DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment vkg and Col4a2

DIOPT Version :9

Sequence 1:NP_001260071.1 Gene:vkg / 33726 FlyBaseID:FBgn0016075 Length:1940 Species:Drosophila melanogaster
Sequence 2:NP_034062.3 Gene:Col4a2 / 12827 MGIID:88455 Length:1707 Species:Mus musculus


Alignment Length:1847 Identity:739/1847 - (40%)
Similarity:890/1847 - (48%) Gaps:282/1847 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 LLGSLVSVTLADGKICNTTL------------------CDCKGIKGRMGAPGPIGVPGLEGPAGD 64
            |.|.|:..|:..|.:..:.|                  |.|...||..|.||.:|..|..||.|.
Mouse    13 LRGWLLLATVTVGLLAQSVLGGVKKLDVPCGGRDCSGGCQCYPEKGARGQPGAVGPQGYNGPPGL 77

  Fly    65 IGPPGRAGPLGEKGDVGEYGEQGEKGHRGDIGPKGEMGYPGIMGKSGEPGTPGPRGIDGCDGRPG 129
            .|.||..   |.|||.||.|..|..|.:||:|.:|..|:||..|..|.||..||||..|.||..|
Mouse    78 QGFPGLQ---GRKGDKGERGVPGPTGPKGDVGARGVSGFPGADGIPGHPGQGGPRGRPGYDGCNG 139

  Fly   130 MQGPSGAPGQNGVRGPPGKPGQQGPPGEAGEGGINSKGTKGN-RGETGQPGGVGPPGFDGDRGSK 193
            .:|.:|..|.:|..|.||.||.|||.|:.||....||..:.. |||.|:||.||..|..|..|..
Mouse   140 TRGDAGPQGPSGSGGFPGLPGPQGPKGQKGEPYALSKEDRDKYRGEPGEPGLVGYQGPPGRPGPI 204

  Fly   194 GDTGYAGLTGEKGDPGLPGPKGDTGAVSELPYSLIGPPGAKGEPGDSLSGVLKPDDTLKGYKGYV 258
            |..|..|..|..|.||.|||||..|...      :|..|.|||.||.            |..|..
Mouse   205 GQMGPMGAPGRPGPPGPPGPKGQPGNRG------LGFYGQKGEKGDI------------GQPGPN 251

  Fly   259 GLQGDEGPQGPT----------GEQGAVGRNGLPG--ARGE---IGGPGERGKPGKDGEPGRFGD 308
            |:..|....|||          ||:|..|..|:||  ::||   :|.||.||.||.|||.|..|.
Mouse   252 GIPSDITLVGPTTSTIHPDLYKGEKGDEGEQGIPGVISKGEEGIMGFPGIRGFPGLDGEKGVVGQ 316

  Fly   309 KGMKGAPGWTGADGLDGSPGERGEDGFTGMPGVQGGAGPPGIYD--PSLTKSLPGPIGSQGDIGP 371
            ||.:|..|:.|..|..|..|||||.   |.||       |.:|.  |||.|...|..|.||..|.
Mouse   317 KGSRGLDGFQGPSGPRGPKGERGEQ---GPPG-------PSVYSPHPSLAKGARGDPGFQGAHGE 371

  Fly   372 PGEQGPPGLPGKPGRRGPI--------GLAGQSGDPGLNGSRGPPGRSERGEAGDYGFIGPPGPQ 428
            ||.:|.||.||..|..||.        ||.|:.|..|.:|..|.|.|    ..|..|..|.||||
Mouse   372 PGSRGEPGEPGTAGPPGPSVGDEDSMRGLPGEMGPKGFSGEPGSPAR----YLGPPGADGRPGPQ 432

  Fly   429 GPPGEAGLPG----RYGLHGEPGQ-NVVGPKGEPGLNGQPGLEGYRGD--RGEV-----GLPGDK 481
            |.||.||.||    .:||.|..|: ...||.|.||..||.|.:|..||  .|:|     ||||.|
Mouse   433 GVPGPAGPPGPDGFLFGLKGSEGRVGYPGPSGFPGTRGQKGWKGEAGDCQCGQVIGGLPGLPGPK 497

  Fly   482 GLPGEGYNIVGPPGSQGPPGFRGLPGDDGYN---GLRGLPGEKGLRGDDCPVCNAGPRGP----- 538
            |.||....: |..|.||.||..|:||..|:.   |:.|.||.||::||...:...|.||.     
Mouse   498 GFPGVNGEL-GKKGDQGDPGLHGIPGFPGFKGAPGVAGAPGPKGIKGDSRTITTKGERGQPGIPG 561

  Fly   539 -RGQEGDTGYPGSHGNRGAIGLTGPRGVQGLQGNPGRAGHKGLPGPAGIPGE---PGKVGAAGPD 599
             .|.:||.|.||..|..|..||.||.| .|::|.||.||..|:||..|.||:   ||: |..|| 
Mouse   562 VHGMKGDDGVPGRDGLDGFPGLPGPPG-DGIKGPPGDAGLPGVPGTKGFPGDIGPPGQ-GLPGP- 623

  Fly   600 GKAIEVGSLRKGEIGDTGDSGHRGDTGDDGEKGRDGSDGSKGERGETGQRGDYGDA--------- 655
                      |||.|..||:|..|..|..|..|..|:.|.:.  .:||.:...|..         
Mouse   624 ----------KGERGFPGDAGLPGPPGFPGPPGPPGTPGQRD--CDTGVKRPIGGGQQVVVQPGC 676

  Fly   656 --GYQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIKGER------GDDGDTGFKGVKGEP 712
              |..|..|:||..|..||.|         :.|.||:.|..||:      ||.|..||.|..|..
Mouse   677 IEGPTGSPGQPGPPGPTGAKG---------VRGMPGFPGASGEQGLKGFPGDPGREGFPGPPGFM 732

  Fly   713 NPGQIYDNTGEPGEDGYTGPKGVKGAKGEQGAIGLRGEI-----GDRGPAGEVIPGPVGAKGYPG 772
            .|......||.||.||..||.|:.|..|..|..|:.||:     |.||.||  :||..|.||.||
Mouse   733 GPRGSKGTTGLPGPDGPPGPIGLPGPAGPPGDRGIPGEVLGAQPGTRGDAG--LPGQPGLKGLPG 795

  Fly   773 PTGD---YGQQGAPGLPGRDGEPGLDGGIGYKGQRGVPGQEVIQGEIGPPGRSGIKGFPGDVGAP 834
            .||.   .|.||.||:||..|:||..|..|..||.|.|||   .|..|.|||.      |.:|.|
Mouse   796 ETGAPGFRGSQGMPGMPGLKGQPGFPGPSGQPGQSGPPGQ---HGFPGTPGRE------GPLGQP 851

  Fly   835 GQYGLAGRPGPKGVKGEQGPDGAVGQTGLPGNKGQRGDFLVGPPGPKGQPGRNGRQAPHGAKGQK 899
            |..||.|.||.:|..|:.|..|.||..||.|::|..|  :.|..|..|.||..|.....|..|||
Mouse   852 GSPGLGGLPGDRGEPGDPGVPGPVGMKGLSGDRGDAG--MSGERGHPGSPGFKGMAGMPGIPGQK 914

  Fly   900 GEVGSLGQNGQNGAKGSIGFSGRRGLLGNAGLQGLPGSPGIPGLPGMIGEIGERGEIG------- 957
            |:.||.|.:|..|..|..|..|..|..|.||..|:||..|:||.||:.|..|:||..|       
Mouse   915 GDRGSPGMDGFQGMLGLKGRQGFPGTKGEAGFFGVPGLKGLPGEPGVKGNRGDRGPPGPPPLILP 979

  Fly   958 ----YNGRQGDIGPRGPNGEFGPKGLSGDDGPDGYPGANGLPGR-------KGETGNPGFPGRPG 1011
                ..|.:||.||.|..|..|.||:.|..|..|..|..|||||       ||:.|.||.||.||
Mouse   980 GMKDIKGEKGDEGPMGLKGYLGLKGIQGMPGVPGVSGFPGLPGRPGFIKGVKGDIGVPGTPGLPG 1044

  Fly  1012 AKGVAAYSGIKGDDGESGLTGPIGYPGAPGAKGQRGPVGDSQPALDGVAGRKGEVGSPGPNGLPG 1076
            ..||:...||.|..|.:|..|..|.||..|..|:.||.||.           |::|.  ...|||
Mouse  1045 FPGVSGPPGITGFPGFTGSRGEKGTPGVAGVFGETGPTGDF-----------GDIGD--TVDLPG 1096

  Fly  1077 RHGLKGQRGDRGLPGQQGRPGEPGAKGLGGYPGRNGI------NGLKGATGFPGPQGPKGPQGES 1135
            ..||||:||..|:||.:|..||.||.|..|:||..|:      .||||.|||||..|.:|||||.
Mouse  1097 SPGLKGERGITGIPGLKGFFGEKGAAGDIGFPGITGMAGAQGSPGLKGQTGFPGLTGLQGPQGEP 1161

  Fly  1136 GVVGLDGRNGQIGDQGPRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRSFYRGFTGDQGLQGERG 1200
            |.:|:.|..|..|..|..||   .|..|.:|..|..|:||.          :||.|..|:...  
Mouse  1162 GRIGIPGDKGDFGWPGVPGL---PGFPGIRGISGLHGLPGT----------KGFPGSPGVDAH-- 1211

  Fly  1201 EQGDMGPIGFIGPPGAKGERGDIG-YAGQLGFDGAEGLKGFQGDQGPRGPPGIT-LPAEKGDEGV 1263
                 |..||.||.|.:|:||:.. ..|.:|..|.:|.:|..|::||.|.||:. .|.......:
Mouse  1212 -----GDPGFPGPTGDRGDRGEANTLPGPVGVPGQKGERGTPGERGPAGSPGLQGFPGISPPSNI 1271

  Fly  1264 AGLDGRAGRPGHFGQKGAPGPPGENGPNGAIGHRGPQIQGPPGPQGDVGFPGAPGHNGRHGLIGP 1328
            :|..|..|.||.||.:|..||||..|||..     |.|:|..|..|..||||..|..|..|..|.
Mouse  1272 SGSPGDVGAPGIFGLQGYQGPPGPPGPNAL-----PGIKGDEGSSGAAGFPGQKGWVGDPGPQGQ 1331

  Fly  1329 KGELGDMGRQGERGESGYAIVGRQGDIGDIGFQGEPGWDGAKGEQGYPGLPGKNGRVGAPG-PR- 1391
            .|.||..|.:|.:||.|:     .|:.|..|..|:.|..|.||:||:||.||..|..|.|| |: 
Mouse  1332 PGVLGLPGEKGPKGEQGF-----MGNTGPSGAVGDRGPKGPKGDQGFPGAPGSMGSPGIPGIPQK 1391

  Fly  1392 -----GPTGDAGWGGIDGMDGLVGPKGQPGVTYSYSMARPGDRGEPGLDGFQGEEGDGGAPGLIG 1451
                 |..|..|..|:.|..|.:||:|.||        .||.||.||..|.||..|....|    
Mouse  1392 IAVQPGTLGPQGRRGLPGALGEIGPQGPPG--------DPGFRGAPGKAGPQGRGGVSAVP---- 1444

  Fly  1452 FQGQRGAVGYRGDQGEVGYTGADGPQGQRGDKGYMGLTGAPGLRGLPGPQGEPAPAPPAPKSRGF 1516
                    |:|||||.:|:   .||.||.|:.   |..|:|||.|:||          ...|.|:
Mouse  1445 --------GFRGDQGPMGH---QGPVGQEGEP---GRPGSPGLPGMPG----------RSVSIGY 1485

  Fly  1517 IFARHSQSVHVPQCPANTNLLWEGYSLSGNVAASRAVGQDLGQSGSCMMRFTTMPYMLCDITNVC 1581
            :..:|||:...|.||...|.||.||||.......:|..||||.:|||:.||:|||::.|:..:||
Mouse  1486 LLVKHSQTDQEPMCPVGMNKLWSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVC 1550

  Fly  1582 HFAQNNDDSLWLSTAEPMPMTMTPIQGRDLMKYISRCVVCETTTRIIALHSQSMSIPDCPGGWEE 1646
            ::|..||.|.||||..|:|  |.|:...::..|||||.|||.....||:|||..|||.||.||..
Mouse  1551 YYASRNDKSYWLSTTAPLP--MMPVAEEEIKPYISRCSVCEAPAVAIAVHSQDTSIPHCPAGWRS 1613

  Fly  1647 MWTGYSYFMSTLDNVGGVGQNLVSPGSCLEEFRAQPVIECH-GHGRCNYYDALASFWLTVIEEQD 1710
            :|.|||:.|.|.....|.||:|||||||||:|||.|.|||: |.|.|:|:....|||||.|.||:
Mouse  1614 LWIGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYFANKYSFWLTTIPEQN 1678

  Fly  1711 QFVQPRQQTLKAD-FTSKISRCTVCRR 1736
            ....|...||||. ..:.||||.||.:
Mouse  1679 FQSTPSADTLKAGLIRTHISRCQVCMK 1705

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
vkgNP_001260071.1 Collagen 60..119 CDD:189968 27/58 (47%)
Collagen 102..152 CDD:189968 24/49 (49%)
Collagen 277..334 CDD:189968 30/61 (49%)
Collagen 534..593 CDD:189968 30/67 (45%)
Collagen 814..871 CDD:189968 24/56 (43%)
Collagen 957..1014 CDD:189968 29/74 (39%)
Collagen 990..1049 CDD:189968 29/65 (45%)
Collagen 1070..1128 CDD:189968 31/63 (49%)
C4 1515..1624 CDD:128421 50/108 (46%)
C4 1625..1737 CDD:128421 60/114 (53%)
Col4a2NP_034062.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 60..253 89/213 (42%)
Collagen 67..121 CDD:189968 25/56 (45%)
Triple-helical region 184..1479 561/1443 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 266..476 92/223 (41%)
Collagen 312..387 CDD:189968 36/84 (43%)
Collagen 489..543 CDD:189968 24/54 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 524..900 156/412 (38%)
Collagen 783..842 CDD:189968 30/63 (48%)
Collagen 864..921 CDD:189968 24/58 (41%)
Collagen 900..959 CDD:189968 25/58 (43%)
Collagen 1007..1070 CDD:189968 27/62 (44%)
Collagen 1102..1161 CDD:189968 30/58 (52%)
Collagen 1147..1206 CDD:189968 28/71 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1195..1476 122/333 (37%)
Collagen 1324..1383 CDD:189968 26/63 (41%)
C4 1485..1589 CDD:279721 47/105 (45%)
C4 1594..1704 CDD:279721 59/109 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BAFZ
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41315at33208
OrthoFinder 1 1.000 - - FOG0000443
OrthoInspector 1 1.000 - - mtm8822
orthoMCL 1 0.900 - - OOG6_100768
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.720

Return to query results.
Submit another query.