DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and Col3a1

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	NP_114474.1	Gene:	Col3a1 / 84032	RGDID:	71029	Length:	1463	Species:	Rattus norvegicus

Alignment Length:	1798	Identity:	620/1798 - (34%)
Similarity:	737/1798 - (40%)	Gaps:	518/1798 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LGVVYLLGSLVSVTLADGKICNTTLCD-----CKGIKGRMGAPGPIGVPGLEGPAGD---IGP-P 68
            ||..||..|..|..:...:.|...:||     |..|   |....|:..|..|.|.|:   |.| |
  Rat    31 LGCNYLGQSYESRDVWKPEPCQICVCDSGSVLCDDI---MCDDEPLDCPNPEIPFGECCAICPQP 92

  Fly    69 GRAGPLGEKGDVGEYGEQGEKGHRGDIGPKGEMGYPGIMGKSGEPGTPGPRGIDGCDGRPGM--- 130
            ....|:...|:..:             ||||:.|.|||.|::|:||.||..|:.|..|.||:
  Rat    93 STPAPVIPDGNRPQ-------------GPKGDPGPPGIPGRNGDPGLPGQPGLPGPPGSPGICES 144

  Fly   131 -------QGP--------SGAPGQNGVRGPPGKPGQQGPPGEAGEGGINSKGTKGNRGETGQPGG 180
                   ..|        ||..|..|..||.|.||..||||.:|..|  |.|:.|.:|..|:||.
  Rat   145 CPTGGQNYSPQFDSYDVKSGVGGMGGYPGPAGPPGPPGPPGSSGHPG--SPGSPGYQGPPGEPGQ 207

  Fly   181 VGPPGFDGDRGSKGDTGYAGLTGEKGDPGLPGPKGDTGAVSELPYSLIGPPGAKGEPGDSLSGVL 245
            .||.|..|..|:.|.:|.||..||.|.||.||.:|       ||    ||||.||..|
  Rat   208 AGPAGPPGPPGAIGPSGPAGKDGESGRPGRPGERG-------LP----GPPGIKGPAG------- 254

  Fly   246 KPDDTLKGYKGYVGLQGDEGPQGPTGEQGAVGRNGLPGARGEIGGPGERGKPGKDGEPGRFGDKG 310
                 :.|:.|..|.:|.:|..|..||.||      ||.:||.|.||:.|.|         |..|
  Rat   255 -----IPGFPGMKGHRGFDGRNGEKGETGA------PGLKGENGLPGDNGAP---------GPMG 299

  Fly   311 MKGAPGWTGADGLDGSPGERGEDGFTGMPGVQGGAGPPGIYDPSLTKSLPGPIGSQGDIGP---P 372
            .:||||..|..||.|:.|.||.||..|..|..|..||||      |...||..|::|::||   |
  Rat   300 PRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPG------TAGFPGSPGAKGEVGPAGSP 358

  Fly   373 GEQGPPGLPGKPGRRGPIGLAGQSGDPGLNGSRGPPGRSERGEAGDYGFIGPPGPQGPPGEAGLP 437
            |..|.||..|:||.:|..|..|..|.||.|||  |.|:.|.|.||..|..|..|.:||||.|
  Rat   359 GSNGSPGQRGEPGPQGHAGAQGPPGPPGNNGS--PGGKGEMGPAGIPGAPGLLGARGPPGPA--- 418

  Fly   438 GRYGLHGEPGQNVVGPKGEPGLNGQPGLEGYRGDRGEVGLPGDKGLPGEGYNIVGPPGSQGPPGF 502
               |.:|.|||.  ||.||||.||..|..|.||:|||.|.|             |.||.:|..|.
  Rat   419 ---GANGAPGQR--GPSGEPGKNGAKGEPGARGERGEAGSP-------------GIPGPKGEDGK 465

  Fly   503 RGLPGDDGYNGLRGLPGEKGLRGDDCPVCNAGPRGPRGQEGDTGYPGSHGNRGAIGLTGPRGVQG 567
            .|.||:.|.||:.|.|||:|.         .|.|||.|..|..|..|..|.||..|..|||||
  Rat   466 DGSPGEPGANGVPGNPGERGA---------PGFRGPAGPNGAPGEKGPAGERGGPGPAGPRGV-- 519

  Fly   568 LQGNPGRAGHKGLPGPAGIPGEPGKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDTGDDGEKG 632
             .|.|||.|..|.||..|:||.||     ||                  |:.|..|..|..||.|
  Rat   520 -AGEPGRDGTPGGPGIRGMPGSPG-----GP------------------GNDGKPGPPGSQGESG 560

  Fly   633 RDGSDGSKGERGETGQRGDYGDAGYQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIKGER 697
            |.|..|..|.||:.|..            |.||..|.|||||:|...      |.||..|:.|..
  Rat   561 RPGPPGPSGPRGQPGVM------------GFPGPKGNDGAPGKNGER------GGPGGPGLPGPA 607

  Fly   698 GDDGDTGFKGVKGEPNPGQIYDNTGEPGEDGYTGPKGVKGAKGEQGAIGLRGEIGDRGPAGEVIP 762
            |.:|:|   |.:|.|.|      ||.||:.|..||.|.:|.   ||..|..|..|:.|..||  |
  Rat   608 GKNGET---GPQGPPGP------TGAPGDKGDAGPPGPQGL---QGIPGTSGPPGENGKPGE--P 658

  Fly   763 GPVGAKGYPGPTGDYGQQGAP---GLPGRDGEPGLDGGIGYKGQRGVPGQEVIQGEIGPPGRSGI 824
            ||.|..|.||..|..|..|||   |.||..|.|||.||      .|.||.|..:|..||||..|.
  Rat   659 GPKGEAGAPGVPGGKGDSGAPGERGPPGTAGTPGLRGG------AGPPGPEGGKGPAGPPGPPGT 717

  Fly   825 KGFPGDVGAPGQYGLAGRPGPKGVKGEQGPDGAVGQTGLPGNKGQRGDF-LVGPPGPKGQPGRNG 888
            .|.||..|.||:.|..|.|||||.|||  |.|| |..|:||..|.||.. .:|||||.|||
  Rat   718 SGPPGLQGMPGERGGPGSPGPKGEKGE--PGGA-GADGVPGKDGPRGPAGPIGPPGPAGQP---- 775

  Fly   889 RQAPHGAKGQKGEVGSLGQNGQNGAKGSIGFSGRRGLLGNAGLQGLPGSPGIPGLPGMIGEIGER 953
                             |..|:.||.|..|.:|.||..|..|..|.||..|.||.||..||.|.:
  Rat   776 -----------------GDKGEGGAPGLPGIAGPRGGPGERGEHGPPGPAGFPGAPGQNGEPGAK 823

  Fly   954 GEIGYNGRQGDIGPRGPNGEFGPKGLSGDDGPDGYPGANGLPGRKGETGNPGFPGRPGAKGVAAY 1018
            ||   .|..|:.|..||.|..||.|.||..||   ||..|:.|.:|..|.||..|.||.:
  Rat   824 GE---RGAPGEKGEGGPPGAAGPPGGSGPAGP---PGPQGVKGERGSPGGPGAAGFPGGR----- 877

  Fly  1019 SGIKGDDGESGLTGPIGYPGAPGAKGQRGPVGDSQPALDGVAGRKGEVGSPGPNGLPGRHGLKGQ 1083
             |:.|..|.:|..||.|..||||..|..||.|:|              ||||..|:.|..|..||
  Rat   878 -GLPGPPGNNGNPGPPGPSGAPGKDGPPGPAGNS--------------GSPGNPGVAGPKGDAGQ 927

  Fly  1084 RGDRGLPGQQGRPGEPGAKGLGGYPGRNGINGLKGATGFPGPQGPKGPQ---GESGVVGLDGRNG 1145
            .|::|.||.||.||.||..|:.|.   .|..||.|..|.|||:|..|||   ||||..|..|.||
  Rat   928 PGEKGPPGAQGPPGSPGPLGIAGL---TGARGLAGPPGMPGPRGSPGPQGIKGESGKPGASGHNG 989

  Fly  1146 QIGDQGPRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRSFYRGFTGDQGLQGERGEQGDMGPIGF 1210
            :.|..||:||.|:.|..||         |||             .|:.|..|:.|..|.
  Rat   990 ERGPPGPQGLPGQPGTAGE---------PGR-------------DGNPGSDGQPGRDGS------ 1026

  Fly  1211 IGPPGAKGERGDIGYAGQLGFDGAEGLKGFQGDQGPRGPPGITLPAEKGDEGVAGLDGRAGRPGH 1275
               ||.||:||:                        .|.|                 |..|.|||
  Rat  1027 ---PGGKGDRGE------------------------NGSP-----------------GAPGAPGH 1047

  Fly  1276 FGQKGAPGPPGENGPNGAIGHRGPQIQGPPGPQGDVGFPGAPGHNGRHGLIGPKGELGDMGRQGE 1340
                  |||||..||:|..|.||.  .||.||.      ||||..|..|..||:|..||.|..||
  Rat  1048 ------PGPPGPVGPSGKNGDRGE--TGPAGPS------GAPGPAGARGAPGPQGPRGDKGETGE 1098

  Fly  1341 RGESGYAIVGRQGDIGDIGFQGEPGWDGAKGEQGYPGLPGKNGRVGAPGPRGPTGDAGWGGIDGM 1405
            ||.:|..        |..||.|.|      |..|.||..|..|.||:|||.||.|.
  Rat  1099 RGSNGIK--------GHRGFPGNP------GPPGSPGAAGHQGAVGSPGPAGPRGP--------- 1140

  Fly  1406 DGLVGPKGQPGVTYSYSMARPGDRGEPGLDGFQGEEGDGGAPGLIGFQGQRGAVGYRGDQGEVGY 1470
               |||.|.|                       |::|..|.||.|
  Rat  1141 ---VGPHGPP-----------------------GKDGSSGHPGPI-------------------- 1159

  Fly  1471 TGADGPQGQRGDKGYMGLTGAPGLRGLPGPQGEPAP---------APPAPKSRGFIFARHSQSVH 1526
             |..||:|.||::|..|..|.||..|.|||.|.|.|         .....||.||       |.:
  Rat  1160 -GPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGGAAIAGVGGEKSGGF-------SPY 1216

  Fly  1527 VPQCP----ANTNLLWEGY-SLSGNVAASRAVGQDLGQSGSCMMRFTTMPYMLCDITNVCHFAQN 1586
            ....|    .||..:.... |::|.:.:.      :...||     ...|...|.....|| .:.
  Rat  1217 YGDDPMDFKINTEEIMSSLKSVNGQIESL------ISPDGS-----RKNPARNCRDLKFCH-PEL 1269

  Fly  1587 NDDSLWLSTAEPMPMTMTPIQG--RDLMKYISRCVVCETTTRIIALHSQSMSIP------DCPGG 1643
            .....|:.          |.||  .|.:|     |.|...|....:::..|::|      |....
  Rat  1270 KSGEYWVD----------PNQGCKMDAIK-----VFCNMETGETCINASPMTVPRKHWWTDAGAE 1319

  Fly  1644 WEEMWTG--------YSY---------------FMSTL-----DNV---------------GGVG 1665
            .:.:|.|        :||               |:..|     .|:               |.|.
  Rat  1320 KKHVWFGESMNGGFQFSYGNPDLPEDVLDVQLAFLRLLSSRASQNITYHCKNSIAYMDQANGNVK 1384

  Fly  1666 QNLVSPGSCLEEFRAQPVIECHGHGRCNYYDALASFWLTVIEE 1708
            ::|...||...||:|:      |:.:..|         ||:|:
  Rat  1385 KSLKLMGSNEGEFKAE------GNSKFTY---------TVLED 1412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	21/62 (34%)
		Collagen	102..152	CDD:189968	25/67 (37%)
		Collagen	277..334	CDD:189968	22/56 (39%)
		Collagen	534..593	CDD:189968	30/58 (52%)
		Collagen	814..871	CDD:189968	30/56 (54%)
		Collagen	957..1014	CDD:189968	24/56 (43%)
		Collagen	990..1049	CDD:189968	23/58 (40%)
		Collagen	1070..1128	CDD:189968	26/57 (46%)
		C4	1515..1624	CDD:128421	22/115 (19%)
		C4	1625..1737	CDD:128421	24/133 (18%)
Col3a1	NP_114474.1	VWC	33..89	CDD:278520	15/58 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..1195		551/1461 (38%)
		Nonhelical region (N-terminal)	155..169		3/13 (23%)
		Triple-helical region	170..1195		526/1375 (38%)
		Collagen	233..292	CDD:189968	32/87 (37%)
		Collagen	278..331	CDD:189968	28/67 (42%)
		Collagen	353..424	CDD:189968	35/78 (45%)
		Collagen	413..472	CDD:189968	35/79 (44%)
		Collagen	452..505	CDD:189968	26/74 (35%)
		Collagen	629..686	CDD:189968	26/61 (43%)
		Collagen	<1061..1103	CDD:189968	23/49 (47%)
		COLFI	1230..1462	CDD:279718	40/225 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	278	1.000	Domainoid score	I1631
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.900