DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and COL1A1

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	NP_000079.2	Gene:	COL1A1 / 1277	HGNCID:	2197	Length:	1464	Species:	Homo sapiens

Alignment Length:	1499	Identity:	572/1499 - (38%)
Similarity:	672/1499 - (44%)	Gaps:	286/1499 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DGKI-CNTTLCD----CKGIKGRMGAPGPIGVPGLEGPAGD---IGPPGRAGPLGEK--GDVGEY 83
            :||: |:..:||    |               ||.|.|.|:   :.|.|...|..::  |..|..
Human    65 NGKVLCDDVICDETKNC---------------PGAEVPEGECCPVCPDGSESPTDQETTGVEGPK 114

  Fly    84 GEQGEKGHRGDIGPKGEMGYPGIMGKSGEPGTPGPRGIDGCDGR-------------------PG 129
            |:.|.:|.||..||.|..|.||..|..|.||.|||.|..|..|.                   ||
Human   115 GDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPG 179

  Fly   130 MQGPSGAPGQNGVRGPPGKPGQQGPPGEAGEGGINSKGTKGNRGETGQPGGVGPPGFDGDRGSKG 194
            ..||||..|..|..|.||..|.||||||.||     .|..|..|..|.|   |||      |..|
Human   180 PMGPSGPRGLPGPPGAPGPQGFQGPPGEPGE-----PGASGPMGPRGPP---GPP------GKNG 230

  Fly   195 DTGYAGLTGEKGDPGLPGPKGDTGAVSELPYSLIGPPGAKGEPGDSLSGVLKPDDTLKGYKGYVG 259
            |.|.||..|..|:.|.|||:|..|.           ||..|.||            :||::|:.|
Human   231 DDGEAGKPGRPGERGPPGPQGARGL-----------PGTAGLPG------------MKGHRGFSG 272

  Fly   260 L---QGDEGPQGPTGEQGAVGRNGLPGARGEIGGPGERGKPGKDGEPGRFGDKGMKGAPGWTGAD 321
            |   :||.||.||.||.|:.|.||.||..|..|.|||||:|               ||||..||.
Human   273 LDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRP---------------GAPGPAGAR 322

  Fly   322 GLDGSPGERGEDGFTGMPGVQGGAGPPGIYDPSLTKSLPGPIGSQGDIGPP---GEQGPPGLPGK 383
            |.||:.|.      .|.||..|.|||||         .||.:|::|:.||.   |.:||.|:.|:
Human   323 GNDGATGA------AGPPGPTGPAGPPG---------FPGAVGAKGEAGPQGPRGSEGPQGVRGE 372

  Fly   384 PGRRGPIGLAGQSGDPGLNGSRGPPG-RSERGEAGDYGFIGPPGPQGPPGEAGLPGRYGLHGEPG 447
            ||..||.|.||.:|:||.:|..|..| ....|.||..||.|..||.||.|..|.||..|..||||
Human   373 PGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPG 437

  Fly   448 ----QNVVGPKGEP---GLNGQPGLEGYRGDRGEVGLPGDKGLPGEGYNIVGPPGSQGPPGFRGL 505
                :...|.||||   |:.|.||..|..|.||..|.||..|||       ||||.:|.||.||.
Human   438 APGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLP-------GPPGERGGPGSRGF 495

  Fly   506 PGDDGYNGLRGLPGEKGLRGDDCPVCNAGPRGPRGQEGDTGYPGSHGNRGAIGLTGPRGVQGLQG 570
            ||.||..|.:|..||:|         :.||.||:|..|:.|.||..|..||.||||..|..|..|
Human   496 PGADGVAGPKGPAGERG---------SPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDG 551

  Fly   571 N---PGRAGHKGLPGPAGIP---GEPGKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDTGDDG 629
            .   ||.||..|.|||.|.|   |:.|.:|..||.|.|.|.|  :.||.|..|..|..|..|.||
Human   552 KTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPG--KAGERGVPGPPGAVGPAGKDG 614

  Fly   630 EKGRDGSDGSKGERGETGQRGDYGDAGYQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIK 694
            |.|..|..|..|..||.|::|..|..|:||..|..|..|..|.||.......   :|.||..|.:
Human   615 EAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGD---LGAPGPSGAR 676

  Fly   695 GERGDDGDTGFKGVKGEPNPGQIYDNTGEPGEDGYTGPKGVKGAKGEQGAIGLRGEIGDRGPAGE 759
            ||||..|:   :||:|.|.|.......|.||.||..|..|..||.|.|||.||:|..|:||.||
Human   677 GERGFPGE---RGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAG- 737

  Fly   760 VIPGPVGAKGYPGPTGDYGQQGAPGLPGRDGEPGLDGGIGYKGQRGVPGQEVIQGEIGPPGRSGI 824
             :|||.|.:      ||.|.:||.|.||:||..||.|.||..|..|.||.:...|..||.|.:|.
Human   738 -LPGPKGDR------GDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGA 795

  Fly   825 KGFPGDVGAPGQYGLAGRPGPKGVKGEQGPDGAVGQTGLPGNKGQRGDFLVGPPGPKGQPGRNGR 889
            :|.|||.|.||.      |||.|..|..|.||..|..|.||:.|.:||  .|||||.|..|
Human   796 RGAPGDRGEPGP------PGPAGFAGPPGADGQPGAKGEPGDAGAKGD--AGPPGPAGPAG---- 848

  Fly   890 QAPHGAKGQKGEVGSLGQNGQNGAKGSIGFSGRRGLLGNAGLQGLPGSPGIPGLPGMIGEIGERG 954
              |.|..|..|..|:.|..|..|..|:.||.|..|.:|..|..|..|.||.||..|..|..|.||
Human   849 --PPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRG 911

  Fly   955 EIGYNGRQGDIGPRGPNGEFGPKGLSGDDGPDGYPGANGLPGRKGETGNPGFPGRPGAKGVAAYS 1019
            |.|..||.|::||.||.|..|.||..|.|||.|.||.   ||.:|..|..|..|.||.:|...:.
Human   912 ETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGT---PGPQGIAGQRGVVGLPGQRGERGFP 973

  Fly  1020 GIKGDDGESGLTGPIGYPGAPGAKGQRGPVGDSQPALDGVAGRKGEVGSPGPNGLPGRHGLKGQR 1084
            |:.|..||.|..||   .||.|.:|..||:|  .|.|.|..|..|..|:||..|.|||.|..|.:
Human   974 GLPGPSGEPGKQGP---SGASGERGPPGPMG--PPGLAGPPGESGREGAPGAEGSPGRDGSPGAK 1033

  Fly  1085 GDRGLPGQQGRPGEPGAKGLGGYPGRNGINGLKGATGFPGPQGPKGPQGESGVVGLDGRNGQIGD 1149
            ||||..|..|.||.|||.|..|..|..|.:|.:|.||..||.||.||.         |..|..|.
Human  1034 GDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPV---------GARGPAGP 1089

  Fly  1150 QGPRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRSFYRGFTGDQGLQGERGEQGDMGPIGFIGPP 1214
            ||||   |::||.|||                         ||:|::|.||..|..||   .|||
Human  1090 QGPR---GDKGETGEQ-------------------------GDRGIKGHRGFSGLQGP---PGPP 1123

  Fly  1215 GAKGERGDIGYAGQLGFDGAEGLKGFQGDQGPRGPPGITLPAEKGDEGVAGLDGRAGRPGHFGQK 1279
            |:.||:|.               .|..|..||||||                 |.||.||..|..
Human  1124 GSPGEQGP---------------SGASGPAGPRGPP-----------------GSAGAPGKDGLN 1156

  Fly  1280 GAPGPPGENGPNGAIGHRGPQIQGPPGPQGDVGFPGAPGHNGRHGLI--GPKGELGDMGRQGERG 1342
            |.|||.|..||.|..|..||  .|||||.|..|.||.|........:  .|:.:..|.||. .|.
Human  1157 GLPGPIGPPGPRGRTGDAGP--VGPPGPPGPPGPPGPPSAGFDFSFLPQPPQEKAHDGGRY-YRA 1218

  Fly  1343 ESGYAIVGRQGDIGDIGFQGEPGWDGAKGEQGYPGLPG-------------KNGRVGAPGPRGPT 1394
            :....:..|..::...........:..:..:|....|.             |:|.......:|..
Human  1219 DDANVVRDRDLEVDTTLKSLSQQIENIRSPEGSRKNPARTCRDLKMCHSDWKSGEYWIDPNQGCN 1283

  Fly  1395 GDA--GWGGIDGMDGLVGPKGQPGVTYS--YSMARPGDR-----GEPGLDGFQGE-EGDGGAPGL 1449
            .||  .:..::..:..|.|. ||.|...  |....|.|:     ||...||||.| .|.|..|..
Human  1284 LDAIKVFCNMETGETCVYPT-QPSVAQKNWYISKNPKDKRHVWFGESMTDGFQFEYGGQGSDPAD 1347

  Fly  1450 IGFQ 1453
            :..|
Human  1348 VAIQ 1351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	24/63 (38%)
		Collagen	102..152	CDD:189968	25/68 (37%)
		Collagen	277..334	CDD:189968	23/56 (41%)
		Collagen	534..593	CDD:189968	31/64 (48%)
		Collagen	814..871	CDD:189968	25/56 (45%)
		Collagen	957..1014	CDD:189968	27/56 (48%)
		Collagen	990..1049	CDD:189968	22/58 (38%)
		Collagen	1070..1128	CDD:189968	28/57 (49%)
		C4	1515..1624	CDD:128421
		C4	1625..1737	CDD:128421
COL1A1	NP_000079.2	VWC	40..95	CDD:278520	11/44 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..1214		530/1310 (40%)
		Nonhelical region (N-terminal)	162..178		0/15 (0%)
		Triple-helical region	179..1192		501/1207 (42%)
		Collagen	239..295	CDD:396114	28/78 (36%)
		Collagen	275..324	CDD:396114	28/63 (44%)
		PRK07764	<449..640	CDD:236090	92/208 (44%)
		Collagen	500..556	CDD:396114	25/64 (39%)
		Collagen	686..741	CDD:396114	27/56 (48%)
		Collagen	719..766	CDD:396114	27/54 (50%)
		Cell attachment site. /evidence=ECO:0000255	745..747		0/7 (0%)
		PRK12678	908..>1111	CDD:237171	102/247 (41%)
		Cell attachment site. /evidence=ECO:0000255	1093..1095		1/4 (25%)
		Nonhelical region (C-terminal)	1193..1218		4/25 (16%)
		COLFI	1227..1463	CDD:396131	27/126 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810