DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and COL4A2

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	NP_001837.2	Gene:	COL4A2 / 1284	HGNCID:	2203	Length:	1712	Species:	Homo sapiens

Alignment Length:	1894	Identity:	764/1894 - (40%)
Similarity:	929/1894 - (49%)	Gaps:	347/1894 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RDLRHLSG-------LLGVVYLLGSLVSVTLA---------DGKICNTTLCDCKGIKGRMGAPGP 52
            ||.|.::|       |||.| .:|.|....||         .|:.|:.. |.|...||..|.|||
Human     3 RDQRAVAGPALRRWLLLGTV-TVGFLAQSVLAGVKKFDVPCGGRDCSGG-CQCYPEKGGRGQPGP 65

  Fly    53 IGVPGLEGPAGDIGPPGRAGPLGEKGDVGEYGEQGEKGHRGDIGPKGEMGYPGIMGKSGEPGTPG 117
            :|..|..||.|..|.||..   |.|||.||.|..|..|.:||:|.:|..|:||..|..|.||..|
Human    66 VGPQGYNGPPGLQGFPGLQ---GRKGDKGERGAPGVTGPKGDVGARGVSGFPGADGIPGHPGQGG 127

  Fly   118 PR---GIDGCDGRPGMQGPSGAPGQNGVRGPP---GKPGQQGPP------------GEAGEGG-I 163
            ||   |.|||:|..|..||.|.||..|..|||   |..||:|.|            ||.||.| :
Human   128 PRGRPGYDGCNGTQGDSGPQGPPGSEGFTGPPGPQGPKGQKGEPYALPKEERDRYRGEPGEPGLV 192

  Fly   164 NSKGTKGNRGETGQ---------PGGVGPPGFDGDRGSKGDTGYAGLTGEKGDPGLPGPKG---D 216
            ..:|..|..|..||         ||..||||..|.:|::| .|:.|:.|||||.|.|||.|   |
Human   193 GFQGPPGRPGHVGQMGPVGAPGRPGPPGPPGPKGQQGNRG-LGFYGVKGEKGDVGQPGPNGIPSD 256

  Fly   217 T-------GAVSELPYSLIGPPGAKGEPGDSLSGV-LKPDDTLKGY---KGYVGL---------- 260
            |       ..|:..|....|..|::||||  :.|: ||.::.:.|:   :||.||
Human   257 TLHPIIAPTGVTFHPDQYKGEKGSEGEPG--IRGISLKGEEGIMGFPGLRGYPGLSGEKGSPGQK 319

  Fly   261 --------QGDEGPQGPTGEQGAVGRNGLP----------GARGEIGGPGERGKPGKDGEPGRFG 307
                    ||.:||:||.||.|..|..|||          ||||:.|.||.:|:||..|||   |
Human   320 GSRGLDGYQGPDGPRGPKGEAGDPGPPGLPAYSPHPSLAKGARGDPGFPGAQGEPGSQGEP---G 381

  Fly   308 DKGMKGAPGWTGADG--LDGSPGERGEDGFTGMPGVQGGAGPPGIYDPSLTKSLPGPIGSQGDIG 370
            |.|:.|.||.:..||  ..|.|||.|..||.|.||:      |.:|.        ||.|..|..|
Human   382 DPGLPGPPGLSIGDGDQRRGLPGEMGPKGFIGDPGI------PALYG--------GPPGPDGKRG 432

  Fly   371 PPGEQGPPGLPGKPGRRGPI----GLAGQSGDPGLNGS---RGPPG-RSERGEA----GDYGFIG 423
            ||   |||||||.||..|.:    |..|::|.|||.||   |||.| :.:.||.    ||....|
Human   433 PP---GPPGLPGPPGPDGFLFGLKGAKGRAGFPGLPGSPGARGPKGWKGDAGECRCTEGDEAIKG 494

  Fly   424 PPGPQGPPGEAGLPGRYGLHGEPGQNVVGPKGEPGLNGQPGLEGYRGDRGEVGLPGDKGLPGEGY 488
            .||..||.|.|      |::||||:.  |.:|:||.:|.||..|.:|..|.:|.||.||..|:..
Human   495 LPGLPGPKGFA------GINGEPGRK--GDRGDPGQHGLPGFPGLKGVPGNIGAPGPKGAKGDSR 551

  Fly   489 NIV-----GPPGSQGPPGFRGLPGDDGYNGLRGLPGEKGLRGDDCPVCNAGPRGPRGQEGDTGYP 548
            .|.     |.||..|.||.:|..|..|.:||.|.||..|..||          |.:|..||.|||
Human   552 TITTKGERGQPGVPGVPGMKGDDGSPGRDGLDGFPGLPGPPGD----------GIKGPPGDPGYP 606

  Fly   549 GSHGNRGAIGLTGPRGVQGLQGNPGRAGHKGLPGPAGIPGEPGKVGAAGPDGKAIEVG---SLRK 610
            |..|.:|..|..||.|:    |.||..|.:|.||.||:||.||.:|..||.|...::.   .:::
Human   607 GIPGTKGTPGEMGPPGL----GLPGLKGQRGFPGDAGLPGPPGFLGPPGPAGTPGQIDCDTDVKR 667

  Fly   611 GEIGDTGDSGHRGDTGDDGEKGRDGSDGSKGERGETGQRGDYGDAGYQGRDGEPGRDGRDGAPGR 675
            ...||..::...|..|     |..|..|..|..|.||.:|..|..|:.|.||.||..|..|..||
Human   668 AVGGDRQEAIQPGCIG-----GPKGLPGLPGPPGPTGAKGLRGIPGFAGADGGPGPRGLPGDAGR 727

  Fly   676 NATTPKVYLIGEPGYDGIKGERGDDGDTGFKGVKGEPNPGQIYDNTGEPGEDGYTG-----PKGV 735
            .         |.||..|..|.||..|..|..|..|.|.|..:....|.|||.|..|     ..|.
Human   728 E---------GFPGPPGFIGPRGSKGAVGLPGPDGSPGPIGLPGPDGPPGERGLPGEVLGAQPGP 783

  Fly   736 KGAKGEQGAIGLRGEIGDRGPAGEVIPGPVGAKGYPGPTGDYGQQGAPGLPGRDGEPGLDGGIGY 800
            :|..|..|..||:|..|||||     ||..|::|.||..|..||   |||||..|:|||.|..|.
Human   784 RGDAGVPGQPGLKGLPGDRGP-----PGFRGSQGMPGMPGLKGQ---PGLPGPSGQPGLYGPPGL 840

  Fly   801 KGQRGVPGQEVIQGEIGPPGRSGIKGFPGDVGAPGQYGLAGRPGPKGVKGEQGPDGAVGQTGLPG 865
            .|..|.||||   |.:|.||..|.:|.|||.|.||..|..|..|.||:.|::|..|..|:.|.||
Human   841 HGFPGAPGQE---GPLGLPGIPGREGLPGDRGDPGDTGAPGPVGMKGLSGDRGDAGFTGEQGHPG 902

  Fly   866 NKGQRG-DFLVGPPGPK---GQPGRNGRQAPHGAKGQKGEVGSLGQNGQNGAKGSIGFSGRRGLL 926
            :.|.:| |.:.|.||.|   |.||.:|.|...|.||:.|..||.|:      .|..|..|.:||.
Human   903 SPGFKGIDGMPGTPGLKGDRGSPGMDGFQGMPGLKGRPGFPGSKGE------AGFFGIPGLKGLA 961

  Fly   927 GNAGLQGLPGSPGIPG-----LPGMIGEIGERGEIGYNGRQGDIGPRGPNGEFGPKGLSGDDGPD 986
            |..|.:|..|.||.||     ||||....||:         ||.||.|..|..|.||:.|..|..
Human   962 GEPGFKGSRGDPGPPGPPPVILPGMKDIKGEK---------GDEGPMGLKGYLGAKGIQGMPGIP 1017

  Fly   987 GYPGANGLPGR-------KGETGNPGFPGRPGAKGVAAYSGIKGDDGESGLTGPIGYPGAPGAKG 1044
            |..|..|||||       ||:.|.||.||.||..|||         |..|:|   |:||..|::|
Human  1018 GLSGIPGLPGRPGHIKGVKGDIGVPGIPGLPGFPGVA---------GPPGIT---GFPGFIGSRG 1070

  Fly  1045 QRGPVGDSQPALDGVAGRKGEVGSPGPNG-------LPGRHGLKGQRGDRGLPGQQGRPGEPGAK 1102
            .:|        ..|.||..||:|:.|..|       ||||.||||:||..|:||.:|..||.|.:
Human  1071 DKG--------APGRAGLYGEIGATGDFGDIGDTINLPGRPGLKGERGTTGIPGLKGFFGEKGTE 1127

  Fly  1103 GLGGYPGRNGIN------GLKGATGFPGPQGPKGPQGESGVVGLDGRNGQIGDQGPRGLIGEQGE 1161
            |..|:||..|:.      ||||.|||||..||.|.|||.|.:||.|..|..|..|..||.|..|.
Human  1128 GDIGFPGITGVTGVQGPPGLKGQTGFPGLTGPPGSQGELGRIGLPGGKGDDGWPGAPGLPGFPGL 1192

  Fly  1162 QGEQGDEGEVGIPGRLENLRDRSFYRGFT--------GDQGLQGERGEQGDMGPIGFI-GPPGAK 1217
            :|.:|..   |:||.          :||.        ||.|..|..||:||.|....: ||.|..
Human  1193 RGIRGLH---GLPGT----------KGFPGSPGSDIHGDPGFPGPPGERGDPGEANTLPGPVGVP 1244

  Fly  1218 GERGDIGYAGQLGFDGAEGLKGFQGDQGPRGPPGITLPAEKGDEGVAGLDGRAGRPGHFGQKGAP 1282
            |::||.|..|:.|..|:.||:||         ||||.|:     .::|..|..|.||.||.||..
Human  1245 GQKGDQGAPGERGPPGSPGLQGF---------PGITPPS-----NISGAPGDKGAPGIFGLKGYR 1295

  Fly  1283 GPPGENGPNGAIGHRGPQIQGPPGPQGDVGFPGAPGHNGRHGLI---GPKGELGDMGRQGERGES 1344
            ||||..| :.|:          ||.:||.|.|||||..|..|..   ||:|..|..|..||:|..
Human  1296 GPPGPPG-SAAL----------PGSKGDTGNPGAPGTPGTKGWAGDSGPQGRPGVFGLPGEKGPR 1349

  Fly  1345 GYAIVGRQGDIGDIGFQGEPGWDGAKGEQGYPGLPGKNGRVGAPGPRG-PTGDAGWGGIDGMDGL 1408
                 |.||.:|:.|..|..|..|.||.:|.||.||..|.|||||..| |.      .|....|.
Human  1350 -----GEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIAGIPQ------KIAVQPGT 1403

  Fly  1409 VGPKGQPGVTYSYSMARPGDRGEPGLDGFQGEEGDGGAPGLIGFQGQRGAV----GYRGDQGEVG 1469
            |||:|:.|        .||..||.|..|..||.|..||||..|.|| ||.|    |:|||:|.:|
Human  1404 VGPQGRRG--------PPGAPGEMGPQGPPGEPGFRGAPGKAGPQG-RGGVSAVPGFRGDEGPIG 1459

  Fly  1470 YTGADGPQGQRGDKGYMGLTGAPGLRGLPGPQGEPAPAPPAPKSRGFIFARHSQSVHVPQCPANT 1534
            :      ||..|.:|..|..|:|||.|:||          ...|.|::..:|||:...|.||...
Human  1460 H------QGPIGQEGAPGRPGSPGLPGMPG----------RSVSIGYLLVKHSQTDQEPMCPVGM 1508

  Fly  1535 NLLWEGYSLSGNVAASRAVGQDLGQSGSCMMRFTTMPYMLCDITNVCHFAQNNDDSLWLSTAEPM 1599
            |.||.||||.......:|..||||.:|||:.||:|||::.|:..:||::|..||.|.||||..|:
Human  1509 NKLWSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPL 1573

  Fly  1600 PMTMTPIQGRDLMKYISRCVVCETTTRIIALHSQSMSIPDCPGGWEEMWTGYSYFMSTLDNVGGV 1664
            |  |.|:...::..|||||.|||.....||:|||.:|||.||.||..:|.|||:.|.|.....|.
Human  1574 P--MMPVAEDEIKPYISRCSVCEAPAIAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAAGDEGG 1636

  Fly  1665 GQNLVSPGSCLEEFRAQPVIECH-GHGRCNYYDALASFWLTVIEEQDQFVQPRQQTLKAD-FTSK 1727
            ||:|||||||||:|||.|.|||: |.|.|:||....|||||.|.||.....|...||||. ..:.
Human  1637 GQSLVSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPEQSFQGSPSADTLKAGLIRTH 1701

  Fly  1728 ISRCTVCRR 1736
            ||||.||.:
Human  1702 ISRCQVCMK 1710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	27/58 (47%)
		Collagen	102..152	CDD:189968	27/55 (49%)
		Collagen	277..334	CDD:189968	30/68 (44%)
		Collagen	534..593	CDD:189968	27/58 (47%)
		Collagen	814..871	CDD:189968	25/56 (45%)
		Collagen	957..1014	CDD:189968	27/63 (43%)
		Collagen	990..1049	CDD:189968	27/65 (42%)
		Collagen	1070..1128	CDD:189968	33/70 (47%)
		C4	1515..1624	CDD:128421	50/108 (46%)
		C4	1625..1737	CDD:128421	61/114 (54%)
COL4A2	NP_001837.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..237		75/180 (42%)
		Collagen	67..121	CDD:189968	25/56 (45%)
		Triple-helical region	184..1484		579/1478 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	271..448		77/198 (39%)
		Collagen	293..346	CDD:189968	15/52 (29%)
		Collagen	493..548	CDD:189968	27/62 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	507..640		60/148 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	690..906		98/235 (42%)
		Collagen	791..849	CDD:189968	32/65 (49%)
		Collagen	821..880	CDD:189968	33/64 (52%)
		Collagen	857..916	CDD:189968	25/58 (43%)
		Collagen	896..950	CDD:189968	23/59 (39%)
		Collagen	1033..1088	CDD:189968	27/74 (36%)
		Collagen	1107..1165	CDD:189968	28/57 (49%)
		Collagen	1155..1212	CDD:189968	25/69 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1157..1480		151/386 (39%)
		Collagen	1341..1394	CDD:189968	26/57 (46%)
		C4	1490..1594	CDD:279721	47/105 (45%)
		C4	1598..1709	CDD:279721	60/110 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41315at33208
OrthoFinder	1	1.000	-	-		FOG0000443
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100768
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720