DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vkg and COL16A1

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	NP_001847.3	Gene:	COL16A1 / 1307	HGNCID:	2193	Length:	1604	Species:	Homo sapiens

Alignment Length:	1655	Identity:	569/1655 - (34%)
Similarity:	673/1655 - (40%)	Gaps:	524/1655 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ADGKICNTTLCDC----------KGIKGRMGAPGPIGVPGLEGPAGD---------------IGP 67
            ::||:  .|.|.|          ..:.||:......|....:..|.|               :.|
Human   270 SEGKV--YTRCFCLEEPQNSEVDAQLTGRISQKAERGAKVHQETAADECPPCVHGARDSNVTLAP 332

  Fly    68 PGRAGPLGEKGDVGEYGEQGEKGHRGD--------------IGPKGEMGYPGIMGKSGEPGTPGP 118
            .|..|..||:|..|..|.:||||.||:              .|||||.|..|.:|.||.||:.|.
Human   333 SGPKGGKGERGLPGPPGSKGEKGARGNDCVRISPDAPLQCAEGPKGEKGESGALGPSGLPGSTGE 397

  Fly   119 RGIDGCDGRPGMQGPSGAPGQNGVRGPPGKPGQQGPPGEAGEGGINSKGTKGNRGETGQPGGVGP 183
            :            |..|..|..|::|.|||||:.|.|||     |...|.||.:|:   ||.|||
Human   398 K------------GQKGEKGDGGIKGVPGKPGRDGRPGE-----ICVIGPKGQKGD---PGFVGP 442

  Fly   184 PGFDGDRGSKGDTGYAGLTGEKGDPGLPGPKGDTGAVSELPYSLIGPPGAKGEPGDSLSGVLKPD 248
                           .||.||.|.||||||.|            ||.||..|:||
Human   443 ---------------EGLAGEPGPPGLPGPPG------------IGLPGTPGDPG---------- 470

  Fly   249 DTLKGYKGYVGLQGDEGPQGPTGEQGAVGRNGLPGARGEIGGPGERGKPGKDGEPGRFGDKGMKG 313
                            ||.||.|::|:   :|:||..    |||  |||||.|.      ||.||
Human   471 ----------------GPPGPKGDKGS---SGIPGKE----GPG--GKPGKPGV------KGEKG 504

  Fly   314 AP---------GWTGADGLDGSPGERGEDG----FTGMPGVQGGAGPPGIYDPSLTKS------- 358
            .|         |:....||.|.||.:||.|    ..|.||:||..|..|  :|.|:.|
Human   505 DPCEVCPTLPEGFQNFVGLPGKPGPKGEPGDPVPARGDPGIQGIKGEKG--EPCLSCSSVVGAQH 567

  Fly   359 LPGPIGSQGDIGPPGEQGPPGLPGKPGRRGPIGLAGQSGDPGLNGSRGPPGRSERGEAGDYGFIG 423
            |....|:.||:|.||.    ||||.|||         :|.|||           :||.|::|..|
Human   568 LVSSTGASGDVGSPGF----GLPGLPGR---------AGVPGL-----------KGEKGNFGEAG 608

  Fly   424 PPGPQGPPGEAGLPGRYGLHGEPGQ-------------NVV---GPKGEPGLNGQP--GLEGYRG 470
            |.|..||||..|..|..|..|||.:             .||   ||.||.|..|.|  ||.|.:|
Human   609 PAGSPGPPGPVGPAGIKGAKGEPCEPCPALSNLQDGDVRVVALPGPSGEKGEPGPPGFGLPGKQG 673

  Fly   471 DRGEVGLPGDKGLPGEGYNIVGPPGSQGPPGFRGLPGDDGYNGLRGLPGEKGLRGDDCPVC---- 531
            ..||.||.|.||       ..|.||..|.||..|.||..|..|::|..|.||.:||.|..|
Human   674 KAGERGLKGQKG-------DAGNPGDPGTPGTTGRPGLSGEPGVQGPAGPKGEKGDGCTACPSLQ 731

  Fly   532 -----------NAGPRGPRGQEGDTGYPGSHGNRGAIGLTGPRGVQGLQGNPGRAGHKGLPGPAG 585
                       ..||:|.:|.|| .|.||..|..|..|:.||.|::|:||.||..| :|:.||.|
Human   732 GTVTDMAGRPGQPGPKGEQGPEG-VGRPGKPGQPGLPGVQGPPGLKGVQGEPGPPG-RGVQGPQG 794

  Fly   586 IPGEPGKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDTGDDGEKGRDGSDGSKGERGETGQRG 650
            .||.||..|..|..|.                    ||..|..||||..||.|.||..|..|..|
Human   795 EPGAPGLPGIQGLPGP--------------------RGPPGPTGEKGAQGSPGVKGATGPVGPPG 839

  Fly   651 DYGDAGYQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIKGERGD--------DGDTGFKG 707
                   ....|.|||||:.|..|         |.|.||..|.:||:|:        .||..|.|
Human   840 -------ASVSGPPGRDGQQGQTG---------LRGTPGEKGPRGEKGEPGECSCPSQGDLIFSG 888

  Fly   708 VKGEP--------NPGQIYDNTGEPGEDGYTGPKGVKGAKGEQGAIGLRG------EIGD----- 753
            :.|.|        .||.    .|.||..|..||.||.|.:|..|..||.|      |:|.
Human   889 MPGAPGLWMGSSWQPGP----QGPPGIPGPPGPPGVPGLQGVPGNNGLPGQPGLTAELGSLPIEQ 949

  Fly   754 ---RGPAGEVIPGPVGAKGYPGPTGDYGQQGAPGLPGRD-----------------------GEP 792
               :...|:.:.|.....||....|:.|.||.||:||.|                       |:|
Human   950 HLLKSICGDCVQGQRAHPGYLVEKGEKGDQGIPGVPGLDNCAQCFLSLERPRAEEARGDNSEGDP 1014

  Fly   793 GLDGGIGYKGQRGVPGQEVIQGEIGPPGRSGIKGFPGDVGAPGQYGLAGRPGPKGVKGEQGPDGA 857
            |..|..|..|..|:|||   :||.||||..|..|.||.:|.||..|..|.||..|::||:
Human  1015 GCVGSPGLPGPPGLPGQ---RGEEGPPGMRGSPGPPGPIGPPGFPGAVGSPGLPGLQGER----- 1071

  Fly   858 VGQTGLPGNKGQRGDFLVGPPGPKGQPGRNGRQAPHGAKGQKGEVGSLGQNGQNGAKGSIGFSGR 922
             |.|||.|:||:        |||.||||..|...|.|..|.|||
Human  1072 -GLTGLTGDKGE--------PGPPGQPGYPGATGPPGLPGIKGE--------------------- 1106

  Fly   923 RGLLGNAGLQGLPGSPGIPGLPGMIGEIGERGEIGYNGRQGDIGPRGPNGEFGPKGLSGDDGPDG 987
            ||..|:||.:|.||.||..|||                  |..||.||.||.||:|.||:.|..|
Human  1107 RGYTGSAGEKGEPGPPGSEGLP------------------GPPGPAGPRGERGPQGNSGEKGDQG 1153

  Fly   988 YPGANGLPGRKGETGNPGFPGRPGAKGVAAYSGIKGDDGESGLTGPIGYPGAPGAKGQRGPVG-D 1051
            :.|..|.||..|..|.||..|.||..|..|..|.:|..|.|||.|.   ||.||..|.:||.| |
Human  1154 FQGQPGFPGPPGPPGFPGKVGSPGPPGPQAEKGSEGIRGPSGLPGS---PGPPGPPGIQGPAGLD 1215

  Fly  1052 SQPALDGVAGRKGEVGSPGPNGLPGRHGLKGQRGDRGLPGQQGRPGEPGAKGLGGYPGRNGINGL 1116
            .....||..|.:|:.|..||.||.|..|.||:.|..||||.:|..|:||..|..|.||..|..|.
Human  1216 GLDGKDGKPGLRGDPGPAGPPGLMGPPGFKGKTGHPGLPGPKGDCGKPGPPGSTGRPGAEGEPGA 1280

  Fly  1117 KGATGFPGPQGPKGPQGESGVVGLDGRNGQIGDQGPRGL--IGEQGEQGEQGDEGEVGIPGRLEN 1179
            .|..|.|||.|..||.|..            |..||.|:  :|.:|::|..|:.|..|:||:
Human  1281 MGPQGRPGPPGHVGPPGPP------------GQPGPAGISAVGLKGDRGATGERGLAGLPGQ--- 1330

  Fly  1180 LRDRSFYRGFTGDQGLQGERGEQGDMGPIGFIGPPGAKGERGDIGYAGQLGFDGAEGLKGFQGDQ 1244
                                     .||.|..|||            |:.|.|||.|.:|..|.|
Human  1331 -------------------------PGPPGHPGPP------------GEPGTDGAAGKEGPPGKQ 1358

  Fly  1245 GPRGPPGITLPAEKGDEGVAGLDGRAGRPGHFGQKGAPGPPGENGPNGAIGHRGPQIQGPPGPQG 1309
            |..||||     .|||.|.||..|:||..|..|..|.||..|..||           .|||||.|
Human  1359 GFYGPPG-----PKGDPGAAGQKGQAGEKGRAGMPGGPGKSGSMGP-----------VGPPGPAG 1407

  Fly  1310 DVGFPGAPGHNGRHGLIGPKGELGDMGRQGE-----RGE--------SGY------------AIV 1349
            :.|.|||||.:|..||.|..|.:|||....|     |.|        ..|            |..
Human  1408 ERGHPGAPGPSGSPGLPGVPGSMGDMVNYDEIKRFIRQEIIKMFDERMAYYTSRMQFPMEMAAAP 1472

  Fly  1350 GRQGDIGDIGFQGEPGWDGAKGEQGYPGLPGKNGRVGAPGPRGPTGDAGWGGIDGMDGLVGPKGQ 1414
            ||         .|.||.|||.|..|.||.||..|::|..|.:|
Human  1473 GR---------PGPPGKDGAPGRPGAPGSPGLPGQIGREGRQG---------------------- 1506

  Fly  1415 PGVTYSYSMARPGDRGEPGLDGFQGEEGDGGAPGLIGFQGQRGAVGYRGDQGEVGY--TGADGPQ 1477
                      .||.||.||.   :||:||.|    ||..|:.|..|..|.||..||  .||.||.
Human  1507 ----------LPGVRGLPGT---KGEKGDIG----IGIAGENGLPGPPGPQGPPGYGKMGATGPM 1554

  Fly  1478 GQRGDKGYMGLTGAPGLRGLPGPQGEPAPA 1507
            ||:         |.||:.|.|||.|:|..|
Human  1555 GQQ---------GIPGIPGPPGPMGQPGKA 1575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	29/87 (33%)
		Collagen	102..152	CDD:189968	18/49 (37%)
		Collagen	277..334	CDD:189968	25/65 (38%)
		Collagen	534..593	CDD:189968	29/58 (50%)
		Collagen	814..871	CDD:189968	27/56 (48%)
		Collagen	957..1014	CDD:189968	25/56 (45%)
		Collagen	990..1049	CDD:189968	26/58 (45%)
		Collagen	1070..1128	CDD:189968	28/57 (49%)
		C4	1515..1624	CDD:128421
		C4	1625..1737	CDD:128421
COL16A1	NP_001847.3	TSPN	50..231	CDD:214560
		Nonhelical region 10 (NC10)	232..374		24/105 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..509		96/295 (33%)
		Triple-helical region 9 (COL9) with 3 imperfections	375..506		78/218 (36%)
		Collagen	375..433	CDD:189968	30/74 (41%)
		Nonhelical region 9 (NC9)	507..521		1/13 (8%)
		Triple-helical region 8 (COL8) with 1 imperfection	522..555		15/34 (44%)
		Cell attachment site. /evidence=ECO:0000255	540..542		0/1 (0%)
		Nonhelical region 8 (NC8)	556..572		3/15 (20%)
		Triple-helical region 7 (COL7) with 1 imperfection	573..631		32/81 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	604..917		128/361 (35%)
		Nonhelical region 7 (NC7)	632..652		2/19 (11%)
		Triple-helical region 6 (COL6) with 1 imperfection	653..723		34/76 (45%)
		Collagen	673..721	CDD:189968	23/54 (43%)
		Nonhelical region 6 (NC6)	724..738		2/13 (15%)
		Triple-helical region 5 (COL5) with 3 imperfections	739..876		63/174 (36%)
		Collagen	756..803	CDD:189968	23/47 (49%)
		Nonhelical region 5 (NC5)	877..887		2/9 (22%)
		Triple-helical region 4 (COL4) with 2 imperfections	888..939		19/54 (35%)
		Nonhelical region 4 (NC4)	940..973		6/32 (19%)
		Triple-helical region 3 (COL3)	974..988		8/13 (62%)
		Nonhelical region 3 (NC3)	989..1011		0/21 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1001..1429		209/554 (38%)
		Cell attachment site. /evidence=ECO:0000255	1006..1008		0/1 (0%)
		Triple-helical region 2 (COL2) with 2 imperfections	1012..1433		211/547 (39%)
		Cell attachment site. /evidence=ECO:0000255	1227..1229		0/1 (0%)
		Nonhelical region 2 (NC2)	1434..1472		5/37 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1468..1517		25/92 (27%)
		Triple-helical region 1 (COL1) with 2 imperfections	1473..1578		55/160 (34%)
		Nonhelical region 1 (NC1)	1579..1604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910