DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and Col11a2

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	XP_006523622.1	Gene:	Col11a2 / 12815	MGIID:	88447	Length:	1820	Species:	Mus musculus

Alignment Length:	1452	Identity:	564/1452 - (38%)
Similarity:	670/1452 - (46%)	Gaps:	282/1452 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 VPGLEGPAGDIGPPGRAGPLGEKGDVGEYGEQGEK----------GHRGDIGPKGEMGYPGIMGK 109
            :|.||....|:    :..|..:.....||||.|..          |:..|...:.|:| |.:..:
Mouse   392 LPFLEEEQTDL----QVSPTADSFQAEEYGEGGTDSPAGFYDYTYGYGDDYREETELG-PALSAE 451

  Fly   110 SGEPG--TPGPRGIDGCDG-----RPGM--QGPSGAPGQNGVRGPPGKPGQQGPPGEAGEGGINS 165
            :...|  ..||||:.|..|     .|||  :||.|..|..|:.||||..|..||.|:.||
Mouse   452 TAHSGAVAHGPRGLKGEKGEPAVLEPGMFVEGPPGPEGPAGLAGPPGIQGNPGPVGDPGE----- 511

  Fly   166 KGTKGNRGETGQPGGVGPPGFDGDR-------GSKGDTGYAGLTGEKGD---------------- 207
               :|..|..|.||..||||..|..       ||.|        |:||.
Mouse   512 ---RGPPGRAGLPGSDGPPGPPGTSLMLPFRFGSSG--------GDKGPVVAAQEAQAQAILQQA 565

  Fly   208 ----PGLPGPKGDTGAVSELPYSLIGPPGAKGEPGDSLSGVLKPDDTLKGYKGYVGLQGDEGPQG 268
                .|.|||.|.||.           ||..|:||.               .|..|..||.||||
Mouse   566 RLALRGPPGPMGYTGR-----------PGPLGQPGS---------------PGLKGESGDLGPQG 604

  Fly   269 PTGEQGAVGRNGLPGARGEIGGPGERGKPGKDGEPGRFGDKGMKGAPGWTGADGLDGSPGERGED 333
            |.|.||..|..|..|.||..|..|.||.|   ||||..||:|.         |||.|.|||:|:.
Mouse   605 PRGPQGLTGPPGKAGRRGRAGADGARGMP---GEPGMKGDRGF---------DGLPGLPGEKGQR 657

  Fly   334 GFTGMPGVQGGAGPPGIYDPSLTKSLPGPIGSQGDIGPPGEQGPPGLPGKPGRRGPIGLAGQSGD 398
            |.||..|                  ||||.|..|:.|..||.||.||||:   .||.||.|..|.
Mouse   658 GDTGAQG------------------LPGPPGEDGERGDDGEIGPRGLPGE---SGPRGLLGPKGP 701

  Fly   399 PGLNGSRGPPG-RSERGEAGDYGFIGPPGPQGPPGEAGLPGRYGLHGEPGQNVVGPKGEPGLNGQ 462
            ||:   .|||| |...|..|..|.:||.|..||||:.|.||..||.|.  |..:||.||.|..|:
Mouse   702 PGI---PGPPGVRGMDGPHGPKGSLGPQGEPGPPGQQGTPGAQGLPGP--QGAIGPHGEKGARGK 761

  Fly   463 PGLEGYRGDRGEVGLPGDKGLPGEGYNIVGPPGSQGPPGFRGLPGDDGYNGLRGLPGEKGLRGDD 527
            |||.|..|..|..|.||.:|.||...| .||.|.|||.|:.|..|..|.:|:|||.|.||.:|:|
Mouse   762 PGLPGMPGSDGLPGHPGKEGPPGTKGN-QGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGED 825

  Fly   528 CPVCNAGPRGPRGQEGDTGYPGSHGNRGAIGLTGPRGVQGLQGNPGRAGHKGLPGPAGIPGEPGK 592
                     |..|.:||.|.   .|:||.:|:.|.||..|.:|..||.|..|.|||.|:.||.||
Mouse   826 ---------GFPGFKGDIGV---KGDRGEVGVPGSRGEDGPEGPKGRTGPTGDPGPTGLMGEKGK 878

  Fly   593 VGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDTGDDGEKGRDGSDGSKGERGETGQRGDYGDAGY 657
            :|..|..|..   |  |:|..|..|..|..|.:|:.|.:|..|..|.:||||.||.||..|..|.
Mouse   879 LGVPGLPGYP---G--RQGPKGSLGFPGFPGASGEKGARGLSGKSGPRGERGPTGPRGQRGPRGA 938

  Fly   658 QGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIKGERGDDGDTGFKGVKGEPNPGQIYDNTG 722
            .|:.|..|..|.||..            |.||..|:.|.:|.:   ||.|.||.|.|
Mouse   939 TGKSGAKGTSGGDGPH------------GPPGERGLPGPQGPN---GFPGPKGPPGP-------- 980

  Fly   723 EPGEDGYTGPKGVKGAKGEQGAIGLRGEIGDRGPAGEVIPGPVGAKGYPGPTGDYGQQGAPGLPG 787
                   .|..|:.|..|::|.:|.:|:.|..||.|.|  ||.|..|..||.|:.|..|.||.||
Mouse   981 -------AGKDGLPGHPGQRGEVGFQGKTGPPGPPGVV--GPQGTAGESGPMGERGHSGPPGPPG 1036

  Fly   788 RDGEPGLDGGIGYKGQRGVPGQEVIQGEIGPPGRSGIKGFPGDVGAPGQYGLAGRPGPKGVKGEQ 852
            ..|.||..|..|.||..|.||..      |..|.:|::||||:.|.||..|     || |:||.:
Mouse  1037 EQGLPGTSGKEGTKGDPGPPGAP------GKDGPAGLRGFPGERGLPGTAG-----GP-GLKGNE 1089

  Fly   853 GPDGAVGQTGLPGNKGQRGDFLVGPPGPKGQPGRNGRQAPHGAKGQKGEVGSLGQNGQNGAKGSI 917
            ||.|..|..|.||.:|     ..|..||.|.|||.|.|.|.||.|:||..|.         ||.|
Mouse  1090 GPAGPPGPAGSPGERG-----AAGSGGPIGPPGRPGPQGPPGAAGEKGVPGE---------KGPI 1140

  Fly   918 GFSGRRGLLGNAGLQGLPGSPGIPGLPGMIGEIGERGEIGYNGRQGDIGPRGPNGEFGPKGLSGD 982
            |.:||.|:.|..||.|..|.||:.|..|..||:|:.|:.|..|.:|:.||.||.|..||.|..|.
Mouse  1141 GPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEHGPPGPPGPIGPVGQPGA 1205

  Fly   983 DGPDGYPGANGLPGR---KGETGNPGFPGRPGAKGVAAYSGIKGDDGESGLTGPIGYPGAPGAKG 1044
            .|.||.|||.|..|.   ||:.|..||.|.||..|:....|..|:.||:|..||:|.||.||.:|
Mouse  1206 AGADGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPSGEKGETGDGGPMGPPGPPGPRG 1270

  Fly  1045 QRGPVGDSQPALDGVAGRKGEVGSPGPNGLPGRHGLKGQRGDRGLPGQQGRPGEPGAKGLGGYPG 1109
            ..||.|     .||..|..|.||:.||   ||.   ||:.|:.|.||.|   ||||.||..|..|
Mouse  1271 PAGPNG-----ADGPQGSPGGVGNLGP---PGE---KGEPGESGSPGVQ---GEPGVKGPRGERG 1321

  Fly  1110 RNGINGLKGATGFPGPQGP---KGPQGESGVVGLDGRNGQIGDQGPRGLIGEQGEQGEQGDEGEV 1171
            ..|.:|..|..|.|||:||   .||:|..|.||..|..|..|:.||||..|.:|::||.|:.|:.
Mouse  1322 EKGESGQAGEAGPPGPKGPTGDNGPKGNPGPVGFPGDPGPPGEAGPRGQDGAKGDRGEDGEPGQP 1386

  Fly  1172 GIPGRLENLRDRSFYRGFTGDQGLQGERGEQGDMGPIGFIGPPGAKGERGDIGYAGQLGFDGAEG 1236
            |.|                               ||.|..||||..|:||.   ||..|.:|.:|
Mouse  1387 GSP-------------------------------GPTGENGPPGPLGKRGP---AGTPGPEGRQG 1417

  Fly  1237 LKGFQGDQGPRGPPGITLPAEKGDEGVAGL---DGRAGRPGHFGQKGAPGPPGENGPNGAIGHRG 1298
            .||.:||.|..|.||.|.|.  |..|:||.   ||..|.||..||:|.||..|:.||.|.:|.
Mouse  1418 EKGAKGDPGAVGAPGKTGPV--GPAGLAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGP-- 1478

  Fly  1299 PQIQGPPGPQGDVGFPGAPGHNGRHGLIGPKGELGDMGRQGERGESGYAIVGRQGDIGDIGFQGE 1363
               .|.||.:||.|..|..||.|..|||||.||      |||:|:.|  :.|.||..|..|..|.
Mouse  1479 ---PGLPGLRGDAGAKGEKGHPGLIGLIGPTGE------QGEKGDRG--LPGPQGSPGQKGETGI 1532

  Fly  1364 PGWDGAKGEQGYPGLPGKNGRVGAPGPRGPTGDAGWGGIDGMDGLVGPKGQPGVTYSYSMARPGD 1428
            ||..|..|..|.|||||.:|..||.|..||.|..|..|:.|..|..||.|:........|.:...
Mouse  1533 PGASGPIGPGGPPGLPGPSGPKGAKGATGPAGPKGEKGVQGPPGHPGPPGEVIQPLPIQMPKKTR 1597

  Fly  1429 RGEPGLDGFQGEEG--DGGAPG 1448
            |...|....|.||.  .|||||
Mouse  1598 RSVDGSKLIQDEEAVPTGGAPG 1619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	14/70 (20%)
		Collagen	102..152	CDD:189968	22/58 (38%)
		Collagen	277..334	CDD:189968	25/56 (45%)
		Collagen	534..593	CDD:189968	25/58 (43%)
		Collagen	814..871	CDD:189968	24/56 (43%)
		Collagen	957..1014	CDD:189968	28/59 (47%)
		Collagen	990..1049	CDD:189968	27/61 (44%)
		Collagen	1070..1128	CDD:189968	26/57 (46%)
		C4	1515..1624	CDD:128421
		C4	1625..1737	CDD:128421
Col11a2	XP_006523622.1	TSPN	32..213	CDD:214560
		PHA03247	<230..518	CDD:223021	42/138 (30%)
		Collagen	583..642	CDD:189968	31/76 (41%)
		Collagen	631..689	CDD:189968	35/87 (40%)
		Collagen	745..804	CDD:189968	29/61 (48%)
		Collagen	811..869	CDD:189968	28/69 (41%)
		Collagen	853..912	CDD:189968	26/63 (41%)
		Collagen	889..946	CDD:189968	24/58 (41%)
		Collagen	1204..1253	CDD:189968	20/48 (42%)
		Collagen	1279..1325	CDD:189968	24/54 (44%)
		Collagen	1375..1433	CDD:189968	29/91 (32%)
		Collagen	1411..1470	CDD:189968	28/60 (47%)
		COLFI	1624..1819	CDD:197483
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	197	1.000	Domainoid score	I3099
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900