DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vkg and Col16a1

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	XP_006502703.1	Gene:	Col16a1 / 107581	MGIID:	1095396	Length:	1598	Species:	Mus musculus

Alignment Length:	1595	Identity:	558/1595 - (34%)
Similarity:	666/1595 - (41%)	Gaps:	473/1595 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 IGPPGRAGPLGEKGDVGEYGEQGEKGHRGD--------------IGPKGEMGYPGIMGKSGEPGT 115
            :||.|..|..||:|..|..|.:||||.||:              .|||||.|..|.:   |.||.
Mouse   330 LGPSGLKGGKGERGLTGPSGPKGEKGARGNDCVRVSPDAPLQCVEGPKGEKGESGDL---GPPGL 391

  Fly   116 PGPRGIDGCDGRPGMQGPSGAPGQNGVRGPPGKPGQQGPPGEAGEGGINSKGTKGNRGETGQPGG 180
            |||         .|.:|..|..|..|::|.|||||:.|.|||     |...|.||.:|:   ||.
Mouse   392 PGP---------TGQKGQKGEKGDGGLKGLPGKPGRDGRPGE-----ICVIGPKGQKGD---PGF 439

  Fly   181 VGPPGFDGDRGSKGDTGYAGLTGEKGDPGLPGPKGDTGAVSELPYSLIGPPGAKGEPGDSLSGVL 245
            |||               .||.||.|.||||||.|            ||.||..|:||    |..
Mouse   440 VGP---------------EGLAGEPGPPGLPGPPG------------IGLPGTPGDPG----GPP 473

  Fly   246 KPDDTLKGYKGYVGLQGDEGPQGPTGEQGAVGRNGLPGARGEIGGP---------------GERG 295
            .|    ||.||..|:.|.|||.|..      |:.|:||.:||.|.|               |..|
Mouse   474 GP----KGEKGSSGIPGKEGPGGKP------GKPGVPGTKGEKGDPCEVCPTLPEGSQNFVGLPG 528

  Fly   296 KPGKDGEPGRFGDKGMKGAPGWTGADGLDGSPGERGEDGFTGMPGVQG----------GA---GP 347
            |||..||||       ..||.|.|. |..|..|:||:.|..||.|.:|          ||   ||
Mouse   529 KPGPKGEPG-------DPAPAWEGL-GTVGLKGDRGDPGIQGMKGEKGEPCSSCSSGVGAQHLGP 585

  Fly   348 -PGIYDPSL--TKSLPGPIGSQGDIGPPGEQGPPGLPGKPGRRGPIGLAGQSGDP-----GLNGS 404
             ||...|.|  |..:|||.|.:|:.|..|:.||.|:||.||..||.|:.|..|:|     .|:..
Mouse   586 SPGHGLPGLPGTSGIPGPRGLKGEKGSFGDTGPAGVPGSPGPVGPAGIKGAKGEPCEPCTALSEL 650

  Fly   405 R----------GPPGRSERGEAGDYGFIGPPGPQGPPGEAGLPGRYGLHGEPGQNVVGPKGEPGL 459
            :          ||.|  |:||.|..|| |.||.||..||.||.|:.|..|.||.     .|.||:
Mouse   651 QDGDMRVVHLPGPAG--EKGEPGSPGF-GLPGKQGKAGERGLKGQKGDAGNPGD-----PGTPGI 707

  Fly   460 NGQPGLEGYRGDRGEVGLPGDKG--------LPGEGYNIVGPPGSQGPPGFRGLPGDDGYNGLRG 516
            .||||:.|..|.||..|..|:||        |.|...::.|.||..||   :|.||.:|. |..|
Mouse   708 TGQPGISGEPGIRGPAGPKGEKGDGCTACPSLQGALTDVSGLPGKPGP---KGEPGPEGV-GHPG 768

  Fly   517 LPGEKGLRGDDCPVCNAGPRGPRGQEGDTGYPGSHGNRGAIGLTGPRGVQGLQGNPGRAGHKGLP 581
            .||:.||.|..      ||.||:|.:|:.|.||:       |..||:|..|.||.||.   :|||
Mouse   769 KPGQPGLPGVQ------GPPGPKGTQGEPGPPGT-------GAEGPQGEPGTQGLPGT---QGLP 817

  Fly   582 GPAGIPGEPGKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDTGDDGEKGRDGSDGSKGERGET 646
            ||.|.||..|:.||.|..|.        ||.||..|..|          .|..|..|.||.|||
Mouse   818 GPRGPPGSAGEKGAQGSPGP--------KGAIGPMGPPG----------AGVSGPPGQKGSRGE- 863

  Fly   647 GQRGDYGDAGYQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIKGERGDDGDTGFKGVKGE 711
              :|:.|:.....| |||...|..||||       :::             |.....|.:|..|.
Mouse   864 --KGEPGECSCPSR-GEPIFSGMPGAPG-------LWM-------------GSSSQPGPQGPPGV 905

  Fly   712 PNPGQIYDNTGEPGEDGYTGPKGVKGAKGEQGAIGLRGEIGD--------RGPAGEVIPGPVGAK 768
            |.|         ||..|..|.:||.|..|..|..||..|:|.        :...|:...|.....
Mouse   906 PGP---------PGPPGMPGLQGVPGHNGLPGQPGLTAELGSLPIEKHLLKSICGDCAQGQTAHP 961

  Fly   769 GYPGPTGDYGQQGAPGLPGRD-----------------------GEPGLDGGIGYKGQRGVPGQE 810
            .:....|:.|.||.||:||.|                       ||||..|..|..|..|:|||
Mouse   962 AFLLEKGEKGDQGIPGVPGFDNCARCFIERERPRAEEARGDNSEGEPGCSGSPGLPGPPGMPGQ- 1025

  Fly   811 VIQGEIGPPGRSGIKGFPGDVGAPGQYGLAGRPGPKGVKGEQGPDGAVGQTGLPGNKGQRGDFLV 875
              :||.||||..|..|.||.:|.||..|..|.||..|::||:      |.|||.|:||:
Mouse  1026 --RGEEGPPGMRGSPGPPGPIGPPGFPGAVGSPGLPGLQGER------GLTGLTGDKGE------ 1076

  Fly   876 GPPGPKGQPGRNGRQAPHGAKGQKGEVGSLGQNGQNGAKGSIGFSGRRGLLGNAGLQGLPGSPGI 940
              |||.||||..|...|.|..|.|||.|..|.:|:.|..|.                  |||.|:
Mouse  1077 --PGPPGQPGYPGAMGPPGLPGIKGERGYTGPSGEKGESGP------------------PGSEGL 1121

  Fly   941 PGLPGMIGEIGERGEIGYNGRQGDIGPRGPNGEFGPKGLSGDDGPDGYPGANGLPGRKGETGNPG 1005
            |                     |..||.||.||.||:|.||:.|..|:.|..|.|   |..|.||
Mouse  1122 P---------------------GPQGPAGPRGERGPQGSSGEKGDQGFQGQPGFP---GPPGPPG 1162

  Fly  1006 FPGRPGAKGVAAYSGIKGDDGESGLTGPIGYPGAPGAKGQRGPVGDSQPALDGVAGRKGEVGSPG 1070
            |||:.||.|.   .|.:.:.|..|:.||.|.||:|                          |.||
Mouse  1163 FPGKAGAPGP---PGPQAEKGSEGIRGPSGLPGSP--------------------------GPPG 1198

  Fly  1071 PNGLPGRHGLKGQRGDRGLPGQQGRPGEPGAKGLGGYPGRNGINGLKGATGFPGPQGPKGPQGES 1135
            |.|:.|..||.|..|..|.||.:|.||..|..||.|.|      |.||.||.||..||||..|:.
Mouse  1199 PPGIQGPAGLDGLDGKDGKPGLRGDPGPAGPPGLMGPP------GFKGKTGHPGLPGPKGDCGKP 1257

  Fly  1136 GVVGLDGR---NGQIGDQGPRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRSFYRGFTGDQGLQG 1197
            |..|..||   .|:.|..||:|..|..|..|.||..|:.|.|| |..:       |..||:|:.|
Mouse  1258 GPPGSSGRPGAEGEPGAMGPQGRPGPPGHLGPQGPPGQPGPPG-LSTV-------GLKGDRGVPG 1314

  Fly  1198 ERGEQGDMGPIGFIGPPGAKGERGDIGYAGQLGFDGAEGLKGFQGDQGPRGPPGITLPAEKGDEG 1262
            ||         |..|.||..|..|..|..|:.|.|||.|.:|..|.||..||||     .|||.|
Mouse  1315 ER---------GLAGLPGQPGTPGHPGPPGEPGSDGAAGKEGPPGKQGLYGPPG-----PKGDPG 1365

  Fly  1263 VAGLDGRAGRPGHFGQKGAPGPPGENGPNGAIGHRGPQIQGPPGPQGDVGFPGAPGHNGRHGLIG 1327
            .||..|:||..   |:.|.||.||::|..|.|        |||||.|:.|.||:||..|..||.|
Mouse  1366 PAGQKGQAGEK---GRSGMPGGPGKSGSMGPI--------GPPGPAGERGHPGSPGPAGNPGLPG 1419

  Fly  1328 PKGELGDMGRQGE----------------------RGESGYAIVGRQGDIGDIGFQGEPGWDGAK 1370
            ..|.:|||....:                      |.:....:....|..|..|..|.||..||.
Mouse  1420 LPGSMGDMVNYDDIKRFIRQEIIKLFDERMAYYTSRMQFPMEVAAAPGRPGPPGKDGAPGRPGAP 1484

  Fly  1371 GEQGYPGLPGKNGRVGAPGPRGPTGDAGWGGIDGMDGLVGPKGQPGVTYSYSMARPGDRGEPGLD 1435
            |..|.||..|:.||.|.||.|                                         ||.
Mouse  1485 GSPGLPGQIGREGRQGLPGMR-----------------------------------------GLP 1508

  Fly  1436 GFQGEEGDGGAPGLIGFQGQRGAVGYRGDQGEVGY--TGADGPQGQRGDKGYMGLTGAPGLRGLP 1498
            |.:||:||.|    :|..|:.|..|..|.||..||  .||.||.||:         |.||:.|.|
Mouse  1509 GTKGEKGDIG----VGIAGENGLPGPPGPQGPPGYGKMGATGPMGQQ---------GIPGIPGPP 1560

  Fly  1499 GPQGEPAPA------------------PPAPKSRG 1515
            ||.|:|..|                  ||....:|
Mouse  1561 GPMGQPGKAGHCNPSDCFGAMPMEQQYPPMKSMKG 1595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	27/67 (40%)
		Collagen	102..152	CDD:189968	19/49 (39%)
		Collagen	277..334	CDD:189968	26/71 (37%)
		Collagen	534..593	CDD:189968	27/58 (47%)
		Collagen	814..871	CDD:189968	27/56 (48%)
		Collagen	957..1014	CDD:189968	26/56 (46%)
		Collagen	990..1049	CDD:189968	22/58 (38%)
		Collagen	1070..1128	CDD:189968	26/57 (46%)
		C4	1515..1624	CDD:128421	1/1 (100%)
		C4	1625..1737	CDD:128421
Col16a1	XP_006502703.1	TSPN	50..231	CDD:214560
		Collagen	584..643	CDD:189968	27/58 (47%)
		PRK07764	<644..867	CDD:236090	103/271 (38%)
		Collagen	751..812	CDD:189968	30/77 (39%)
		Collagen	1089..1142	CDD:189968	27/91 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910