DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and let-2

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	NP_510663.1	Gene:	let-2 / 181708	WormBaseID:	WBGene00002280	Length:	1759	Species:	Caenorhabditis elegans

Alignment Length:	1815	Identity:	778/1815 - (42%)
Similarity:	943/1815 - (51%)	Gaps:	169/1815 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LGVVYLLGSLVSVTLADGKICNTTLCDCKGIKGRMGAPGPIGVPGLEGPAGDIGPPGRAGPLGEK 77
            |.::.||......:.|..:.|:...|.|.|.||.||||||.|.||.:|..|..||.|.|||.|.|
Worm    13 LAILALLAVSYVQSQATCRDCSNRGCFCVGEKGSMGAPGPQGPPGTQGIRGFPGPEGLAGPKGLK 77

  Fly    78 GDVGEYGEQGEKGHRGDIGPKGEMGYPGIMGKSGEPGTPGPRGIDGCDGRPGMQGPSGAPGQNGV 142
            |..|..|..|.||.||.:|..|..|..|..|:.||||.||..|.|||:|..|..|..|.||..|:
Worm    78 GAQGPPGPVGIKGDRGAVGVPGFPGNDGGNGRPGEPGPPGAPGWDGCNGTDGAPGIPGRPGPPGM 142

  Fly   143 RGPPGKPGQQGPPGEAGEGGINSKGTKGNRGETGQPGGVGPPGFD---GDRGSKGDTGYA---GL 201
            .|.||.||..|..||...|...:.|.||:.|..|.||..||.|.|   |::|.:||||.|   |.
Worm   143 PGFPGPPGMDGLKGEPAIGYAGAPGEKGDGGMPGMPGLPGPSGRDGYPGEKGDRGDTGNAGPRGP 207

  Fly   202 TGEKGDPGLP-----GPKGDTGAVSELPYSLIGPPGAKGEPGDSLSGVLKPDDTLKGYKGYVGLQ 261
            .||.|.||.|     |||||.|.        ||..|..|.||...|.:.|  .|:.|.||.:|.:
Worm   208 PGEAGSPGNPGIGSIGPKGDPGD--------IGAMGPAGPPGPIASTMSK--GTIIGPKGDLGEK 262

  Fly   262 GDEGPQGPTGEQ------GAVGRNGLPGARGEIGGPGERGKPGKDGEPGRFGDKGMKGAPGWTGA 320
            |::|..|..|::      |..|:.||||.:||.|..|..|..||:|.||..|..|.||..|..|.
Worm   263 GEKGEPGEGGQRGYPGNGGLSGQPGLPGMKGEKGLSGPAGPRGKEGRPGNAGPPGFKGDRGLDGL 327

  Fly   321 DGLDGSPGERGEDGFTGMPGVQGGAGPPGIYDP---SLTKSLPGPIGSQGDIGPPGEQGPPGLPG 382
            .|:.|.||::||.|:.|..|.:|.:||||  .|   :.....|||.|..|..|.||..|..|.||
Worm   328 GGIPGLPGQKGEAGYPGRDGPKGNSGPPG--PPGGGTFNDGAPGPPGLPGRPGNPGPPGTDGYPG 390

  Fly   383 KPGRRGPIGLAGQSGDPGLNGSRGPPGRSERGEAGDYGFIGPPGPQGPPGEAGLP---GRYGLHG 444
            .||..||||..|..|.||..|:.|.||  .:|:.||.|..|.||..||.|..|||   |..|..|
Worm   391 APGPAGPIGNTGGPGLPGYPGNEGLPG--PKGDKGDGGIPGAPGVSGPSGIPGLPGPKGEPGYRG 453

  Fly   445 EPGQNVVGPKGEPGLNGQPGLEGYRGDRGEVGLPGDKGLPGEGYN-IVGPPGSQGPPGFRGLPGD 508
            .|||::   .|.||.:|:|||:|..|.:||.||||.:|.||:..| :.|.||.:|.||..|..|.
Worm   454 TPGQSI---PGLPGKDGKPGLDGAPGRKGENGLPGVRGPPGDSLNGLPGAPGQRGAPGPNGYDGR 515

  Fly   509 DGYNGLRGLPGEKGLRGDDCPVCNAGPRGPRGQEGDTGYPGSHGNRGAIGLTGPRGVQGLQGNPG 573
            ||.|||.|.||.||.||..|..|..|.:|.:|..|.:|.||..|:||..|:.||.|..|..|.||
Worm   516 DGVNGLPGAPGTKGDRGGTCSACAPGTKGEKGLPGYSGQPGPQGDRGLPGMPGPVGDAGDDGLPG 580

  Fly   574 RAGHKGLPGPAGIPGEPGKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDTGDDGEKGRDGSDG 638
            .||..|.|||   ||:.|..|..|..|:..:: :||.|..|..|..|..|..|..|..|..|..|
Worm   581 PAGRPGSPGP---PGQDGFPGLPGQKGEPTQL-TLRPGPPGYPGLKGENGFPGQPGVDGLPGPSG 641

  Fly   639 SKGERGETGQRGDYGDAGYQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIKGERGD---- 699
            ..|..|..|..|:.||||..|..|:||:||..|.||......    .|:||..|..|.:||
Worm   642 PVGPPGAPGYPGEKGDAGLPGLSGKPGQDGLPGLPGNKGEAG----YGQPGQPGFPGAKGDGGLP 702

  Fly   700 --DGDTGFKGVKGEPNPGQIYDNTGEPGEDGYTGPKGVKGAKGEQGAIGLRGEIGD--------- 753
              .|..|.:|:.|||.|    :|...|...|..|..|:.|.|||.|..|..||:|.
Worm   703 GLPGTPGLQGMPGEPAP----ENQVNPAPPGQPGLPGLPGTKGEGGYPGRPGEVGQPGFPGLPGM 763

  Fly   754 RGPAGEVIPGPVGAKGYPGPTGDYGQQGAPGLPGRD------GEPGLDGGIGYKGQR--GVPGQE 810
            :|.:|  :|||.|..|:||..||.|..|.|||||..      |.|||.|..|.||:.  |||||
Worm   764 KGDSG--LPGPPGLPGHPGVPGDKGFGGVPGLPGIPGPKGDVGNPGLPGLNGQKGEPGVGVPGQ- 825

  Fly   811 VIQGEIGPPGRSGIKGFPGDVGAPGQYGLAGRPGPKGVKGEQGPDGAVGQTGLPGNKGQRGDFLV 875
              .|..|.||..|..|.||..|.||..|..|.||..|:||..|..|..||.|.||.||..|  |.
Worm   826 --PGSPGFPGLKGDAGLPGLPGTPGLEGQRGFPGAPGLKGGDGLPGLSGQPGYPGEKGDAG--LP 886

  Fly   876 GPPGPKGQPGRNGRQAPHGAKGQKGEVGSLGQNGQNGAKGSIGF---SGRRGLLGNAGLQGLPGS 937
            |.||.:|.||..|:....|..|.|||.|..|..|..|.||.:|.   ||..||.|..|..|:.|:
Worm   887 GVPGREGSPGFPGQDGLPGVPGMKGEDGLPGLPGVTGLKGDLGAPGQSGAPGLPGAPGYPGMKGN 951

  Fly   938 PGIPGLPGMIGEIGERGEIGYNGRQGDIGPRGPNGEFGPKGLSGDDGPDGYPGANGLPGRKGETG 1002
            .||||:||..|:.|..|..|.||.:|:.|..|..|..|.||..|..|..|..|.:|:||.||:.|
Worm   952 AGIPGVPGFKGDGGLPGLPGLNGPKGEPGVPGMPGTPGMKGNGGLPGLPGRDGLSGVPGMKGDRG 1016

  Fly  1003 NPGFPGRPGAKGVAAYSGIKGD---DGESGL---TGPIGYPGAPGAKGQRGPVGDSQPALDGVAG 1061
            ..|.||..|..|.||..|.|||   .|:.||   .||.|.||.||.||:.|..|..||
Worm  1017 FNGLPGEKGEAGPAARDGQKGDAGLPGQPGLRGPQGPSGLPGVPGFKGETGLPGYGQP------- 1074

  Fly  1062 RKGEVGSPGPNGLPGRHGLKGQRGDRGLPGQQGRPGEPGAKGLGGYPGRNGINGLKGATGFPGPQ 1126
                 |.||..||||..|..|::|..|.|||.|.||.||.||..||||::|:.|..|..|.||.:
Worm  1075 -----GQPGEKGLPGIPGKAGRQGAPGSPGQDGLPGFPGMKGESGYPGQDGLPGRDGLPGVPGQK 1134

  Fly  1127 GPKGPQGESGVVGLDGRNGQIGDQGPRGLIGEQGEQGEQGDEGEVGIPGRL-ENLRDRSFYRGFT 1190
            |..|..|:.|:.|..|.:||.|..|.||..|:.|..|..||.|..|.||:. ||        |:.
Worm  1135 GDLGQSGQPGLSGAPGLDGQPGVPGIRGDKGQGGLPGIPGDRGMDGYPGQKGEN--------GYP 1191

  Fly  1191 GDQGLQGERGEQGDMGPIGFIGPPGAKGERGDIGYAGQLGFDGAEGLKGFQGDQGPRGPPGIT-L 1254
            |..||.|..||:      ||.|.||..|.:|..||.||   ||..|:.|.:||.|..|.||.. |
Worm  1192 GQPGLPGLGGEK------GFAGTPGFPGLKGSPGYPGQ---DGLPGIPGLKGDSGFPGQPGQEGL 1247

  Fly  1255 PAEKGDEGVAGLDGRAGRPGH--FGQKGAPGPPGENGPNGAIGHRGPQIQGPPGPQGDVGFPGAP 1317
            |...|::|:.||.|..|:||.  .|..|.||.||..|.:|.     |.:.|..|..|..|.||||
Worm  1248 PGLSGEKGMGGLPGMPGQPGQSIAGPVGPPGAPGLQGKDGF-----PGLPGQKGESGLSGLPGAP 1307

  Fly  1318 ---GHNGRHGLIGPKGELGDMGRQGERGESGY----------AIVGRQGDIGDIGFQGEPGW--- 1366
               |.:|..|..|.||:||..|..|:|||.|.          .|.|.:|::|..|..|:||:
Worm  1308 GLKGESGMPGFPGAKGDLGANGIPGKRGEDGLPGVPGRDGQPGIPGLKGEVGGAGLPGQPGFPGI 1372

  Fly  1367 DGAKGEQGYPGLPGKNGRV------GAPGPRGPTGDAGWGGIDGMDGLV---GPKGQPGVTYSYS 1422
            .|.|||.|.||.||..|..      |.||..|..||.|..|:.|.|||.   ||.|.||.:...:
Worm  1373 PGLKGEGGLPGFPGAKGEAGFPGTPGVPGYAGEKGDGGLPGLPGRDGLPGADGPVGPPGPSGPQN 1437

  Fly  1423 MARPGDRGEPGLDGFQGEEGDGGAPGLIGFQGQRGAVGYRGDQGEVGYTGADGPQGQRGD---KG 1484
            :..||::|.|||.|..|..|:.|.|||.|..|..|..|..|.:|..||.||.|..|::|.   .|
Worm  1438 LVEPGEKGLPGLPGAPGLRGEKGMPGLDGPPGNDGPPGLPGQRGNDGYPGAPGLSGEKGMGGLPG 1502

  Fly  1485 YMGLTGAPGLRGLPGPQGEPAPAPPAPKSRGFIFARHSQSVHVPQCPANTNLLWEGYSL---SGN 1546
            :.||.|.||..|.||..|.|..|.||.:. ||:..:|||:..||:||.....||:||||   .||
Worm  1503 FPGLDGQPGGPGAPGLPGAPGAAGPAYRD-GFVLVKHSQTTEVPRCPEGQTKLWDGYSLLYIEGN 1566

  Fly  1547 VAASRAVGQDLGQSGSCMMRFTTMPYMLCDITNVCHFAQNNDDSLWLSTAEPMPMTMTPIQGRDL 1611
               .::..||||.:|||:.||:|||::.||..|||::|..||.|.||||:|.:|  |.|:..|::
Worm  1567 ---EKSHNQDLGHAGSCLQRFSTMPFLFCDFNNVCNYASRNDKSYWLSTSEAIP--MMPVNEREI 1626

  Fly  1612 MKYISRCVVCETTTRIIALHSQSMSIPDCPGGWEEMWTGYSYFMSTLDNVGGVGQNLVSPGSCLE 1676
            ..|||||.|||.....||:|||::.||:||.||..:|.|||:.|.|.....|.||:|.|||||||
Worm  1627 EPYISRCAVCEAPANTIAVHSQTIQIPNCPAGWSSLWIGYSFAMHTGAGAEGGGQSLSSPGSCLE 1691

  Fly  1677 EFRAQPVIECHG-HGRCNYYDALASFWLTVIEEQDQFVQPRQQTLKA-DFTSKISRCTVC 1734
            :|||.|.|||:| .|.|:|:....|||||.|:...:|..|..||||: :..:::|||.||
Worm  1692 DFRATPFIECNGARGSCHYFANKFSFWLTTIDNDSEFKVPESQTLKSGNLRTRVSRCQVC 1751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	29/58 (50%)
		Collagen	102..152	CDD:189968	25/49 (51%)
		Collagen	277..334	CDD:189968	27/56 (48%)
		Collagen	534..593	CDD:189968	27/58 (47%)
		Collagen	814..871	CDD:189968	27/56 (48%)
		Collagen	957..1014	CDD:189968	24/56 (43%)
		Collagen	990..1049	CDD:189968	31/64 (48%)
		Collagen	1070..1128	CDD:189968	29/57 (51%)
		C4	1515..1624	CDD:128421	55/111 (50%)
		C4	1625..1737	CDD:128421	56/112 (50%)
let-2	NP_510663.1	Collagen	181..240	CDD:189968	28/66 (42%)
		Collagen	429..490	CDD:189968	31/63 (49%)
		Collagen	470..531	CDD:189968	32/60 (53%)
		Collagen	791..844	CDD:189968	26/55 (47%)
		Collagen	821..879	CDD:189968	29/60 (48%)
		Collagen	899..958	CDD:189968	25/58 (43%)
		Collagen	1004..1061	CDD:189968	26/56 (46%)
		Collagen	1072..1131	CDD:189968	31/70 (44%)
		Collagen	1117..1176	CDD:189968	23/58 (40%)
		Collagen	1202..1253	CDD:189968	24/59 (41%)
		Collagen	1308..1367	CDD:189968	20/58 (34%)
		Collagen	1347..1405	CDD:189968	21/57 (37%)
		C4	1533..1637	CDD:279721	52/108 (48%)
		C4	1641..1751	CDD:279721	54/109 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41315at33208
OrthoFinder	1	1.000	-	-		FOG0000443
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100768
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820