DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and Col7a1

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	NP_001100328.2	Gene:	Col7a1 / 301012	RGDID:	1311417	Length:	2944	Species:	Rattus norvegicus

Alignment Length:	1665	Identity:	668/1665 - (40%)
Similarity:	802/1665 - (48%)	Gaps:	328/1665 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GIKGRMGAPGPIGVPGL------------EGPAGDIGPPGRAGPLGEKGDVGEYGEQGEKGHRGD 94
            |:.||.|||||.|.||.            |||.|..|.||..|..|.||..|..|.:|::|.||.
  Rat  1276 GLPGRTGAPGPQGAPGSTQAKGERGFPGPEGPPGSPGLPGVPGSPGVKGSPGWSGPRGDRGERGP 1340

  Fly    95 IGPKGEMGYPGIMGKSGEPGTPGPRGIDGCDGRPGMQGPSGAPGQNGVRGPPGKP---------- 149
            .|||||.|.||.:...|.||.||.:|..|..|.||..||.|.||.   |||||.|
  Rat  1341 QGPKGEPGEPGQVIGGGRPGLPGKKGDPGPSGPPGPHGPLGDPGP---RGPPGLPGTSVKGDKGD 1402

  Fly   150 -GQQGPPGEAGEGGINSKGTKGNRGETGQPGGVGPPGFDGDRGSKGDTGYAGLTGEKGDPGLPGP 213
             |::||||..  .|.:.:|:.|..|..|.||..||||..|::|.|||.       |.|.|||||.
  Rat  1403 RGERGPPGPG--TGASEQGSPGLPGLPGSPGPQGPPGRTGEKGEKGDC-------EDGGPGLPGQ 1458

  Fly   214 KGDTGAVSELPYSLIGPPGAKGEPGDSLSGVLKPDDTLKGYKGYVGLQGDEGPQGPTGEQGAVGR 278
            .|       :|    |.||.:|.||  ::|. |.|..|.|..|..|.:|:.||.||.|.||..|.
  Rat  1459 PG-------VP----GEPGLRGAPG--VTGP-KGDRGLTGTPGEPGEKGERGPPGPVGPQGLPGA 1509

  Fly   279 NGLPGARGEIGGPGERGKPGKDGEPGRFGD----------KGMKGAPGWTGADGLDGSPGERGED 333
            .|.||..|..|.||..|:.|:.|||||.||          ||.||..|..|..|..|..||:|..
  Rat  1510 AGRPGVEGPEGPPGPPGRRGEKGEPGRPGDPALGPGGAGAKGEKGDAGLPGPRGASGIKGEQGAP 1574

  Fly   334 GFTGMPGVQGGAGPPGIYDPSLTKSLPGPIGSQGDIGPPGEQGPPGLPGKPGRRGPIGLAGQSGD 398
            |. .:||..|..|.||...|.   .|.|..|..||.|||||:|.||.||.||..||.|..|::|:
  Rat  1575 GL-ALPGDPGPKGDPGDRGPI---GLTGRAGPTGDSGPPGEKGEPGRPGSPGPVGPRGRDGEAGE 1635

  Fly   399 PGLNGSRGPPGRSERGEAGDYGFIGPPGPQGPPGEAGLPGRYGLHGEPGQNVVGPKGEPGLNGQP 463
            .|..|:.|.||..  |:||:.|..|.|||:||.||.      |..|:|        ||.|.||.|
  Rat  1636 KGDEGAPGEPGLP--GKAGERGLRGAPGPRGPVGEK------GNEGDP--------GEDGRNGTP 1684

  Fly   464 GLEGYRGDRGEVGLPG-------------DKGLPGEGYNIVGPPGSQGPPGFRGLPGDDGYNGLR 515
            |..|.:|||||.|.||             |||.||:    .||.|.:|.||..|..|:.|.:|||
  Rat  1685 GPSGPKGDRGEPGPPGLPGRLVDAALESRDKGEPGQ----EGPRGPKGDPGPPGASGERGIDGLR 1745

  Fly   516 GLPGEKGLRGDDCPVCNAGPRGPRGQEGDTGYPGSHGNR------GAIGLTGPRGVQGLQGNPGR 574
            |.||.:|         :.|.|||.|.:||.|.||..|..      ||.|..|..|..|..|:|||
  Rat  1746 GPPGPQG---------DPGVRGPAGDKGDRGSPGLDGRNGLDGKPGAPGPPGLHGASGKAGDPGR 1801

  Fly   575 AGHKGL---------PGPAGIPGEPGKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDTGDDGE 630
            .|..||         |||.|:||:||..|..|.:||        .||.||.|:.|.:|:.||.|.
  Rat  1802 DGLPGLRGEHGPPGPPGPPGVPGKPGDDGKPGLNGK--------NGEPGDPGEDGRKGEKGDSGV 1858

  Fly   631 KGRDGSDGSKGERGETGQRGDYGDAGYQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIKG 695
            .||:|.||.|||||..|..|..|..|..|:.|.||: |..|.||  .|.||    |:.|..|.||
  Rat  1859 PGREGPDGPKGERGAPGNPGLQGPPGLPGQVGPPGQ-GFPGVPG--VTGPK----GDRGETGSKG 1916

  Fly   696 ERGDDGDTGFKGVKGE-PNP--------------GQIYDNTGE---------------PGEDGYT 730
            |:|..|:.|.:|..|. ||.              .:|.|..||               .|:.|..
  Rat  1917 EQGLPGERGLRGEPGSLPNAERFLETAGIKVSALREIVDTWGESSGSFLLVPERRQGPKGDPGDP 1981

  Fly   731 GPKGVKGAKGEQGAIGLRGEIGDRGPAGEVIPG-PVGAKGYPGPTGDYGQQGAPGLPGRDGEPGL 794
            ||.|.:|:.|..|..||:||.||.||.|.  || .:|.:|.|||:|..|:.|.||:||..|..|.
  Rat  1982 GPPGKEGSIGLPGERGLKGERGDPGPQGP--PGLALGERGPPGPSGLAGEPGKPGIPGLPGRAGA 2044

  Fly   795 DGGIGYKGQRGVPGQEVIQGEIGPPGRSGIKGFPGDVGAPGQY--------GLA---GRPGPKGV 848
            .|..|..|:||..|:   :||.|..||.|..|.||..|.||..        |.|   |.||.||.
  Rat  2045 AGEAGRPGERGERGE---KGERGEQGRDGHPGLPGPPGPPGPKVAIEELGPGPAREQGPPGLKGA 2106

  Fly   849 KGEQGPDGAVGQTGLPGNKGQRGDFLVGPPGPKGQPGRNGRQAPHGAKGQKGEVGSLGQNGQNGA 913
            |||.|.|      |:||.||.|     |.||.||..|..|::.|.|..|..||      .|.:|.
  Rat  2107 KGEPGSD------GVPGPKGDR-----GVPGIKGDAGEPGKRGPDGNPGLPGE------RGVSGP 2154

  Fly   914 KGSIGFSGRRGLLGNAGLQGLPGSPGIPGLPGMIGEIGERGEIGYNGRQGDIGP--RGPNGEFGP 976
            :|..|..|.||..|..|..   |.||.||.||:.|..|.:|..|..|..|:.||  ||..|..|.
  Rat  2155 EGKPGLQGPRGTPGPVGSH---GDPGPPGAPGLAGPAGPQGPSGLKGEPGETGPPGRGLPGPTGA 2216

  Fly   977 KGLSGDDGPDGY---PGANGLPGRKGETGNPGFPGRPGAK---------GVAAYSGIKGDDGESG 1029
            .||.|..||.|.   .|:.||||:.||||.||.|||.|:.         ||....|:.|..|..|
  Rat  2217 VGLPGPPGPSGLVGPQGSPGLPGQVGETGKPGPPGRDGSSGKDGERGGPGVPGLPGLPGPVGPKG 2281

  Fly  1030 LTGPIGYP-----GAPGAKGQRGPVGDSQPALDGVAGRKGEVGSPGPNGLPGRHGLKGQRGDRGL 1089
            ..||:|.|     |.|||||::|..||...||.|..|.||:.|.|||.|..|..|..|:.||.|.
  Rat  2282 EPGPVGAPGQVVVGPPGAKGEKGAPGDLAGALLGEPGAKGDRGLPGPRGEKGEAGHAGEPGDPGE 2346

  Fly  1090 PGQQGRP------GEPGAKGLGGYPGRNGINGLK------------GATGFPGPQGPK------G 1130
            .||:|.|      ||||. |:.|.||.:|..|:|            |..||||..||:      |
  Rat  2347 DGQKGAPGLKGLKGEPGI-GVQGPPGPSGPPGMKGDLGPPGAPGAPGIVGFPGQPGPRGETGQPG 2410

  Fly  1131 PQGESGVVGLDGRN---GQIGDQGPRGLIGEQGEQGEQGDEGE--VGIPGRLENLRDRSFYRGFT 1190
            |.||.|:.|..||.   |.:|..||.|.:|..|..|.:||:|:  .|:||.          ||..
  Rat  2411 PVGERGLAGPPGREGAPGPLGPPGPPGSVGAPGASGFKGDKGDSGAGLPGP----------RGER 2465

  Fly  1191 GDQGLQGERGEQGDMGPIGFIGPPGAKGERGDIGYAGQLGFDGAEGLKGFQGD----QGPRGPPG 1251
            |:.||:||.|..|..||.|.:||||::|||      |:.|..||.||||.:||    :||.||.|
  Rat  2466 GEPGLRGEDGHPGQEGPRGLMGPPGSRGER------GEKGDPGAAGLKGDKGDSAVIEGPAGPRG 2524

  Fly  1252 ITLPAEKGDEGVAGLD------GRAGRPGHFGQKGAPGPPGENGPNGAIGHRGPQIQGPPGPQGD 1310
              ...:.|:.|..|:|      |.:|.||..|.||.||..|..|..|..|..||  :|.||..|.
  Rat  2525 --AKGDMGERGPRGIDGDQGPRGESGDPGDKGSKGEPGDKGSAGSTGVRGLTGP--KGEPGAAGI 2585

  Fly  1311 VGFPGAPGHNGRHGLIGPKGELGDMGRQGERGESGYAIV----GRQGDIGDIGFQGEPGWDGAKG 1371
            .|.|||||.:|..|..|.||::|..|.:|.:||.|....    |.:||.|:.||.|.||..|.||
  Rat  2586 PGEPGAPGKDGAPGFRGDKGDIGFTGPRGLKGERGVKGTCGRDGEKGDKGEAGFPGRPGLSGKKG 2650

  Fly  1372 EQGYPGLPGKNGRVGAPGPRGPTGDAGWGGIDGMDGLVGPKGQPGVTYSYSMARPGDRGEPGLDG 1436
            :.|.||:||::|..|..|..||.||.|:      ||..||||..|        ..|:||.||:.|
  Rat  2651 DMGDPGIPGQSGAPGKEGLIGPKGDRGF------DGQSGPKGDQG--------EKGERGPPGVGG 2701

  Fly  1437 FQGEEGDGGAPGLIGFQGQRGAVGYRGDQGEVGYTGADGPQGQRGDKGYMG--LTGAPGLRGLPG 1499
            |.|..|:.|:.            |..|..|.:|..|.:|.|||:|::|..|  :.||||..|.||
  Rat  2702 FPGPRGNDGSS------------GPPGPPGSIGPKGPEGLQGQKGERGPPGESVVGAPGAPGTPG 2754

  Fly  1500 PQGE---PAPAPPAPKS----------RGFIFARHSQSVH 1526
            .:||   |.||.|..:.          |||:  |...|.|
  Rat  2755 ERGEQGRPGPAGPRGEKGEAALTEDDIRGFV--RQEMSQH 2792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	29/58 (50%)
		Collagen	102..152	CDD:189968	25/60 (42%)
		Collagen	277..334	CDD:189968	28/66 (42%)
		Collagen	534..593	CDD:189968	32/73 (44%)
		Collagen	814..871	CDD:189968	29/67 (43%)
		Collagen	957..1014	CDD:189968	30/70 (43%)
		Collagen	990..1049	CDD:189968	32/72 (44%)
		Collagen	1070..1128	CDD:189968	29/75 (39%)
		C4	1515..1624	CDD:128421	5/12 (42%)
		C4	1625..1737	CDD:128421
Col7a1	NP_001100328.2	vWA_collagen_alphaI-XII-like	38..202	CDD:238759
		fn3	236..318	CDD:394996
		fn3	334..406	CDD:394996
		fn3	427..488	CDD:394996
		FN3	510..589	CDD:238020
		FN3	599..681	CDD:238020
		FN3	688..772	CDD:238020
		fn3	778..856	CDD:394996
		fn3	868..935	CDD:394996
		FN3	959..1045	CDD:238020
		VWA	1055..1223	CDD:395045
		PRK07764	<1509..1714	CDD:236090	93/224 (42%)
		Collagen	1580..1635	CDD:396114	27/57 (47%)
		Collagen	1613..1668	CDD:396114	27/56 (48%)
		Collagen	1839..1894	CDD:396114	27/54 (50%)
		Collagen	1878..1932	CDD:396114	24/60 (40%)
		PHA03169	2053..>2202	CDD:223003	66/171 (39%)
		Collagen	2102..2158	CDD:396114	29/72 (40%)
		Collagen	2315..2363	CDD:396114	21/47 (45%)
		PRK12678	2403..>2636	CDD:237171	99/252 (39%)
		Collagen	2457..2511	CDD:396114	30/69 (43%)
		Collagen	2533..2589	CDD:396114	23/57 (40%)
		Collagen	2611..2666	CDD:396114	23/54 (43%)
		Collagen	2728..2774	CDD:396114	20/45 (44%)
		KU	2877..2932	CDD:238057
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810