DRSC/TRiP Functional Genomics Resources

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Protein Alignment vkg and COL4A5

DIOPT Version :9

Sequence 1:NP_001260071.1 Gene:vkg / 33726 FlyBaseID:FBgn0016075 Length:1940 Species:Drosophila melanogaster
Sequence 2:XP_011529151.2 Gene:COL4A5 / 1287 HGNCID:2207 Length:1696 Species:Homo sapiens


Alignment Length:1796 Identity:783/1796 - (43%)
Similarity:922/1796 - (51%) Gaps:212/1796 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 LADGKI----CNT-TLCDCKGIKGRMGA---PGPIGVPGLEGPAGDIGPPGRAGPLGEKGDVGEY 83
            |.||.:    |:. :.|||.||||..|.   ||..|.|||.|..|..|||   ||.|:|||.|..
Human    27 LYDGLLACYGCSPGSKCDCSGIKGEKGERGFPGLEGHPGLPGFPGPEGPP---GPRGQKGDDGIP 88

  Fly    84 GEQGEKGHRGDIGPKGEMGYPGIMGKSGEPGTPGPRGIDGCDGRPGMQGPSGAPGQNGVRGPPGK 148
            |..|.||.||..|..|..|.||:.|..|..|.|||:||.||:|..|.:|..|:||..|::||||.
Human    89 GPPGPKGIRGPPGLPGFPGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGP 153

  Fly   149 PGQQGPPGEAGEGGINS-KGTKGNRGETGQPGGVGPPGFDGDRGSKGDTGYAGLTGEKGDPGLPG 212
            ||..|..||.|...::| .|.|||.|..|.||..|.||..|..|..|..|..||.|..|.|||||
Human   154 PGIPGMKGEPGSIIMSSLPGPKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPG 218

  Fly   213 PKGDTGAVSELPYSLIGPPGAKGE--------PGDSLSGVLKPDDTLKGYKGYVGLQGDEGPQGP 269
            |||:.|      .:..||.|.|||        |...:|...:|.| ::..||..||.||.||.||
Human   219 PKGNMG------LNFQGPKGEKGEQGLQGPPGPPGQISEQKRPID-VEFQKGDQGLPGDRGPPGP 276

  Fly   270 TGEQGAVG-RNGLPGARGEIGGPGERGKPGKDGEPGRFGDKGMKGAPGWTGADGLDGSPGERGED 333
            .|.:|..| ..|..|.:||.|.||:|||||||||.|:.|..|:.|.||:.|..|.|   ||:|:.
Human   277 PGIRGPPGPPGGEKGEKGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGRD---GEKGQK 338

  Fly   334 GFTGMPGVQGGAGPPGIYDP----SLT------KSLPGPIGSQGDIGPPGEQGPPGLPGKPGR-- 386
            |.||.|      ||||:..|    .:|      ..|||..|.:|:.|.||.||||||||.||.  
Human   339 GDTGPP------GPPGLVIPRPGTGITIGEKGNIGLPGLPGEKGERGFPGIQGPPGLPGPPGAAV 397

  Fly   387 RGPIGLAGQSGDPGLNGSRGPPGRSERGEAGDYGFIGPPGPQGPPGEAGLPGRYGLHG------- 444
            .||.|..|..|:.|..|..||||.|         ..||||..|.||..||||..|..|       
Human   398 MGPPGPPGFPGERGQKGDEGPPGIS---------IPGPPGLDGQPGAPGLPGPPGPAGPHIPPSD 453

  Fly   445 ---EPGQNVVGPKGEPGLNGQPGLEGYRGDRGEV----------GLPGDKGLPGEGYNIVGPPGS 496
               |||.  .||.|.||..|..|.:|.:||:|:.          |.||..||||    :.|||||
Human   454 EICEPGP--PGPPGSPGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPGQPGLPG----LPGPPGS 512

  Fly   497 QGPPGFRGLPGDDGYNGLRGLPGEKGLRGDDCPVCNAGPRGPRGQEGD-TGYPGSHGNRGAIGLT 560
            .|.||.:|..|..|..|.:||||..|..|  .|    |..|.:|:.|| ..:||..|::|.:|..
Human   513 LGFPGQKGEKGQAGATGPKGLPGIPGAPG--AP----GFPGSKGEPGDILTFPGMKGDKGELGSP 571

  Fly   561 GPRGVQGLQGNPGRAGHKGLPGPAGIPGEPGKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDT 625
            |..|:.||.|.||:.|..|||||.|.||                 |...|||.|..|:.|..|..
Human   572 GAPGLPGLPGTPGQDGLPGLPGPKGEPG-----------------GITFKGERGPPGNPGLPGLP 619

  Fly   626 GDDGEKGRDGSDGSKGERGETGQRGDYGDAGYQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGY 690
            |:.|..|..|.       |..|..|:.|..|..|..|:||..|..|.||:..|        :||.
Human   620 GNIGPMGPPGF-------GPPGPVGEKGIQGVAGNPGQPGIPGPKGDPGQTIT--------QPGK 669

  Fly   691 DGIKGERGDDGDTGFKGVKGEPNPGQIYDNTGEPGEDGYTGPKGVKGAKGEQG--AIGLRGEIGD 753
            .|:.|..|.|||.|.               .|:||..|..|..|:.|:|||.|  .|||.|..|.
Human   670 PGLPGNPGRDGDVGL---------------PGDPGLPGQPGLPGIPGSKGEPGIPGIGLPGPPGP 719

  Fly   754 RGPAGEVIPGPVGAKGYPGPTGDYGQQGAPGLPGRDGEPGLDGGIGYKGQRGVPGQEVIQGEIGP 818
            :|..|  ||||.||.|.||..|..|..|.||.||..|||    |....|..|.||....:|.:||
Human   720 KGFPG--IPGPPGAPGTPGRIGLEGPPGPPGFPGPKGEP----GFALPGPPGPPGLPGFKGALGP 778

  Fly   819 PGRSGIKGFPGDVGAPGQYGLAGRPGPKGVKGEQGPDGAVGQTGLPGNKGQRGDFLVGPPGPKGQ 883
               .|.:||||..|.||:.||.|.|||||..|..|..|.:|..||||...|      |||||.|.
Human   779 ---KGDRGFPGPPGPPGRTGLDGLPGPKGDVGPNGQPGPMGPPGLPGIGVQ------GPPGPPGI 834

  Fly   884 PGRNGRQAPHGAKGQKGEVGSLGQN--GQNGAKGSIGFSGRRGLLGNAGLQGLPGSPGIPGLPGM 946
            ||..|:...||..|:||:.|..|.:  |..|.:||.|..|..|.:|.      |||||:||..|.
Human   835 PGPIGQPGLHGIPGEKGDPGPPGLDVPGPPGERGSPGIPGAPGPIGP------PGSPGLPGKAGA 893

  Fly   947 IGEIGERGEIGYNGRQGDIGPRGPNGEFGPKGLSGDDGPDGYPGANGLPGRKGETGNPGFPGRPG 1011
            .|..|.:||:|..|..|..||.|..|..|..||.||||..|.||..|..|.||..|.||.||.||
Human   894 SGFPGTKGEMGMMGPPGPPGPLGIPGRSGVPGLKGDDGLQGQPGLPGPTGEKGSKGEPGLPGPPG 958

  Fly  1012 AKGVAAYSGIKGDDGESGL------TGPIGYPGAPGAKGQRGPVGDSQPALDGVAGRKGEVGSPG 1070
            ... ....|.||:.||.||      :||.||.|.||..||.|..|  ||.|.|..|.||..|.||
Human   959 PMD-PNLLGSKGEKGEPGLPGIPGVSGPKGYQGLPGDPGQPGLSG--QPGLPGPPGPKGNPGLPG 1020

  Fly  1071 PNGLPGRHGLKGQRGDRGLPGQQGRPGEPGAKGLGGYPGRNGINGLKG--------ATGFPGPQG 1127
            ..||.|..||||..||.|.||.||..|.||..|:.|.||..|:.|.||        :.|.||..|
Human  1021 QPGLIGPPGLKGTIGDMGFPGPQGVEGPPGPSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPG 1085

  Fly  1128 PKGPQGESGVVGLDGRNGQIGDQGPRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRSFYRGFTGD 1192
            |||..|..|..|..|..|.:||.|..||.|..|.:|:.|..|..|.||.    .......|..|:
Human  1086 PKGEPGLPGYPGNPGIKGSVGDPGLPGLPGTPGAKGQPGLPGFPGTPGP----PGPKGISGPPGN 1146

  Fly  1193 QGLQGERGEQGDMGPIGFIGPPGAKGERGDIGYAGQLGFDGAEGLKGFQGDQGPRGPPGITLPAE 1257
            .||.||.|..|..|..|..||||.||:.|..|..|..|..|..|..|| |:.||.|.||  |..:
Human  1147 PGLPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGEPGQPGF-GNPGPPGLPG--LSGQ 1208

  Fly  1258 KGDEGVAGLDGRAGRPGHFGQKGAPGPPGENGPNGAIGHRGPQIQGP---PGPQGDVGFPGAPGH 1319
            |||.|:.|:.|..|.||..|:.|..|.||..||.|..|..||.::||   |||||..|.||..|.
Human  1209 KGDGGLPGIPGNPGLPGPKGEPGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQGPPGRPGPTGF 1273

  Fly  1320 NGRHGLIGPKGELGDMGRQGERGESGY----AIVGRQGDIGDIGFQGEPGWDGAKGEQGYPGLPG 1380
            .|..|..||.|..|:.|.:||:|..|.    .:.|.:||.|..|.||.||..|..|.:|.|||||
Human  1274 QGLPGPEGPPGLPGNGGIKGEKGNPGQPGLPGLPGLKGDQGPPGLQGNPGRPGLNGMKGDPGLPG 1338

  Fly  1381 KNGRVGAPGPRGPTGDAGWGGIDGMDGLVGPKGQPGV--TYSYSMARPGDRGEPGLDGFQGEEGD 1443
            .   .|.||.:||:|..|..|.:|..||:||.|.||:  ....|:...||.|.||:   .|:.|.
Human  1339 V---PGFPGMKGPSGVPGSAGPEGEPGLIGPPGPPGLPGPSGQSIIIKGDAGPPGI---PGQPGL 1397

  Fly  1444 GGAPGLIGFQGQRGAVGYRGDQGEVGYTGADGPQGQRGDKGYMGLTGAPGLRGLPGPQG-EPAPA 1507
            .|.||..|.||..|..|..||.|..|..|.||..|::||.|..|..|..||.|.|||.| :..|.
Human  1398 KGLPGPQGPQGLPGPTGPPGDPGRNGLPGFDGAGGRKGDPGLPGQPGTRGLDGPPGPDGLQGPPG 1462

  Fly  1508 PPAPKS--RGFIFARHSQSVHVPQCPANTNLLWEGYSL---SGNVAASRAVGQDLGQSGSCMMRF 1567
            ||...|  .||:..||||:...||||..|..::||:||   .||   .||.|||||.:|||:.||
Human  1463 PPGTSSVAHGFLITRHSQTTDAPQCPQGTLQVYEGFSLLYVQGN---KRAHGQDLGTAGSCLRRF 1524

  Fly  1568 TTMPYMLCDITNVCHFAQNNDDSLWLSTAEPMPMTMTPIQGRDLMKYISRCVVCETTTRIIALHS 1632
            :|||:|.|:|.|||:||..||.|.||||.|||||:|.|::|:.:..:||||.|||....:||:||
Human  1525 STMPFMFCNINNVCNFASRNDYSYWLSTPEPMPMSMQPLKGQSIQPFISRCAVCEAPAVVIAVHS 1589

  Fly  1633 QSMSIPDCPGGWEEMWTGYSYFMSTLDNVGGVGQNLVSPGSCLEEFRAQPVIECHGHGRCNYYDA 1697
            |::.||.||.||:.:|.|||:.|.|.....|.||.|.||||||||||:.|.|||||.|.||||..
Human  1590 QTIQIPHCPQGWDSLWIGYSFMMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRGTCNYYAN 1654

  Fly  1698 LASFWLTVIEEQDQFVQPRQQTLKA-DFTSKISRCTVCRRR 1737
            ..||||..::..|.|.:|:.:|||| |..::||||.||.:|
Human  1655 SYSFWLATVDVSDMFSKPQSETLKAGDLRTRISRCQVCMKR 1695

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
vkgNP_001260071.1 Collagen 60..119 CDD:189968 28/58 (48%)
Collagen 102..152 CDD:189968 26/49 (53%)
Collagen 277..334 CDD:189968 29/57 (51%)
Collagen 534..593 CDD:189968 26/59 (44%)
Collagen 814..871 CDD:189968 28/56 (50%)
Collagen 957..1014 CDD:189968 28/56 (50%)
Collagen 990..1049 CDD:189968 29/64 (45%)
Collagen 1070..1128 CDD:189968 29/65 (45%)
C4 1515..1624 CDD:128421 62/111 (56%)
C4 1625..1737 CDD:128421 60/112 (54%)
COL4A5XP_011529151.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 133 1.000 Domainoid score I5070
eggNOG 1 0.900 - - E33208_3BAFZ
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41315at33208
OrthoFinder 1 1.000 - - FOG0000443
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100768
Panther 1 1.100 - - O PTHR24023
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.820

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