DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and Col4a2

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	XP_038951185.1	Gene:	Col4a2 / 306628	RGDID:	1308085	Length:	1707	Species:	Rattus norvegicus

Alignment Length:	1877	Identity:	751/1877 - (40%)
Similarity:	908/1877 - (48%)	Gaps:	347/1877 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GLLGVVYLLGSLVSVTLADGKICNTTLCDCKGIKGRMGAPGPIGVPGLEGPAGDIGPPGRAGPLG 75
            |||....|.|...|.....|:.|:.. |.|...||..|.||.:|..|..||.|..|.||..   |
  Rat    25 GLLAQSVLGGVKKSDVPCGGRDCSGG-CQCFPEKGARGQPGEVGPQGYNGPPGLQGFPGLQ---G 85

  Fly    76 EKGDVGEYGEQGEKGHRGDIGPKGEMGYPGIMGKSGEPGTPGPRGIDGCDGRPGMQGPSGAPGQN 140
            .|||.||.|..|..|.:||:|.:|..|:||..|..|.||..||||..|.||..|.:|.:|..|.:
  Rat    86 RKGDKGERGAPGPTGPKGDVGARGVSGFPGADGIPGHPGQGGPRGRPGYDGCNGTRGDAGPQGPS 150

  Fly   141 GVRGPPGKPGQQGPPGEAGEGGINSKGTKGN-RGETGQPGGV---GPPGFDGDRGSKGDTGYAGL 201
            |..|.||.||.|||.|:.||....||..:.. |||.|:||.|   ||||..|.         .|.
  Rat   151 GTGGFPGLPGPQGPKGQKGEPYALSKEDRDKYRGEPGEPGSVGYQGPPGRPGP---------IGQ 206

  Fly   202 TGEKGDPGLPGPKGDTGAVSELPYSLIGPPGAKGEPGDSLSGVLKPDDTLKGYKGYVGLQGDEG- 265
            .|..|.||.|||.              ||||.||:||:...|....    ||.||.||..|..|
  Rat   207 MGPMGAPGRPGPP--------------GPPGPKGQPGNRGLGFYGE----KGEKGDVGQPGPNGI 253

  Fly   266 PQ-----GPT----------GEQGAVGRNGLPG--ARGE---IGGPGERGKPGKDGEPGRFGDKG 310
            |.     |||          ||:|:.|..|:||  .:||   :|.||.||.||.|||.|..|.||
  Rat   254 PSDITLIGPTPSTYHPDMYKGEKGSQGEPGIPGITLKGEEGIMGFPGTRGFPGLDGEKGVSGQKG 318

  Fly   311 MKGAPGWTGADGLDGSPGERGEDGFTGMPGVQGGAGPPG--IYD--PSLTKSLPGPIGSQGDIGP 371
            .:|..|:.|..|..|..|||||            .||||  .|.  |||.|      |::||.|.
  Rat   319 SRGLDGFQGPSGPRGPKGERGE------------LGPPGPPAYSPHPSLAK------GARGDPGF 365

  Fly   372 PGEQGPPGLPGKPGRRGPIGLAGQS-GDP----GLNGSRGPPGRS-ERGEAGDY----GFIGPPG 426
            .|..|.||..|:||..||:|..|.| ||.    ||.|..||.|.| |.|.:..|    |..|.||
  Rat   366 QGAHGEPGSRGEPGDPGPVGPPGLSIGDEDSKRGLPGEMGPKGFSGEPGPSAYYPGPPGADGKPG 430

  Fly   427 PQGPPGEAGLPG----RYGLHGEPGQ-NVVGPKGEPGLNGQPGLEGYRGD--RGEV-----GLPG 479
            |||.||.||.||    .:||.|..|: ...||.|.||..||.|.:|..||  .|:|     ||||
  Rat   431 PQGLPGPAGPPGPDGFLFGLKGSEGRVGYPGPSGFPGGRGQKGWKGEAGDCQCGQVIPGLPGLPG 495

  Fly   480 DKGLPGEGYNIVGPPGSQGPPGFRGLPGDDGYN---GLRGLPGEKGLRGDDCPVCNAGPRGPRGQ 541
            .||.||..... |..|.||.||..|:||..|:.   |:.|.||.||::||...:..      :|:
  Rat   496 PKGFPGVNGEF-GKKGDQGDPGLHGIPGFPGFKGAPGIAGAPGPKGVKGDSRTITT------KGE 553

  Fly   542 EGDTGYPGSHGNRGAIGLTGPRGVQGLQGNPGRAGH--KGLPGPAGIPGEPGKVGAAGPDGKAIE 604
            .|..|.||.||.:|..|:.|..|:.|..|.||..|.  ||.||.||:||.||..|.
  Rat   554 RGQPGIPGVHGMKGDDGVPGRDGLDGFPGLPGPPGDGIKGPPGDAGLPGTPGTKGF--------- 609

  Fly   605 VGSLRKGEIGDTGDSGHRGDTGDDGEKGRDGSDGSKGERGETGQRGDYGDAGYQGRDGEPGRDGR 669
                 .||:|..|                .|..|.|||||..      ||||..|..|.||..|.
  Rat   610 -----PGEVGPPG----------------QGLPGPKGERGFP------GDAGLPGPPGFPGPPGL 647

  Fly   670 DGAPGRNATTPKVYLIGEPGYDGIKGERGDDGDTGFK-----GVKGEPNPGQIYDNTGEPGEDGY 729
            .|.||:                       .|.|||.|     |.:....||.:....|.||:.|.
  Rat   648 PGTPGQ-----------------------ADCDTGVKRPIGGGQQVVIQPGCVEGPAGSPGQPGP 689

  Fly   730 TGPKGVKGAKGEQGAIGLRGEIGDRGPAGEVIPGPVGAKGYPGP---TGDYGQQGAPGLPGRDGE 791
            .||.|.||.:|..|..|..||.|.:|     .||..|.:|:|||   .|..|.:|||||||.||.
  Rat   690 PGPTGAKGIRGIPGFPGASGEQGLKG-----FPGDPGREGFPGPPGFMGPRGSKGAPGLPGPDGP 749

  Fly   792 P---GLDGGIGYKGQRGVPGQEVI------QGEIGPPGRSGIKGFPGDVGAPGQYGLAGRPGPKG 847
            |   ||.|..|..|.||:|| ||:      :|:.|.||:.|:|||||::||||..|..|.||..|
  Rat   750 PGPIGLPGPAGPPGDRGIPG-EVLGAQPGARGDAGLPGQPGLKGFPGEIGAPGFRGSQGMPGMPG 813

  Fly   848 VKGEQGPDGAVGQTGLPGNKGQRG----------------DFLVGPPGPKGQPGRNGRQAPHGAK 896
            :||:.|..|..||.||.|..||.|                ..|.|.||.:|:||..|...|.|.|
  Rat   814 LKGQPGFPGPSGQPGLSGPPGQHGFPGAPGREGPLGLPGSPGLGGLPGDRGEPGEPGEPGPVGMK 878

  Fly   897 GQKGEVGSLGQNGQNGAKGSIGFSGRRGLLGNAGLQGLPGSPGI------------PGLPGMIGE 949
            |..|:.|..|.:|:.|..||.||.|..|:.|..|.:|..||||:            ||.||:.||
  Rat   879 GVSGDRGDAGVSGERGHPGSPGFKGMAGMPGIPGQKGDRGSPGMDGFQGMLGLKGRPGFPGIKGE 943

  Fly   950 IGERGEIGYNGRQGDIGPRGPNGEFGP--------------KGLSGDDGP---DGY---PGANGL 994
            .|..|..|..|..|:.|.:|..|:.||              ||..||:||   .||   .|..|:
  Rat   944 AGFFGVPGLKGLPGEPGVKGNRGDRGPPGPPPLILPGMKDIKGEKGDEGPMGLKGYLGLKGIQGM 1008

  Fly   995 PGRKGETGNPGFPGRP----GAKGVAAYSGIKGDDGESGLTGPIGYPGAPGAKGQRGPVGDSQPA 1055
            ||..|.:|.||.||||    ||||.....|..|..|..|::||.|..|.||..|.||..|  .|.
  Rat  1009 PGVPGLSGIPGLPGRPGFIKGAKGDIGVPGTPGLPGFPGVSGPPGITGFPGFTGSRGEKG--TPG 1071

  Fly  1056 LDGVAGRKGEVGSPGPNG----LPGRHGLKGQRGDRGLPGQQGRPGEPGAKGLGGYPGRNGI--- 1113
            :.||.|..|..|..|..|    |||..||||:||..|:||.:|..||.||:|..|:||..|:
  Rat  1072 VAGVFGETGPTGDFGDIGDTVDLPGSPGLKGERGVTGIPGLKGLFGEKGAEGDVGFPGITGMAGA 1136

  Fly  1114 ---NGLKGATGFPGPQGPKGPQGESGVVGLDGRNGQIGDQGPRGLIGEQGEQGEQGDEGEVGIPG 1175
               .||||.|||||..|.:|||||.|.:|:.|..   ||.|..|:.|..|..|.:|..|..|:||
  Rat  1137 QGSPGLKGQTGFPGLTGLQGPQGEPGRIGIPGDK---GDFGWPGVPGRPGIPGIRGISGLHGLPG 1198

  Fly  1176 RLENLRDRSFYRGFT--------GDQGLQGERGEQGDMGPIGFI-GPPGAKGERGDIGYAGQLGF 1231
            .          :||.        ||.|..|..|::||.|....: ||.||.|::|:.|..|:.|.
  Rat  1199 T----------KGFPGSPGVDAHGDPGFPGPTGDRGDRGEANTLPGPVGAPGQKGEQGIPGERGP 1253

  Fly  1232 DGAEGLKGFQGDQGPRGPPGITLPAEKGDEGVAGLDGRAGRPGHFGQKGAPGPPGENGPNGAIGH 1296
            .|:.||:||         |||:.|:     .::||.|..|.||.||.:|..||||..|||...|.
  Rat  1254 VGSPGLQGF---------PGISPPS-----NISGLPGDVGAPGIFGLQGYQGPPGPPGPNALPGI 1304

  Fly  1297 RGPQ----IQGPPGPQGDVGFPGAPGHNGRHGLIGPKGELGDMGRQGERGESGYAIVGRQGDIGD 1357
            :|.:    ..|.||.:|.||.||..|..|.|||.|.||..|:.|..|..|.||..     ||.|.
  Rat  1305 KGDEGSSGAAGFPGEKGWVGDPGPQGQPGVHGLPGEKGPKGEQGFMGNTGPSGAV-----GDRGP 1364

  Fly  1358 IGFQGEPGWDGAKGEQGYPGLPGKNGRVGA-PGPRGPTGDAGWGGIDGMDGLVGPKGQPGVTYSY 1421
            .|.:|:.|:.||.|..|.||:||...::.. ||..||.|..   |:.|..|.:||:|.||
  Rat  1365 KGPKGDQGFPGAPGSMGSPGIPGIPQKIAVQPGTMGPQGRR---GLPGALGEMGPQGPPG----- 1421

  Fly  1422 SMARPGDRGEPGLDGFQGEEGDGGAPGLIGFQGQRGAVGYRGDQGEVGYTGADGPQGQRGDKGYM 1486
               .||.||.||..|.||..|....|            |:|||||.:|:   .||.||.|:.
  Rat  1422 ---DPGFRGAPGKAGPQGRGGVSAVP------------GFRGDQGPMGH---QGPIGQEGEP--- 1465

  Fly  1487 GLTGAPGLRGLPGPQGEPAPAPPAPKSRGFIFARHSQSVHVPQCPANTNLLWEGYSLSGNVAASR 1551
            |..|:|||.|:||          ...|.|::..:|||:...|.||...|.||.||||.......:
  Rat  1466 GRPGSPGLPGMPG----------RSVSIGYLLVKHSQTDQEPMCPVGMNKLWSGYSLLYFEGQEK 1520

  Fly  1552 AVGQDLGQSGSCMMRFTTMPYMLCDITNVCHFAQNNDDSLWLSTAEPMPMTMTPIQGRDLMKYIS 1616
            |..||||.:|||:.||:|||::.|:..:||::|..||.|.||||..|:|  |.|:...::..|||
  Rat  1521 AHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLP--MMPVAEEEIKPYIS 1583

  Fly  1617 RCVVCETTTRIIALHSQSMSIPDCPGGWEEMWTGYSYFMSTLDNVGGVGQNLVSPGSCLEEFRAQ 1681
            ||.|||.....||:|||.:|||.||.||..:|.|||:.|.|.....|.||:|||||||||:|||.
  Rat  1584 RCSVCEAPAVAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRAT 1648

  Fly  1682 PVIECH-GHGRCNYYDALASFWLTVIEEQDQFVQPRQQTLKAD-FTSKISRCTVCRR 1736
            |.|||: |.|.|:|:....|||||.|.||:....|...||||. ..:.||||.||.:
  Rat  1649 PFIECNGGRGTCHYFANKYSFWLTTIPEQNFQSTPSADTLKAGLIRTHISRCQVCMK 1705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	27/58 (47%)
		Collagen	102..152	CDD:189968	24/49 (49%)
		Collagen	277..334	CDD:189968	30/61 (49%)
		Collagen	534..593	CDD:189968	26/60 (43%)
		Collagen	814..871	CDD:189968	30/56 (54%)
		Collagen	957..1014	CDD:189968	30/80 (38%)
		Collagen	990..1049	CDD:189968	29/62 (47%)
		Collagen	1070..1128	CDD:189968	33/67 (49%)
		C4	1515..1624	CDD:128421	50/108 (46%)
		C4	1625..1737	CDD:128421	60/114 (53%)
Col4a2	XP_038951185.1	Collagen	70..121	CDD:396114	24/53 (45%)
		Collagen	291..347	CDD:396114	30/67 (45%)
		Collagen	488..538	CDD:396114	21/50 (42%)
		Collagen	777..833	CDD:396114	28/55 (51%)
		Collagen	903..959	CDD:396114	20/55 (36%)
		Collagen	1135..1189	CDD:396114	25/56 (45%)
		Med15	1212..>1492	CDD:312941	127/337 (38%)
		Collagen	1327..1383	CDD:396114	25/60 (42%)
		C4	1485..1589	CDD:396133	47/105 (45%)
		C4	1595..1704	CDD:396133	59/108 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41315at33208
OrthoFinder	1	1.000	-	-		FOG0000443
OrthoInspector	1	1.000	-	-		otm45195
orthoMCL	1	0.900	-	-		OOG6_100768
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820