DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and Col11a1

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	XP_006501032.1	Gene:	Col11a1 / 12814	MGIID:	88446	Length:	1816	Species:	Mus musculus

Alignment Length:	1722	Identity:	614/1722 - (35%)
Similarity:	746/1722 - (43%)	Gaps:	442/1722 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 GDIGPPGRAGPLGEKGDVGEYG--EQGEKGHRGDIGPKGEMGYPGI------------------- 106
            |:.|..||...|...||:|||.  |..|...|....|..|.| ||:
Mouse   371 GNKGVDGRDSDLLVDGDLGEYDFYEYKEYEERTTTSPNEEFG-PGVPAETDFTETSINGHGAYGE 434

  Fly   107 MGKSGEP----------GTPGPRGIDGCDGRPGMQGPSGAPGQNGVRGPPGKPGQQGPPGEAGEG 161
            .|:.|||          |.|||.|..|..|.||:|||||.||..|.|||||:||..|..|..
Mouse   435 KGQKGEPAVVEPGMLVEGPPGPAGPAGLMGPPGLQGPSGLPGDPGDRGPPGRPGLPGADGLP--- 496

  Fly   162 GINSKGTKGNRGETGQPGGVGPPG--------FDGDRGSKGDT-----GYAGLTGEKGDPGLPGP 213
                                ||||        :.|| ||||.|     ..|....::....|.||
Mouse   497 --------------------GPPGTMLMLPFRYGGD-GSKGPTISAQEAQAQAILQQARIALRGP 540

  Fly   214 KGDTGAVSELPYSLIGPPGAKGEPGDSLSGVLKPDDTLKGYKGYVGLQGDEGPQGPTGEQGAVGR 278
            .|        |..|.|.||..|.||.:               |..|..||.|||||.|.||.
Mouse   541 PG--------PMGLTGRPGPVGGPGSA---------------GAKGESGDPGPQGPRGVQGP--- 579

  Fly   279 NGLPGARGEIGGPGERGKPGKDGEPGRFGDKGMKGAPGWTGADGLDGSPGERGEDGFTGMPGVQG 343
               ||..|:   ||:||:||.||..|..|:.|.||..|:.|..||.|..|.|||         :|
Mouse   580 ---PGPTGK---PGKRGRPGADGGRGMPGESGSKGDRGFDGLPGLPGDKGHRGE---------RG 629

  Fly   344 GAGPPGIYDPSLTKSLPGPIGSQGDIGPPGEQGPPGLPGKPGRR---GPIGLAGQSGDPGLNGSR 405
            ..||||         |||..|.:|:   .||.||.||||:.|.|   ||.|..|..|.||:.|..
Mouse   630 PQGPPG---------LPGDDGMRGE---DGEIGPRGLPGEAGPRGLLGPRGTPGPPGQPGIGGID 682

  Fly   406 GPPGRSERGEAGDYGFIGPPGPQGPPGEAGLPGRYGLHGEPGQNVVGPKGEPGLNGQPGLEGYRG 470
            ||.|  .:|..|..|..||||.||.||..||||..|..|.||:.  ||:|:|||.|.||.:|..|
Mouse   683 GPQG--PKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEK--GPQGKPGLAGLPGADGPPG 743

  Fly   471 DRGEVGLPGDKGLPGEGYNIVGPPGSQGPPGFRGLPGDDGYNGLRGLPGEKGLRGDDCPVCNAGP 535
            ..|:.|..|:||       .:||||.|||.|:.|..|..|.:|:|||.|.||.:|:|
Mouse   744 HPGKEGQSGEKG-------ALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGED-------- 793

  Fly   536 RGPRGQEGDTGYPGSHGNRGAIGLTGPRGVQGLQGNPGRAGHKGLPGPAGIPGEPGKVGAAGPDG 600
             |..|.:||.|.   .|:||.:|..||||..|.:|..||||..|.|||:|..||.||:|..|..|
Mouse   794 -GFPGFKGDMGL---KGDRGEVGQVGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPG 854

  Fly   601 KAIEVGSLRKGEIGDTGDSGHRGDTGDDGEKGRDGSDGSKGERGETGQRGDYGDAGYQGRDGEPG 665
            ..   |  |:|..|.||..|..|..|:.|.:|..|..|.:|:||.||.||..|..|..|:.|..|
Mouse   855 YP---G--RQGPKGSTGFPGFPGANGEKGARGIAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKG 914

  Fly   666 RDGRDGAPGRNATTPKVYLIGEPGYDGIKGERGDDGDTGFKGVKGEPNPGQIYDNTGEPGEDGYT 730
            ..|.||.|            |.||.   :|.:|..|..||.|.||.|.|      .|:.|..|:.
Mouse   915 TSGGDGPP------------GPPGE---RGPQGPQGPVGFPGPKGPPGP------AGKDGLPGHP 958

  Fly   731 GPKGVKGAKGEQGAIGLRGEIGDRGPAGEVIPGPVGAKGYPGPTGDYGQQGAPGLPGRDGEPGLD 795
            |.:|..|.:|:.|..|..|.:|.:||.||.  ||:|.:|:|||.|..|:||.||..|::
Mouse   959 GQRGETGFQGKTGPPGPGGVVGPQGPTGET--GPIGERGHPGPPGPPGEQGLPGAAGKE------ 1015

  Fly   796 GGIGYKGQRGVPGQEVIQGEIGPPGRSGIKGFPGDVGAPGQYGLAGRPGPKGVKGEQGPDGAVGQ 860
                  |.:|.||.:.|.|:.||   :||:||||:.|.|   |..|.||.||.:|.|||.|.||.
Mouse  1016 ------GAKGDPGPQGISGKDGP---AGIRGFPGERGLP---GAQGAPGLKGGEGPQGPQGPVGS 1068

  Fly   861 TGLPGNKGQRGDFLVGPPGPKGQPGRNGRQAPHGAKGQKGEVGSLGQNGQNGAKGSIGFSGRRGL 925
               ||.:|.     .|..||.|.|||.|.|.|.|..|:||..|.         ||..|.:||.|:
Mouse  1069 ---PGERGS-----AGTAGPIGLPGRPGPQGPPGPAGEKGAPGE---------KGPQGPAGRDGV 1116

  Fly   926 LGNAGLQGLPGSPGIPGLPGMIGEIGERGEIGYNGRQGDIGPRGPNGEFGP---KGLSGDDGPDG 987
            .|..||.|..|..|.||..|..|||||.|:.|..|.:|:.||.||.|..||   .|::|.||..|
Mouse  1117 QGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPG 1181

  Fly   988 YPGANGLPGRKGETGNPGFPGRPGAKGVAAYSGIKGDDGESGLTGPIGYPGAPGAKGQRGPVGDS 1052
            ..|..|:.|:||:.|..||||.||..|:....|..|:.||:|..||:|.||.||.:|.:||
Mouse  1182 PRGQQGMFGQKGDEGARGFPGLPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGP---- 1242

  Fly  1053 QPALDGVAGRKGEVGSPGPNGLPGRHGLKGQRGDRGLPGQQGRPGEPGAKGLGGYPGRNGINGLK 1117
                         .|:.||.|.||..|..|..||:|.||:.|.||.||..|.||..|..|..|..
Mouse  1243 -------------NGADGPQGPPGSIGSVGVVGDKGEPGEAGNPGPPGEAGSGGLKGERGEKGEA 1294

  Fly  1118 GATGFPGPQGPKGPQGESGVVGLDGRNGQIGDQGPRGLIGEQGEQGEQGDEGEVGIPGRLENLRD 1182
            |..|..||.|.|||.|:.|..|..|..|..||.||.|..|..|:.|..||:||.|.|
Mouse  1295 GPPGAAGPAGIKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDP-------- 1351

  Fly  1183 RSFYRGFTGDQGLQGERGEQGDMGPIGFIGPPGAKGERGDIGYAGQLGFDGAEGLKGFQGDQGPR 1247
                             |:.|..||.|..||||..|:||..|.:|.   :|.:|.||.:|:.|..
Mouse  1352 -----------------GQPGPPGPSGEAGPPGPPGKRGPPGASGS---EGRQGEKGAKGEAGAE 1396

  Fly  1248 GPPGITLPAEKGDEGVAGLDGRAGRPGHFGQKGAPGPPGENGPNGAIGHRGPQIQGPPGPQGDVG 1312
            ||||.|        |..|..|.:|:||..|.:|.|||.||.|..||.|.     .|||||.|..|
Mouse  1397 GPPGKT--------GPVGPQGPSGKPGPEGLRGIPGPVGEQGLPGAAGQ-----DGPPGPLGPPG 1448

  Fly  1313 FPGAPGHNGRHGLIGPKGELGDMGRQGERGESGYAIVGRQGDIGDIGFQGEPGWDGAKGEQGYPG 1377
            .|                                            |.:|:|   |:|||:|:||
Mouse  1449 LP--------------------------------------------GLKGDP---GSKGEKGHPG 1466

  Fly  1378 LPGKNGRVGAPGPRGPTGDAGWGGIDGMDGLVGPKGQPGVTYSYSMARPGDRGEPGLDGFQGEEG 1442
            |                           .||:||.|:.|        ..||||.||..|..|.:|
Mouse  1467 L---------------------------IGLIGPPGEQG--------EKGDRGLPGTQGSPGAKG 1496

  Fly  1443 DGGAPGLIGFQGQRGAVGYRGDQGEVGYTGADGPQGQRGDKGYMGLTGAPGLRGLPGPQGE---P 1504
            |||.||..|..|..|..|..|..|..|..|:.||.||:||      :|.||..|.|||.||   |
Mouse  1497 DGGIPGPAGPIGPPGPPGLPGPAGPKGNKGSSGPTGQKGD------SGMPGPPGPPGPPGEVIQP 1555

  Fly  1505 APAPPAPKSRGFIFARHSQSVHVPQCPANTNLLWEGYSLSGNVAASRAVGQDLGQSGSCMMRF-- 1567
            .|.....|:|     ||::|:   |..|..|:|.....:.....:..::.||:..     |:|
Mouse  1556 LPILSPKKTR-----RHTESI---QGDAGDNILDYSDGMEEIFGSLNSLKQDIEH-----MKFPM 1607

  Fly  1568 --TTMPYMLCDITNVCHFAQNNDDSLWLSTAEPMPMTMTPIQG--RDLMKYISRCVVCETTTRII 1628
              .|.|...|....:.| ....|...|:.          |.||  .|..|     |.|..|.
Mouse  1608 GTQTNPARTCKDLQLSH-PDFPDGEYWID----------PNQGCSGDSFK-----VYCNFTA--- 1653

  Fly  1629 ALHSQSMSIPD--------------CPGGWEEMWTGYSYF-----MSTLDNVGGVGQNLVS---- 1670
              ..::...||              .||.|      ||.|     :|.|| |.|...|:|.
Mouse  1654 --GGETCIYPDKKSEGVRISSWPKEKPGSW------YSEFKRGKLLSYLD-VEGNSINMVQMTFL 1709

  Fly  1671 ---PGSCLEEFRAQPVIECHGHGRCNYYDALA 1699
               ..|..:.|    ...||....  :||.|:
Mouse  1710 KLLTASARQNF----TYNCHQSAA--WYDVLS 1735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	25/86 (29%)
		Collagen	102..152	CDD:189968	31/78 (40%)
		Collagen	277..334	CDD:189968	25/56 (45%)
		Collagen	534..593	CDD:189968	27/58 (47%)
		Collagen	814..871	CDD:189968	27/56 (48%)
		Collagen	957..1014	CDD:189968	27/59 (46%)
		Collagen	990..1049	CDD:189968	27/58 (47%)
		Collagen	1070..1128	CDD:189968	27/57 (47%)
		C4	1515..1624	CDD:128421	24/114 (21%)
		C4	1625..1737	CDD:128421	22/101 (22%)
Col11a1	XP_006501032.1	TSPN	37..228	CDD:214560
		Collagen	809..866	CDD:189968	28/61 (46%)
		Collagen	851..910	CDD:189968	25/63 (40%)
		Collagen	1106..1155	CDD:189968	22/48 (46%)
		Collagen	1388..1437	CDD:189968	24/56 (43%)
		COLFI	1585..1814	CDD:366624	40/190 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1573
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810