DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and COL11A1

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	XP_016855823.1	Gene:	COL11A1 / 1301	HGNCID:	2186	Length:	1857	Species:	Homo sapiens

Alignment Length:	1721	Identity:	621/1721 - (36%)
Similarity:	746/1721 - (43%)	Gaps:	458/1721 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 GRAGPLGEKGDVGEYG------------------------------EQGEKGHRGDIGPKGEMGY 103
            ||...|...||:|||.                              |....|| |..|.||:.|.
Human   418 GRDSDLLVDGDLGEYDFYEYKEYEDKPTSPPNEEFGPGVPAETDITETSINGH-GAYGEKGQKGE 481

  Fly   104 PGIMGKSGEP-----GTPGPRGIDGCDGRPGMQGPSGAPGQNGVRGPPGKPGQQGPPGEAGEGGI 163
            |.::    ||     |.|||.|..|..|.||:|||:|.||..|.|||||:||..|..|..
Human   482 PAVV----EPGMLVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLP----- 537

  Fly   164 NSKGTKGNRGETGQPGGVGPPG--------FDGDRGSKGDT-----GYAGLTGEKGDPGLPGPKG 215
                              ||||        :.|| ||||.|     ..|....::....|.||.|
Human   538 ------------------GPPGTMLMLPFRYGGD-GSKGPTISAQEAQAQAILQQARIALRGPPG 583

  Fly   216 DTGAVSELPYSLIGPPGAKGEPGDSLSGVLKPDDTLKGYKGYVGLQGDEGPQGPTGEQGAVGRNG 280
                    |..|.|.||..|.||.|               |..|..||.|||||.|.||.
Human   584 --------PMGLTGRPGPVGGPGSS---------------GAKGESGDPGPQGPRGVQGP----- 620

  Fly   281 LPGARGEIGGPGERGKPGKDGEPGRFGDKGMKGAPGWTGADGLDGSPGERGEDGFTGMPGVQGGA 345
                      ||..|||||.|.||..|.:||.|.|         |:.|:||.||..|:||.:|..
Human   621 ----------PGPTGKPGKRGRPGADGGRGMPGEP---------GAKGDRGFDGLPGLPGDKGHR 666

  Fly   346 GPPGIYDPSLTKSLPGPIGSQGDIGPPGEQGPPGLPGKPGRR---GPIGLAGQSGDPGLNGSRGP 407
            |..|...|      |||.|..|..|..||.||.||||:.|.|   ||.|..|..|.||:.|..||
Human   667 GERGPQGP------PGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGAPGQPGMAGVDGP 725

  Fly   408 PGRSERGEAGDYGFIGPPGPQGPPGEAGLPGRYGLHGEPGQNVVGPKGEPGLNGQPGLEGYRGDR 472
            ||  .:|..|..|..||||.||.||..||||..|..|.||:.  ||:|:|||.|.||.:|..|..
Human   726 PG--PKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEK--GPQGKPGLAGLPGADGPPGHP 786

  Fly   473 GEVGLPGDKGLPGEGYNIVGPPGSQGPPGFRGLPGDDGYNGLRGLPGEKGLRGDDCPVCNAGPRG 537
            |:.|..|:||       .:||||.|||.|:.|..|..|.:|:|||.|.||.:|:|         |
Human   787 GKEGQSGEKG-------ALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGED---------G 835

  Fly   538 PRGQEGDTGYPGSHGNRGAIGLTGPRGVQGLQGNPGRAGHKGLPGPAGIPGEPGKVGAAGPDGKA 602
            ..|.:||.|.   .|:||.:|..||||..|.:|..||||..|.|||:|..||.||:|..|..|..
Human   836 FPGFKGDMGL---KGDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYP 897

  Fly   603 IEVGSLRKGEIGDTGDSGHRGDTGDDGEKGRDGSDGSKGERGETGQRGDYGDAGYQGRDGEPGRD 667
               |  |:|..|.||..|..|..|:.|.:|..|..|.:|:||.||.||..|..|..|:.|..|..
Human   898 ---G--RQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTS 957

  Fly   668 GRDGAPGRNATTPKVYLIGEPGYDGIKGERGDDGDTGFKGVKGEPNPGQIYDNTGEPGED---GY 729
            |.||.|            |.||.   :|.:|..|..||.|.||.|.|         ||:|   |:
Human   958 GGDGPP------------GPPGE---RGPQGPQGPVGFPGPKGPPGP---------PGKDGLPGH 998

  Fly   730 TGPKGVKGAKGEQGAIGLRGEIGDRGPAGEVIPGPVGAKGYPGPTGDYGQQGAPGLPGRDGEPGL 794
            .|.:|..|.:|:.|..|..|.:|.:||.||.  ||:|.:|:|||.|..|:||.||..|::
Human   999 PGQRGETGFQGKTGPPGPGGVVGPQGPTGET--GPIGERGHPGPPGPPGEQGLPGAAGKE----- 1056

  Fly   795 DGGIGYKGQRGVPGQEVIQGEIGPPGRSGIKGFPGDVGAPGQYGLAGRPGPKGVKGEQGPDGAVG 859
                   |.:|.||.:.|.|:.||   :|::||||:.|.|      |..|..|:||.:||.
Human  1057 -------GAKGDPGPQGISGKDGP---AGLRGFPGERGLP------GAQGAPGLKGGEGPQ---- 1101

  Fly   860 QTGLPGNKGQRGDFLVGPPGPKGQPGRNGRQAPHGAKGQKGEVGSLGQNGQNGAKGSIGFSGRRG 924
                            |||||.|.|                                    |.||
Human  1102 ----------------GPPGPVGSP------------------------------------GERG 1114

  Fly   925 LLGNAGLQGLPGSPGIPGLPGMIGEIGERGEIGYNGRQGDIGPRGPNGEFGPKGLSGDDGPDGYP 989
            ..|.||..||||.||..|.||..||.|..||      :|..||.|.:|..||.||.|..||.|.|
Human  1115 SAGTAGPIGLPGRPGPQGPPGPAGEKGAPGE------KGPQGPAGRDGVQGPVGLPGPAGPAGSP 1173

  Fly   990 GANGLPGRKGETGNPGFPGRPGAKGVAAYSGIKGDDGESGLTGPIGYPGAPGAKGQRGPVGDSQP 1054
            |.:   |.|||.|.||            ..|.|||.||:         |.||..|.:||||
Human  1174 GED---GDKGEIGEPG------------QKGSKGDKGEN---------GPPGPPGLQGPVG---- 1210

  Fly  1055 ALDGVAGRKGEVGSPGPNGLPGRHGLKGQRGDRGLPGQQGRPGEPGAKGLGGYPGRNGINGLKGA 1119
             ..|:||..||   |||.|..|..|.||..|.||.||.   ||..|.:||.|.||..|.||..|.
Human  1211 -APGIAGGDGE---PGPRGQQGMFGQKGDEGARGFPGP---PGPIGLQGLPGPPGEKGENGDVGP 1268

  Fly  1120 TGFPGPQGPKGPQGESGVVGLDGRNGQIGDQGPRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRS 1184
            .|.|||.||:||||.         ||..|.|||.|.:|..|..||:|:.||.|.||.
Human  1269 MGPPGPPGPRGPQGP---------NGADGPQGPPGSVGSVGGVGEKGEPGEAGNPGP-------- 1316

  Fly  1185 FYRGFTGDQGLQGERGEQGDMGPIGFIGPPGAKGERGDIGYAGQLGFDGAEGLKGFQGDQGPRGP 1249
              .|..|..|.:|||||:|:.||.|..|||||||..||.|..|.      .|..||.||.||.|.
Human  1317 --PGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGN------PGPVGFPGDPGPPGE 1373

  Fly  1250 PGITLPAEK----GDEGVAGLDGRAGRPGHFGQKGAPGPPGENGPNGAIGHRGPQIQGPPGPQGD 1310
            ||   ||.:    ||:|..|..|:.|.||..|:.|.|||||:.||.||.|..|.  ||..|.:|:
Human  1374 PG---PAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGR--QGEKGAKGE 1433

  Fly  1311 VGFPGAPGHNGRHGLIGPKGELGDMGRQGERGESGYAIVGRQGDIGDIGFQGEPGWDGAKGEQGY 1375
            .|..|.|   |:.|.:||:|..|..|.:|.|        |..|.:|:.|..|..|.||..|..|.
Human  1434 AGAEGPP---GKTGPVGPQGPAGKPGPEGLR--------GIPGPVGEQGLPGAAGQDGPPGPMGP 1487

  Fly  1376 PGLPGKNGRVGAPGPRGPTGDAGWGGIDGMDGLVGPKGQPGVTYSYSMARPGDRGEPGLDGFQGE 1440
            |||||..|..|:.|.:|.         .|:.||:||.|:.|        ..||||.||..|..|.
Human  1488 PGLPGLKGDPGSKGEKGH---------PGLIGLIGPPGEQG--------EKGDRGLPGTQGSPGA 1535

  Fly  1441 EGDGGAPGLIGFQGQRGAVGYRGDQGEVGYTGADGPQGQRGDKGYMGLTGAPGLRGLPGPQGE-- 1503
            :||||.||..|..|..|..|..|.||..|..|:.||.||:||      :|.||..|.|||.||
Human  1536 KGDGGIPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGD------SGLPGPPGSPGPPGEVI 1594

  Fly  1504 -PAPAPPAPKSRGFIFARHSQSVHVPQCPANTNLLWEGYSLSGNVAASRAVGQDLGQSGSCMMRF 1567
             |.|...:.|:|     ||::.:   |..|:.|:|.....:.....:..::.||:..     |:|
Human  1595 QPLPILSSKKTR-----RHTEGM---QADADDNILDYSDGMEEIFGSLNSLKQDIEH-----MKF 1646

  Fly  1568 ----TTMPYMLCDITNVCHFAQNNDDSLWLSTAEPMPMTMTPIQG--RDLMKYISRCVVCETTTR 1626
                .|.|...|....:.| ....|...|:.          |.||  .|..|     |.|..|:
Human  1647 PMGTQTNPARTCKDLQLSH-PDFPDGEYWID----------PNQGCSGDSFK-----VYCNFTS- 1694

  Fly  1627 IIALHSQSMSIPD--------------CPGGWEEMWTGYSYF-----MSTLDNVGGVGQNLVS-- 1670
                ..::...||              .||.|      :|.|     :|.|| |.|...|:|.
Human  1695 ----GGETCIYPDKKSEGVRISSWPKEKPGSW------FSEFKRGKLLSYLD-VEGNSINMVQMT 1748

  Fly  1671 -----PGSCLEEFRAQPVIECHGHGRCNYYD 1696
                 ..|..:.|      ..|.|....:||
Human  1749 FLKLLTASARQNF------TYHCHQSAAWYD 1773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	22/84 (26%)
		Collagen	102..152	CDD:189968	27/54 (50%)
		Collagen	277..334	CDD:189968	19/56 (34%)
		Collagen	534..593	CDD:189968	27/58 (47%)
		Collagen	814..871	CDD:189968	17/56 (30%)
		Collagen	957..1014	CDD:189968	22/56 (39%)
		Collagen	990..1049	CDD:189968	19/58 (33%)
		Collagen	1070..1128	CDD:189968	28/57 (49%)
		C4	1515..1624	CDD:128421	23/114 (20%)
		C4	1625..1737	CDD:128421	20/98 (20%)
COL11A1	XP_016855823.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	286	1.000	Domainoid score	I1603
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810