DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and Mp

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	NP_001246651.1	Gene:	Mp / 38769	FlyBaseID:	FBgn0260660	Length:	1039	Species:	Drosophila melanogaster

Alignment Length:	916	Identity:	241/916 - (26%)
Similarity:	301/916 - (32%)	Gaps:	392/916 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   699 DDGDTGFKGVKGEP-----------------NPG----QIYDNTG--EPGEDGYTGPKGVKGAKG 740
            |||...::| .||.                 |.|    .|:|.:|  .||:..||..:..:|.||
  Fly   246 DDGSIFYEG-SGENILFEDSTEANILSDDFWNTGDEATDIFDASGMQPPGQTQYTHERPYRGIKG 309

  Fly   741 EQGAIGLRGEIGDRGPAGEVIPGPVGAKGYPGPTGDYGQ-------------------------- 779
            |:         |:|||.|:.|.||.|..|.|||.|:...
  Fly   310 EK---------GERGPKGDSIRGPPGPPGPPGPKGETAPYPPFVETTSAGAKYTGECTCNASDIL 365

  Fly   780 -------------QGAPGLPGRDGEPGLDGGIGYKGQRGVPGQEVIQGEIGPPGRSGIKGFPGDV 831
                         :||||.||:||:|                        |.||.:|..|.||..
  Fly   366 EAIKDNESLRESLRGAPGTPGKDGKP------------------------GTPGHTGATGVPGAR 406

  Fly   832 GAPGQYGLAGRPGPKGVKGEQGPDGAVGQTGLPGNKGQRGDFLVGPPGPKGQPGR---------- 886
            ||      .|..|.:|:|||.|.|      ||||        ::|||||.|.||.
  Fly   407 GA------RGSEGAQGLKGEPGVD------GLPG--------VMGPPGPPGPPGLPENYDESLMV 451

  Fly   887 ------NGRQAPHGAKGQKGEVGSLGQNGQNGAKGSIGFSGRRGLLGNAGLQGLPGSPGIPGLPG 945
                  .|...| ||||..||.|..||.|:.|.      .|.:|..|.:|.:|.||.||.|||||
  Fly   452 NSMGAFRGTTQP-GAKGVPGEKGDAGQKGERGD------PGHKGAHGPSGAKGEPGEPGTPGLPG 509

  Fly   946 MIGEIGERGEIGYNGRQGDIGPRGPNGEFGPKGLSGDDGPDGYPGANGLPGRKGETGNPGFPGRP 1010
            :.|::|:.|                             |.||...|||..|.|||.|..|..||.
  Fly   510 LPGQVGQPG-----------------------------GLDGLASANGTKGEKGEKGEKGMRGRR 545

  Fly  1011 GAKGVAAYSGIKGDDGESGLTGPIGYPGAPGAKGQRGPVGDSQPALDGVAGRKGEVGSPGPNG-L 1074
            |.               :|.|||||.||.||..|..|..|  :|   |:.|.|||:|..||.| .
  Fly   546 GG---------------TGATGPIGPPGKPGPMGDIGHSG--RP---GMTGPKGEMGPKGPKGDS 590

  Fly  1075 PGRHGLKGQRGDRGLPGQQGRPGEPGAKGLGGYPGRNGINGLKGATGFPGPQGPKGPQGESGVVG 1139
            .||.||||.:||||..|:.|.||.||....||..|.:|  |:: ....|||.||.||.|..|
  Fly   591 GGREGLKGDKGDRGQDGRDGLPGPPGLPSTGGGDGDSG--GVQ-YIPMPGPPGPPGPPGLPG--- 649

  Fly  1140 LDGRNGQIGDQGPRGLIGEQGEQGEQGDEGEVGIPG------------RLENLRDRSFYRGFTGD 1192
                   :...||:|..|........||....|.||            .|::||||
  Fly   650 -------LSISGPKGEPGVDSRSSFFGDASYYGRPGARSSLDELKALRELQDLRDR--------- 698

  Fly  1193 QGLQGERGEQGDMGPIGFIGPPGAKGERGDIGYAGQLGF-DGAE----------------GLKGF 1240
                          |.|...||...|....  :...||. ||.|                |...|
  Fly   699 --------------PDGTAEPPRQPGHSHK--HEETLGLVDGEEPYFSASSSNMNMKIVPGAVTF 747

  Fly  1241 QG-----DQGPRGPPG----------ITLPAEKGDEGVAGLDGRAGRPGHFGQKGAPGPPGENGP 1290
            |.     .:....|||          :.:...||.:.:|        .|.......|.||....|
  Fly   748 QNIDEMTKKSALNPPGTLAYITEEEALLVRVNKGWQYIA--------LGTLVPIATPAPPTTVAP 804

  Fly  1291 NGAIGHRGPQIQGPPGPQGDVGFPGAPGHNGRHGLIGPKGELGDMGRQGERGESGYAIVGRQGDI 1355
            :.....:...:...|.|
  Fly   805 SMRFDLQSKNLLNSPPP------------------------------------------------ 821

  Fly  1356 GDIGFQGEPGWDGAKGEQGYPGLPGKNGRVGA---PGPRGPTGDAGWGGIDGMD----------G 1407
                ....|.|        ||.:.    ||.|   |.    |||.  .||.|.|          |
  Fly   822 ----LLNTPTW--------YPRML----RVAALNEPS----TGDL--QGIRGADFACYRQGRRAG 864

  Fly  1408 LVGPKGQPGVTYSY----------SMARPGD--------RGEPGLDGFQG-EEGDGG----APGL 1449
            |:|       |:..          ::.||.|        ||:...:.::| ..|.||    ||.:
  Fly   865 LLG-------TFKAFLSSRVQNLDTIVRPADRDLPVVNTRGDVLFNSWKGIFNGQGGFFSQAPRI 922

  Fly  1450 IGFQGQ 1455
            ..|.|:
  Fly   923 YSFSGK 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968
		Collagen	102..152	CDD:189968
		Collagen	277..334	CDD:189968
		Collagen	534..593	CDD:189968
		Collagen	814..871	CDD:189968	21/56 (38%)
		Collagen	957..1014	CDD:189968	15/56 (27%)
		Collagen	990..1049	CDD:189968	24/58 (41%)
		Collagen	1070..1128	CDD:189968	27/58 (47%)
		C4	1515..1624	CDD:128421
		C4	1625..1737	CDD:128421
Mp	NP_001246651.1	LamG	58..222	CDD:304605
		Collagen	378..432	CDD:189968	30/97 (31%)
		Collagen	464..518	CDD:189968	27/59 (46%)
		Collagen	494..615	CDD:189968	66/169 (39%)
		Endostatin-like	831..999	CDD:238151	28/115 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461338
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840