DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and col11a1a

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	XP_005162870.1	Gene:	col11a1a / 565402	ZFINID:	ZDB-GENE-070209-167	Length:	1814	Species:	Danio rerio

Alignment Length:	1539	Identity:	576/1539 - (37%)
Similarity:	679/1539 - (44%)	Gaps:	398/1539 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 GLEGPAGD--IGPPGRAGPLG------EKGDVGEYGEQGEKGHRGDIGPKGEMGY---------- 103
            ||:..|..  :.|.|.|.|:|      ::.|:.||...|...::.:.||..|.|.
Zfish   343 GLDPTAASEAVLPSGTADPIGVDSYDFKEYDLKEYDVTGLDKNQYEYGPYDEFGNVAPNPTSNYE 407

  Fly   104 ----PGI----------------MGKSGEPGTPGPRGIDGCDGRPGM--QGPSGAPGQNGVRGPP 146
                ||:                :|:.||.|.|...       .|||  :||||.||..|:   |
Zfish   408 DTFGPGVAAETDIAETDLGGGAALGQKGEKGEPAVI-------EPGMLIEGPSGPPGPAGL---P 462

  Fly   147 GKPGQQGPPGEAGEGGINSKGTKGNRGETGQPGGVGPPGF----------DGDRG---------- 191
            |.||.|||||.||:.|  .:|..|..|..|..|..||||.          ||::|
Zfish   463 GPPGLQGPPGLAGDPG--DRGPPGRAGLPGADGLPGPPGTMLMLPFRFGGDGEKGPVVSAQEAQA 525

  Fly   192 ----------SKGDTGYAGLTGEKGDPGLPGPKGDTGAVSELPYSLIGPPGAKGEPGDSLSGVLK 246
                      .:|..|..||||..|..|||                 ||||.|||
Zfish   526 QAILSQARLAMRGPPGPMGLTGRSGPVGLP-----------------GPPGLKGE---------- 563

  Fly   247 PDDTLKGYKGYVGLQGDEGPQGPTGEQGAVGRNGLPGARGEIGGPGERGKPGKDGEPGRFGDKGM 311
                          .||.|||||.|.||..|:.|.||.||..|..|.||.|   ||.|..||:|.
Zfish   564 --------------SGDHGPQGPRGIQGPPGQIGKPGKRGRAGADGARGMP---GESGSKGDRGF 611

  Fly   312 KGAPGWTGADGLDGSPGERGEDGFTGMPGVQGGAGPPGIYDPSLTKSLPGPIGSQGDIGPPGEQG 376
                     |||.|.|||:|..|.|      |.|||            |||.|..|..|..||.|
Zfish   612 ---------DGLPGLPGEKGHRGET------GPAGP------------PGPTGEDGPRGEDGEIG 649

  Fly   377 PPGLPGKPGRR---GPIGLAGQSGDPGLNGSRGPPGRSERGEAGDYGFIGPPGPQGPPGEAGLPG 438
            |.||.|:.|.|   ||.|..|..|.||:.|..||.|  .:|..|..|..||||.||.||..||||
Zfish   650 PRGLAGESGPRGLLGPRGPPGPPGQPGIAGVDGPQG--PKGNMGPQGEPGPPGQQGIPGGQGLPG 712

  Fly   439 RYGLHGEPGQNVVGPKGEPGLNGQPGLEGYRGDRGEVGLPGDKGLPGEGYNIVGPPGSQGPPGFR 503
            ..|..|.||:.  ||:|..||.|.||.:|..|..|:.|.||:||       .:|.||.|||.|:.
Zfish   713 PQGPIGPPGEK--GPQGRSGLPGLPGADGPPGHPGKEGPPGEKG-------ALGQPGPQGPIGYP 768

  Fly   504 GLPGDDGYNGLRGLPGEKGLRGDDCPVCNAGPRGPRGQEGDTGYPGSHGNRGAIGLTGPRGVQGL 568
            |..|..|.:|:|||.|.||.:|:|         |..|.:||.|.   .|:||.:||.||||..|.
Zfish   769 GPRGVKGADGVRGLKGGKGEKGED---------GFPGFKGDMGL---KGDRGELGLAGPRGEDGP 821

  Fly   569 QGNPGRAGHKGLPGPAGIPGEPGKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDTGDDGEKGR 633
            :|..||||..|..||.|..||.||:|..|..|..   |  |:|..|.||..|..|..|:.|.:|.
Zfish   822 EGPKGRAGPNGESGPQGSAGEKGKLGVPGLPGYP---G--RQGPKGSTGFPGFPGANGEKGGRGV 881

  Fly   634 DGSDGSKGERGETGQRGDYGDAGYQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIKGERG 698
            .|..|.:|:||.||.||..|..|..|:.|..|..|.||.|            |.||.   :|.:|
Zfish   882 AGKAGPRGQRGPTGPRGARGARGPTGKPGPKGTAGNDGPP------------GPPGE---RGPQG 931

  Fly   699 DDGDTGFKGVKGEPNPGQIYDNTGEPGED---GYTGPKGVKGAKGEQGAIGLRGEIGDRGPAGEV 760
            ..|..||.|.||.|.|         ||:|   |:.|.:|..|.:|:.|..|..|.:|.:||.||.
Zfish   932 PQGPVGFPGPKGPPGP---------PGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGET 987

  Fly   761 IPGPVGAKGYPGPTGDYGQQGAPGLPGRDGEPGLDGGIGYKGQRGVPGQEVIQGEIGPPGRSGIK 825
              ||:|.:|:|||.|..|:||.||..|::|..      |..|.:|.||::      |||   |::
Zfish   988 --GPIGERGHPGPPGPPGEQGLPGAGGKEGAK------GDPGPQGSPGKD------GPP---GLR 1035

  Fly   826 GFPGDVGAPGQYGLAGRPGPKGVKGEQGPDGAVGQTGLPGNKGQRGDFLVGPPGPKGQPGRNGRQ 890
            ||||:.|.||.      .||.|:||.:||.                    |||||.|.|
Zfish  1036 GFPGERGLPGV------TGPPGLKGAEGPQ--------------------GPPGPVGSP------ 1068

  Fly   891 APHGAKGQKGEVGSLGQNGQNGAKGSIGFSGRRGLLGNAGLQGLPGSPGIPGLPGMIGEIGERGE 955
                                          |.||..|:||..||||..|..|.||..||.|..||
Zfish  1069 ------------------------------GERGAAGSAGPIGLPGRTGPQGPPGPAGEKGAPGE 1103

  Fly   956 IGYNGRQGDIGPRGPNGEFGPKGLSGDDGPDGYPGANGLPGRKGETGNPGFPGRPGAKGVAAYSG 1020
                  :|.:||.|.:|..||.||.|..||.|.|         ||.|:.|..|.||.||..|..|
Zfish  1104 ------RGPLGPAGRDGVQGPVGLPGPAGPQGPP---------GEDGDKGEVGEPGQKGSKADKG 1153

  Fly  1021 IKGDDGESGLTGPIGYPGAPGAKGQRGPVGDSQPALDGVAGRKGEVGSPGPNGLPGRHGLKGQRG 1085
            .:|..|..||.||||.||..||.|:                       |||.|..|..|.||..|
Zfish  1154 EQGPPGPPGLQGPIGAPGPAGADGE-----------------------PGPRGQQGMFGQKGDEG 1195

  Fly  1086 DRGLPGQQGRPGEPGAKGLGGYPGRNGINGLKGATGFPGPQGPKGPQGESGVVGLDGRNGQIGDQ 1150
            .||.||.   ||..|.:||.|.||..|.||..|..|.|||.||:||||..|.   ||..|..|..
Zfish  1196 SRGFPGP---PGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPPGA---DGPQGPPGGI 1254

  Fly  1151 GPRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRSFYRGFTGDQGLQGERGEQGDMGPIGFIGPPG 1215
            |..|.:||:|||||.|:.|..|.|                |..|.:|||||:|:.||.|..||.|
Zfish  1255 GGMGAVGEKGEQGEAGNPGPPGEP----------------GPGGPKGERGEKGEAGPPGAAGPAG 1303

  Fly  1216 AKGERGDIGYAGQLGFDGAEGLKGFQGDQGPRGPPGITLPAEKGDEGVAGLDGRAGRPGHFGQKG 1280
            .||..||.|..|.      .|..||.||.||.|.|           ||||:||..|..|..|:.|
Zfish  1304 PKGPPGDDGPKGN------PGPVGFPGDPGPPGEP-----------GVAGIDGGPGEKGEDGESG 1351

  Fly  1281 APGPPGENGPNGAIGHRGPQ-IQGPPGPQGDVGFPGAPGHNGRHGLIGPKGELGDMGRQGERGES 1344
            .||||   ||:|..|..||. .:||||..|..|..|..|..|..||.||.|:.|.:|.||..|:.
Zfish  1352 QPGPP---GPSGEAGPPGPPGKRGPPGAHGAEGRQGEKGAKGEAGLEGPPGKTGPVGPQGPSGKP 1413

  Fly  1345 G-YAIVGRQGDIGDIGFQGEPGWDGAKGEQGYPGLPGKNGRVGAPGPRGPTGDAGWGGIDGMDGL 1408
            | ..:.|..|.:|:.|..|.||.||..|..|.|||||..|..|:.|.:|.         .|:.||
Zfish  1414 GPEGLRGIPGPVGEQGLPGAPGQDGPPGPMGPPGLPGLKGDPGSKGEKGH---------PGLIGL 1469

  Fly  1409 VGPKGQPGVTYSYSMARPGDRGEPGLDGFQGEEGDGGAPGLIGFQGQRGAVGYRGDQGEVGYTGA 1473
            :||.|:.|        ..||||.||..|..|.:||.|..|..|..|..|..|..|.||..|..|:
Zfish  1470 IGPPGEQG--------EKGDRGLPGPQGAAGSKGDNGISGASGPIGPPGPPGLPGPQGPKGSKGS 1526

  Fly  1474 DGPQGQRGDKGYMGLTGAPGLRGLPGPQGE---PAPAPPAPKSR 1514
            .||.||:||      ||..|..|.|||.||   |.|.....|||
Zfish  1527 TGPAGQKGD------TGTVGPPGPPGPPGEVIQPLPIHSPKKSR 1564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	21/96 (22%)
		Collagen	102..152	CDD:189968	22/81 (27%)
		Collagen	277..334	CDD:189968	25/56 (45%)
		Collagen	534..593	CDD:189968	27/58 (47%)
		Collagen	814..871	CDD:189968	18/56 (32%)
		Collagen	957..1014	CDD:189968	21/56 (38%)
		Collagen	990..1049	CDD:189968	24/58 (41%)
		Collagen	1070..1128	CDD:189968	28/57 (49%)
		C4	1515..1624	CDD:128421	576/1539 (37%)
		C4	1625..1737	CDD:128421
col11a1a	XP_005162870.1	TSPN	43..233	CDD:214560
		Collagen	571..630	CDD:189968	33/76 (43%)
		Collagen	722..778	CDD:189968	26/64 (41%)
		Collagen	814..873	CDD:189968	29/63 (46%)
		Collagen	862..915	CDD:189968	22/52 (42%)
		Collagen	<1383..1425	CDD:189968	16/41 (39%)
		COLFI	1586..1812	CDD:279718
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1547
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900