DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vkg and col7a1l

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	XP_009298585.1	Gene:	col7a1l / 559516	ZFINID:	ZDB-GENE-030131-9861	Length:	2161	Species:	Danio rerio

Alignment Length:	1066	Identity:	350/1066 - (32%)
Similarity:	431/1066 - (40%)	Gaps:	403/1066 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 PGPIGVPGLEGPAGDIGPPGRAGPLGEKGDVGEYG----EQGEKGHRGDIGPKGEMGYPGIMGKS 110
            |..:..|  |||.    |....|..|||||...:|    :|| .||......|       :.|:.
Zfish  1157 PEALAKP--EGPC----PLNCKGQKGEKGDGFGHGGLRLQQG-PGHFDSFSLK-------VKGEK 1207

  Fly   111 GEPGTPGPRGIDGCDGRPGMQGPSGAPGQNGVRGPPGKPGQQGPPGEAGEGGINSKGTKGNRGET 175
            ||.|.||..||.|..||||..||.|:|||   |||.|.||..||||        :.|.||.|||.
Zfish  1208 GERGLPGTDGIPGLPGRPGRTGPPGSPGQ---RGPSGIPGDMGPPG--------NTGPKGQRGER 1261

  Fly   176 GQPGGVGP-----PGFDGDRGSKGDTGYAGLTGEKGDPGLPGPKGDTGAVSELPYSLIGPPGAKG 235
            |:||.|..     ||..|:.||.|.:|..|:.|..|.||||                 |.||..|
Zfish  1262 GEPGYVMGGMEVLPGRKGEPGSSGPSGAPGVPGVSGPPGLP-----------------GLPGPSG 1309

  Fly   236 EPGDSLSGVLKPDDTLKGYKGYVGLQGDEGPQGPTGEQGAVGRNGLPGARGEIGGPGERGKPGKD 300
            .||.|:.|.                .|:.||:||                        |||||:.
Zfish  1310 SPGLSIKGE----------------SGEPGPKGP------------------------RGKPGQK 1334

  Fly   301 GEPGRFGDKGMKGAPGWTGADGLDGSPGERGEDGFTGMPGVQGGAGPPGIYDPSLTKSLPGPIGS 365
            ||.|..|:.|:.|.||..|.|||.|..|::||.|..|: |.||..|||
Zfish  1335 GEKGEQGNNGLPGLPGPVGVDGLPGLAGQKGEKGQDGI-GTQGAQGPP----------------- 1381

  Fly   366 QGDIGPPGEQGPPGLPGKPGRRGPIGLAGQSGDPGLNGSRGPPGRSERGEAGDYGFIGPPGPQGP 430
                |||||:                     |:.||:||:           |:.|..|..|..||
Zfish  1382 ----GPPGEK---------------------GNTGLSGSK-----------GEVGIQGLQGIAGP 1410

  Fly   431 PGEAGLPGRYGLHGEPGQNVVGPKGEPGLNGQPGLEGYRGDRGEVGLPGDKGLPGEGYNIVGPPG 495
            .|:.||.|..|..|..|:|  ||.|.||:.|.||..|.:||.|:.|.||:   |.:|  |:||
Zfish  1411 RGKKGLKGDQGEKGAQGEN--GPIGSPGIAGFPGAAGRKGDEGQRGAPGE---PAKG--ILGP-- 1466

  Fly   496 SQGPPGFRGLPGDDGYNGLRGLPGEKGLRGDDCPVCNAGPRGPRGQEGDTGYPGSHGNRGAIGLT 560
                                  ||:||.|||                              |||.
Zfish  1467 ----------------------PGKKGARGD------------------------------IGLV 1479

  Fly   561 GPRGVQGLQGNPGRAGHKGLPGPAGIPGEPGKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDT 625
            ||.|.||::|:.|..|.||.|| .||||:|                       |..|:||.||:.
Zfish  1480 GPPGPQGIKGDRGDKGEKGNPG-FGIPGQP-----------------------GPKGESGERGNV 1520

  Fly   626 GDDGEKGRDGSDGSKGERGETGQRGDYGDAGYQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGY 690
            |..|:.|..|:|||||::||         .|..|..|.||..|:||.||..
Zfish  1521 GLSGKPGPKGNDGSKGDKGE---------IGLPGTSGSPGLRGKDGVPGLK-------------- 1562

  Fly   691 DGIKGERGDDGDTGFKGVKGEPNPGQIYDNTGEPGEDGYTGPKGVKGAKGEQGAIGLRGEIGDRG 755
                      ||||               :.||||.                     |||.||||
Zfish  1563 ----------GDTG---------------SRGEPGS---------------------RGEPGDRG 1581

  Fly   756 PAGEVIPGPVGAKGYPGPTGDYGQQGAPGLPGRDGEPGLDGGIGYKGQRGVPGQEVIQGEIGPPG 820
                 :.||:|..|.||..||.|:.|..||||.:|..||      ||:.|:|         ||||
Zfish  1582 -----VKGPLGLPGRPGDPGDKGEPGKLGLPGPEGHKGL------KGEPGLP---------GPPG 1626

  Fly   821 ------------RSGIKGFPGDVGAPGQYGLAGRPGPKGVKGEQGPDG------AVGQTGLPGNK 867
                        ...|||.||:.|.||..|..|||||.|.:|:.||.|      :.|:.||.|
Zfish  1627 VTQFTTSDNTVLTRAIKGEPGESGLPGPPGETGRPGPPGPEGKPGPPGNSLFGSSTGKDGLDG-- 1689

  Fly   868 GQRGDFLVGPPGPKGQPGRNGRQAPHGAKGQKGEVGSLGQNGQNGAKGSIGFSGRRGLLGNAGLQ 932
                  |.|.||.||:            .|||||.||.|:.|.:               |.||:.
Zfish  1690 ------LPGIPGSKGE------------AGQKGEPGSKGEKGDH---------------GRAGIT 1721

  Fly   933 GLPGSPGIPGLPGMIGEIGERGEIGYNGRQGDIGPRGPNGEFGPKGLSGDDGPDGYPGANGLPGR 997
            |:||.||.||.||:.|:.|..|:               :||.||||..|:.|..|.|||||..|:
Zfish  1722 GMPGLPGTPGKPGVDGKRGVSGK---------------DGERGPKGDEGEKGVKGEPGANGNEGQ 1771

  Fly   998 KGETGNPGFPGRPGAKGVAAYSGIKGDDGESGLTGPIGYPGAPGAKGQRGPVGDSQPALDGVAGR 1062
            |||.|:||.||.|    :....|:..:|.:.....|:|.|||.|..|.:|..|:.     |:.|.
Zfish  1772 KGEQGSPGLPGPP----IVLQEGMSIEDMKKAFPLPMGPPGATGPPGMKGEKGEM-----GLKGE 1827

  Fly  1063 KGEVGSPGP-------NGLPGRHGLK 1081
            ||:.|:||.       .||...:|:|
Zfish  1828 KGDAGAPGRAVEMKDIEGLFDSYGIK 1853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	21/62 (34%)
		Collagen	102..152	CDD:189968	25/49 (51%)
		Collagen	277..334	CDD:189968	21/56 (38%)
		Collagen	534..593	CDD:189968	20/58 (34%)
		Collagen	814..871	CDD:189968	27/74 (36%)
		Collagen	957..1014	CDD:189968	24/56 (43%)
		Collagen	990..1049	CDD:189968	24/58 (41%)
		Collagen	1070..1128	CDD:189968	5/19 (26%)
		C4	1515..1624	CDD:128421
		C4	1625..1737	CDD:128421
col7a1l	XP_009298585.1	vWFA	33..198	CDD:294047
		FN3	236..327	CDD:238020
		fn3	330..410	CDD:278470
		fn3	422..487	CDD:278470
		fn3	509..581	CDD:278470
		fn3	604..678	CDD:278470
		FN3	698..781	CDD:238020
		fn3	785..862	CDD:278470
		vWFA	954..1118	CDD:294047
		Collagen	1208..1265	CDD:189968	35/67 (52%)
		Collagen	1316..1371	CDD:189968	28/94 (30%)
		Collagen	1403..1459	CDD:189968	27/60 (45%)
		Collagen	1439..1500	CDD:189968	35/119 (29%)
		Collagen	1503..1560	CDD:189968	30/88 (34%)
		Collagen	1542..1601	CDD:189968	34/123 (28%)
		Collagen	1683..1739	CDD:189968	32/90 (36%)
		Collagen	1722..1784	CDD:189968	35/76 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910