DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and Col5a2

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	NP_031763.2	Gene:	Col5a2 / 12832	MGIID:	88458	Length:	1497	Species:	Mus musculus

Alignment Length:	1648	Identity:	568/1648 - (34%)
Similarity:	687/1648 - (41%)	Gaps:	479/1648 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GIKGRMGAPGPIGVPGLEGPAGDIGPPGRAGPLGEKGDVGEYGEQGEKGHRGDIGPKGEMGYPG- 105
            ||:||   |||.|.||.:||.||.||.||.||.|.:|..||.|..|:.|..   ||.|...:||
Mouse   124 GIRGR---PGPAGPPGSQGPRGDRGPKGRPGPRGPQGIDGEPGVPGQPGAP---GPPGHPSHPGP 182

  Fly   106 --------------------------IMGKSGEPGTPGPRGIDGCDGRPGMQGPSGAPGQNGVRG 144
                                      :.|..|..|..||:|:.|..|..|..||.|.||:.|..|
Mouse   183 DGMSRPFSAQMAGLDEKSGLGSQVGLMPGSVGPVGPRGPQGLQGQQGGVGPAGPPGEPGEPGPMG 247

  Fly   145 PPGKPGQQGPPGEAGEGGINSKGTKGNRGE---TGQPGGVGPPGFDGDRGSKGDTGYAGLTGEKG 206
            |.|..|.:||||:.||.|  ..|..||.||   :|.||..|.||..|..|.||..|:.||.|.||
Mouse   248 PIGSRGPEGPPGKPGEDG--EPGRNGNTGEVGFSGSPGARGFPGAPGLPGLKGHRGHKGLEGPKG 310

  Fly   207 DPGLPGPKGDTGAVSELPYSLIGPPGAKGEPGDSLSGVLKPDDTLKGYKGYVGLQGDEGPQGPTG 271
            :.|.||.||:.|...  |...:||.|.:|.||:                     :|..||||..|
Mouse   311 EIGAPGAKGEAGPTG--PMGAMGPLGPRGMPGE---------------------RGRLGPQGAPG 352

  Fly   272 EQGAVGRNGLPGARGEIGGPGERGKPGKDGEPGRFGDKGMKGAPGWTGADGLDGSPGERGEDGFT 336
            ::||.|..|.||..|.:|.||..|.|         |:.||||..|.|||.|.:|..|:|||   |
Mouse   353 KRGAHGMPGKPGPMGPLGIPGSSGFP---------GNPGMKGEAGPTGARGPEGPQGQRGE---T 405

  Fly   337 GMPGVQGGAGPPGIYDPSLTKSLPGPIGSQGDIGPPGEQGPPGLPGKPGRRGPIGLAGQSGDPGL 401
            |.||..|..|.||......|....||.||.|..||||..||||.||..|..||.|:.|||||||:
Mouse   406 GPPGPAGSQGLPGAVGTDGTPGAKGPTGSAGTSGPPGLAGPPGSPGPQGSTGPQGIRGQSGDPGV 470

  Fly   402 NGSRGPPGRSERGEAGDYGFIGPPGPQGPPGEAGLPGRYGLHGEPGQNVVGPKGEPGLNGQPGLE 466
            .|.:|..|  .:||.|.:|.   .||.|||||.|..              ||:|:||..|.|
Mouse   471 PGFKGEAG--PKGEPGPHGI---QGPIGPPGEEGKR--------------GPRGDPGTVGPP--- 513

  Fly   467 GYRGDRGEVGLPGDKGLPGEGYNIVGPPGSQGPPGFRGLPGDDGYNGLRGLPGEKGLRGDDCPVC 531
                                     ||.|.:|.||.||.||.|      ||||.||.:|:..||
Mouse   514 -------------------------GPMGERGAPGNRGFPGSD------GLPGPKGAQGERGPV- 546

  Fly   532 NAGPRGPRGQEGDTGYPGSHGNRGAIGLTGPRGVQGLQGN------PGRAGHKGLPGPAGIPGEP 590
              |..||:|.:||.|.||..|..||.||||..||||.:|.      ||..|..|.||..||.|:|
Mouse   547 --GSSGPKGGQGDPGRPGEPGLPGARGLTGNPGVQGPEGKLGPLGAPGEDGRPGPPGSIGIRGQP 609

  Fly   591 GKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDTGDDGEKGRDGSDGSKGERGETGQRGDYGDA 655
            |.:|..||                                         ||..|:.|:.|:.|:|
Mouse   610 GSMGLPGP-----------------------------------------KGSSGDLGKPGEAGNA 633

  Fly   656 GYQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIKGERGDDGDTGFKGVKGEPNPGQIYDN 720
            |..|:.|.||:||..|..|.         :|.||..|.:||:|..|.|||:|:.|.|.|
Mouse   634 GVPGQRGAPGKDGEVGPSGP---------VGPPGLAGERGEQGPPGPTGFQGLPGPPGP------ 683

  Fly   721 TGEPGEDGYTGPKGVKGAKGEQGAIGLRGEIGDRGPAGEVIPGPVGAKGYPGPTGDYGQQGAPGL 785
               |||.|..|.:||.|..|..|.:|.|||                 :|.|      |::|.||:
Mouse   684 ---PGEGGKAGDQGVPGEPGAVGPLGPRGE-----------------RGNP------GERGEPGI 722

  Fly   786 PGRDGEPGLDGGIGYKGQRGVPGQEVIQGEIGPPGRSGIKGFPGDVGAPGQYGLAGRPGPKGVKG 850
            .|..||.|:.||.|..|.:|.||.....|:.||||..|:         ||:.|:||.|||||.:|
Mouse   723 TGLPGEKGMAGGHGPDGPKGNPGPTGTIGDTGPPGLQGM---------PGERGIAGTPGPKGDRG 778

  Fly   851 EQGPDGAVGQTGLPGNKGQRGDFLVGPPGPKGQPGRNGRQAPHGAKGQKGEVGSLGQNGQNGAKG 915
            ..|..||.|..|..|.:|..|.  :|||||.|..|..|...|.|..|..|..|:.|..|:||..|
Mouse   779 GIGEKGAEGTAGNDGARGLPGP--LGPPGPAGPTGEKGEPGPRGLVGPPGSRGNPGSRGENGPTG 841

  Fly   916 SIGFSGRRGLLGNAGLQGLPGSPGIPGLPGMIGEIGERGEIGYNGRQGDIGPRGPNGEFGPKGLS 980
            ::||         ||.||..|.||:.|.|   ||.|::|:.|..|.||..|..||:|..|..||.
Mouse   842 AVGF---------AGPQGPDGQPGVKGEP---GEPGQKGDAGSPGPQGLAGSPGPHGPHGVPGLK 894

  Fly   981 GDDGPDGYPGANGLPGRKGETGNPGFPGRPGAKGVAAYSGIKGDDGESGLTGPIGYPGAPGAKGQ 1045
            |..|..|.|||.|.||..|..|.||..|.||..|.|      |:.|:.|..|..|.||:.|..|.
Mouse   895 GGRGTQGPPGATGFPGSAGRVGPPGPAGAPGPAGPA------GEPGKEGPPGLRGDPGSHGRVGD 953

  Fly  1046 RGPVGDSQPALDGVAGRKGEVGSPGPNGLPGRHGLKGQRGDRGLPGQQGRPGEPGAKGLGGYPGR 1110
            |||.|  .|...|..|..||.|.|||:|.||..|..||||..|:|||:|..|.||..|..|.||:
Mouse   954 RGPAG--PPGSPGDKGDPGEDGQPGPDGPPGPAGTTGQRGIVGMPGQRGERGMPGLPGPAGTPGK 1016

  Fly  1111 NGINGLKGATGFPGPQGPKGPQGESGVVGLDGRNGQIGDQGPRGLIGEQGEQGEQGDEGEVGIPG 1175
            .|..   ||||..||.||.||.|.         ||.:|:.||            :|..|..|.||
Mouse  1017 VGPT---GATGDKGPPGPVGPPGS---------NGPVGEPGP------------EGPAGNDGTPG 1057

  Fly  1176 RLENLRDRSFYRGFTGDQGLQGERGEQGDMGPIGFIGPPGAKGERGDIGYAGQLGFDGAEGLKGF 1240
            |                                     .||.|||||
Mouse  1058 R-------------------------------------DGAVGERGD------------------ 1067

  Fly  1241 QGDQGPRGPPGITLPAEKGDEGVAGLDGRAGRPGHFGQKGAPGPPGENGPNGAIGHRGPQIQGPP 1305
            :||.||.|.|        |.:|..|..|..|.||..||:|.||..|..||.|..|.||  :.||.
Mouse  1068 RGDPGPAGLP--------GSQGAPGTPGPVGAPGDAGQRGEPGSRGPVGPPGRAGKRG--LPGPQ 1122

  Fly  1306 GPQGDVGFPGAPGHNGRHGLIGPKGELGDMGRQGERGESGYAIVGRQGDIGDIGFQGEPGWDGAK 1370
            ||:||                  ||:.||.|.:|::|..|:.           |.||.||..|..
Mouse  1123 GPRGD------------------KGDNGDRGDRGQKGHRGFT-----------GLQGLPGPPGPN 1158

  Fly  1371 GEQGYPGLPGKNGRVGAPGPRGPTGDAGWGGIDGMDGLVGPKGQPGVTYSYSMARPGDRGEPGLD 1435
            ||||..|:||..|..|.|||.||:|.      :|..|.:||.|.|||
Mouse  1159 GEQGSAGIPGPFGPRGPPGPVGPSGK------EGNPGPLGPIGPPGV------------------ 1199

  Fly  1436 GFQGEEGDGGAPGLIGFQGQRGAVGYRGDQGEVGYTGADGPQGQRGDKGYMGLTGAPGLRGLPGP 1500
                                         :|.||..|.:||.|:                  |||
Mouse  1200 -----------------------------RGSVGEAGPEGPPGE------------------PGP 1217

  Fly  1501 QGEPAPAPPAPKSRGFIFARHSQSVHVP--------QCPANTNLLWEGY-----SLSGNVAASRA 1552
            .|.|.|......:.|.|...:.:::..|        ..|.:||....|.     |||..:...|:
Mouse  1218 PGPPGPPGHLTAALGDIMGHYDENMPDPLPEFTEDQAAPDDTNKTDPGIHVTLKSLSSQIETMRS 1282

  Fly  1553 VGQDLGQSGSCMMRFTTMPYMLCDITNVCHFAQNNDDSLWLSTAEPMPMTMTPIQG--RDLMKYI 1615
                  ..||     ...|...||...:||..:.:.: .|:.          |.||  .|.:|
Mouse  1283 ------PDGS-----KKHPARTCDDLKLCHPTKQSGE-YWID----------PNQGSAEDAIK-- 1323

  Fly  1616 SRCVVCETTTRIIALHSQSMSIP 1638
               |.|...|....:.:...|:|
Mouse  1324 ---VYCNMETGETCISANPASVP 1343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	26/85 (31%)
		Collagen	102..152	CDD:189968	21/76 (28%)
		Collagen	277..334	CDD:189968	25/56 (45%)
		Collagen	534..593	CDD:189968	32/64 (50%)
		Collagen	814..871	CDD:189968	24/56 (43%)
		Collagen	957..1014	CDD:189968	27/56 (48%)
		Collagen	990..1049	CDD:189968	25/58 (43%)
		Collagen	1070..1128	CDD:189968	29/57 (51%)
		C4	1515..1624	CDD:128421	26/123 (21%)
		C4	1625..1737	CDD:128421	3/14 (21%)
Col5a2	NP_031763.2	VWC	40..95	CDD:214564
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..1265		545/1541 (35%)
		Cell attachment site. /evidence=ECO:0000255	141..143		0/1 (0%)
		Collagen	268..326	CDD:189968	27/59 (46%)
		Collagen	310..368	CDD:189968	26/80 (33%)
		Collagen	358..417	CDD:189968	31/70 (44%)
		Collagen	493..551	CDD:189968	34/108 (31%)
		Cell attachment site. /evidence=ECO:0000255	504..506		0/1 (0%)
		Collagen	523..581	CDD:189968	34/66 (52%)
		Collagen	589..647	CDD:189968	27/98 (28%)
		Collagen	700..757	CDD:189968	26/79 (33%)
		Collagen	730..787	CDD:189968	28/65 (43%)
		Collagen	817..875	CDD:189968	26/69 (38%)
		Cell attachment site. /evidence=ECO:0000255	942..944		0/1 (0%)
		Collagen	1042..1098	CDD:189968	30/130 (23%)
		Cell attachment site. /evidence=ECO:0000255	1065..1067		1/1 (100%)
		Cell attachment site. /evidence=ECO:0000255	1068..1070		0/1 (0%)
		Collagen	1072..1131	CDD:189968	31/86 (36%)
		Cell attachment site. /evidence=ECO:0000255	1125..1127		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	1134..1136		0/1 (0%)
		COLFI	1265..1496	CDD:279718	23/106 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1573
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810