DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and COL22A1

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	NP_690848.1	Gene:	COL22A1 / 169044	HGNCID:	22989	Length:	1626	Species:	Homo sapiens

Alignment Length:	1530	Identity:	555/1530 - (36%)
Similarity:	653/1530 - (42%)	Gaps:	451/1530 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 TTLCDC-KGIKGRMGAPGPIGVPGLEGPAGDIGPPGRAGPLGEKGDV--GEYGEQGEKGHRGDIG 96
            |..|.| .|.||.||..||:|:||.:|..|.|||.|..||.||||||  |.:| |||||.:|.:
Human   473 TINCSCPAGEKGEMGVAGPMGLPGPKGDIGAIGPVGAPGPKGEKGDVGIGPFG-QGEKGEKGSL- 535

  Fly    97 PKGEMGYPGIMGKSGEPGTPGPRGIDGCDGRPGMQGPSGAPGQNGVRGPPGKPGQQGPPGEAGEG 161
                          |.||.||..|..|..|.||..|..|.||:.|:|||.|.||..||||..|..
Human   536 --------------GLPGPPGRDGSKGMRGEPGELGEPGLPGEVGMRGPQGPPGLPGPPGRVGAP 586

  Fly   162 GI----NSKGTKGNRGETGQPGGVGPPGFDGDRGSKGDTGYAGLTGEKGDPGLPGPKGDTGAVSE 222
            |:    ..|||:|.:||.|..|..|.||..|.:|..|.:|.||..|||||
Human   587 GLQGERGEKGTRGEKGERGLDGFPGKPGDTGQQGRPGPSGVAGPQGEKGD--------------- 636

  Fly   223 LPYSLIGPPGAKGEPGDSLSGVLKPDDTLKGYKGYVGLQGDEGPQGPTGEQGAVGRNGLPGARGE 287
                 :||.|..|.||    .|::.:          ||:|::|..||.|.|||.|.   |||||.
Human   637 -----VGPAGPPGVPG----SVVQQE----------GLKGEQGAPGPRGHQGAPGP---PGARGP 679

  Fly   288 IGGPGERGKPGKDGEPGRFGDKGMKGAPGWTGADGLDGSPGERGEDGFTGMPGVQGGAGPPGIYD 352
            ||..|..|.||..|..|:.||.|..|.||..|..|..|.||..|..|..|.||:.|..|.||...
Human   680 IGPEGRDGPPGLQGLRGKKGDMGPPGIPGLLGLQGPPGPPGVPGPPGPGGSPGLPGEIGFPGKPG 744

  Fly   353 PSLTKSLPGPIGSQGDIGPPGEQGPPGLPGKPGRRGPIGLAGQSGDPGLNGSRGPPGRSERGEAG 417
            |      |||.|..|..||.|..||||..|:||.||..||.|:   |||           |||.|
Human   745 P------PGPTGPPGKDGPNGPPGPPGTKGEPGERGEDGLPGK---PGL-----------RGEIG 789

  Fly   418 DYGFIGPPGPQGPPGEAGLPGRYGLHGEPGQNVVGPKGEPGLNGQPGLEGYRGDRGEVGLPGDKG 482
            :.|..|.||.:|..|..|.||..|:.||.|..  |.|||.||   |||:|.||::||.|..|..|
Human   790 EQGLAGRPGEKGEAGLPGAPGFPGVRGEKGDQ--GEKGELGL---PGLKGDRGEKGEAGPAGPPG 849

  Fly   483 LPGEGYNIVGP----PGSQGPPGFRGLPGDDGYNGLRGLPGEKGLRGDDCPVCNAGPRGPRGQEG 543
            |||. .::..|    ||.|||.|.:|.||..|..||:|.|||            .||:||
Human   850 LPGT-TSLFTPHPRMPGEQGPKGEKGDPGLPGEPGLQGRPGE------------LGPQGP----- 896

  Fly   544 DTGYPGSHGNRGAIGLTGPRGVQGLQGNPGRAGHKGLPGPAGIPGEPGKVGAAGPDGKAIEVGSL 608
             ||.||:.|..||      .|..|..||||..||.|.|||:   |.||.|||
Human   897 -TGPPGAKGQEGA------HGAPGAAGNPGAPGHVGAPGPS---GPPGSVGA------------- 938

  Fly   609 RKGEIGDTGDSGHRGDTGDDGEKGRDGSDGSKGERGETGQRGDYGDAGYQGRDGEPGRDGRDGAP 673
                      .|.||..|.|||:|..|:.|.:|..|..|.|||            ||..|..|.|
Human   939 ----------PGLRGTPGKDGERGEKGAAGEEGSPGPVGPRGD------------PGAPGLPGPP 981

  Fly   674 GRNATTPKVYLIGEPGYDGIKGERGDDGDTGFKGVKGEPNPGQIYDNTGEPGEDGYTGPKGVKGA 738
            |                      :|.||:.|.:|..|.|                  ||.|.|.|
Human   982 G----------------------KGKDGEPGLRGSPGLP------------------GPLGTKAA 1006

  Fly   739 KG-----EQGAIGLRGEIGDRGPAGEVIPGPVGAKGYPGPTGDYGQQGAPGLPGRDGEPGLDGGI 798
            .|     |..|:|           |:.:            .||.|..|.||.||..|:||:
Human  1007 CGKVRGSENCALG-----------GQCV------------KGDRGAPGIPGSPGSRGDPGI---- 1044

  Fly   799 GYKGQRGVPGQEVIQGEIGPPGRSGIKGFPGDVGAPGQYGLAGRPGPKGVKGEQGPDGAVGQTGL 863
                           |..||||.||.   |||.|:||..||.|.|||      |||   .|:.|.
Human  1045 ---------------GVAGPPGPSGP---PGDKGSPGSRGLPGFPGP------QGP---AGRDGA 1082

  Fly   864 PGNKGQRGDFLVGPPGPKGQPGRNGRQAPHGAKGQKGEVGSLGQNGQNGAKGSIGFSGRRGLLGN 928
            |||.|:|        ||.|:||.:...:|       |::..|.::..|...
Human  1083 PGNPGER--------GPPGKPGLSSLLSP-------GDINLLAKDVCNDCP-------------- 1118

  Fly   929 AGLQGLPGSPGIPGLPGMIGEIGERGEIGYNGRQGDIGPRGPNGEFGPKGLSGDDGPDGYPGANG 993
                  ||.||:||||                                 |..||.|..|.||..|
Human  1119 ------PGPPGLPGLP---------------------------------GFKGDKGVPGKPGREG 1144

  Fly   994 LPGRKGETGNPGFPGRPGAKGVAAYSGIKGDDGESGLTGPIGYPGAPGAKGQRGPVGDSQPALDG 1058
            ..|:|||.|.||.||.||..|.....|.:|.|||.|..|..|:||.||..|..|..|  .|..||
Human  1145 TEGKKGEAGPPGLPGPPGIAGPQGSQGERGADGEVGQKGDQGHPGVPGFMGPPGNPG--PPGADG 1207

  Fly  1059 VAGRKGEVGSPGPNGLPGRHGLKGQRGDRGLPGQQGRPGEPGAKGLGGYPGRNGINGLKGATGFP 1123
            :|   |..|.||..|.||:.|..|.:|..|||   |.|||.|.:|..|.||..|..|..|..|.|
Human  1208 IA---GAAGPPGIQGSPGKEGPPGPQGPSGLP---GIPGEEGKEGRDGKPGPPGEPGKAGEPGLP 1266

  Fly  1124 GPQGPKGPQGESGVVGLDGRNGQIGDQGPRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRSFYRG 1188
            ||:|.:||.      |..|..|..|..|||      ||.|..|..|:.|:||:
Human  1267 GPEGARGPP------GFKGHTGDSGAPGPR------GESGAMGLPGQEGLPGK------------ 1307

  Fly  1189 FTGDQGLQGERGEQGDMGPIGFIGPPGAKGERGDIGYAGQLGFDGAEGLKGFQGDQGPRGPPGIT 1253
             .||.|..|.:|.||..||.|..|.||:.||.|..|..||.|..|..|..|..|..|||||||
Human  1308 -DGDTGPTGPQGPQGPRGPPGKNGSPGSPGEPGPSGTPGQKGSKGENGSPGLPGFLGPRGPPG-- 1369

  Fly  1254 LPAEKGDEGVAGLDGRAGRPGHFGQKGAPGPPGENGPNGAIGHRGPQIQGPPGPQGDVGFPGAPG 1318
               |.|::||.|.:|..|:||..|.||..|.||..|.           :||||.:|..|.||.||
Human  1370 ---EPGEKGVPGKEGVPGKPGEPGFKGERGDPGIKGD-----------KGPPGGKGQPGDPGIPG 1420

  Fly  1319 HNGRHGLIGPKGELGDMGRQGERGESGYAIVGRQGDIGDIGFQGEPGWDGAKGE----------- 1372
            |.|..||:||:|                 :.|..|.:|..|..|:||:.|.:||
Human  1421 HKGHTGLMGPQG-----------------LPGENGPVGPPGPPGQPGFPGLRGESPSMETLRRLI 1468

  Fly  1373 ---------------------------QGYPGLPGKNGRVGAPGPRGPTGD---AGWGGIDGMDG 1407
                                       ||.||.||..|:.|.||..||.|:   .|.||::|..|
Human  1469 QEELGKQLETRLAYLLAQMPPAYMKSSQGRPGPPGPPGKDGLPGRAGPMGEPGRPGQGGLEGPSG 1533

  Fly  1408 LVGPKGQPGVTYSYSMARPGDRGEPGLDGFQGEEGDGGAPGLIGFQGQRGAVGYRGDQGEVGYTG 1472
            .:||||:.|.        .||.|.||: |.:||.|..|.|      ||.|..||..|    |..|
Human  1534 PIGPKGERGA--------KGDPGAPGV-GLRGEMGPPGIP------GQPGEPGYAKD----GLPG 1579

  Fly  1473 ADGPQGQRGDKGYMGLTGAPGLRGLPGPQGEPAPA 1507
            ..||||:.|..|:      |||.|.|||.|:..|:
Human  1580 IPGPQGETGPAGH------PGLPGPPGPPGQCDPS 1608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	27/60 (45%)
		Collagen	102..152	CDD:189968	21/49 (43%)
		Collagen	277..334	CDD:189968	26/56 (46%)
		Collagen	534..593	CDD:189968	26/58 (45%)
		Collagen	814..871	CDD:189968	28/56 (50%)
		Collagen	957..1014	CDD:189968	19/56 (34%)
		Collagen	990..1049	CDD:189968	28/58 (48%)
		Collagen	1070..1128	CDD:189968	26/57 (46%)
		C4	1515..1624	CDD:128421
		C4	1625..1737	CDD:128421
COL22A1	NP_690848.1	vWFA	36..219	CDD:294047
		LamG	239..426	CDD:304605
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..1002		256/676 (38%)
		Collagen	585..635	CDD:189968	20/49 (41%)
		Collagen	654..704	CDD:189968	27/52 (52%)
		Collagen	772..826	CDD:189968	27/69 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1019..1103		47/145 (32%)
		Collagen	1028..1095	CDD:189968	41/105 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1119..1458		167/437 (38%)
		Collagen	1260..1307	CDD:189968	22/58 (38%)
		Collagen	1330..1395	CDD:189968	33/69 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1491..1609		57/143 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910