DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and Col27a1

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	NP_942042.1	Gene:	Col27a1 / 298101	RGDID:	735115	Length:	1855	Species:	Rattus norvegicus

Alignment Length:	1365	Identity:	508/1365 - (37%)
Similarity:	613/1365 - (44%)	Gaps:	374/1365 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GIKGRMGAPGPIGVPGLEGPAGDIGPPGRAGPLGEKGDVGEYGEQGEKGHRG------DIGPKGE 100
            |.||..|.|||.|:|||.|..|..||.|..||.|..|..|..|.:|:||..|      ..|.||.
  Rat   622 GSKGDCGLPGPPGLPGLPGSPGPRGPRGPPGPFGNPGLPGPPGAKGQKGDPGLSPGQAHDGAKGN 686

  Fly   101 MGYPGIMGKSGEPGTPGPRGIDGCDGRPGMQGPSGAPGQNGVRGPPGKPGQQGPPGEAG-EGGIN 164
            ||.||:      .|.|||.|..|..|.|   |.:|.||:.|..||.|.||.:|.||..| .|.:.
  Rat   687 MGLPGL------AGNPGPMGRKGHKGHP---GAAGHPGEQGQPGPEGSPGAKGYPGRQGFPGPVG 742

  Fly   165 SKGTKGNRGETGQPGGVGPPGFDGDRGSKGDTGYAGLTGEKGDPGLPGPKGDTGAVSELPYSLIG 229
            ..|.||:||..|.||..|.||.||:||.   .|..|..||.|.||.||..|:.           |
  Rat   743 DPGPKGSRGYIGLPGLFGLPGSDGERGL---PGIPGKRGEMGRPGFPGDFGER-----------G 793

  Fly   230 PPGAKGEPGDSLSGVLKPDDTLKGYKGYVGLQGDEGPQGPTGEQGAVGRNGLPGARGE---IGGP 291
            |||..|.||:.         .|.|..|.:||.||.|..||.|..|..|..||.|..||   .|..
  Rat   794 PPGLDGNPGEI---------GLPGPPGVLGLLGDMGALGPVGYPGPKGMKGLMGGVGEPGLKGDK 849

  Fly   292 GERGKPGKDGEPGRFGDKGMKGAPGWTGADGLDGSPGERGEDGFTGMPGVQGGAGPPGIYDPSLT 356
            ||:|.||..|:||..||||..|.||:.||.|..|..|:.|:.|..|:||.
  Rat   850 GEQGVPGVSGDPGFQGDKGSHGLPGFPGARGKPGPMGKAGDKGSLGLPGP--------------- 899

  Fly   357 KSLPGPIGSQGDIGPPGEQGPPGLPGKPGRRG-PIGLAGQSGDPGLNGSRGPPGRSERGEAGDYG 420
               |||.|..|||||||:.||.|:.||||.|| |                ||||:
  Rat   900 ---PGPEGFPGDIGPPGDNGPEGMKGKPGARGLP----------------GPPGQ---------- 935

  Fly   421 FIGPPGPQGPPGEAGLPGRYGLHGEPGQNVVGPKGEPGLNGQPGLEGYRGDRGEVGLPGDKGLPG 485
             :||.|.:||.|..|:|   ||.|:||:     ||.|   |:|||:|.:|:      |||.|.|
  Rat   936 -LGPEGDEGPMGPPGVP---GLEGQPGR-----KGFP---GRPGLDGSKGE------PGDPGRP- 981

  Fly   486 EGYNIVGPPGSQGPPGFRGLPGDDGYNGLRGLPGEKGLRGDDCPVCNAGPRGPRGQEGDTGYPGS 550
                  ||.|.||..||.||.|:.      |:.||||.||      ..||.|..|.:|..|:||:
  Rat   982 ------GPVGEQGLMGFVGLVGEP------GIVGEKGDRG------VMGPPGAPGPKGSMGHPGT 1028

  Fly   551 HGNRGAIGLTGPRGVQGLQGNPGRAGHKGLPGPAGIPGEPGKVGAAGPDGKAIEVGSLRKGEIGD 615
                       |.||    |:||..|..|.||..|:||                   :|
  Rat  1029 -----------PGGV----GDPGEPGPWGPPGSRGLPG-------------------MR------ 1053

  Fly   616 TGDSGHRGDTGDDGEKGRDGSDGSKGERGETGQRGDYGDAGYQGRDGEPGRDGRDGAPGRNATTP 680
             |..||||..|.||..|..||.|.||.            .|.:||.|:||:.|
  Rat  1054 -GAKGHRGPRGPDGPAGEQGSKGLKGR------------VGPRGRPGQPGQQG------------ 1093

  Fly   681 KVYLIGEPGYDGIKGERGDDGDTGFKGVKGEPNPGQIYDNTGEPGEDGYTGPKGVKGAKGEQGAI 745
               ..||.|:.|.||..|..|.:|..|.||.|         |||            |::|.||.:
  Rat  1094 ---AAGERGHSGAKGFLGIPGPSGPPGAKGLP---------GEP------------GSQGPQGPV 1134

  Fly   746 GLRGEIGDRGPAGEVIPGPVGAKGYPGPTGDYGQQGAPGLPGRDGEPGLDGGIGYKGQRGVPGQE 810
            |..||:|.:||     ||.||..|.||.:|..|..|..|.||..         |..||||.||
  Rat  1135 GPPGEMGPKGP-----PGAVGEPGLPGDSGMKGDLGPLGPPGEQ---------GLIGQRGEPG-- 1183

  Fly   811 VIQGEIGPPGRSGIKGFPGDVGAPGQYGLAGRPGPKGVKGEQGPDGAVGQTGLPGNKGQRGDFLV 875
             ::|::||.|..|:||..||            |||.|..||:|.:|..|:.|||
  Rat  1184 -LEGDLGPVGPDGLKGDRGD------------PGPDGEHGEKGQEGLKGEEGLP----------- 1224

  Fly   876 GPPGPKGQPGRNGRQAPHGAKGQKGEVGSLGQNGQNGAKGSIGFSGRRGLLGNAGLQGLPGSPGI 940
            ||||..            |.:|::|:.||.|:.||.||||:.|:.|:   ||..|:.|.||.||.
  Rat  1225 GPPGIT------------GVRGREGKPGSQGEKGQRGAKGAKGYQGQ---LGEMGIPGDPGPPGT 1274

  Fly   941 P------------GLPGMIGEIGERGEIGYNGRQGDIGPRGPNGEFGPKGLSGDD----GPDGYP 989
            |            |.||.:|..||.|..||||.:|..||.||.|..|.||..|:|    |..|.|
  Rat  1275 PGPKGSRGTLGPMGAPGRMGAQGEPGLAGYNGHKGITGPLGPPGPKGEKGEQGEDGKTEGAPGPP 1339

  Fly   990 GANGLPGRKGETGNPGFPGRPGAKGVAAYSGIKGDDGESGLTGPIGYPGAPGAKGQRGPVGDSQP 1054
            |..|..|.:|:.|.||.||.||.:||....|..|..|:.|..||.|.||..|:||:.||.|  :|
  Rat  1340 GERGPVGDRGDRGEPGDPGYPGQEGVQGLRGEPGQQGQPGHPGPRGRPGPKGSKGEEGPKG--KP 1402

  Fly  1055 ALDGVAGRKGEVGSPGPNGLPGRHGLKGQRGDRGLPGQQGRPGEPGAKGLGGYPGRNGINGLKGA 1119
               |.||..|..|:.|..||||..|:.|::|..|:.||.|.||.         .||.|..|.:|.
  Rat  1403 ---GKAGASGRRGTQGLQGLPGPRGVVGRQGPEGMAGQDGNPGR---------DGRPGYQGEQGN 1455

  Fly  1120 TGFPGPQGPKGPQGESGVVGLDGRNGQIGDQGPRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRS 1184
            .|.|||.||.|.:|..||.||.|..|..|.:|..||.|:.|..|::|.||..|:||.
  Rat  1456 DGDPGPVGPAGRRGNPGVAGLPGAQGPPGFKGESGLPGQLGPPGKRGTEGGTGLPGN-------- 1512

  Fly  1185 FYRGFTGDQGLQGERGEQGDMGPIGFIGPPGAKGERGDIGYAGQLGFDGAEGLKGFQGDQGPRGP 1249
                 .|:.|.:|:.|:.|:||..|..|..|.||..|||               ||:|.||||||
  Rat  1513 -----QGEPGSKGQPGDSGEMGFPGVAGLFGPKGPPGDI---------------GFKGIQGPRGP 1557

  Fly  1250 PGITLPAEKGDEGVAGLDGRAGRPGHFGQKGAPGPPGENGPNGAIGHRGPQIQGPPGPQGDVGFP 1314
            ||:     .|.||:      .|.||..|..|.|||.|:.|..|..|.:||  :|||||:|..|.|
  Rat  1558 PGL-----MGKEGI------IGPPGMLGPSGLPGPKGDRGSRGDWGLQGP--RGPPGPRGRPGPP 1609

  Fly  1315 GAPGHNGRHGLIGPKGELGDMGRQGERGESGYAIVGRQGDIGDIGFQGEPGWDGAKG----EQGY 1375
            |.|.|                           .:..:|.|: :..||   .|..|.|    ||||
  Rat  1610 GPPWH---------------------------PVQFQQDDL-EAAFQ---TWMDAHGAVRLEQGY 1643

Fly 1376 1375
Rat 1644 1643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	25/64 (39%)
		Collagen	102..152	CDD:189968	21/49 (43%)
		Collagen	277..334	CDD:189968	28/59 (47%)
		Collagen	534..593	CDD:189968	21/58 (36%)
		Collagen	814..871	CDD:189968	21/56 (38%)
		Collagen	957..1014	CDD:189968	29/60 (48%)
		Collagen	990..1049	CDD:189968	26/58 (45%)
		Collagen	1070..1128	CDD:189968	23/57 (40%)
		C4	1515..1624	CDD:128421
		C4	1625..1737	CDD:128421
Col27a1	NP_942042.1	LamG	52..230	CDD:304605
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..428
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..580
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	617..787		78/176 (44%)
		Triple-helical region	619..1612		495/1301 (38%)
		Collagen	688..746	CDD:189968	26/66 (39%)
		Collagen	718..777	CDD:189968	28/61 (46%)
		Collagen	754..810	CDD:189968	29/78 (37%)
		Collagen	826..884	CDD:189968	27/57 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	838..1617		394/1085 (36%)
		Collagen	913..984	CDD:189968	43/121 (36%)
		Collagen	1047..1105	CDD:189968	29/110 (26%)
		Collagen	1139..1193	CDD:189968	27/70 (39%)
		Collagen	1168..1227	CDD:189968	32/93 (34%)
		Collagen	1201..1259	CDD:189968	31/92 (34%)
		Collagen	1334..1391	CDD:189968	25/56 (45%)
		Collagen	1376..1433	CDD:189968	27/61 (44%)
		Collagen	1439..1498	CDD:189968	28/67 (42%)
		Collagen	1472..1529	CDD:189968	24/69 (35%)
		Collagen	1511..1570	CDD:189968	31/97 (32%)
		COLFI	1656..1854	CDD:295304
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910