DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and COL4A6

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	XP_006724680.1	Gene:	COL4A6 / 1288	HGNCID:	2208	Length:	1708	Species:	Homo sapiens

Alignment Length:	1847	Identity:	743/1847 - (40%)
Similarity:	921/1847 - (49%)	Gaps:	264/1847 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLGVVYLLGSLVSVTLAD----------GKICN----TTLCDCKGIKGRMGAPGPIGVPGLEGPA 62
            |:..::||  ||::.|.:          ||.|.    :..|.|...||..|.|||||:.|..||.
Human     2 LINKLWLL--LVTLCLTEELAAAGEKSYGKPCGGQDCSGSCQCFPEKGARGRPGPIGIQGPTGPQ 64

  Fly    63 GDIGPPGRAGPLGEKGDVGEYGEQGEKGHRGDIGPKGEMGYPGIMGKSGEPGTPGPRGIDGCDGR 127
            |..|..|.:|..||:|..|..|..|.||.:|.:|..|.:|..||.|..|:||..||.|:|||:|.
Human    65 GFTGSTGLSGLKGERGFPGLLGPYGPKGDKGPMGVPGFLGINGIPGHPGQPGPRGPPGLDGCNGT 129

  Fly   128 PGMQGPSGAPGQNGVRGPPGKPGQQGPPGEAGEGGINSKGTKGNRGETGQPGGVGPPGFDGDRGS 192
            .|..|..|..|..|:.||||.|||              ||:||:       ..:.|..|.|.:|.
Human   130 QGAVGFPGPDGYPGLLGPPGLPGQ--------------KGSKGD-------PVLAPGSFKGMKGD 173

  Fly   193 KGDTGYAGLTGEKGDPGLPGPKGDTGAVSELPYSLIGPPGAKGEPGDSLSGVLKPDDTL-KGYKG 256
            .|..|..|:||.:|.||.||..|..           ||||.:|.||.  .|.|.||..: .|::|
Human   174 PGLPGLDGITGPQGAPGFPGAVGPA-----------GPPGLQGPPGP--PGPLGPDGNMGLGFQG 225

  Fly   257 YVGLQGDEGPQGPTGEQGAVGRNGLPGARGEI---GGPGERGKPGKDGEPGRFGDKGMKGAPGWT 318
            ..|::||.|..||.|.         |.:.||:   |.|  :||.|..||||..|..|:.|.||:.
Human   226 EKGVKGDVGLPGPAGP---------PPSTGELEFMGFP--KGKKGSKGEPGPKGFPGISGPPGFP 279

  Fly   319 GADGLDGSPGERGEDGFTGMPGVQGGAGPPGIYDPSLTKSLPGPIGSQGDIGPPGEQGPPGLPGK 383
            |. |..|..||:||.|..|:||.:                  ||:||:|..||||:||..|..|.
Human   280 GL-GTTGEKGEKGEKGIPGLPGPR------------------GPMGSEGVQGPPGQQGKKGTLGF 325

  Fly   384 PGRRGPIGLAGQSGDPGLNGS-----------RGPPGRSERGEAGDYGFIGPPGPQGPPGEAGLP 437
            ||..|..|:.||.||.||.|.           .|.||  :.|..|..|..|..|.||..|.:|:|
Human   326 PGLNGFQGIEGQKGDIGLPGPDVFIDIDGAVISGNPG--DPGVPGLPGLKGDEGIQGLRGPSGVP 388

  Fly   438 GRYGLHGEPGQNVVGPKGEPGLNGQPGLEGYRGDRGEVGLPGDKGLPGEGYNIVGPPGSQGPP-- 500
            |...|.|.||  .:||:|.|||.|..|..| |...|..||||..|||       ||||..|||
Human   389 GLPALSGVPG--ALGPQGFPGLKGDQGNPG-RTTIGAAGLPGRDGLP-------GPPGPPGPPSP 443

  Fly   501 ------------GFRGLPGDDGYNGLRGLPGEKGLRGDD--CPVCNAG-PRGPRGQEGDTGYPGS 550
                        ||.||.|:.|..|..||   ||::||.  | .|:.| |        :||.||.
Human   444 EFETETLHNKESGFPGLRGEQGPKGNLGL---KGIKGDSGFC-ACDGGVP--------NTGPPGE 496

  Fly   551 HGNRGAIGLTGPRGVQGLQGNPGRAGHKGLPGPAGIPGEPGKVGAAGPDGKAIE-VGSLRKGEIG 614
            .|..|..||.|..|::|.:|:.|..|.:   ||||.||..|.:|.:||.||..| :.|..:|..|
Human   497 PGPPGPWGLIGLPGLKGARGDRGSGGAQ---GPAGAPGLVGPLGPSGPKGKKGEPILSTIQGMPG 558

  Fly   615 DTGDSGHRGDTGDDGEKGRDGSDGSKGERGETGQRGDYGDAGYQGRDGEPGRDGRDGAPGRNATT 679
            |.||||.:|..|..||.|:||..|..|..|..|. |..|..|.:|..|.||..|..|.||    .
Human   559 DRGDSGSQGFRGVIGEPGKDGVPGLPGLPGLPGD-GGQGFPGEKGLPGLPGEKGHPGPPG----L 618

  Fly   680 PKVYLIGEPGYDGIKGERGDDGDTGFKGVKGEPN------------------------PGQIYDN 720
            |...|.|.||..|:.|::|.||..|.:|:.|...                        ||. |..
Human   619 PGNGLPGLPGPRGLPGDKGKDGLPGQQGLPGSKGDCCCREVGKGDLDTERGITLPCIIPGS-YGP 682

  Fly   721 TGEPGEDGYTGPKGVKGAKGEQGAIGLRGEIGDRGPAGEV----IPGPVGAKGYPGPTGDYGQQG 781
            :|.||..|:.||||.:|..|..|..|..|..|:.|..|.|    :|      |:|||.|:.|..|
Human   683 SGFPGTPGFPGPKGSRGLPGTPGQPGSSGSKGEPGSPGLVHLPELP------GFPGPRGEKGLPG 741

  Fly   782 APGLPGRDGEPGLDGGIGYKGQRGVPGQEVIQGEIGPPGRSGI------KGFPGDVGAPGQYGLA 840
            .|||||:||.||:.|..|..|.:|..| ::...|.|.||..|:      |||.||.|.||..|:.
Human   742 FPGLPGKDGLPGMIGSPGLPGSKGATG-DIFGAENGAPGEQGLQGLTGHKGFLGDSGLPGLKGVH 805

  Fly   841 GRPGPKGVKGEQGPDGAVGQTGLPGNKGQRGDFLV----GPPGPKGQPGRNGRQAPHGAKGQKGE 901
            |:||..|.|||:|..|..||.|.||..|..|.:.:    |.||..|.||.:|.....|.:|:||.
Human   806 GKPGLLGPKGERGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPGFPGISGHPGKKGTRGKKGP 870

  Fly   902 VGSLGQNGQNGAKGSIGFSGRRGLLGNAGLQGLPGSPGIPGLPGMIGEIGERGEIGYNGRQGDIG 966
            .||:.:.|..|.|   |..|..||:   ||:|.|||||:.|||.:.|..||:|.:|:.|..|..|
Human   871 PGSIVKKGLPGLK---GLPGNPGLV---GLKGSPGSPGVAGLPALSGPKGEKGSVGFVGFPGIPG 929

  Fly   967 PRGPNGEFGPKGLSGDDGPDGYPGANGLPGRKGETGNPGFPGRPGAKGVAAYSGIKGDDGESGLT 1031
            ..|..|..|.||:.|..|..|..|..|.||.||:.||||..|.|..:...:...:|||.|..|..
Human   930 LPGIPGTRGLKGIPGSTGKMGPSGRAGTPGEKGDRGNPGPVGIPSPRRPMSNLWLKGDKGSQGSA 994

  Fly  1032 GPIGYPGAPGAKGQRGPVGDSQPALDGVAGR----KGEVGSPGPNGLPGRHGLKGQRGDRGLPGQ 1092
            |..|:||..|.||:.|..|  .|.|.|..|.    ||..|.|||.|..|..||.|.:|..|:.|.
Human   995 GSNGFPGPRGDKGEAGRPG--PPGLPGAPGLPGIIKGVSGKPGPPGFMGIRGLPGLKGSSGITGF 1057

  Fly  1093 QGRPGEPGAKGL---GGYPGRNGINGLKGATG----FPGPQGPKGPQGESGVVGLDGRNGQIGDQ 1150
            .|.|||.|::|:   .|.||.:|:.||||..|    ..|..||||..||||..|..||:|.||:
Human  1058 PGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGSPGPKGQPGESGFKGTKGRDGLIGN- 1121

  Fly  1151 GPRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRSFYRGFTGDQGLQGE---RGEQGDMGPIGFIG 1212
              .|..|.:||.|:.|..|:||:||.          .||.|..|::||   .|..|..|.||.:|
Human  1122 --IGFPGNKGEDGKVGVSGDVGLPGA----------PGFPGVAGMRGEPGLPGSSGHQGAIGPLG 1174

  Fly  1213 PPGAKGERGDIGYAGQLGFDGAEGLKGFQGDQGPR-----GPPGITLPAEKGDEGVAGLD-GRAG 1271
            .||..|.:|..|:.|..|.:|..|.||..|..||.     ||.|  ||..||::|..|:. |..|
Human  1175 SPGLIGPKGFPGFPGLHGLNGLPGTKGTHGTPGPSITGVPGPAG--LPGPKGEKGYPGIGIGAPG 1237

  Fly  1272 RPGHFGQKGAPGPPGENGPNGAIGHRGPQIQGP---PGPQGDVGFPGAPGHNGRHGLIGPKGELG 1333
            :||..||||..|.||..||.|..|  .|.|..|   .|..||.|.||..|..||.|..||.|..|
Human  1238 KPGLRGQKGDRGFPGLQGPAGLPG--APGISLPSLIAGQPGDPGRPGLDGERGRPGPAGPPGPPG 1300

  Fly  1334 DMGRQGERGESGY-AIVGRQGDIGDIGFQGEPGWDGAKGEQGYPGLPGKNGRVGAPGPRGPTGDA 1397
            ....||:.|:.|: .|.|.:|..||   ||.||:.|..||.|..|:.|:.|.:|.||..||.||.
Human  1301 PSSNQGDTGDPGFPGIPGPKGPKGD---QGIPGFSGLPGELGLKGMRGEPGFMGTPGKVGPPGDP 1362

  Fly  1398 GWGGIDGMDGLVGPKGQPGV--------TYSYSMARPGDRGEPGLDGFQGEEGDGGAPGLIGFQG 1454
            |:   .||.|..||:|..|:        |.......||..|.||:||..|..||.||.|.:|.||
Human  1363 GF---PGMKGKAGPRGSSGLQGDPGQTPTAEAVQVPPGPLGLPGIDGIPGLTGDPGAQGPVGLQG 1424

  Fly  1455 QRGAVGYRGDQGEVGYTGADGPQGQRGDKGYMGLTGAPGLRGLPGPQGE-PAPAPPAPKSR-GFI 1517
            .:|..|..|..|.   :|..||.|..||.|..||.|.||..|.||.||. ..|..|....| |:.
Human  1425 SKGLPGIPGKDGP---SGLPGPPGALGDPGLPGLQGPPGFEGAPGQQGPFGMPGMPGQSMRVGYT 1486

  Fly  1518 FARHSQSVHVPQCPANTNLLWEGYSLSGNVAASRAVGQDLGQSGSCMMRFTTMPYMLCDITNVCH 1582
            ..:||||..||.||...:.||.||||.......:|..||||.:|||:.||:|||::.|:|..|||
Human  1487 LVKHSQSEQVPPCPIGMSQLWVGYSLLFVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCH 1551

  Fly  1583 FAQNNDDSLWLSTAEPMPMTMTPIQGRDLMKYISRCVVCETTTRIIALHSQSMSIPDCPGGWEEM 1647
            :|:.||.|.||||..|:|  |.|:....:.:|||||.|||..::.||:|||.::||.||.||..:
Human  1552 YARRNDKSYWLSTTAPIP--MMPVSQTQIPQYISRCSVCEAPSQAIAVHSQDITIPQCPLGWRSL 1614

  Fly  1648 WTGYSYFMSTLDNVGGVGQNLVSPGSCLEEFRAQPVIECHG-HGRCNYYDALASFWLTVIEEQDQ 1711
            |.|||:.|.|.....|.||:|||||||||:|||.|.|||.| .|.|:|:....|||||.:||:.|
Human  1615 WIGYSFLMHTAAGAEGGGQSLVSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQ 1679

  Fly  1712 FVQ-PRQQTLKA-DFTSKISRCTVCRR 1736
            |.: |..:|||| ...:::|||.||.:
Human  1680 FGELPVSETLKAGQLHTRVSRCQVCMK 1706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	25/58 (43%)
		Collagen	102..152	CDD:189968	25/49 (51%)
		Collagen	277..334	CDD:189968	24/59 (41%)
		Collagen	534..593	CDD:189968	23/59 (39%)
		Collagen	814..871	CDD:189968	29/62 (47%)
		Collagen	957..1014	CDD:189968	24/56 (43%)
		Collagen	990..1049	CDD:189968	25/58 (43%)
		Collagen	1070..1128	CDD:189968	26/64 (41%)
		C4	1515..1624	CDD:128421	53/108 (49%)
		C4	1625..1737	CDD:128421	59/115 (51%)
COL4A6	XP_006724680.1	Collagen	359..416	CDD:189968	26/60 (43%)
		Collagen	681..740	CDD:189968	24/64 (38%)
		Collagen	800..859	CDD:189968	25/58 (43%)
		Collagen	905..964	CDD:189968	25/58 (43%)
		Collagen	1029..1088	CDD:189968	27/58 (47%)
		Collagen	1150..1208	CDD:189968	22/57 (39%)
		C4	1485..1589	CDD:279721	50/105 (48%)
		C4	1593..1705	CDD:279721	58/111 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148266
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41315at33208
OrthoFinder	1	1.000	-	-		FOG0000443
OrthoInspector	1	1.000	-	-		otm41900
orthoMCL	1	0.900	-	-		OOG6_100768
Panther	1	1.100	-	-	O	PTHR24023
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.750