DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and col2a1b

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	NP_001268407.1	Gene:	col2a1b / 503730	ZFINID:	ZDB-GENE-050302-9	Length:	1493	Species:	Danio rerio

Alignment Length:	1367	Identity:	541/1367 - (39%)
Similarity:	638/1367 - (46%)	Gaps:	275/1367 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KIC----NTTLCD---CK-------------------------------GIKGRMGAPGPI-GVP 56
            :||    .|.|||   |:                               |.||:.|.||.| .|.
Zfish    58 RICVCDSGTVLCDEIVCEELRDCAKPEIPLGECCPVCASADASTPERLPGAKGQKGEPGDITDVV 122

  Fly    57 GLEGPAGDIGPPGRAGPLGEKGDVGEYGEQGEKGHRGDIGPKGEMGYPGIMGKSGEPGTPGPRGI 121
            |..||:|.:||||..||.|::         ||||.:|..||:|..|.||..|..|.||.|||.|.
Zfish   123 GPRGPSGPMGPPGEQGPRGDR---------GEKGEKGSPGPRGRDGEPGTPGNPGPPGPPGPNGP 178

  Fly   122 DGCDGR------PGMQGPSGAPGQNGVRGPPGKPGQQGPPGEAGEGGINSKGTKGNRGETGQPGG 180
            .|..|.      .|....:||.....::||.|..|.:||||..|..|  .:|.:||.||.|:||.
Zfish   179 PGLGGNFASQMAGGFDDKAGAAQMGVMQGPMGPMGPRGPPGPNGAPG--PQGFQGNPGEGGEPGS 241

  Fly   181 VGPPGFDGDRGSKGDTGYAGLTGEKGDPGLPGPKGDTGAVSELPYSLIGPPGAKGEPG-DSLSGV 244
            .||      .|.:|..|..|..|:.|:||.||..|:.|..        ||.||:|.|| ..|.|:
Zfish   242 SGP------MGPRGPPGPPGKPGDDGEPGKPGNGGERGPP--------GPQGARGFPGTPGLPGI 292

  Fly   245 LKPDDTLKGYKGYVGLQGDEGPQGPT---GEQGAVGRNGLPGARGEIGGPGERGKPGKDGEPGRF 306
                   ||::||.||.|.:|..|.|   ||.|:.|.:|.||..|..|.|||||:||..|..|..
Zfish   293 -------KGHRGYTGLDGAKGESGATGAKGESGSPGESGAPGPMGPRGLPGERGRPGPSGASGAR 350

  Fly   307 GDKGMKGAPGWTGADGLDGSPGERGEDGFTGMPGVQGGAGPPGIYDPSLTKSLPGPIGSQGDIGP 371
            |:.|:.|..|..|..|..|||      ||.|.||.:|.|||.|...|.      |..|.:|:.|.
Zfish   351 GNDGLPGGAGPPGPVGTAGSP------GFPGSPGAKGEAGPTGARGPE------GAQGPRGESGV 403

  Fly   372 PGEQGPPGLPGKPGRRGPIGLAGQSGDPGLNGSRGPPGRSERGEAGDYGFIGPPGPQGPPGEAGL 436
            ||..||.|:.|.||..|..|..|..|.||:.|:.|.||  .||..|..|..||.||:|..|::||
Zfish   404 PGASGPSGVSGNPGSDGMPGAKGSVGAPGIGGAPGFPG--PRGPPGPQGATGPLGPKGQSGDSGL 466

  Fly   437 PGRYGLHGEPGQNVVGPKGE---PGLNGQPGLEGYRGDRGEVGLPGDKGLPGEGYNIVGPPGSQG 498
            .   |..||     .|||||   .||.|.||..|..|.||..|.||..|.|       ||.|.:|
Zfish   467 A---GFKGE-----AGPKGEIGNAGLQGAPGPAGEEGKRGPRGEPGAAGPP-------GPTGERG 516

  Fly   499 PPGFRGLPGDDGYNGLRGLPGEKGLRGDDCPVCNAGPRGPRGQEGDTGYPGSHGNRGAIGLT--- 560
            .||.||.||.||..|.:|.|||:|         .||..||:|..||.|.||..|..||.|||
Zfish   517 TPGNRGFPGQDGLAGPKGAPGERG---------PAGVSGPKGAGGDPGRPGEPGLPGARGLTGRP 572

  Fly   561 ---GPRGVQGLQGNPGRAGHKGLPGPAGIPGEPGKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHR 622
               ||:|..|..|.||..|..|.|||.|:.|:||.:|..||.|...|.|  :.||.|..|..|.|
Zfish   573 GDAGPQGKVGPSGAPGEDGRPGPPGPQGVRGQPGVMGFPGPKGGNGEAG--KAGEKGLAGAPGLR 635

  Fly   623 GDTGDDGEKGRDGSDGSKGERGETGQRGDYGDAGYQGRDGEPGRDGRDGAPGRNATTPKVYLIGE 687
            |..|.|||.|..|..|..|..||.|::|..|.:|:||..|.|      |.||..         |:
Zfish   636 GLPGKDGETGAAGPPGPAGSAGERGEQGQPGPSGFQGLPGPP------GPPGEG---------GK 685

  Fly   688 PGYDGIKGERGDDGDTGFKGVKGEPNPGQIYDNTGEPGEDGYTGPKGVKGAKGEQGAIGLRGEIG 752
            ||..|:.||.|..|.||.:|.:            |.|||.|..||:|::|.:|..|.
Zfish   686 PGDQGVPGEAGGAGATGPRGER------------GFPGERGGAGPQGLQGPRGLPGT-------- 730

  Fly   753 DRGPAGEVIPGPVGAKGYPGPTGDYGQQGAPGLPGRDGEPGLDGGIGYKGQRGVPGQEVIQGEIG 817
                     ||..|.||..||.|..|.||.|||.|..||.|..|..|.||.||..|.   :|..|
Zfish   731 ---------PGTDGPKGGVGPAGTAGAQGPPGLQGMPGERGTSGNPGPKGDRGDNGD---KGPEG 783

  Fly   818 PPGRSGIKGFPGDVGAPGQYGLAGRPGPKGVKGEQGPDGAVGQTGLPGNKGQRGD----FLVGPP 878
            .||:.|.:|..|.:|..|.   ||..|.||..|..||.|..|..|:||::|:.|.    ...|||
Zfish   784 APGKDGSRGLTGPIGPTGP---AGPNGEKGESGPAGPSGVAGTRGVPGDRGETGPPGPAGFAGPP 845

  Fly   879 GPKGQPGRNGRQAPHGAKGQKGEVGSLGQNGQNGAKGSIGFSGRRGLLGNAGLQGLPGSPGIPGL 943
            |..||||..|.|   |..||||:.|:.|..|.:||.|..|.:|..|..|..|.||.||:.|.||.
Zfish   846 GADGQPGVKGEQ---GEGGQKGDAGAPGPQGPSGAPGPQGPTGVSGPKGARGAQGPPGATGFPGA 907

  Fly   944 PGMIGEIGERGEIGYNGRQGDIGPRGPNGEFGPKGLSGDDGPDGYPGANGLPGRKGETGNPGFPG 1008
            .|.:|..|.      ||..|..||.||.|:.||||:.||.||.|.||..||.|..|..|..|.||
Zfish   908 AGRVGPPGP------NGNPGPAGPAGPPGKDGPKGVRGDGGPPGRPGDAGLRGSAGPAGEKGDPG 966

  Fly  1009 R---------------PGAKGVAAYSGIKGDDGESGLTGPIGYP---GAPGAKGQRGPVGD-SQP 1054
            .               .|.:|:....|.:|:.|..||.||.|.|   ||||..|.|||.|. ..|
Zfish   967 EDGPHGPDGPAGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGGPGDRGPPGPVGAP 1031

  Fly  1055 ALDGVAGRKGEVGSPGPNGLPGRHGLKGQRGDRGLPGQQGRPGEPGAKGLGGYPGRNGINGLKGA 1119
            .|.|.||..|..|:||.:|.|||.|..|.:||||..|..|.||.||..|.   ||..|..|.:|.
Zfish  1032 GLTGAAGEPGREGNPGSDGPPGRDGSAGIKGDRGDTGPAGAPGAPGGPGA---PGPVGPTGKQGD 1093

  Fly  1120 TGFPGPQGPKGPQGESGVVGLDGRNGQIGDQGPRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRS 1184
            .|..||.||.||.|.:|..|:.      |.||||   |::||.|:.||.|:.|
Zfish  1094 RGEAGPHGPSGPPGPAGARGMP------GPQGPR---GDKGEGGDSGDRGQKG------------ 1137

  Fly  1185 FYRGFTGDQGLQGERGEQGDMGPIGFIGPPGAKGERGDIGYAGQLGFDGAEGLKGFQGDQGPRGP 1249
             :|||||.|||.|..|:.||.|..|..||.||:|..|.:|.||:   |||.||      .||.||
Zfish  1138 -HRGFTGLQGLPGSPGQPGDQGASGPSGPGGARGPPGPVGPAGK---DGANGL------PGPIGP 1192

  Fly  1250 PGITLPAEKGDEGVAGLDGRAGRPGHFGQKGAPGPPGENGPNGAIGHRGPQIQGPPGPQGDV-GF 1313
            ||   |.           ||:|..|..|..|.|||||.              .|||||..|: .|
Zfish  1193 PG---PR-----------GRSGETGPSGPPGTPGPPGP--------------PGPPGPGIDMSAF 1229

  Fly  1314 PG 1315
            .|
Zfish  1230 AG 1231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	27/58 (47%)
		Collagen	102..152	CDD:189968	20/55 (36%)
		Collagen	277..334	CDD:189968	24/56 (43%)
		Collagen	534..593	CDD:189968	31/64 (48%)
		Collagen	814..871	CDD:189968	23/56 (41%)
		Collagen	957..1014	CDD:189968	28/71 (39%)
		Collagen	990..1049	CDD:189968	27/76 (36%)
		Collagen	1070..1128	CDD:189968	26/57 (46%)
		C4	1515..1624	CDD:128421
		C4	1625..1737	CDD:128421
col2a1b	NP_001268407.1	VWC	39..94	CDD:278520	7/35 (20%)
		Collagen	264..322	CDD:189968	27/72 (38%)
		Collagen	315..389	CDD:189968	37/79 (47%)
		Collagen	368..424	CDD:189968	27/67 (40%)
		Collagen	468..526	CDD:189968	31/69 (45%)
		Collagen	498..557	CDD:189968	32/74 (43%)
		Collagen	537..585	CDD:189968	23/56 (41%)
		Collagen	711..769	CDD:189968	28/74 (38%)
		Collagen	744..803	CDD:189968	27/64 (42%)
		Collagen	795..852	CDD:189968	24/59 (41%)
		Collagen	828..899	CDD:189968	31/73 (42%)
		Collagen	954..1012	CDD:189968	17/57 (30%)
		COLFI	1260..1492	CDD:279718
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910