DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and COL5A1

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	NP_000084.3	Gene:	COL5A1 / 1289	HGNCID:	2209	Length:	1838	Species:	Homo sapiens

Alignment Length:	1680	Identity:	616/1680 - (36%)
Similarity:	725/1680 - (43%)	Gaps:	440/1680 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 APGPIGVPGLEGPAG-DIGPPGRAGPLGEKGDVGEYGEQGEKGHRGDIGPKGEMGYPGIMGKSGE 112
            :|..|| ||:  ||. |....|..||.||||..||                     |.|:    |
Human   426 SPSEIG-PGM--PANQDTIYEGIGGPRGEKGQKGE---------------------PAII----E 462

  Fly   113 P-----GTPGPRGIDGCDGRPGMQGPSGAPGQNGVRGPPGKPGQQGPPGEAGEGGINSKGTKGNR 172
            |     |.|||.|..|..|.||..||:|..|..|.|||||:||..|..|..
Human   463 PGMLIEGPPGPEGPAGLPGPPGTMGPTGQVGDPGERGPPGRPGLPGADGLP-------------- 513

  Fly   173 GETGQPGGVGPPGF----------DGDRGSKG-----DTGYAGLTGEKGDPGLPGPKGDTGAVSE 222
                     ||||.          .||.||||     ....|....::....|.||.|
Human   514 ---------GPPGTMLMLPFRFGGGGDAGSKGPMVSAQESQAQAILQQARLALRGPAG------- 562

  Fly   223 LPYSLIGPPGAKGEPGDSLSGVLKPDDTLKGYKGYVGLQGDEGPQGPTGEQGAVGRNGLPGARGE 287
             |..|.|.||..|.||   ||.||            |..||.|||||.|.||..|..|.||.||.
Human   563 -PMGLTGRPGPVGPPG---SGGLK------------GEPGDVGPQGPRGVQGPPGPAGKPGRRGR 611

  Fly   288 IGGPGERGKPGKDGEPGRFGDKGMKGAPGWTGADGLDGSPGERGEDGFTGMPGVQGGAGPPGIYD 352
            .|..|.||.||:                        .|..|:||.||..|:||.:|..|.||...
Human   612 AGSDGARGMPGQ------------------------TGPKGDRGFDGLAGLPGEKGHRGDPGPSG 652

  Fly   353 PSLTKSLPGPIGSQGDIGPPGEQGPPGLPGKPGRR---GPIGLAGQSGDPGLNGSRGPPGRSERG 414
            |      |||.|..|:.|..||.||.||||:||.|   ||.|..|..|.||:.|..|.||  .:|
Human   653 P------PGPPGDDGERGDDGEVGPRGLPGEPGPRGLLGPKGPPGPPGPPGVTGMDGQPG--PKG 709

  Fly   415 EAGDYGFIGPPGPQGPPGEAGLPGRYGLHGEPGQNVVGPKGEPGLNGQPGLEGYRGDRGEVGLPG 479
            ..|..|..||||.||.||..||||..|..|.||:.  ||.|:|||.|.||.:|..|..|:.|.||
Human   710 NVGPQGEPGPPGQQGNPGAQGLPGPQGAIGPPGEK--GPLGKPGLPGMPGADGPPGHPGKEGPPG 772

  Fly   480 DKGLPGEGYNIVGPPGSQGPPGFRGLPGDDGYNGLRGLPGEKGLRGDDCPVCNAGPRGPRGQEGD 544
            :||  |:     ||||.|||.|:.|..|..|.:|:|||.|.||.:|:|         |..|.:||
Human   773 EKG--GQ-----GPPGPQGPIGYPGPRGVKGADGIRGLKGTKGEKGED---------GFPGFKGD 821

  Fly   545 TGYPGSHGNRGAIGLTGPRGVQGLQGNPGRAGHKGLPGPAGIPGEPGKVGAAGPDGKAIEVGSLR 609
            .|.   .|:||.||..||||..|.:|..||.|..|.|||.|.|||.||:|..|..|..   |  |
Human   822 MGI---KGDRGEIGPPGPRGEDGPEGPKGRGGPNGDPGPLGPPGEKGKLGVPGLPGYP---G--R 878

  Fly   610 KGEIGDTGDSGHRGDTGDDGEKGRDGSDGSKGERGETGQRGDYGDAGYQGRDGEPGRDGRDGAPG 674
            :|..|..|..|..|..|:.|.:|..|..|.:|:||.||.||:.|..|..|:.|..|..|.||.
Human   879 QGPKGSIGFPGFPGANGEKGGRGTPGKPGPRGQRGPTGPRGERGPRGITGKPGPKGNSGGDGP-- 941

  Fly   675 RNATTPKVYLIGEPGYDGIKGERGDDGDTGFKGVKGEPNPGQIYDNTGEPGED---GYTGPKGVK 736
                      .|.||.   :|..|..|.|||.|.||.|.|         ||:|   |:.|.:|..
Human   942 ----------AGPPGE---RGPNGPQGPTGFPGPKGPPGP---------PGKDGLPGHPGQRGET 984

  Fly   737 GAKGEQGAIGLRGEIGDRGPAGEVIPGPVGAKGYPGPTGDYGQQGAPGLPGRDGEPGLDGGIGYK 801
            |.:|:.|..|..|.:|.:||.||.  ||:|.:|:|||.|..|:||.|||.|::|..      |..
Human   985 GFQGKTGPPGPPGVVGPQGPTGET--GPMGERGHPGPPGPPGEQGLPGLAGKEGTK------GDP 1041

  Fly   802 GQRGVPGQEVIQGEIGPPGRSGIKGFPGDVGAPGQYGLAGRPGPKGVKGEQGPDGAVGQTGLPGN 866
            |..|:||::      |||   |::|||||.|.||..|..      |:||.:||.
Human  1042 GPAGLPGKD------GPP---GLRGFPGDRGLPGPVGAL------GLKGNEGPP----------- 1080

  Fly   867 KGQRGDFLVGPPGPKGQPGRNGRQAPHGAKGQKGEVGSLGQNGQNGAKGSIGFSGRRGLLGNAGL 931
                     |||||.|.||..|   |.||                                 ||.
Human  1081 ---------GPPGPAGSPGERG---PAGA---------------------------------AGP 1100

  Fly   932 QGLPGSPGIPGLPGMIGEIGERGEIGYNGRQGDIGPRGPNGEFGPKGLSGDDGPDGYPGANGLPG 996
            .|:||.||..|.||..||.|..||      :|..||.|.:|..||.||.|..||.|.||.:   |
Human  1101 IGIPGRPGPQGPPGPAGEKGAPGE------KGPQGPAGRDGLQGPVGLPGPAGPVGPPGED---G 1156

  Fly   997 RKGETGNPGFPGRPGAKGVAAYSGIKGDDGESGLTGPIGYPGAPGAKGQRGPVGDSQPALDGVAG 1061
            .|||.|.||            ..|.|||.||.         |.||..|.:||:|  ||      |
Human  1157 DKGEIGEPG------------QKGSKGDKGEQ---------GPPGPTGPQGPIG--QP------G 1192

  Fly  1062 RKGEVGSPGPNGLPGRHGLKGQRGDRGLPGQQGRPGEPGAKGLGGYPGRNGINGLKGATGFPGPQ 1126
            ..|..|.|||.   |:.||.||:||.   |.:|.||.||..||.|.||..|..|..|..|..||.
Human  1193 PSGADGEPGPR---GQQGLFGQKGDE---GPRGFPGPPGPVGLQGLPGPPGEKGETGDVGQMGPP 1251

  Fly  1127 GPKGPQGESGVVGLDGRNGQIGDQGPRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRSFYRGFTG 1191
            ||.||:|.||..|.|      |.|||.|.||..|..||:|:.||.|.||          ..|..|
Human  1252 GPPGPRGPSGAPGAD------GPQGPPGGIGNPGAVGEKGEPGEAGEPG----------LPGEGG 1300

  Fly  1192 DQGLQGERGEQGDMGPIGFIGPPGAKGERGDIGYAGQLGFDGAEGLKGFQGDQGPRGPPGITLPA 1256
            ..|.:|||||:|:.||.|..||||.||..||.|.      .|:.|..||.||.||.|.||   ||
Human  1301 PPGPKGERGEKGESGPSGAAGPPGPKGPPGDDGP------KGSPGPVGFPGDPGPPGEPG---PA 1356

  Fly  1257 EKGDEGVAGLDGRAGRPGHFGQKGAPGPPGENGPNGAIGHRGPQIQGPPGPQGDVGFPGAPGHNG 1321
              |.:|..|..|..|.|   ||.|:|||.||.||:|..|.|||  .||.||:
Human  1357 --GQDGPPGDKGDDGEP---GQTGSPGPTGEPGPSGPPGKRGP--PGPAGPE------------- 1401

  Fly  1322 RHGLIGPKGELGDMGRQGERGESGYA-IVGRQGDIGDIGFQGEPGWDGAKGEQGYPGLPGKNGRV 1385
                          |||||:|..|.| :.|..|..|.||.||.||..|..|.:|.||..|:.|..
Human  1402 --------------GRQGEKGAKGEAGLEGPPGKTGPIGPQGAPGKPGPDGLRGIPGPVGEQGLP 1452

  Fly  1386 GAPGPRGPTGDAGWGGIDGMDGLVGPKGQPGVTYSYSMARPGDRGEPGLDGFQGEEGDGGAPGLI 1450
            |:|||.||.|..|..|:.|:.|..||||:.|        .||..|..|..|.|||:||.|.||..
Human  1453 GSPGPDGPPGPMGPPGLPGLKGDSGPKGEKG--------HPGLIGLIGPPGEQGEKGDRGLPGPQ 1509

  Fly  1451 GFQGQRGAVGYRGDQGEV---GYTGADGPQGQRGDKGYMGLTGAPGLRGLPGPQGEPAPAPPAPK 1512
            |..|.:|..|..|..|.:   |..|..||.|.:|.||..|.||..|..|.|||.|.|.|.....:
Human  1510 GSSGPKGEQGITGPSGPIGPPGPPGLPGPPGPKGAKGSSGPTGPKGEAGHPGPPGPPGPPGEVIQ 1574

  Fly  1513 SRGFIFARHSQSVHVPQCPANTNLLWEGYSLSGNVAASRAVGQD--LGQSGSCMMRFTTM----- 1570
            ......:|..:::...|      ||.:|   :|......|.|.:  .|...|..:....|
Human  1575 PLPIQASRTRRNIDASQ------LLDDG---NGENYVDYADGMEEIFGSLNSLKLEIEQMKRPLG 1630

  Fly  1571 ----PYMLCDITNVCHFAQNNDDSLWLSTAEPMPMTMTPIQG--RDLMKYI-------SRCVVCE 1622
                |...|....:|| ....|...|:.          |.||  ||..|..       |.||..:
Human  1631 TQQNPARTCKDLQLCH-PDFPDGEYWVD----------PNQGCSRDSFKVYCNFTAGGSTCVFPD 1684

  Fly  1623 TTT---RIIALHSQSMSIPDCPGGWEEMWTGYSYF-----MSTLDNVG---GVGQ 1666
            ..:   ||.:...::      ||.|      :|.|     :|.:|..|   ||.|
Human  1685 KKSEGARITSWPKEN------PGSW------FSEFKRGKLLSYVDAEGNPVGVVQ 1727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	19/64 (30%)
		Collagen	102..152	CDD:189968	25/54 (46%)
		Collagen	277..334	CDD:189968	16/56 (29%)
		Collagen	534..593	CDD:189968	28/58 (48%)
		Collagen	814..871	CDD:189968	18/56 (32%)
		Collagen	957..1014	CDD:189968	22/56 (39%)
		Collagen	990..1049	CDD:189968	19/58 (33%)
		Collagen	1070..1128	CDD:189968	26/57 (46%)
		C4	1515..1624	CDD:128421	26/128 (20%)
		C4	1625..1737	CDD:128421	13/53 (25%)
COL5A1	NP_000084.3	TSPN	39..230	CDD:214560
		Nonhelical region	231..443		8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..269
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..457		15/33 (45%)
		Interrupted collagenous region	444..558		47/161 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..520		26/72 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..545		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..1574		521/1309 (40%)
		Triple-helical region	559..1570		521/1305 (40%)
		Collagen	726..>767	CDD:189968	21/42 (50%)
		Collagen	871..930	CDD:189968	24/63 (38%)
		Collagen	1474..1519	CDD:189968	22/52 (42%)
		Nonhelical region	1571..1605		6/42 (14%)
		COLFI	1610..1836	CDD:279718	31/141 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	286	1.000	Domainoid score	I1603
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810