DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vkg and CG42342

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	NP_001189234.1	Gene:	CG42342 / 7354466	FlyBaseID:	FBgn0259244	Length:	831	Species:	Drosophila melanogaster

Alignment Length:	709	Identity:	249/709 - (35%)
Similarity:	300/709 - (42%)	Gaps:	213/709 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 SGEPGTPGPRGIDGCDGRPGMQGPSGAPGQNGVRGPPGKPGQQGPPGEAGEGGINSKGTKGNRGE 174
            |||.|:.|.:    |..:||..||.|.||:.|.||..|..|::|.||..|..|  .||..|..|:
  Fly   228 SGEGGSGGGQ----CQCQPGPPGPPGPPGKRGKRGKKGDSGEKGDPGLNGISG--EKGAAGKPGD 286

  Fly   175 TGQPGGVGPPG---FDGDRGSK--------GDTGYAGLTGEKGDPGLPGPKGDTGAVSELPYSLI 228
            .||.|.||.||   |...:|.|        |..|||.:...| |....|.......|.:|
  Fly   287 KGQKGDVGHPGMDVFQTVKGLKRSVTTLHGGTLGYAEIVAVK-DLQEAGVNVSASTVIKL----- 345

  Fly   229 GPPGAKGEPGDSLSGVLKPDDTLKGYKGYVGLQGDEGPQGPTGEQGAVGRNGLPGARGEIGGPGE 293
                 ||||                        |:.||.||.||.|.      |||.||.|.|||
  Fly   346 -----KGEP------------------------GEPGPPGPPGEAGQ------PGAPGERGPPGE 375

  Fly   294 RGKPGKDGEPGRFGDKGMKGAPGWTGADGLDGSPGERGEDGFTGMPGVQGGAGPPGIYDPSLTKS 358
            .|..|..||.|:   .|:.|.||..||.|..|..|:||:.|.|  ..::|...|.||.:
  Fly   376 IGAQGPQGEAGQ---PGVAGPPGVAGAPGTKGDKGDRGDRGLT--TTIKGDEFPTGIIE------ 429

  Fly   359 LPGPIGSQGDIGPPGEQGPPGLPGKPGRRGPIGLAGQSGDPGLNGSRGPPGRSERGEAG-----D 418
                       ||||..||||.||:||.||..|..|.:|.||..|.||..|:...|..|     |
  Fly   430 -----------GPPGPAGPPGPPGEPGARGEPGPIGPAGPPGEKGPRGKRGKRIFGPGGTKIDED 483

  Fly   419 YG------FIGPPGPQGPPGEAGLPGRYGLHGEPGQ----NVVGPKGEPGLNGQPGLEGYRGDRG 473
            |.      ..|||||.|..|:.|..||.|..||||:    ..:||:|..||.|:||:||..|..|
  Fly   484 YDDPPVTLLRGPPGPPGIAGKDGRDGRDGSKGEPGEPGEPGSLGPRGLDGLPGEPGIEGPPGLPG 548

  Fly   474 EVGLPGDKGLPGEGYNIVGPPGSQGPPGFRGLPGDDGYNGLRGLPGEKGLRGD------------ 526
            ..|.||:||..|:    :||||..|||   ||||..||.|::   |:||.|||
  Fly   549 YQGPPGEKGDRGD----IGPPGLMGPP---GLPGPPGYPGVK---GDKGDRGDSYRKMRRRQDDG 603

  Fly   527 --DCPVCNA-----GPRGPRGQEGDTGYPGSHGNRGAIGLTGPRGVQGLQGNPGRAGHKGLPGPA 584
              |.|....     ||.||.|..|..|:.||.|.         ||:.|.:|:||..||||..||.
  Fly   604 MSDAPHMPTIEYLYGPPGPPGPMGPPGHTGSQGE---------RGLDGRKGDPGEKGHKGDQGPM 659

  Fly   585 GIPGEPGKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDTGDDGEKGRDGSDGSKGERGETGQR 649
            |:||..|..|.:||.                       |.:|..|..|..|.||.||.:||||.:
  Fly   660 GLPGPMGMRGESGPS-----------------------GPSGKAGIPGPPGLDGMKGAQGETGHK 701

  Fly   650 GDYGDAGYQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIKGERGDDGDTGFKGVKGEPNP 714
            |:.||.|..|.||.||::|           |:          |.:|.|||.|..|.:|.||:
  Fly   702 GERGDPGLPGTDGIPGQEG-----------PR----------GEQGSRGDAGPPGKRGRKGD--- 742

  Fly   715 GQIYDNTGEPGEDGYTGPKGVKGAKGEQGAIGLRGEIGDRGPAGEVIPGPVGAKGYPGP 773
                                 :|.|||||..||..            |.|:||.|.|.|
  Fly   743 ---------------------RGDKGEQGVPGLDA------------PCPLGADGLPLP 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	5/8 (63%)
		Collagen	102..152	CDD:189968	18/41 (44%)
		Collagen	277..334	CDD:189968	25/56 (45%)
		Collagen	534..593	CDD:189968	26/58 (45%)
		Collagen	814..871	CDD:189968
		Collagen	957..1014	CDD:189968
		Collagen	990..1049	CDD:189968
		Collagen	1070..1128	CDD:189968
		C4	1515..1624	CDD:128421
		C4	1625..1737	CDD:128421
CG42342	NP_001189234.1	DUF4763	130..>210	CDD:292582
		Collagen	366..413	CDD:189968	23/49 (47%)
		Collagen	660..718	CDD:189968	28/80 (35%)
		Collagen	690..748	CDD:189968	30/102 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24023
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100