DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vkg and LOC100537277

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	XP_003201728.4	Gene:	LOC100537277 / 100537277	-ID:	-	Length:	943	Species:	Danio rerio

Alignment Length:	961	Identity:	340/961 - (35%)
Similarity:	402/961 - (41%)	Gaps:	302/961 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 SKGDTGYAGLTGE-KGDPGLPGPKGDTGAVSELPYSLI--GPPGAKGE-----PGDSLSGVLKPD 248
            ::|||    |.|. ..||       :|..|.||.:.||  .|..|:.|     |...:....:||
Zfish   215 TEGDT----LIGRLDSDP-------NTSVVFELQWMLIHCDPKRAQRESCTELPLAEMFANAEPD 268

  Fly   249 DTLKGYKGYVGLQGDEGPQGPTGEQGAVGRNGLPGARGEIGGPGERGKPGKDGEPGRFGDKGMKG 313
            .  |...|..|..|.|||:||.||.|..||:|:||..|.   ||.:|..|..||.|..|.:|::|
Zfish   269 P--KPIPGPPGSPGPEGPRGPAGEDGRDGRDGIPGTPGT---PGAQGSKGDRGEVGLPGQRGLQG 328

  Fly   314 APGWTGADGLDGSPGERGEDGFTGMPGVQGGAGPPGIYDPSLTKSLPGPIGSQGDIGPPGEQGPP 378
            |||..|.   .|..|.||..|..|:||..|.|||||                      |...|||
Zfish   329 APGPVGP---MGPMGPRGPVGERGLPGFPGPAGPPG----------------------PETVGPP 368

  Fly   379 GLPGKPGRRGPIGLAGQSGDPGLNGSRGPPGRSERGEAGDYGFIGPPGPQGPPGEAGLPGRYGLH 443
            |||||         ||..||.|..|..|||        |..|.||.|||.||||.||
Zfish   369 GLPGK---------AGTPGDEGNIGPEGPP--------GPRGAIGLPGPPGPPGPAG-------- 408

  Fly   444 GEPGQNVVGPKGEPGLNGQPGLEGYRGDRGEVGLPGDKGLPGEGYNIVGPPGSQGPPGFRGLPGD 508
                  ..||:|.    |.|  ||    .||...           ....|.|.||.||..|:.|.
Zfish   409 ------PAGPQGA----GNP--EG----SGETQC-----------QTTCPAGPQGLPGLPGMKGH 446

  Fly   509 DGYNGLRGLPGEKGLRGDDCPVCNAGPRGPRGQEGDTGYPGSHGNRGAIGLTGPRGVQGLQGNPG 573
            .|.:|:.|:||.:|.:||         ||..|:.|..|.||..|.||.||.|||.|.:|.:|.|
Zfish   447 RGLSGVDGVPGIQGEKGD---------RGAAGEPGPAGRPGDDGQRGPIGFTGPHGDKGDRGPP- 501

  Fly   574 RAGHKGLPGPAGIPGEPGKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDTGDDGEKGRDGSDG 638
              |..|:|||.|.||.||           :|               |.||..|..|.||.||:.|
Zfish   502 --GFNGIPGPTGPPGSPG-----------VE---------------GIRGREGHPGPKGDDGAIG 538

  Fly   639 SKGERGETGQRGDYGDAGYQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIKGERGDDGDT 703
            :.||:|..|.:||.|:||..|.|||||..|.                        |||.|..|..
Zfish   539 APGEKGAAGVKGDTGEAGNPGADGEPGATGE------------------------KGEPGLPGAI 579

  Fly   704 GFKGVKGEPNPGQIYDNTGEPGEDGYTGPKGVK---GAKGEQGAIGLRGEIGDRGPAGEVIPGPV 765
            |.:|:.|.|         |.||:.|..||.|.|   ||:|..|.:||.|:.|..||     ||..
Zfish   580 GVRGIVGIP---------GLPGKQGLVGPAGQKGDTGAEGATGPVGLPGKDGAVGP-----PGED 630

  Fly   766 GAKGYPGPTGDYGQQGAPGLPGRDGEPGLDGGIGYKGQRGVPGQEVIQGEIGPPGRSGIKGFPGD 830
            ||.|..|.|||.|:||..|..|:.|..|..|..|..|.||:.|....:|:.||.|..|.||..||
Zfish   631 GAPGPKGATGDTGKQGPVGPTGQQGIQGEKGDHGLMGPRGIKGHTGHKGDQGPMGLVGPKGSEGD 695

  Fly   831 VGAPGQYGLAGRPGPKGVKGEQGPDGAVGQTGLPGNKGQRGDFLVGPPGPKGQPGRNGRQAPHGA 895
            .|.||.         .||||:|||      ||:||.||:||:        |||         .||
Zfish   696 PGVPGD---------PGVKGDQGP------TGIPGTKGERGE--------KGQ---------RGA 728

  Fly   896 KGQKGEVGSLGQNGQNGAKGSIGFSGRRGLLGNAGLQGLPGSP---------------------- 938
            .|..|..|..|..|..|.:|:.|..|.|||:|..|.:||||..
Zfish   729 TGADGRPGQPGHEGLTGPQGARGLEGERGLVGPPGPRGLPGPKIQDEKIREICSAVVEEHLDAYK 793

  Fly   939 ----------GIPGLPGMIGEIGERGEIGYNGRQGDIGPRGPNGEFGPKGLSGDDGPDGYPGANG 993
                      |.||.||::|.            .|..||.||.||.||:|:.|..||.||
Zfish   794 KELAKKPLPLGAPGTPGLMGP------------PGPPGPAGPAGEAGPRGVMGPKGPQGY----- 841

  Fly   994 LPGRKGETGNPGFPGRPGAKGVAAYSGIKGDDGESGLTGPIGYPGAPGAKGQRGPVGDSQPALDG 1058
                      .|.||:|||||   .||.|||.|::|:                           |
Zfish   842 ----------YGLPGKPGAKG---DSGQKGDKGDNGI---------------------------G 866

  Fly  1059 VAGRKGEVGSPGPNGLPGRHGLKGQRGDRGLPGQQGRPGEPGAKGLGGYPG 1109
            :||..||.|..||.|.|| .|..||.|.:|.||..|.||.|||:|..|.||
Zfish   867 IAGLPGEPGPQGPAGKPG-IGKDGQDGAKGEPGLNGTPGTPGARGATGAPG 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968
		Collagen	102..152	CDD:189968
		Collagen	277..334	CDD:189968	24/56 (43%)
		Collagen	534..593	CDD:189968	29/58 (50%)
		Collagen	814..871	CDD:189968	25/56 (45%)
		Collagen	957..1014	CDD:189968	21/56 (38%)
		Collagen	990..1049	CDD:189968	15/58 (26%)
		Collagen	1070..1128	CDD:189968	22/40 (55%)
		C4	1515..1624	CDD:128421
		C4	1625..1737	CDD:128421
LOC100537277	XP_003201728.4	TSPN	52..245	CDD:214560	13/40 (33%)
		Collagen	295..342	CDD:189968	22/52 (42%)
		Collagen	433..491	CDD:189968	28/66 (42%)
		PHA03169	519..>664	CDD:223003	71/197 (36%)
		Collagen	643..702	CDD:189968	25/67 (37%)
		Collagen	697..756	CDD:189968	32/90 (36%)
		Collagen	866..916	CDD:189968	26/50 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000