DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and col19a1

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	XP_031758203.1	Gene:	col19a1 / 100488633	XenbaseID:	XB-GENE-6050958	Length:	1128	Species:	Xenopus tropicalis

Alignment Length:	1210	Identity:	425/1210 - (35%)
Similarity:	499/1210 - (41%)	Gaps:	426/1210 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 KGEPGPEGDTGLDGQKGEKGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGNPGQKGEPG 376
            ||:||..|..||.||||||||               .|..|.|||      .|:||..|:|||.|
Frog   285 KGDPGLPGVAGLPGQKGEKGL---------------QGENGTKGD------IGIPGQIGEKGEEG 328

  Fly   377 RAGATGKPGLLGPPGPPGGGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQKGGAGL 441
            .:|:||.             :|.||..|.||.:|.:|..|.||..|..||||..|.:
Frog   329 TSGSTGL-------------KGEPGHNGSKGEKGEMGEKGNQGEIGPFGLPGNDGSD-------- 372

  Fly   442 PGRPGNEGPPGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQKGDAGLP--GYGIQGSKGDAGIP 504
             ||||.:||.|.|||||..               |||||      |.||  ..||:|.||..|..
Frog   373 -GRPGIQGPIGPKGEKGEV---------------GPPGP------AVLPIVAGGIKGDKGPEGPQ 415

  Fly   505 GYPGLKGSKGERGFKGNAGAPGDSKLGRPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGK 569
            |.||.:|.:|.||           |.|.||.||..|.         ||.||:.|..|.|||
Frog   416 GPPGNEGQRGRRG-----------KPGPPGNPGPLGP---------PGVPGESGPSGKKGD---- 456

  Fly   570 CSSCRAGPKGDKGTSGLPGIPGKDG--ARGPPGERGYPGERGHDGINGQTGPPGEKGEDGRTGLP 632
                    |||.|..||||:||..|  ::|..||.|....:|..|:.|:||.|         |||
Frog   457 --------KGDVGQRGLPGLPGLVGSVSKGEKGEPGGTDNKGEQGVKGETGNP---------GLP 504

  Fly   633 GATGEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGAEGLPGIPGPKGEFGFKGEKGLSGA 697
            |.||.||            ::|.||.|||.|..|..|.:|..|:||..|.||:
Frog   505 GMTGLPG------------IQGQKGEPGAIGQPGEMGLRGEHGIPGKQGVKGD------------ 545

  Fly   698 PGNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCALDEIKMPAKG 762
                                   |||||        |.:|..|..|.||:.|.        |..|
Frog   546 -----------------------KGEPG--------GVEGPIGPPGPKGDTGP--------PGAG 571

  Fly   763 NKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQGPP--GVEGPRGLNGPRGEKGNQGAVGVPG 825
            .:||||.:|..|.||..|..||||..|::|..|..|||  |||||:|..||.||.|.||..|:||
Frog   572 LQGEPGPSGTSGAPGPRGPKGERGLPGVQGLPGEAGPPGTGVEGPQGPRGPPGEPGIQGPRGLPG 636

  Fly   826 NPGKDGLRGIPGRNGQPGPRGEPGISRPGPMGPPGLNGLQGEKGDRGPT-------GPIGFPGAD 883
            .||..|..|:|||:|:||..|.||    .|:..|.|       ||.|..       .|||.|
Frog   637 VPGLPGAEGVPGRDGRPGLPGPPG----DPIALPLL-------GDIGAVLKNVCSHCPIGGP--- 687

  Fly   884 GSVGYPGDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEPGSPGL 948
                              |..||.|||||                  :|:.|:.|.||:||.
Frog   688 ------------------GNTGIKGEKGD------------------EGIIGQHGVKGDPGP--- 713

  Fly   949 VGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPG 1013
                  :|..|.||.:||||.         :|..|.||:||.|||:|..|:            ||
Frog   714 ------RGPSGVPGKEGPKGI---------KGERGFPGLSGEKGDQGMQGI------------PG 751

  Fly  1014 APGLMGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLPG----------------DASE 1062
            .|||:|..|..|..|.||..|..|..|||||:|.||:.||||.||                .|:.
Frog   752 LPGLIGPPGPSGHLGRPGHPGPAGSKGEKGNEGSPGVPGPPGPPGIPVPERNGMGSLYKIQGAAS 816

  Fly  1063 KGQKGEPGPSGLRGDTGP---AGTPGWPGEKGLPG-LAVHGRAGPPGEKGDQGRSGIDGRDGING 1123
            ....|.|||.|.:||.||   ||..|.||.:|||| ....|:.||||..|..||:|..|..|..|
Frog   817 AVYMGPPGPPGPKGDQGPMGEAGPMGLPGLEGLPGEKGERGQIGPPGIAGIPGRNGAPGPPGYPG 881

  Fly  1124 EKGEQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYPGDRGDKGEPGLSGLPGLK 1188
            |.||:|..|..|.||.:|..   |:||..|.|||||:.||||.   |||||.|||
Frog   882 ESGERGPVGDIGFPGPEGPA---GVPGKNGNDGLPGSVGAPGR---PGDRGPKGE---------- 930

  Fly  1189 GETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGERGYTGEKGEQGERGLTGPAG 1253
                                   ||.||:|       ||:|.|||||..|..|.:|:.|..||
Frog   931 -----------------------RGDPGIP-------GDQGPQGERGKPGPSGYKGDMGTVGP-- 963

  Fly  1254 VAGAKGDRGLQGPPGASGLNGIPGAKGDIGPRGEIGYPGVTIKGEKGLPGRPGRNGRQGLIGAPG 1318
                      |||||..|..|.||..|..||                 |||||       |....
Frog   964 ----------QGPPGDRGYQGHPGKDGQPGP-----------------PGRPG-------ISTEN 994

  Fly  1319 LIGERGLPGLAGE----------PGLVGLPGPIGPAGSKGERGLAGSPGQPGQDGFPGAPGLKGD 1373
            ::.|.....:..|          ..|..|..|.....::|.    |.||.||.||.||.|   ||
Frog   995 ILFEEMKKYIKQEVLRIFEERMAELLSQLKSPAALLAAQGH----GKPGPPGNDGLPGPP---GD 1052

  Fly  1374 TGPQGFKGERGLNGFEGQKGDKGDRGLQGPSGLPGLVGQKGDTGYPGLNGNDGPVGAPGERGFTG 1438
            .||.|.:|.|      ||||::|:.|:    ||||..|..|.||.|
Frog  1053 PGPPGQQGLR------GQKGERGEFGI----GLPGSPGPAGPTGMP------------------- 1088

  Fly  1439 PKGRDGRDGTPGLPGQKGEPGMLPPPGPKGEPGQPGRNGP 1478
                    |:||.||         |.||.|.||..||..|
Frog  1089 --------GSPGTPG---------PSGPSGPPGIGGRCNP 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968
		Collagen	322..380	CDD:189968	23/57 (40%)
		Collagen	413..465	CDD:189968	22/51 (43%)
		Collagen	499..561	CDD:189968	21/61 (34%)
		Collagen	574..632	CDD:189968	22/59 (37%)
		Collagen	657..714	CDD:189968	14/56 (25%)
		Collagen	765..824	CDD:189968	33/60 (55%)
		Collagen	854..911	CDD:189968	15/63 (24%)
		Collagen	884..943	CDD:189968	13/58 (22%)
		Collagen	923..982	CDD:189968	16/58 (28%)
		Collagen	1028..1085	CDD:189968	31/75 (41%)
		Collagen	1229..1287	CDD:189968	24/57 (42%)
		Collagen	1318..1376	CDD:189968	18/67 (27%)
		Collagen	1399..1458	CDD:189968	15/58 (26%)
		Collagen	1477..1534	CDD:189968	1/2 (50%)
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
col19a1	XP_031758203.1	LamG	50..231	CDD:419873
		Collagen	343..396	CDD:396114	31/82 (38%)
		Med15	460..>779	CDD:312941	161/470 (34%)
		Collagen	490..544	CDD:396114	28/74 (38%)
		Collagen	566..610	CDD:396114	21/51 (41%)
		Collagen	709..763	CDD:396114	29/83 (35%)
		Collagen	848..914	CDD:396114	32/68 (47%)
		Collagen	896..951	CDD:396114	36/100 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910