Protein Alignment vkg and col4a6

DIOPT Version :10

• Sequence 1: NP_477190.1
• Gene: vkg / 33726
• FlyBaseID: FBgn0016075
• Length: 1940
• Species: Drosophila melanogaster
• Sequence 2: XP_012824447.1
• Gene: col4a6 / 100493153
• XenbaseID: XB-GENE-6034568
• Length: 1709
• Species: Xenopus tropicalis
• Alignment Length: 1862
• Identity: 741/1862 - (39%)
• Similarity: 898/1862 - (48%)
• Gaps: 344/1862 - (18%)

  Fly    30 GKICNTTLCDCKGIKGRMGAPGPIGVPGLEGPAGDIGPPGRAGP---LGEKGDVGEYGEQGEKGH 91
            |:.|:.. |.|...||..|.||.:      ||.|.:||||.:||   .|:||:.|:||.|||.|.
 Frog    35 GRDCSGG-CKCFPEKGARGRPGQL------GPQGPMGPPGFSGPEGVAGQKGERGDYGFQGEAGP 92

  Fly    92 RGDIGPKGEMGYPGIMGKSGEPGTPGPRGIDGCDGRPGMQGPSGAPGQNGVRGPPGKPGQQGPPG 156
            :||:|.:|..|:.|..|..|..|..|.||:.|.||..|..|.||.||.||..|..|.||..||.|
 Frog    93 KGDLGHRGVTGFDGNDGTPGHVGQAGHRGLPGLDGCNGTIGDSGFPGSNGFPGQSGLPGPIGPKG 157

  Fly   157 EAGEGGINSKGTKGNRGETGQPG--GV-GPPGFDGDRGSKGDTGYAGLTGEKGDPGLPGPKGDTG 218
            :.||....|...:|.:||.|.||  |: ||.|..|..|..|..|:.|:.|..|.||:|||.|:.|
 Frog   158 QKGEPSFISSDIRGLKGEDGIPGQEGLPGPRGPPGPEGMSGTAGFPGVPGPPGLPGMPGPTGNRG 222

  Fly   219 AVSELPYSLIGPPGAKGEPGDSLSGVLKPDDTLKGYKGYVGLQGDEGPQGPTGE----------Q 273
            .            |..||.||               ||.||..|..||:..||.          |
 Frog   223 V------------GYYGENGD---------------KGDVGPPGPPGPRASTGPVEFTESAKGIQ 260

  Fly   274 GAVGRNGLPGARGEIGGP--------GERGKPGKDGEPGRFGDKGMKGAPGWTGADGLDGSPGER 330
            |..|..||||.|||.|.|        ||:|:.|..|.||..|..|:.|:.|:.|..|..|.||..
 Frog   261 GDKGDRGLPGFRGEQGFPGLEGFGFSGEKGEKGILGLPGPRGFPGLDGSNGYPGRKGQPGLPGFD 325

  Fly   331 GEDGFTGMPGVQGGAGPPG--IY---DPSLTKSLPGPIGSQGDIGPPGE---QGPPGLPGKPGR- 386
            |..|||||.|.||..|.||  ||   |.......||..|..|.:|.||:   .||||.||:||.
 Frog   326 GLHGFTGMKGEQGNIGLPGTPIYIDEDGLAITGPPGDPGPSGFLGMPGDDGISGPPGPPGQPGLP 390

  Fly   387 ---RGPIGLAGQSGDPGLNGSRGPPGRSERGEAGDYGFIGPPGPQGPPGEAGLPGRYGLHGEPGQ 448
               ||..|.:|..|..||.|.:|.||:...|..|:.|.:|.|||.|||||.|..|....|    |
 Frog   391 SFVRGNPGPSGFPGVQGLKGEQGNPGKPGFGPPGNTGRVGQPGPPGPPGEDGPSGEIAGH----Q 451

  Fly   449 NVVGPKGEPGLNGQPGLEGYRGDRGEVGLPGDKGLPG----EGYNI-VGPPGSQGPPGFRGLPGD 508
            ..:   |||||   ||:.|.||..|::|..|.||..|    ||.:: .|.|||.|.||.||.|
 Frog   452 TAL---GEPGL---PGVPGNRGPPGQIGPKGYKGADGDCACEGGDLSKGSPGSPGLPGQRGSP-- 508

  Fly   509 DGYNGLRGLPGEKGLRGDD-CPVCNAGP---------RGPRGQEGDTGYPGSHGNRGAIGLTGPR 563
             |::||.|:||:.|.||.| .|    ||         .||:|::||..|....|.||..|..|||
 Frog   509 -GFSGLNGIPGDPGRRGSDGLP----GPPGSPGLPWFPGPKGEKGDPVYSTGKGPRGDPGSVGPR 568

  Fly   564 GVQGLQGNPGRAGHKGLPGPAGIPGEPGKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDTGDD 628
            |..|..|.|||.|:.||||..|.||                                    ||..
 Frog   569 GAFGAVGKPGRYGYPGLPGLKGAPG------------------------------------TGGS 597

  Fly   629 GEKGRDGSDGSKGERGETGQRG-DY-GDAGYQGRDGEPGRDGRDGAPG----------------- 674
            ||||..|..|.||.|||||..| .| |..|.:|..|:||:.|..|.||
 Frog   598 GEKGYPGLLGPKGSRGETGPPGIGYPGSPGPRGLPGDPGQAGLPGQPGLAGPPGDCCCGANVGNG 662

  Fly   675 ----RNATTPKVYLIGEPGYDGIKGE------------RGDDGDTGFKGVKGEPNPGQIYDNTGE 723
                ...||....:.||||..||:|.            .|..|..||.|.||:|         |.
 Frog   663 DLVTEGGTTLPCVIAGEPGPPGIRGTPGFPGRKGNMGFPGVPGQQGFDGAKGQP---------GN 718

  Fly   724 PGEDGYTGPKGVKGAKGEQGAIGLRGEIGDRGPAGEV-IPGPVGAKGYPGPT--GDYGQQGAPGL 785
            ||..|..||.|..|.:||:||.|..|..|..|..|:. |||..|.||..|..  ...|..|.|||
 Frog   719 PGFGGIPGPPGFPGPRGEEGAPGFNGLPGSEGLPGKFGIPGSPGLKGLRGEVLGATPGAPGEPGL 783

  Fly   786 PGRDGEPGLDGGIGYKGQRGVPGQEVIQGEIGPPGRSGIKGFPGDVGAPGQYGLAGRPGPKGVKG 850
            ||.:|:.||.|..|..||||..|:..:.|..|..|.||..|.||..|.|| :|     |..|:||
 Frog   784 PGINGDKGLPGDAGLSGQRGFDGRPGLMGAKGERGNSGFPGSPGPKGQPG-FG-----GSMGIKG 842

  Fly   851 EQGPDGAVGQ------TGLPGNKGQRGDFLVGPPGPKGQPGRNGRQAPHGAKGQKGEVGSLGQNG 909
            :|||.|.:|.      .|.|||||..||  .|.||..|..||.|  || |..|:.||:|..|..|
 Frog   843 KQGPPGDIGYPGSPGCQGFPGNKGVPGD--RGIPGIAGMKGRPG--AP-GDAGRPGELGLPGLPG 902

  Fly   910 QNGAKGSIGFSGRRGLLGNAGLQGLPGSPGIPGLPGMI---------GEIGERGEIGYNGRQGDI 965
            ..|.:|..||.|.:|..|..|::|..|.||||||||:.         |:.|::|..|..|.:|..
 Frog   903 TGGREGLPGFQGLKGEKGFPGVRGFAGMPGIPGLPGVSGYKGICGSPGQDGQKGNDGIKGVKGLP 967

  Fly   966 GPRGPNGEFGP-------KGLSGDDGPDGYP------GANGLPGRKGETGNPGFPGRPGAKGVAA 1017
            |.|||.|...|       ||..|:.||.|.|      |..|.||..|..|||||||.||..
 Frog   968 GDRGPPGAVMPPPPGLLSKGAQGEQGPSGPPGFTGPRGDKGFPGLPGIPGNPGFPGNPGRD---- 1028

  Fly  1018 YSGIKGDDGESGLTGPIGYPGAPGAKGQRGPVGDSQPALDGVAGRKGEVGSPGPNGLPGRHGLKG 1082
                ||..|:.|..|..|.||.||.||:.|.:|     ..|:.|..|..|.||.:|.||..||.|
 Frog  1029 ----KGFPGDPGFPGAFGRPGFPGPKGEPGIIG-----FPGMPGPNGADGIPGVSGFPGSPGLPG 1084

  Fly  1083 QRGDRGLPGQQGRPGEPGAKGLGGYPGRNGINGLK------GATGFPGPQGPKGPQGESGVVGLD 1141
            .:|:||  ...|:||.||.||..|.||.:|:.|..      |:.|..|..|||||.||.|.:|..
 Frog  1085 PKGERG--ETLGQPGRPGVKGETGIPGISGLRGFDGMPGDVGSIGISGNPGPKGPPGEFGRIGQP 1147

  Fly  1142 GRNGQIGDQGPRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRSFYRGFTGDQ------GLQGERG 1200
            |..||.|.:|..||:|..|..|..|..|..|.||          .:||.|.|      ||.|.:|
 Frog  1148 GNPGQQGYRGNPGLVGSSGLPGSPGSPGYPGAPG----------LKGFPGSQGIGGLNGLAGSKG 1202

  Fly  1201 EQG-----DMGPIGFIGPPGAKGER-------GDIGYAGQLGFDGAEGLKGFQGDQGPRGPPGIT 1253
            ..|     :.|..|..|.||.||||       |..|:.|..||.|..||.|..|..|..||||.:
 Frog  1203 SPGTPGLSEAGRPGTPGFPGPKGERGSPSTISGQPGFPGSKGFPGERGLPGAVGLPGLPGPPGFS 1267

  Fly  1254 ----LPAEKGDEGVAGLDGRAGRPGHFGQKGAPGPPGENGPNGAIGHRGPQIQGPPGPQGDVGFP 1314
                :|...||.|..|.||.||.||..|.:|.|||....|..|..|:  |.|.|.||.:|:.|.|
 Frog  1268 FPSAIPGRPGDPGFPGRDGEAGLPGLPGPRGPPGPGSNQGDTGDSGY--PGIPGRPGIKGEPGIP 1330

  Fly  1315 GAPGHNGRHGLIGPKGELGDMGRQGERGESGYAIVGRQGDIGDIGFQGEPGWDGAKGEQGYPGLP 1379
            |.||..|..||.|.:|:.|.:|..           |::|.:||      ||:.|.|||:|.||||
 Frog  1331 GNPGSPGAPGLKGLRGDPGFIGSP-----------GKEGSVGD------PGFPGLKGERGNPGLP 1378

  Fly  1380 GKNGRVGAPGP-------RGPTGDAGWGGIDGMDGLVGPKGQPGVTYSYSMARPGDRGEPGLDGF 1437
            |..||   |||       :.|.|..|..||:|.||::|..|.||..     ..||.:|.||..|.
 Frog  1379 GPQGR---PGPPPSIEDYQIPIGLPGLPGINGFDGVLGEIGSPGPN-----GPPGAKGFPGRSGQ 1435

  Fly  1438 QGEEGDGGAPGLIGFQGQRGAVGYRGDQGEVGYTGADGPQGQRGDKGYMGLTGAPGLRGLPGPQG 1502
            .|..|..||||.|            ||.||:|..|..|.:|..|.:|.:||.|.|| |.:
 Frog  1436 MGRNGPPGAPGPI------------GDPGEIGIPGTSGLEGSPGKQGAVGLPGMPG-RSV----- 1482

  Fly  1503 EPAPAPPAPKSRGFIFARHSQSVHVPQCPANTNLLWEGYSLSGNVAASRAVGQDLGQSGSCMMRF 1567
                      ..|:...:||||..:|.||.....||:||||.......:|..||||.:|||:.||
 Frog  1483 ----------GVGYTLVKHSQSEQIPPCPLGMARLWDGYSLLFVEGQEKAHNQDLGLAGSCLPRF 1537

  Fly  1568 TTMPYMLCDITNVCHFAQNNDDSLWLSTAEPMPMTMTPIQGRDLMKYISRCVVCETTTRIIALHS 1632
            :|||::.|:|..||::|..||.|.||||..|:|  |.|:...::..|||||.|||.:::.:|:||
 Frog  1538 STMPFIYCNINEVCYYASRNDKSYWLSTTAPIP--MMPVGSTEIKNYISRCSVCEASSQAVAVHS 1600

  Fly  1633 QSMSIPDCPGGWEEMWTGYSYFMSTLDNVGGVGQNLVSPGSCLEEFRAQPVIECHG-HGRCNYYD 1696
            |..:||.||.||..:|.|||:.|.|.....|.||:|||||||||:|||.|.|||.| .|.|:|:.
 Frog  1601 QDNTIPQCPDGWRSLWIGYSFLMHTAAGAEGGGQSLVSPGSCLEDFRATPFIECSGARGTCHYFA 1665

  Fly  1697 ALASFWLTVIEEQDQFVQ-PRQQTLKA-DFTSKISRCTVCRR 1736
            ...|||||.:||..||.: |..:|||: ...:::|||.||.:
 Frog  1666 NKYSFWLTTVEETRQFARPPTSETLKSGQLRTRVSRCQVCMK 1707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_477190.1	gly_rich_SclB	<63..>349	CDD:468478	126/309 (41%)
		gly_rich_SclB	<465..>712	CDD:468478	104/296 (35%)
		gly_rich_SclB	<637..>871	CDD:468478	105/277 (38%)
		gly_rich_SclB	<894..>1132	CDD:468478	106/265 (40%)
		gly_rich_SclB	<1078..>1342	CDD:468478	115/291 (40%)
		gly_rich_SclB	<1228..1515	CDD:468478	111/297 (37%)
		C4	1515..1624	CDD:128421	51/108 (47%)
		C4	1625..1737	CDD:128421	57/115 (50%)
col4a6	XP_012824447.1	gly_rich_SclB	<70..>338	CDD:468478	118/294 (40%)
		gly_rich_SclB	<455..>715	CDD:468478	110/305 (36%)
		gly_rich_SclB	<677..>893	CDD:468478	96/235 (41%)
		gly_rich_SclB	<791..>1050	CDD:468478	115/277 (42%)
		gly_rich_SclB	<983..>1230	CDD:468478	107/271 (39%)
		gly_rich_SclB	<1145..>1373	CDD:468478	96/256 (38%)
		gly_rich_SclB	<1281..>1480	CDD:468478	94/238 (39%)
		C4	1486..1591	CDD:460201	49/106 (46%)
		C4	1594..1707	CDD:460201	57/112 (51%)