Protein Alignment Col4a1 and col4a5

DIOPT Version :10

• Sequence 1: NP_723044.1
• Gene: Col4a1 / 33727
• FlyBaseID: FBgn0000299
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: XP_004916922.2
• Gene: col4a5 / 100492984
• XenbaseID: XB-GENE-6041869
• Length: 1691
• Species: Xenopus tropicalis
• Alignment Length: 1810
• Identity: 822/1810 - (45%)
• Similarity: 975/1810 - (53%)
• Gaps: 251/1810 - (13%)

  Fly    74 TAGYAGC--VPKC-----IAEKGNRGLPGPLGPTGLKGEMGFPGMEGPSGDKGQKGDPGPYGQRG 131
            :|...||  |.||     ..|||.||||      ||:|.:|.||..||      :|.|||.|.:|
 Frog    28 SAACQGCTSVSKCDCSGVKGEKGERGLP------GLEGHLGLPGFPGP------EGPPGPRGPKG 80

  Fly   132 DKGERGSPGLHGQAGVPGVQGPAGNPGAPGINGKDGCDGQDGIPGLEGLSGMPGPRGYAGQLGSK 196
            |.|..||||..|..|.||..|..||||.||:.|.|               |.|||.|..|..|:|
 Frog    81 DSGLSGSPGPKGIRGPPGPPGFPGNPGQPGLPGHD---------------GEPGPAGIPGCNGTK 130

  Fly   197 GEKGEPAKENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKGPRGEHGLKGEKGA 261
            |::|.|            |.||:.||.|:.||.|.||.||:.|:|.|. |.|.:|:.||
 Frog   131 GDRGFP------------GGPGFSGTPGIPGPPGLPGVKGDPGESFPL-APGQKGDPGL------ 176

  Fly   262 SCYGPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPRGDMGQKGEPGLVGRKGEPGPEGDTGLD-- 324
                   ||.||:.|..|      |:    .|.||.|..|..|.||..|..|.|||:|:.||:
 Frog   177 -------PGLPGLPGRTG------PI----GVQGPVGRPGPAGLPGSPGVPGPPGPKGNMGLNFQ 224

  Fly   325 ---GQKGEKGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGN-------------PGQKG 373
               |:|||.|:.|.||..|:.....||.:|.|||::|.||..|.||.             .|:||
 Frog   225 GSKGEKGEPGIQGLPGPPGQLEQVEPPQTTIQKGEKGIPGDQGFPGERGPMGPPGPPGGAKGEKG 289

  Fly   374 EPGRAGATGKPGLLGPPGPPGGG--RGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQK 436
            |||..|..||||..|..|.|||.  ||.||.||  ||    |..|.:|..|.:|||||.|....:
 Frog   290 EPGEPGKIGKPGKDGKIGLPGGEGFRGDPGLPG--GP----GRDGDKGQKGENGLPGPPGEVISR 348

  Fly   437 GGAGLPGRPGNEGPP---GKKGEKGTAGLNGPKG--------SIGPIGHPGPPGPEGQKGDAGLP 490
            .|.|..|..||.|||   |.||::|..||.||.|        |:||.|:||.||..|||||.|.|
 Frog   349 PGTGRVGPKGNTGPPGITGPKGDRGFPGLQGPPGFPGTPGTSSVGPSGNPGLPGERGQKGDDGPP 413

  Fly   491 GY---GIQGSKGDAGIPGYPGLKGSKGERGFKGNAGAPGDSKLGRPGTPGAAGAPGQKGDAGRPG 552
            |.   |:.||:|.||.||.|||            .|.||.|.:|    |.....||..|..|.||
 Frog   414 GISIPGLPGSEGLAGPPGPPGL------------PGRPGTSAVG----PAMVCQPGLPGTQGLPG 462

  Fly   553 TPGQKGDMGIKGDVGGKCSSCRA----GPKGDKGTSGLPGIPGKDGARGPPGERGYPGERGHDGI 613
            .||..|:.|.|||.|..|.:|..    |||||.|..|.||.||..||.|..|..|.|      |.
 Frog   463 DPGFLGERGQKGDKGDTCYNCIGNGILGPKGDPGLPGFPGSPGSPGAPGQKGAMGIP------GT 521

  Fly   614 NGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGAEGLPG 678
            ||..||||..|..|.:|.||..||||:.    :..|:..|||.|:||..|:.|:.|..|.:|.||
 Frog   522 NGLPGPPGFPGNPGISGRPGPKGEPGEV----IGEIKGEKGDPGFPGPAGSPGLDGVPGRDGTPG 582

  Fly   679 IPGPKGE---FGFKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFG 740
            |||||||   |..||::|.   ||:.|.||..|..|..|.||....|.||..|..|..|..|:.|
 Frog   583 IPGPKGEPGGFVLKGDRGF---PGDIGFPGHPGDRGLMGPPGFGPSGPPGEKGIQGVSGRPGAPG 644

  Fly   741 RSGEKGEPGSCALDEIKMPAKGNKGEPGQTGMP---GPPGEDGSPGERGYTGLKGNTGPQGPPGV 802
            ..|.||.||...::      ||:.|.||..|:|   |.|||.|.||:.|..|:.|:.|..|.||:
 Frog   645 IPGPKGSPGQTVME------KGDFGPPGLPGIPGDAGTPGEPGLPGQPGIPGVPGSKGEPGIPGI 703

  Fly   803 EGPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPGISRPGPMGPPGLNGLQGE 867
             |..|..|.:|..||.|..|.||..|:.|..|.||:.|.|||:|:||...||..|.||..||
 Frog   704 -GLPGSAGAKGFPGNTGPPGAPGLAGRPGSDGSPGQPGLPGPKGDPGFGLPGLPGSPGPAGL--- 764

  Fly   868 KGDRGPTGPIGFPGA---------DGSVGYPGDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVAG 923
            ||.:||.|..||||:         ||.||..||.|..||||..|.||:.|..|. ||.|..|:.|
 Frog   765 KGSQGPKGESGFPGSPGLPGRAGFDGPVGPKGDSGQNGLPGTPGPPGVPGAGGQ-GPPGQPGLPG 828

  Fly   924 PPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVS 988
            |.|.||..|..|..|.||:||:||. .|||..||||:||..|.:||.|..|.||.:|..|:||.|
 Frog   829 PAGPPGPTGNTGIQGEKGDPGAPGF-DMPGPPGDRGSPGFPGERGFTGPPGPPGAQGRDGLPGFS 892

  Fly   989 GAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGP 1053
            ||||:.|..|..|:.||.|.   ||.|||.|.||:.   |.|||.||.|:||.:|.:|..||.||
 Frog   893 GAKGEMGVMGPPGSVGPAGN---PGNPGLPGSKGND---GNPGQPGLSGLPGAEGEKGERGLPGP 951

  Fly  1054 PGLPGDAS--EKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHGRAGPPGEKGDQGRSGID 1116
            ||....|:  .||.|||               ||.||..||.|  ..|.||.||..|..|:.||.
 Frog   952 PGRVDSANLQFKGVKGE---------------PGLPGSSGLSG--AKGAAGLPGNSGSPGQIGIP 999

  Fly  1117 GRDGINGEKGEQGL---QGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYPGD---RGD 1175
            |..|:.|.||:.||   .|..|.||.|||:|..|:||.||..|.||..|.||:.|.||.   :|:
 Frog  1000 GSPGLPGLKGDSGLPGQPGTSGPPGLKGSMGEMGLPGPPGSKGSPGQPGRPGSAGSPGFSGLKGE 1064

  Fly  1176 KGEPGLS--GLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGERGYTG 1238
            |||||:|  |:||..|:.|..|..||.|:||.||..|..|.||||.    |.|.||..|..|:.|
 Frog  1065 KGEPGISGAGIPGFPGQKGEPGQNGFPGSPGSKGNPGNPGLPGLPG----ISGPKGDPGLPGFPG 1125

  Fly  1239 EKGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGD------IGPRGEIGYPGVTIKG 1297
            ..|..|.:|:.||.|.:|..|..||:|..|..|..|.||.||.      .||.|..|.||:...|
 Frog  1126 SPGSPGLKGVDGPTGNSGLPGSPGLRGESGRPGPQGTPGEKGQPGQDGIPGPSGLKGEPGLPGFG 1190

  Fly  1298 EKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGLVGLPGPIGPAGS-----------KGERG 1351
            ..||||.||..|::|..|..|..|..||||..|:.|..|.|||.||.|.           ||:.|
 Frog  1191 SPGLPGLPGSQGQKGDAGLSGSPGNPGLPGFKGDQGFPGSPGPQGPTGQPGLPGPRTEGPKGDPG 1255

  Fly  1352 LAGSPGQPGQDGFPGAPGLKGDTGPQ---GFKGERGLNGFEGQKGDKGDRGLQGPSGLPGLVGQK 1413
            ..|.||:||..|:||.||.:|..||.   |||||:|..||.||.|..|.:|..|.||.|
 Frog  1256 PVGPPGRPGPQGYPGPPGSEGPRGPPGDGGFKGEKGNPGFPGQPGLTGSKGEHGASGFP------ 1314

  Fly  1414 GDTGYPGLNGNDGPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGM--LPP-PGPKGE------ 1469
            ||.|.|||||..|..|.||..||.|.||..|..|..||.|:.|.||.  ||. ||||||
 Frog  1315 GDPGRPGLNGMKGDQGVPGVPGFPGMKGPGGPPGLAGLKGESGLPGAIGLPGLPGPKGEYREIKG 1379

  Fly  1470 ----PGQPGRNGPKGEPGRPGERGLIGIQGERGEKGERGLIGETGNVGRPGPKGDRGEPGERGYE 1530
                ||.|||.|..|.||.||..||.|..|..|:.|..||.|..|.:||.|.:|..|:||.||..
 Frog  1380 APGLPGPPGRPGVNGPPGPPGSPGLPGSLGLPGDTGRDGLPGFEGQLGRKGDRGLPGQPGSRGIN 1444

  Fly  1531 GAIGLIGQKGEPGAPAPAALDYLTGILITRHSQSETVPACSAGHTELWTGYSLLYVDGNDYAHNQ 1595
            |..|..|.:|.||.|...::.:  |.||||||||...|.|..|.|.::.|||||||.||:.||.|
 Frog  1445 GPPGPDGLQGPPGPPGLGSVAH--GFLITRHSQSTDAPGCPFGTTRIYDGYSLLYVQGNERAHGQ 1507

  Fly  1596 DLGSPGSCVPRFSTLPVLSCGQNNVCNYASRNDKTFWLTTNAAIPMM--PVENIEIRQYISRCVV 1658
            |||:.|||:.||||:|.:.|..|||||:|||||.::||:|...:||.  |:...:|:.:||||.|
 Frog  1508 DLGTAGSCLRRFSTMPFMFCNINNVCNFASRNDYSYWLSTPEPMPMSMEPLRGRDIQPFISRCAV 1572

  Fly  1659 CEAPANVIAVHSQTIEVPDCPNGWEGLWIGYSFLMHTAVGNGGGGQALQSPGSCLEDFRATPFIE 1723
            |||||.|||||||||::|.||.||..|||||||:|||:.|..|.||||.|||||||:||:.||||
 Frog  1573 CEAPAMVIAVHSQTIQIPQCPQGWSSLWIGYSFMMHTSAGAEGSGQALASPGSCLEEFRSAPFIE 1637

  Fly  1724 CNGAKGTCHFYETMTSFWMYNLESSQPFERPQQQTIKAGERQSHVSRCQVCMKNS 1778
            |:| :|||::|....|||:..:|.|:.|.:||.:|:|||:.::.|||||||||.:
 Frog  1638 CHG-RGTCNYYANSYSFWLATVEMSEMFSKPQSETLKAGDLRTRVSRCQVCMKRT 1691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	gly_rich_SclB	<107..>361	CDD:468478	101/258 (39%)
		gly_rich_SclB	<355..>642	CDD:468478	140/319 (44%)
		gly_rich_SclB	<543..820	CDD:468478	123/286 (43%)
		gly_rich_SclB	<727..>968	CDD:468478	113/252 (45%)
		gly_rich_SclB	<969..>1218	CDD:468478	120/258 (47%)
		gly_rich_SclB	<1186..>1420	CDD:468478	109/253 (43%)
		gly_rich_SclB	<1321..>1547	CDD:468478	117/252 (46%)
		C4	1555..1662	CDD:128421	61/108 (56%)
		C4	1663..1777	CDD:128421	70/113 (62%)
col4a5	XP_004916922.2	gly_rich_SclB	<47..>310	CDD:468478	129/325 (40%)
		gly_rich_SclB	<286..>587	CDD:468478	150/332 (45%)
		gly_rich_SclB	<710..>954	CDD:468478	125/254 (49%)
		gly_rich_SclB	<843..>1069	CDD:468478	118/249 (47%)
		gly_rich_SclB	<959..1248	CDD:468478	132/309 (43%)
		gly_rich_SclB	<1131..>1371	CDD:468478	110/245 (45%)
		C4	1468..1575	CDD:460201	59/106 (56%)
		C4	1578..1689	CDD:460201	68/111 (61%)