DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and col2a1a

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	NP_571367.1	Gene:	col2a1a / 562496	ZFINID:	ZDB-GENE-980526-192	Length:	1491	Species:	Danio rerio

Alignment Length:	1613	Identity:	581/1613 - (36%)
Similarity:	718/1613 - (44%)	Gaps:	364/1613 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KIC----NTTLCD---CKGIK---GRMGAPG------------PIGVPGLEGPAGD-------IG 66
            ::|    .|.|||   |:.:.   ..:.:||            |||..|.:|..|:       :|
Zfish    57 RVCVCDSGTVLCDEVICEDLNDCANPIISPGECCPICPADTDDPIGSLGAKGQKGEPGDITDVVG 121

  Fly    67 PPGRAGPLGEKGDVGEYGEQGEKGHRGDIGPKGEMGYPGIMGKSGEPGTPGPRGIDGCDGRPGMQ 131
            |.|.|||:|..|:.|..||:|.||.:|..||:|..|.||..|..|.||.|||.|..|..|....|
Zfish   122 PRGPAGPMGPPGEQGTRGERGAKGEKGSPGPRGRDGEPGTPGNPGPPGPPGPNGPPGLGGNFAAQ 186

  Fly   132 GPSG----APG-QNGV-RGPPGKPGQQGPPGEAGEGGINSKGTKGNRGETGQP---GGVGPPGFD 187
            ...|    |.| |.|| :||.|..|.:||||.:|..|  .:|.:||.||||:|   |.:||.|..
Zfish   187 MAGGFDEKAGGAQMGVMQGPMGPMGPRGPPGPSGAPG--PQGFQGNPGETGEPGPAGALGPRGPP 249

  Fly   188 GDRGSKGDTGYAGLTGEKGDPGLPGPKGDTGAVSELPYSLIGPPGAKGEPGDSLSGVLKPDDTLK 252
            |..|..|..|.||..|:.|:.|.|||:|..|.           ||..|.||            :|
Zfish   250 GPPGKPGSDGEAGKPGKAGERGPPGPQGARGF-----------PGTPGLPG------------IK 291

  Fly   253 GYKGYVGL---QGDEGPQGPTGEQGAVGRNGLPGARGEIGGPGERGKPGKDGEPGRFGDKGMKGA 314
            |::|:.||   :|:.|..|..||.|:.|.:|.||..|..|.|||||:||..|..|..|:.|:.|.
Zfish   292 GHRGHPGLDGAKGEAGAAGAKGEAGSNGESGAPGPMGPRGLPGERGRPGATGAAGARGNDGLPGP 356

  Fly   315 PGWTGADGLDGSPGERGEDGFTGMPGVQGGAGPPGIYDPSLTKSLPGPIGSQGDIGPPGEQGPPG 379
            .|..|..|..|:|      ||.|.||.:|.|||.|...|...:...|..|:.|..||.|..|.||
Zfish   357 AGPPGPVGPAGAP------GFPGSPGSKGEAGPTGARGPEGAQGPRGEAGTPGSPGPAGASGNPG 415

  Fly   380 LPGKPGRRGPIGLAGQSGDPGLNGSRGPPGRSERGEAGDYGFIGPPGPQGPPGEAGLPGRYGLHG 444
            ..|.||.:|..|.:|.:|.||..|.||||        |..|..||.||:|..|:.|:||..|..|
Zfish   416 TDGIPGAKGSAGASGIAGAPGFPGPRGPP--------GPQGATGPLGPKGQSGDPGIPGFKGEAG 472

  Fly   445 EPGQ-NVVGPKGEPGLNGQPGLEGYRGDRGEVGLPGDKGLPGEGYNIVGPPGSQGPPGFRGLPGD 508
            ..|: .|:||:|.||.:|:   ||.||.|||   ||..| |      :||||.:|.||.||.||.
Zfish   473 PKGERGVLGPQGPPGPSGE---EGKRGPRGE---PGSAG-P------LGPPGERGAPGNRGFPGQ 524

  Fly   509 DGYNGLRGLPGEKGLRGDDCPVCNAGPRGPRGQEGDTGYPGSHGNRGAIGLTGPRGVQGLQGN-- 571
            ||..|.:|.||::|:         .|..||:|..||.|.||..|..||.||||..|..|.||.
Zfish   525 DGLAGAKGAPGDRGV---------PGLSGPKGGTGDPGRPGEPGLPGARGLTGRPGDAGAQGKVG 580

  Fly   572 ----PGRAGHKGLPGPAGIPGEPGKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDTGDDGEKG 632
                ||..|..|.|||.|..|:||.:|..||.|...|.|  :.||.|..|.:|.||..|.|||.|
Zfish   581 ATGAPGEDGRPGPPGPLGARGQPGVMGFPGPKGANGEPG--KPGEKGLVGRTGLRGLPGKDGETG 643

  Fly   633 RDGSDGSKGERGETGQRGDYGDAGYQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIKGER 697
            ..|..|..|..||.|::|..|.:|:||.   ||..|..|.||:            ||..|:.||.
Zfish   644 PSGPPGPVGAVGERGEQGQPGPSGFQGL---PGPTGAPGEPGK------------PGDQGVPGEG 693

  Fly   698 GDDGDTGFKGVKGEPNPGQIYDNTGEPGEDGYTGPKGVKGAKGEQGAIGLRGEIGDRGPAGEVIP 762
            |..|.||.:|.:            |.|||.|..||:|::|.:|..|.                 |
Zfish   694 GAAGPTGPRGER------------GFPGERGGAGPQGLQGPRGLPGT-----------------P 729

  Fly   763 GPVGAKGYPGPTGDYGQQGAPGLPGRDGEPGLDGGIGYKGQRGVPGQEVIQGEIGPPGRSGIKGF 827
            |..|.||..||.|..|.||.|||.|..||.|..|..|.||.||..|:   :|..|.||:.|.:|.
Zfish   730 GTDGPKGAIGPAGAAGAQGPPGLQGMPGERGAVGISGAKGDRGDSGE---KGPEGAPGKDGSRGL 791

  Fly   828 PGDVGAPGQYGLAGRPGPKGVKGEQGPDGAVGQTGLPGNKGQRGDF-------LVGPPGPKGQPG 885
            .|.:|.||.      .||.|.|||.||.|::|..|..|..|.||:.       ..||||..||||
Zfish   792 TGPIGPPGP------SGPNGAKGETGPIGSIGAPGARGAPGDRGEIGAPGPAGFAGPPGADGQPG 850

  Fly   886 RNGRQAPHGAKGQKGEVGSLGQNGQNGAKGSIGFSGRRGLLGNAGLQGLPGSPGIPGLPGMIGEI 950
            ..|.|   |..||||:.|:.|..|.:||.|.:|.:|..|..|..|.||.||:.|.||..|.:|..
Zfish   851 NKGEQ---GESGQKGDSGAPGPQGPSGAPGPVGPTGVTGPKGARGAQGAPGATGFPGAAGRVGPP 912

  Fly   951 GERGEIGYNGRQGDIGPRGPNGEFGPKGLSGDDGPDGYPGANGLPGRKGETGNPGFPGRPGAKGV 1015
            |.      ||..|..||.||:|:.||||:.||.||                     |||.
Zfish   913 GP------NGNPGAAGPAGPSGKDGPKGVRGDAGP---------------------PGRA----- 945

  Fly  1016 AAYSGIKGDDGESGLTGPIGYPGAPGAKGQRGPVGDSQPALDGVAGRKGEVGSPGPNGLPGRHGL 1080
                      |::||.||   |||||.||:                 .||.|.|||:|..|..||
Zfish   946 ----------GDAGLRGP---PGAPGEKGE-----------------AGEDGPPGPDGPSGPAGL 980

  Fly  1081 KGQRGDRGLPGQQGRPGEPGAKGLGGYPGRNGINGLKGATGFPGPQGPKGPQGESGVVGLDGRNG 1145
            .||||..|||||:|..|.||..|..|.||:   .|..|.:|..||.||.||.|.:|..|..||.|
Zfish   981 AGQRGIVGLPGQRGERGFPGLPGPSGEPGK---QGAPGGSGDRGPPGPVGPPGLTGPAGETGREG 1042

  Fly  1146 QIGDQGPRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRSFYRGFTGDQGLQGERGEQGDMGPIGF 1210
            ..|..||.|..|..|.:||:|:.|.:|.|                   |..|..|..|.:|||
Zfish  1043 NPGSDGPPGRDGAAGVKGERGNTGPIGAP-------------------GAPGAPGAPGSVGPI-- 1086

  Fly  1211 IGPPGAKGERGDIGYAGQLGFDGAEGLKGFQGDQGPRGPPGITLPAEKGDEGVAGLDGRAGRPGH 1275
                |.:|:||:.|..|..|..|..|.:|..|.|||||        :||:.|.||..|:.|..|.
Zfish  1087 ----GKQGDRGENGPQGPAGPPGPAGARGMVGPQGPRG--------DKGEAGEAGERGQKGHRGF 1139

  Fly  1276 FGQKGAPGPPGENGPNGAIGHRGPQIQGPPGPQGDVGFPGAPGHNGRHGLIGPKGELGDMGRQGE 1340
            .|.:|.|||||..|..||.|..||  .|..||.|.||..|..|.||:.|.|||
Zfish  1140 TGLQGLPGPPGSPGDQGAAGPAGP--SGAKGPSGPVGPAGKDGSNGQPGPIGP------------ 1190

  Fly  1341 RGESGYAIVGRQGDIGDIGFQGEPGWDGAKGEQGYPGLPGKNGRVGAPGPRGPTGDAGWGGID-- 1403
                                   ||..|..||.|..|.||..|..|.|||.||       |||
Zfish  1191 -----------------------PGPRGRSGESGPVGPPGNPGPPGPPGPPGP-------GIDMS 1225

  Fly  1404 GMDGLVGP-KGQPGVTY------SYSMARPGDRGEPGLDGFQGEEGDGGAPGLIGFQGQRGAVGY 1461
            ...||..| ||...:.|      |.|:.:.....:..|....|:..|..:|.
Zfish  1226 AFAGLSQPEKGPDPLRYMRADEASSSLRQHDVEVDATLKSINGQIEDIRSPD------------- 1277

  Fly  1462 RGDQGEVGYTGAD----GPQGQRGDKGY-----MGLTGAPGLRGLPGPQ-GEPAPAPPAPK--SR 1514
             |.:.....:..|    .|:.:.||  |     :| :.|..::.....: ||....|..||  .:
Zfish  1278 -GSRKNPARSCRDLKLCHPEWKSGD--YWVDPNLG-SAADAIKVFCNMETGETCVKPSTPKIPRK 1338

  Fly  1515 GFIFARHSQSVHVPQCPANTNLLWEGYSLSGNVAASRAVGQDLGQSGSCMMRF 1567
            .:..::.....||          |.|.|::|....|.|.|.....:.:..:.|
Zfish  1339 NWWTSKSKAQKHV----------WFGESMNGGFHFSYADGSQTPSTTTIQLNF 1381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	29/65 (45%)
		Collagen	102..152	CDD:189968	24/55 (44%)
		Collagen	277..334	CDD:189968	23/56 (41%)
		Collagen	534..593	CDD:189968	31/64 (48%)
		Collagen	814..871	CDD:189968	23/56 (41%)
		Collagen	957..1014	CDD:189968	19/56 (34%)
		Collagen	990..1049	CDD:189968	15/58 (26%)
		Collagen	1070..1128	CDD:189968	28/57 (49%)
		C4	1515..1624	CDD:128421	10/53 (19%)
		C4	1625..1737	CDD:128421
col2a1a	NP_571367.1	VWC	38..93	CDD:278520	8/35 (23%)
		Collagen	262..336	CDD:189968	33/96 (34%)
		Collagen	372..428	CDD:189968	22/55 (40%)
		Med15	<381..>704	CDD:312941	153/369 (41%)
		Collagen	496..555	CDD:189968	33/77 (43%)
		Collagen	670..729	CDD:189968	28/102 (27%)
		PRK07764	<772..966	CDD:236090	95/267 (36%)
		Collagen	820..879	CDD:189968	26/61 (43%)
		Collagen	856..907	CDD:189968	23/50 (46%)
		Collagen	937..1010	CDD:189968	45/128 (35%)
		COLFI	1255..1490	CDD:366624	27/154 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810