Frog    81 DSGLSGSPGPKGIRGPPGPPGFPGNPGQPGLPGHD---------------GEPGPAGIPGCNGTK 130

  Fly   197 GEKGEPAKENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKGPRGEHGLKGEKGA 261
            |::|.|            |.||:.||.|:.||.|.||.||:.|:|.|. |.|.:|:.||
Frog   131 GDRGFP------------GGPGFSGTPGIPGPPGLPGVKGDPGESFPL-APGQKGDPGL------ 176

  Fly   262 SCYGPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPRGDMGQKGEPGLVGRKGEPGPEGDTGLD-- 324
                   ||.||:.|..|      |:    .|.||.|..|..|.||..|..|.|||:|:.||:
Frog   177 -------PGLPGLPGRTG------PI----GVQGPVGRPGPAGLPGSPGVPGPPGPKGNMGLNFQ 224

  Fly   325 ---GQKGEKGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGN-------------PGQKG 373
               |:|||.|:.|.||..|:.....||.:|.|||::|.||..|.||.             .|:||
Frog   225 GSKGEKGEPGIQGLPGPPGQLEQVEPPQTTIQKGEKGIPGDQGFPGERGPMGPPGPPGGAKGEKG 289

  Fly   374 EPGRAGATGKPGLLGPPGPPGGG--RGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQK 436
            |||..|..||||..|..|.|||.  ||.||.||  ||    |..|.:|..|.:|||||.|....:
Frog   290 EPGEPGKIGKPGKDGKIGLPGGEGFRGDPGLPG--GP----GRDGDKGQKGENGLPGPPGEVISR 348

  Fly   437 GGAGLPGRPGNEGPP---GKKGEKGTAGLNGPKG--------SIGPIGHPGPPGPEGQKGDAGLP 490
            .|.|..|..||.|||   |.||::|..||.||.|        |:||.|:||.||..|||||.|.|
Frog   349 PGTGRVGPKGNTGPPGITGPKGDRGFPGLQGPPGFPGTPGTSSVGPSGNPGLPGERGQKGDDGPP 413

  Fly   491 GY---GIQGSKGDAGIPGYPGLKGSKGERGFKGNAGAPGDSKLGRPGTPGAAGAPGQKGDAGRPG 552
            |.   |:.||:|.||.||.|||            .|.||.|.:|    |.....||..|..|.||
Frog   414 GISIPGLPGSEGLAGPPGPPGL------------PGRPGTSAVG----PAMVCQPGLPGTQGLPG 462

  Fly   553 TPGQKGDMGIKGDVGGKCSSCRA----GPKGDKGTSGLPGIPGKDGARGPPGERGYPGERGHDGI 613
            .||..|:.|.|||.|..|.:|..    |||||.|..|.||.||..||.|..|..|.|      |.
Frog   463 DPGFLGERGQKGDKGDTCYNCIGNGILGPKGDPGLPGFPGSPGSPGAPGQKGAMGIP------GT 521

  Fly   614 NGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGAEGLPG 678
            ||..||||..|..|.:|.||..||||:.    :..|:..|||.|:||..|:.|:.|..|.:|.||
Frog   522 NGLPGPPGFPGNPGISGRPGPKGEPGEV----IGEIKGEKGDPGFPGPAGSPGLDGVPGRDGTPG 582

  Fly   679 IPGPKGE---FGFKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFG 740
            |||||||   |..||::|.   ||:.|.||..|..|..|.||....|.||..|..|..|..|:.|
Frog   583 IPGPKGEPGGFVLKGDRGF---PGDIGFPGHPGDRGLMGPPGFGPSGPPGEKGIQGVSGRPGAPG 644

  Fly   741 RSGEKGEPGSCALDEIKMPAKGNKGEPGQTGMP---GPPGEDGSPGERGYTGLKGNTGPQGPPGV 802
            ..|.||.||...::      ||:.|.||..|:|   |.|||.|.||:.|..|:.|:.|..|.||:
Frog   645 IPGPKGSPGQTVME------KGDFGPPGLPGIPGDAGTPGEPGLPGQPGIPGVPGSKGEPGIPGI 703

  Fly   803 EGPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPGISRPGPMGPPGLNGLQGE 867
             |..|..|.:|..||.|..|.||..|:.|..|.||:.|.|||:|:||...||..|.||..||
Frog   704 -GLPGSAGAKGFPGNTGPPGAPGLAGRPGSDGSPGQPGLPGPKGDPGFGLPGLPGSPGPAGL--- 764

  Fly   868 KGDRGPTGPIGFPGA---------DGSVGYPGDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVAG 923
            ||.:||.|..||||:         ||.||..||.|..||||..|.||:.|..|. ||.|..|:.|
Frog   765 KGSQGPKGESGFPGSPGLPGRAGFDGPVGPKGDSGQNGLPGTPGPPGVPGAGGQ-GPPGQPGLPG 828

  Fly   924 PPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVS 988
            |.|.||..|..|..|.||:||:||. .|||..||||:||..|.:||.|..|.||.:|..|:||.|
Frog   829 PAGPPGPTGNTGIQGEKGDPGAPGF-DMPGPPGDRGSPGFPGERGFTGPPGPPGAQGRDGLPGFS 892

  Fly   989 GAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGP 1053
            ||||:.|..|..|:.||.|.   ||.|||.|.||:.   |.|||.||.|:||.:|.:|..||.||
Frog   893 GAKGEMGVMGPPGSVGPAGN---PGNPGLPGSKGND---GNPGQPGLSGLPGAEGEKGERGLPGP 951

  Fly  1054 PGLPGDAS--EKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHGRAGPPGEKGDQGRSGID 1116
            ||....|:  .||.|||               ||.||..||.|  ..|.||.||..|..|:.||.
Frog   952 PGRVDSANLQFKGVKGE---------------PGLPGSSGLSG--AKGAAGLPGNSGSPGQIGIP 999

  Fly  1117 GRDGINGEKGEQGL---QGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYPGD---RGD 1175
            |..|:.|.||:.||   .|..|.||.|||:|..|:||.||..|.||..|.||:.|.||.   :|:
Frog  1000 GSPGLPGLKGDSGLPGQPGTSGPPGLKGSMGEMGLPGPPGSKGSPGQPGRPGSAGSPGFSGLKGE 1064

  Fly  1176 KGEPGLS--GLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGERGYTG 1238
            |||||:|  |:||..|:.|..|..||.|:||.||..|..|.||||.    |.|.||..|..|:.|
Frog  1065 KGEPGISGAGIPGFPGQKGEPGQNGFPGSPGSKGNPGNPGLPGLPG----ISGPKGDPGLPGFPG 1125

  Fly  1239 EKGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGD------IGPRGEIGYPGVTIKG 1297
            ..|..|.:|:.||.|.:|..|..||:|..|..|..|.||.||.      .||.|..|.||:...|
Frog  1126 SPGSPGLKGVDGPTGNSGLPGSPGLRGESGRPGPQGTPGEKGQPGQDGIPGPSGLKGEPGLPGFG 1190

  Fly  1298 EKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGLVGLPGPIGPAGS-----------KGERG 1351
            ..||||.||..|::|..|..|..|..||||..|:.|..|.|||.||.|.           ||:.|
Frog  1191 SPGLPGLPGSQGQKGDAGLSGSPGNPGLPGFKGDQGFPGSPGPQGPTGQPGLPGPRTEGPKGDPG 1255

  Fly  1352 LAGSPGQPGQDGFPGAPGLKGDTGPQ---GFKGERGLNGFEGQKGDKGDRGLQGPSGLPGLVGQK 1413
            ..|.||:||..|:||.||.:|..||.   |||||:|..||.||.|..|.:|..|.||.|
Frog  1256 PVGPPGRPGPQGYPGPPGSEGPRGPPGDGGFKGEKGNPGFPGQPGLTGSKGEHGASGFP------ 1314

  Fly  1414 GDTGYPGLNGNDGPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGM--LPP-PGPKGE------ 1469
            ||.|.|||||..|..|.||..||.|.||..|..|..||.|:.|.||.  ||. ||||||
Frog  1315 GDPGRPGLNGMKGDQGVPGVPGFPGMKGPGGPPGLAGLKGESGLPGAIGLPGLPGPKGEYREIKG 1379

  Fly  1470 ----PGQPGRNGPKGEPGRPGERGLIGIQGERGEKGERGLIGETGNVGRPGPKGDRGEPGERGYE 1530
                ||.|||.|..|.||.||..||.|..|..|:.|..||.|..|.:||.|.:|..|:||.||..
Frog  1380 APGLPGPPGRPGVNGPPGPPGSPGLPGSLGLPGDTGRDGLPGFEGQLGRKGDRGLPGQPGSRGIN 1444

  Fly  1531 GAIGLIGQKGEPGAPAPAALDYLTGILITRHSQSETVPACSAGHTELWTGYSLLYVDGNDYAHNQ 1595
            |..|..|.:|.||.|...::.:  |.||||||||...|.|..|.|.::.|||||||.||:.||.|
Frog  1445 GPPGPDGLQGPPGPPGLGSVAH--GFLITRHSQSTDAPGCPFGTTRIYDGYSLLYVQGNERAHGQ 1507

  Fly  1596 DLGSPGSCVPRFSTLPVLSCGQNNVCNYASRNDKTFWLTTNAAIPMM--PVENIEIRQYISRCVV 1658
            |||:.|||:.||||:|.:.|..|||||:|||||.::||:|...:||.  |:...:|:.:||||.|
Frog  1508 DLGTAGSCLRRFSTMPFMFCNINNVCNFASRNDYSYWLSTPEPMPMSMEPLRGRDIQPFISRCAV 1572

  Fly  1659 CEAPANVIAVHSQTIEVPDCPNGWEGLWIGYSFLMHTAVGNGGGGQALQSPGSCLEDFRATPFIE 1723
            |||||.|||||||||::|.||.||..|||||||:|||:.|..|.||||.|||||||:||:.||||
Frog  1573 CEAPAMVIAVHSQTIQIPQCPQGWSSLWIGYSFMMHTSAGAEGSGQALASPGSCLEEFRSAPFIE 1637

  Fly  1724 CNGAKGTCHFYETMTSFWMYNLESSQPFERPQQQTIKAGERQSHVSRCQVCMKNS 1778
            |:| :|||::|....|||:..:|.|:.|.:||.:|:|||:.::.|||||||||.:
Frog  1638 CHG-RGTCNYYANSYSFWLATVEMSEMFSKPQSETLKAGDLRTRVSRCQVCMKRT 1691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	27/56 (48%)
		Collagen	322..380	CDD:189968	29/75 (39%)
		Collagen	413..465	CDD:189968	24/54 (44%)
		Collagen	499..561	CDD:189968	23/61 (38%)
		Collagen	574..632	CDD:189968	27/61 (44%)
		Collagen	657..714	CDD:189968	28/59 (47%)
		Collagen	765..824	CDD:189968	27/61 (44%)
		Collagen	854..911	CDD:189968	30/65 (46%)
		Collagen	884..943	CDD:189968	29/58 (50%)
		Collagen	923..982	CDD:189968	31/58 (53%)
		Collagen	1028..1085	CDD:189968	23/58 (40%)
		Collagen	1229..1287	CDD:189968	24/63 (38%)
		Collagen	1318..1376	CDD:189968	29/68 (43%)
		Collagen	1399..1458	CDD:189968	28/58 (48%)
		Collagen	1477..1534	CDD:189968	26/56 (46%)
		C4	1555..1662	CDD:128421	61/108 (56%)
		C4	1663..1777	CDD:128421	70/113 (62%)
col4a5	XP_004916922.2	Collagen	704..749	CDD:396114	20/44 (45%)
		Collagen	751..801	CDD:396114	23/52 (44%)
		Med15	899..>1240	CDD:312941	164/367 (45%)
		Collagen	1092..1148	CDD:396114	26/59 (44%)
		Collagen	1122..1177	CDD:396114	20/54 (37%)
		C4	1468..1574	CDD:396133	58/105 (55%)
		C4	1578..1688	CDD:396133	67/110 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	1.000	Domainoid score	I3912
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1305	1.000	Inparanoid score	I154
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41315at33208
OrthoFinder	1	1.000	-	-		FOG0000443
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24023
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1239
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.160