DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vkg and Col13a1

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	XP_038954943.1	Gene:	Col13a1 / 499431	RGDID:	1595704	Length:	798	Species:	Rattus norvegicus

Alignment Length:	1022	Identity:	321/1022 - (31%)
Similarity:	398/1022 - (38%)	Gaps:	356/1022 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 GPIGSQGDIGPPGEQGPPGLPGKPGRRGPIGLAGQSG---DPGLNG------------------- 403
            ||    ||:|.||.             |.:.||.|..   .||..|
  Rat    16 GP----GDLGAPGP-------------GTVALAEQCARLPSPGCCGLLALALCSLALSLLAHFRT 63

  Fly   404 ----SRGPPGRSERGEAGDYGFIGPPGPQGPPGEAGLPGRYG-LHGE----------------PG 447
                :|.....|||||              ...|..:.||.. |..|                ||
  Rat    64 AELQARVLRLESERGE--------------QQMEKAILGRVNQLLDEKWKFYSRRRREAPKMSPG 114

  Fly   448 QNVVGPKGEPGLNGQPGLEGYRGDRGEVGLPGDKGLPGEGYNIVGPPGSQGPPGFRGLPGDDGYN 512
            .|.  |.|.||..|:|||.   ||:|.:|:||..|:.|:             ||.:|.|||.|
  Rat   115 CNC--PPGPPGPTGRPGLP---GDKGAIGMPGRVGVKGQ-------------PGEKGAPGDAG-- 159

  Fly   513 GLRGLPGEKGLRGDDCPVCNAGPRGPRGQEGDTGYPGSHGNRGAIGLTGPRGVQGLQGNPGRAGH 577
                             :...|||||.||.|..|:|         |..||.|:.|..|:||..|.
  Rat   160 -----------------ISIIGPRGPPGQPGTRGFP---------GFPGPIGLDGRPGHPGPKGE 198

  Fly   578 KGLPGPAGIPGEPGKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDTGDDGEKGRDGSDGSKGE 642
            .||.||.|.|                                                  |.:|:
  Rat   199 TGLVGPRGQP--------------------------------------------------GPQGQ 213

  Fly   643 RGETGQRGDYGDAGYQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIKGERGDDGDTGFKG 707
            :||.||.|:|           |.|:...|......:.|.:.|...|..:.::
  Rat   214 KGEKGQCGEY-----------PHREYPSGTLAALRSNPIISLKLLPLLNSVR------------- 254

  Fly   708 VKGEPNPGQIYDNTGEPGEDGYTGPKGVKGA--KGEQGAIGLRGEIGDRGPAGEVIPGPVGAKGY 770
                                 ...|..:|..  :|||...|::|..|..||     |||:|..|:
  Rat   255 ---------------------LAPPPVIKRRTFQGEQSQAGIQGPPGPPGP-----PGPIGPLGH 293

  Fly   771 PGPTGDYGQQGAPGLPGRDGEPGLDGGIGYKGQRGVPGQEVIQGEIGPPG--RSGIKGFPGDVGA 833
            ||..|..|..|.||.||..|:||:.|..|.||:||:||.....|..|.||  .:|:||.||..||
  Rat   294 PGLPGPIGPPGLPGPPGPKGDPGIQGYHGRKGERGLPGMPGKHGAKGAPGIAVAGMKGEPGTPGA 358

  Fly   834 PGQYGLAGRPGPKGVKGEQGPDGAV--GQTGLPGNKGQRGDFLVGPPGPKGQPGRNGRQAPHGAK 896
            .|:.|..|.||..|.|||:|..|..  |..|.||..|     |.|||||||:.|.:|:..|.|.:
  Rat   359 KGEKGATGSPGLLGQKGEKGDAGNAIGGGRGEPGPPG-----LPGPPGPKGEAGVDGQAGPPGQQ 418

  Fly   897 GQKGEVGSLGQNGQNGAKGSIGFSGR-------------------RGLLGNAGLQGLPGSPGIPG 942
            |.||:.|:.|:.|..|.|||.|..|:                   ..|:|..||.|..|.||.||
  Rat   419 GDKGQPGAAGEPGPTGPKGSKGEPGKGEMVDYNSSINEALQEIRTLALMGPPGLPGQTGPPGPPG 483

  Fly   943 LPGMIGEIGERGEIGYNGRQGDIGPRGPNGEFGPKGLSGDDGPDGYPGANGLPGRKGETGNPGFP 1007
            .||..||||..|..|::   ||.||||..|:.||.      ||.|.||.:|.||.|||.|.||.|
  Rat   484 TPGQRGEIGLPGPPGHD---GDKGPRGKPGDMGPA------GPQGPPGKDGPPGMKGEVGPPGNP 539

  Fly  1008 GRPGAKGVAAYSGIKGDDGESGLTGPIGYPGAPGAKGQRGPVGDSQPALDGVAGRKGEVGSPGPN 1072
                           |:.||:|..||   ||..|..|::|..||.        ||.|..|.|||.
  Rat   540 ---------------GEKGETGQAGP---PGLDGPTGEKGEPGDE--------GRPGATGLPGPI 578

  Fly  1073 GLPGRHGLKGQRGDRGLPGQQGRPGEPGAKGLGGYPGRNGINGLKGATGFPGPQGPKGPQGESGV 1137
            ||||..|.||:.|::         |:|||:                   .|||.||:||.|..|:
  Rat   579 GLPGFTGEKGEAGEK---------GDPGAE-------------------VPGPPGPEGPPGPPGL 615

  Fly  1138 VGLDGRNGQIGDQGPRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRSFYRGFTGDQGLQGERGEQ 1202
            .|:.|..|:.|..|.:   ||:|.|||:||.|.:|:||.                .||.|..|..
  Rat   616 QGIPGPKGEAGLDGSK---GEKGSQGEKGDRGPLGLPGA----------------SGLDGRPGPP 661

  Fly  1203 GDMGPIGFIGPPGAKGERGDIGYAGQLGFDGAEGLKGFQGDQGPRGPPGITLPAEKGDEGVAGLD 1267
            |..||||..||.|.|||||..|..|..|..||.||.|.      .||||     :||:.|..|..
  Rat   662 GTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAAGLPGL------HGPPG-----DKGNRGHRGFK 715

  Fly  1268 GRAGRPGHFGQKGAPGPPGENGPNGAIGHRGPQIQGPPGPQGDVGFP 1314
            |..|.|      |.||..|.:.|...:.|..|.:       ..:|:|
  Rat   716 GEKGEP------GLPGLDGLDAPCPLVWHFPPCV-------ASLGYP 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968
		Collagen	102..152	CDD:189968
		Collagen	277..334	CDD:189968
		Collagen	534..593	CDD:189968	25/58 (43%)
		Collagen	814..871	CDD:189968	27/60 (45%)
		Collagen	957..1014	CDD:189968	25/56 (45%)
		Collagen	990..1049	CDD:189968	22/58 (38%)
		Collagen	1070..1128	CDD:189968	17/57 (30%)
		C4	1515..1624	CDD:128421
		C4	1625..1737	CDD:128421
Col13a1	XP_038954943.1	Collagen	175..220	CDD:396114	22/103 (21%)
		Collagen	531..582	CDD:396114	28/76 (37%)
		Collagen	680..728	CDD:396114	23/64 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910