DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and Col3a1

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	NP_034060.2	Gene:	Col3a1 / 12825	MGIID:	88453	Length:	1464	Species:	Mus musculus

Alignment Length:	1777	Identity:	608/1777 - (34%)
Similarity:	720/1777 - (40%)	Gaps:	525/1777 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ICNTTLCD---------------CKGIKGRMGAPGPIGVP---GLEGPAGDIGPPGRAGPLGEKG 78
            :|:..:||               |..|..:...|.|: :|   |.:||.||.||||..|..|:.|
Mouse    62 LCDDIICDEEPLDCPNPEIPFGECCAICPQPSTPAPV-LPDGHGPQGPKGDPGPPGIPGRNGDPG 125

  Fly    79 DVGEYGEQGEKGHRG-------------------DI--GPKGEMGYPGIMGKSGEPGTPGPRGID 122
            ..|:.|..|..|..|                   |:  |..|..||||..|..|.||.||..|..
Mouse   126 LPGQPGLPGPPGSPGICESCPTGGQNYSPQFDSYDVKSGVGGMGGYPGPAGPPGPPGPPGSSGHP 190

  Fly   123 GCDGRPGMQGPSGAPGQNGVRGPPGKPGQQGPPGEAGEGGINSK-GTKGNRGETGQPGGVGPPGF 186
            |..|.||.|||.|.|||.|..||||.||..||.|.||:.|.:.: |..|.||..|.||..||.|.
Mouse   191 GSPGSPGYQGPPGEPGQAGPAGPPGPPGALGPAGPAGKDGESGRPGRPGERGLPGPPGIKGPAGM 255

  Fly   187 DGDRGSKGDTGYAGLTGEKGDPGLPGPKGDTGAVSELPYSLIGPPGAKGEPGDSLSGVLKPDDTL 251
            .|..|.||..|:.|..||||:.|.||.||:.|.                 |||:
Mouse   256 PGFPGMKGHRGFDGRNGEKGETGAPGLKGENGL-----------------PGDN----------- 292

  Fly   252 KGYKGYVGLQGDEGPQGPTGEQGAVGRNGLPGARGEIGGPGERGKPGKDGEPGRFGDKGMKGAPG 316
                      |..||.||.|..|..||.|||||.|..|..|.|   |.||:|         |.||
Mouse   293 ----------GAPGPMGPRGAPGERGRPGLPGAAGARGNDGAR---GSDGQP---------GPPG 335

  Fly   317 WTGADGLDGSPGERGEDGFTGMPGVQGGAGPPGIYDPSLTKSLPGPIGSQGDIGPPGEQGPPGLP 381
            ..|..|..||||.:||.|..|.||..|..|..|         .|||.|..|..|||   ||||..
Mouse   336 PPGTAGFPGSPGAKGEVGPAGSPGSNGSPGQRG---------EPGPQGHAGAQGPP---GPPGNN 388

  Fly   382 GKPGRRGPIGLAGQSGDPGLNGSRGPPGRSERGEAGDYGFIGPPGPQGPPGEAGLPGRYGLHGEP 446
            |.||.:|.:|.||..|.|||.|:||||                    ||.|..|:||..|..|||
Mouse   389 GSPGGKGEMGPAGIPGAPGLIGARGPP--------------------GPAGTNGIPGTRGPSGEP 433

  Fly   447 GQNVVGPKGEPGLNGQPGLEGYRGDRGEVGLPGDKGLPGEGYNIVGPPGSQGPPGFRGLPGDDGY 511
            |:|  |.|||||.         ||:|||.|.|             |.||.:|..|..|.||:.|.
Mouse   434 GKN--GAKGEPGA---------RGERGEAGSP-------------GIPGPKGEDGKDGSPGEPGA 474

  Fly   512 NGLRGLPGEKGLRGDDCPVCNAGPRGPRGQEGDTGYPGSHGNRGAIGLTGPRGVQGLQGNPGRAG 576
            |||.|..||:            ||.|.||..|..|.||..|..|..|..||.|.:|:.|.|||.|
Mouse   475 NGLPGAAGER------------GPSGFRGPAGPNGIPGEKGPPGERGGPGPAGPRGVAGEPGRDG 527

  Fly   577 HKGLPGPAGIPGEPGKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDTGDDGEKGRDGSDGSKG 641
            ..|.||..|:||.||     ||                  |:.|..|..|..||.||.|..|..|
Mouse   528 TPGGPGIRGMPGSPG-----GP------------------GNDGKPGPPGSQGESGRPGPPGPSG 569

  Fly   642 ERGETGQRGDYGDAGYQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIKGERGDDGDTGFK 706
            .||:.|..            |.||..|.|||||:|...      |.||..|:.|..|.:|:||.:
Mouse   570 PRGQPGVM------------GFPGPKGNDGAPGKNGER------GGPGGPGLPGPAGKNGETGPQ 616

  Fly   707 GVKGEPNPGQIYDNTGEPGEDGYTGPKGVKGAKGEQGAIGLRGEIGDRGPAGEVIPGPVGAKGYP 771
            |..|...|      .|:.|:.|..||:|::|..|..|..|..|:.|:.||.||     |||.|.|
Mouse   617 GPPGPTGP------AGDKGDSGPPGPQGLQGIPGTGGPPGENGKPGEPGPKGE-----VGAPGAP 670

  Fly   772 GPTGDYGQQGAPGLPGRDGEPGLDGGIGYKGQRGVPGQEVIQGEIGPPGRSGIKGFPGDVGAPGQ 836
            |..||.|..|..|.||..|.||..||      .|.||.|..:|..||||..|..|.||..|.||:
Mouse   671 GGKGDSGAPGERGPPGTAGIPGARGG------AGPPGPEGGKGPAGPPGPPGASGSPGLQGMPGE 729

  Fly   837 YGLAGRPGPKGVKGEQGPDGAVGQTGLPGNKGQRGDF-LVGPPGPKGQPGRNGRQAPHGAKGQKG 900
            .|..|.|||||.|||  |.|| |..|:||..|.||.. .:|||||.|||
Mouse   730 RGGPGSPGPKGEKGE--PGGA-GADGVPGKDGPRGPAGPIGPPGPAGQP---------------- 775

  Fly   901 EVGSLGQNGQNGAKGSIGFSGRRGLLGNAGLQGLPGSPGIPGLPGMIGEIGERGEIGYNGRQGDI 965
                 |..|:.|:.|..|.:|.||..|..|..|.||..|.||.||..||.|.:||.|..|.:|:.
Mouse   776 -----GDKGEGGSPGLPGIAGPRGGPGERGEHGPPGPAGFPGAPGQNGEPGAKGERGAPGEKGEG 835

  Fly   966 GPRGPNGEFGPKGLSGDDGPDGYPGANGLPGRKGETGNPGFPGRPGAKGVAAYSGIKGDDGESGL 1030
            ||.||   .||.|.||..||   ||..|:.|.:|..|.||..|.||.:      |:.|..|.:|.
Mouse   836 GPPGP---AGPTGSSGPAGP---PGPQGVKGERGSPGGPGTAGFPGGR------GLPGPPGNNGN 888

  Fly  1031 TGPIGYPGAPGAKGQRGPVGDSQPALDGVAGRKGEVGSPGPNGLPGRHGLKGQRGDRGLPGQQGR 1095
            .||.|..||||..|..||.|:|              ||||..|:.|..|..||.|::|.||.||.
Mouse   889 PGPPGPSGAPGKDGPPGPAGNS--------------GSPGNPGIAGPKGDAGQPGEKGPPGAQGP 939

  Fly  1096 PGEPGAKGLGGYPGRNGINGLKGATGFPGPQGPKGPQ---GESGVVGLDGRNGQIGDQGPRGLIG 1157
            ||.||..|:.|.   .|..||.|..|.|||:|..|||   ||||..|..|.||:.|..||:||.|
Mouse   940 PGSPGPLGIAGL---TGARGLAGPPGMPGPRGSPGPQGIKGESGKPGASGHNGERGPPGPQGLPG 1001

  Fly  1158 EQGEQGEQGDEGEVGIPGRLENLRDRSFYRGFTGDQGLQGERGEQGDMGPIGFIGPPGAKGERGD 1222
            :.|..||         |||             .|:.|..|:.|..|.         ||.||:||:
Mouse  1002 QPGTAGE---------PGR-------------DGNPGSDGQPGRDGS---------PGGKGDRGE 1035

  Fly  1223 IGYAGQLGFDGAEGLKGFQGDQGPRGPPGITLPAEKGDEGVAGLDGRAGRPGHFGQKGAPGPPGE 1287
                                    .|.|                 |..|.|||      |||||.
Mouse  1036 ------------------------NGSP-----------------GAPGAPGH------PGPPGP 1053

  Fly  1288 NGPNGAIGHRGPQIQGPPGPQGDVGFPGAPGHNGRHGLIGPKGELGDMGRQGERGESGYAIVGRQ 1352
            .||:|..|.||.  .||.||.      ||||..|..|..||:|..||.|..||||.:|..
Mouse  1054 VGPSGKSGDRGE--TGPAGPS------GAPGPAGARGAPGPQGPRGDKGETGERGSNGIK----- 1105

  Fly  1353 GDIGDIGFQGEPGWDGAKGEQGYPGLPGKNGRVGAPGPRGPTGDAGWGGIDGMDGLVGPKGQPGV 1417
               |..||.|.|      |..|.||..|..|.:|:|||.||.|.            |||.|.|
Mouse  1106 ---GHRGFPGNP------GPPGSPGAAGHQGAIGSPGPAGPRGP------------VGPHGPP-- 1147

  Fly  1418 TYSYSMARPGDRGEPGLDGFQGEEGDGGAPGLIGFQGQRGAVGYRGDQGEVGYTGADGPQGQRGD 1482
                                 |::|..|.||.||..|.||..|.||.:|..|:.|..||.|..|.
Mouse  1148 ---------------------GKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGA 1191

  Fly  1483 KGYMGLTGAPGLRGLPGPQGEPAPAPPAPKSRGFIFARHSQSVHVPQCP----ANTNLLWEGY-S 1542
            .|.....||..:.|:.|           .||.||       |.:....|    .||..:.... |
Mouse  1192 PGPCCGGGAAAIAGVGG-----------EKSGGF-------SPYYGDDPMDFKINTEEIMSSLKS 1238

  Fly  1543 LSGNVAASRAVGQDLGQSGSCMMRFTTMPYMLCDITNVCHFAQNNDDSLWLSTAEPMPMTMTPIQ 1607
            ::|.:.:.      :...||     ...|...|.....|| .:......|:.          |.|
Mouse  1239 VNGQIESL------ISPDGS-----RKNPARNCRDLKFCH-PELKSGEYWVD----------PNQ 1281

  Fly  1608 G--RDLMKYISRCVVCETTTRIIALHSQSMSIP------DCPGGWEEMWTG--------YSY--- 1653
            |  .|.:|     |.|...|....:::..|::|      |.....:.:|.|        :||
Mouse  1282 GCKMDAIK-----VFCNMETGETCINASPMTVPRKHWWTDSGAEKKHVWFGESMNGGFQFSYGPP 1341

  Fly  1654 ------------FMSTL-----DNV---------------GGVGQNLVSPGSCLEEFRAQPVIEC 1686
                        |:..|     .|:               |.|.::|...||...||:|:
Mouse  1342 DLPEDVVDVQLAFLRLLSSRASQNITYHCKNSIAYMDQASGNVKKSLKLMGSNEGEFKAE----- 1401

  Fly  1687 HGHGRCNYYDALASFWLTVIEE 1708
             |:.:..|         ||:|:
Mouse  1402 -GNSKFTY---------TVLED 1413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	29/79 (37%)
		Collagen	102..152	CDD:189968	29/49 (59%)
		Collagen	277..334	CDD:189968	26/56 (46%)
		Collagen	534..593	CDD:189968	29/58 (50%)
		Collagen	814..871	CDD:189968	30/56 (54%)
		Collagen	957..1014	CDD:189968	25/56 (45%)
		Collagen	990..1049	CDD:189968	23/58 (40%)
		Collagen	1070..1128	CDD:189968	26/57 (46%)
		C4	1515..1624	CDD:128421	22/115 (19%)
		C4	1625..1737	CDD:128421	24/133 (18%)
Col3a1	NP_034060.2	VWC	33..89	CDD:278520	4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..1195		550/1462 (38%)
		Nonhelical region (N-terminal)	155..169		3/13 (23%)
		Triple-helical region	170..1195		528/1388 (38%)
		Collagen	233..292	CDD:189968	28/75 (37%)
		Collagen	278..331	CDD:189968	30/93 (32%)
		Collagen	353..422	CDD:189968	38/100 (38%)
		Collagen	413..472	CDD:189968	36/102 (35%)
		Collagen	449..502	CDD:189968	28/77 (36%)
		Collagen	1016..1095	CDD:189968	43/142 (30%)
		Collagen	1064..1135	CDD:189968	36/92 (39%)
		COLFI	1231..1463	CDD:279718	40/225 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900