Protein Alignment Col4a1 and col17a1

DIOPT Version :10

• Sequence 1: NP_723044.1
• Gene: Col4a1 / 33727
• FlyBaseID: FBgn0000299
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: XP_031761733.1
• Gene: col17a1 / 100490199
• XenbaseID: XB-GENE-6467921
• Length: 1487
• Species: Xenopus tropicalis
• Alignment Length: 1617
• Identity: 457/1617 - (28%)
• Similarity: 555/1617 - (34%)
• Gaps: 630/1617 - (38%)

  Fly    54 SYD--IVDSAGVARGDLPPKNCTAGYAGCVPKCIAEKGNRGLPGPLGPTGLKGEMGFPGMEGPSG 116
            |||  |:|||      ||....|:                .||......|.:..|||
 Frog   211 SYDTTILDSA------LPSYMWTS----------------TLPAGSSMGGYQNNMGF-------- 245

  Fly   117 DKGQKGDPGPYGQRGDKGERGSPGLHGQAGVPGVQGPAGN--PGAPGINGKDGCDGQDGIPGLE- 178
                                 |..:...|....|.|...|  |.:|.:|  .|......:.|::
 Frog   246 ---------------------SSSMLNAASTGSVFGVPNNLAPSSPSLN--SGYTSSSAVFGVQN 287

  Fly   179 GLSGMPGPRGYAGQLGSKGEKGEPAKENGDYAKGEKGEPGWRGTAGLAGPQG------------F 231
            .|:.||.|......:.:....|...::|..::.|..|.............||            .
 Frog   288 NLTPMPAPGPIVSSVAASTASGYGVQKNVTHSSGGHGSTVTTSAVTSTKTQGDDILGKDYKFLLL 352

  Fly   232 PGEKG---ERGD-------------SGPYGAKGPRGEHGLKGEKGASCY----GPMKPGAPG--- 273
            ..|||   :.||             :...|..|...|..||.||  .|:    ...|..|.|
 Frog   353 EKEKGPSKKEGDVLIMSKDTGKVFTASNGGVSGTYEEDSLKKEK--QCFTSTEASYKTEANGGLK 415

  Fly   274 -------------IKGEK--------GEPASSFPVKPTHTVMGP--------------------- 296
                         :.|:|        ||....     |..|.||
 Frog   416 VRKDKATYAEIQRVDGQKAAATYQDGGEGGGG-----TDAVCGPCASCCKWWMWALGLLLGLLFL 475

  Fly   297 -------------------RGDMGQKGEP-----------GLVGRKGEPGPEGDTGLDGQKGEKG 331
                               |....::.:|           ..:...|.........:|......|
 Frog   476 LGLLFGLLSLWQDVKNLTTRVKTLEESQPNSKVVAEYLQANRINAVGSAPGASSADIDLSSNTLG 540

  Fly   332 LPGGPGDRGRQ--------------GNF-GPPGSTGQKGDRGEPGLNGLPGNPGQKGEPGRAGAT 381
            :..|..|:.::              |.| |..|.:|||||.         |..|::||.|.||..
 Frog   541 VGAGFTDQNKEAFWDYMKRRMQQERGVFIGEKGESGQKGDM---------GMQGERGERGYAGPQ 596

  Fly   382 GKPGLLGPPGPPGGGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQKGGAGLPGRPG 446
            |.|||:       |..|..||.|.||..|..|..||.|..|.:|||||:               |
 Frog   597 GAPGLI-------GHTGAEGPKGQKGNAGDTGVEGPSGQRGREGLPGPR---------------G 639

  Fly   447 NEGPPGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQKGDAGLPGYGIQGSKGDAGIPGYPGLKG 511
            :.|||| .||||..|:.|..|.   .|.||.||..|.||..||        :|..|:||.||::|
 Frog   640 DPGPPG-TGEKGDRGIAGEPGQ---SGQPGLPGQIGLKGAMGL--------QGSPGVPGTPGIQG 692

  Fly   512 SKGERGFKGNAGAPGDSKLGRPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAG 576
            .:||                       ||.||.|||.|..|.||.|||.|.||..|   .:...|
 Frog   693 FRGE-----------------------AGLPGPKGDKGGVGPPGVKGDQGEKGSRG---LTGEPG 731

  Fly   577 PKGDKGTSGLPGIPGKDGARGPPGERGYPGERGHDGINGQTGPPGEKGEDGRTGLPGATGEPGKP 641
            |:|..|.:|.||..|..|::||.|.:|..||:|..|:.|..||||..|:.|..|||||.|.||.|
 Frog   732 PRGLPGPTGEPGPKGSSGSQGPDGIQGQRGEQGLLGLPGPRGPPGSSGDPGLPGLPGAQGPPGPP 796

  Fly   642 ALCDLSLIEPLKGDKGYPGAPGAKGVQGFKG----AEG----LPGIPGPKGEFGFKGEKGLSGAP 698
                           |.||..|.||..|..|    .||    :||.|||.|..         |.|
 Frog   797 ---------------GTPGRGGPKGDPGDPGRVIAQEGNTYSIPGPPGPAGPI---------GPP 837

  Fly   699 GNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCALDEIKMPAKGN 763
            |:.|.||..|..|.||.||  :|         ||:||:|..|.|..:.|..:
 Frog   838 GSPGVPGPVGPAGLPGQPG--VK---------GAQGDQGDPGVSISRQESSA------------- 878

  Fly   764 KGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVPGNPG 828
                .|..:|||||..|.||..|.            |||.|| .:.||.|:.|.||.   ||.||
 Frog   879 ----AQQTLPGPPGPPGPPGSPGI------------PGVAGP-SIQGPPGQAGVQGP---PGPPG 923

  Fly   829 KDGLRGIPGRNGQPGPRGEPGISRPGPMGPPGLNGLQGEKGDRGPTGPIGFPGADGSVGYPGDRG 893
            ..||.| .|:.|.|||        |||.|||||      .|...||....|.|.      ||..|
 Frog   924 PQGLAG-DGKEGPPGP--------PGPQGPPGL------PGSFVPTSETFFAGP------PGPPG 967

  Fly   894 DAGLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGIDGVRGRDG--AKGEPGSPGLVGMPGNKG 956
            ..||||.:|.|||.|:               ||.||:.|..||||  |.|.|||||..|.||.
 Frog   968 PPGLPGSTGEPGIPGD---------------PGQPGLPGAPGRDGPVAVGPPGSPGSPGFPGQ-- 1015

  Fly   957 DRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIK 1021
                ||..|.:|.||:.|||      ||||.|                    |||||
 Frog  1016 ----PGPQGERGEAGIPGAP------GIPGSS--------------------RGPPG-------- 1042

  Fly  1022 GDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLPGDASEKGQKGEP----------------- 1069
                 .|.|||    |:||.      ||..||||.||.:...|:..|.
 Frog  1043 -----GGRPGQ----GLPGP------PGPPGPPGPPGSSDSSGRVAEEVQQYIAQYLQSENVRTY 1092

  Fly  1070 --GPSGLRGDTGPAGTPGWPGEKGLPGLAVHGRAGPPGEKGDQGR-----------------SGI 1115
              ||.                             ||||.|||.|:                 ||:
 Frog  1093 LIGPQ-----------------------------GPPGPKGDSGQDVDYAELASRVMSYIRGSGL 1128

  Fly  1116 DGRDGINGEKG-------------EQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAGAP--- 1164
            ...||..|..|             ..|||           :|.||.||.||..||||:....
 Frog  1129 TSSDGGQGFVGPRVTYDEILSVLRSSGLQ-----------IGVPGPPGPPGQPGLPGSGYGDITA 1182

  Fly  1165 --------GAVGYPGDRGDKGEPGLSGLPGLKGETGPVG-----------------LQG---FTG 1201
                    |.||.||..|..|.||..|.||..|..||.|                 ||.   .:|
 Frog  1183 LLENSEFRGIVGPPGPPGQPGRPGRVGSPGPPGPMGPPGNPETSRTSFGVEEISSYLQSVGYISG 1247

  Fly  1202 APGPKGERGIRGQPGLPATVPDIRGDKG--SQGERGYTGEK----------GEQGERGLTGPAGV 1254
            .|||.|..|..|.||.|.      |..|  |..|..|:.::          .:...|.::||||.
 Frog  1248 PPGPPGPPGPPGSPGSPG------GGGGLVSYAENAYSSDRLRTELIEYLTSDNIRRYISGPAGP 1306

  Fly  1255 AGAKGDRGLQGPPGASGL----------NGIPGAKGDIGPRGE-----------IGYPGVTIK-- 1296
            .|..|.:||:||.|.||:          :|...:.|.....|.           :.|..|..:
 Frog  1307 PGPPGPQGLRGPKGDSGIISPSSGSSLSSGYSISSGSSQSSGSSFGSSSDSSFLLDYDEVANRVT 1371

  Fly  1297 ---GEKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGLV---------------------GL 1337
               ..:||......|..:|.:..|     :|.||..|.||:.                     .:
 Frog  1372 EKIQSQGLLAEVSYNIARGNVAGP-----QGPPGPQGPPGICQVYATHANITTDLMELFRAHGTI 1431

  Fly  1338 PGPIGPAGSKGERGLAGSPGQPGQDGFPGAPGLKGDTGPQGFKGERGLNGFEGQKGD 1394
            .||.|..|.||||            |||||   |||.||.|:.||.|..|.:|:|||
 Frog  1432 QGPPGLTGQKGER------------GFPGA---KGDRGPTGYTGEPGPIGHKGEKGD 1473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	gly_rich_SclB	<107..>361	CDD:468478	62/378 (16%)
		gly_rich_SclB	<355..>642	CDD:468478	112/286 (39%)
		gly_rich_SclB	<543..820	CDD:468478	105/284 (37%)
		gly_rich_SclB	<727..>968	CDD:468478	88/242 (36%)
		gly_rich_SclB	<969..>1218	CDD:468478	89/328 (27%)
		gly_rich_SclB	<1186..>1420	CDD:468478	79/288 (27%)
		gly_rich_SclB	<1321..>1547	CDD:468478	33/95 (35%)
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
col17a1	XP_031761733.1	gly_rich_SclB	<567..>761	CDD:468478	99/262 (38%)
		gly_rich_SclB	<692..>868	CDD:468478	88/236 (37%)
		Collagen	1432..>1472	CDD:460189	24/54 (44%)